metronidazole has been researched along with Acute Lymphoid Leukemia in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diarrhea is common in oncology patients; if it becomes chronic and relapsing, it can be debilitating, hinder planned management, and be difficult to treat." | 1.32 | Probiotics in relapsing and chronic diarrhea. ( Benchimol, EI; Mack, DR, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Castro, CG | 1 |
| Ganc, AJ | 1 |
| Ganc, RL | 1 |
| Petrolli, MS | 1 |
| Hamerschlack, N | 1 |
| Benchimol, EI | 1 |
| Mack, DR | 1 |
| Smedts Walters, H | 1 |
| Bader-Meunier, B | 1 |
| Dommergues, JP | 1 |
| Bromiker, R | 1 |
| Korman, SH | 1 |
| Or, R | 1 |
| Hardan, I | 1 |
| Naparstek, E | 1 |
| Cohen, P | 1 |
| Ben-Shahar, M | 1 |
| Engelhard, D | 1 |
1 trial available for metronidazole and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Fecal microbiota transplant after hematopoietic SCT: report of a successful case.
Topics: Allografts; Anti-Bacterial Agents; Clostridioides difficile; Enterocolitis, Pseudomembranous; Feces; | 2015 |
3 other studies available for metronidazole and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Probiotics in relapsing and chronic diarrhea.
Topics: Anti-Infective Agents; Bone Marrow Transplantation; Child, Preschool; Chronic Disease; Clostridioide | 2004 |
-Hemophagocytic syndrome associated with strongyloidiasis in a child treated for acute lymphoblastic leukemia.
Topics: Antinematodal Agents; Antineoplastic Combined Chemotherapy Protocols; Antitrichomonal Agents; Child; | 1998 |
Severe giardiasis in two patients undergoing bone marrow transplantation.
Topics: Adult; Anemia, Aplastic; Animals; Bone Marrow Transplantation; Gastrointestinal Diseases; Giardia; G | 1989 |