metronidazole has been researched along with Sigmoid Colon Diseases in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case of pneumatosis cystoides intestinalis in the large bowel with complete resolution after eight weeks of metronidazole treatment is reported." | 3.67 | Treatment of pneumatosis coli with metronidazole. Endoscopic follow-up of one case. ( Jauhonen, P; Karttunen, T; Lehtola, J, 1987) |
| "There was no recurrence of the volvulus at 1 to 6 years follow up but 8 patients (9." | 2.68 | Extraperitonealization for sigmoid volvulus: a reappraisal. ( Khanna, AK; Kumar, K; Misra, MK, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rebai, W | 1 |
| Makni, A | 1 |
| Azouz, H | 1 |
| Ksantini, R | 1 |
| Kourda, J | 1 |
| Chebbi, F | 1 |
| Daghfous, A | 1 |
| Ayadi, S | 1 |
| Ftériche, F | 1 |
| Bedioui, H | 1 |
| Jouini, M | 1 |
| Kacem, M | 1 |
| Ammous, A | 1 |
| Ben Safta, Z | 1 |
| Ea, HK | 1 |
| Zeller, V | 1 |
| Chicheportiche, V | 1 |
| Desplaces, N | 1 |
| Ziza, JM | 1 |
| Descloux, A | 1 |
| Wiens, M | 1 |
| Khanna, AK | 1 |
| Misra, MK | 1 |
| Kumar, K | 1 |
| Antonelli, D | 1 |
| Kustrup, JF | 1 |
| Jauhonen, P | 1 |
| Lehtola, J | 1 |
| Karttunen, T | 1 |
1 review available for metronidazole and Sigmoid Colon Diseases
| Article | Year |
|---|---|
Large bowel obstruction due to intrauterine device: associated pelvic inflammatory disease.
Topics: Actinomycosis; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Colostomy; Diagnosis, Diffe | 1999 |
1 trial available for metronidazole and Sigmoid Colon Diseases
| Article | Year |
|---|---|
Extraperitonealization for sigmoid volvulus: a reappraisal.
Topics: Adolescent; Adult; Aged; Ampicillin; Colectomy; Drug Therapy, Combination; Elective Surgical Procedu | 1995 |
4 other studies available for metronidazole and Sigmoid Colon Diseases
| Article | Year |
|---|---|
[Complicated sigmoid tumor: perforated amebiasis].
Topics: Antiprotozoal Agents; Colectomy; Colon, Sigmoid; Dysentery, Amebic; Humans; Intestinal Perforation; | 2010 |
Polybacterial pyomyositis following laparoscopic colectomy for complicated diverticulosis.
Topics: Abdominal Abscess; Aged; Anti-Bacterial Agents; Ceftriaxone; Colectomy; Colon, Sigmoid; Diverticulit | 2007 |
[Paraduodenal hernia: case report of an operative accidental diagnosis].
Topics: Aged; Anti-Bacterial Agents; Anti-Infective Agents; Ceftriaxone; Diverticulitis, Colonic; Duodenal D | 2007 |
Treatment of pneumatosis coli with metronidazole. Endoscopic follow-up of one case.
Topics: Colonoscopy; Female; Follow-Up Studies; Humans; Metronidazole; Middle Aged; Pneumatosis Cystoides In | 1987 |