metronidazole has been researched along with Birth Weight in 10 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Birth Weight: The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether metronidazole reduces early preterm labour in asymptomatic women with positive vaginal fetal fibronectin (fFN) in the second trimester of pregnancy." | 5.12 | A randomised controlled trial of metronidazole for the prevention of preterm birth in women positive for cervicovaginal fetal fibronectin: the PREMET Study. ( Briley, A; Crawshaw, S; Hawken, J; Jones, G; Poston, L; Seed, P; Shennan, A, 2006) |
| "To ascertain whether adjuvant ampicillin and metronidazole given to women in preterm labour with intact membranes would prolong pregnancy and decrease the perinatal mortality and morbidity." | 5.07 | Ampicillin and metronidazole treatment in preterm labour: a multicentre, randomised controlled trial. ( de Jong, P; de Souza, J; Kirsten, G; Moller, G; Norman, K; Pattinson, RC, 1994) |
| "Sexually transmitted diseases were reduced: Trichomonas vaginalis (rate ratio, 0." | 2.70 | Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda. ( Abramowsky, C; Gray, RH; Kigozi, G; Meehan, M; Moulton, LH; O'Brien, KL; Quinn, TC; Robb, M; Serwadda, D; Sewankambo, NK; Wabwire-Mangen, F; Wawer, MJ, 2001) |
| " Driven by these differences and recent legislation mandating the study of drugs in children and neonates, an increasing number of pharmacokinetic studies of antibiotics are being performed in neonates." | 1.46 | Dosing antibiotics in neonates: review of the pharmacokinetic data. ( Cohen-Wolkowiez, M; Greenberg, RG; Rivera-Chaparro, ND, 2017) |
| "Metronidazole population PK was best described by a 1-compartment model." | 1.38 | Population pharmacokinetics of metronidazole evaluated using scavenged samples from preterm infants. ( Benjamin, DK; Cohen-Wolkowiez, M; James, LP; Kashuba, AD; Newman, N; Ouellet, D; Ross, A; Smith, PB; Sullivan, JE; Walsh, MC; White, NR; Zadell, A, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rivera-Chaparro, ND | 1 |
| Cohen-Wolkowiez, M | 2 |
| Greenberg, RG | 1 |
| Briery, CM | 1 |
| Chauhan, SP | 1 |
| Magann, EF | 1 |
| Cushman, JL | 1 |
| Morrison, JC | 1 |
| Ouellet, D | 1 |
| Smith, PB | 1 |
| James, LP | 1 |
| Ross, A | 1 |
| Sullivan, JE | 1 |
| Walsh, MC | 1 |
| Zadell, A | 1 |
| Newman, N | 1 |
| White, NR | 1 |
| Kashuba, AD | 1 |
| Benjamin, DK | 1 |
| Kazy, Z | 2 |
| Puhó, E | 2 |
| Czeizel, AE | 2 |
| Sen, A | 1 |
| Mahalanabis, D | 1 |
| Mukhopadhyay, S | 1 |
| Chakrabarty, K | 1 |
| Singh, AK | 1 |
| Bisai, S | 1 |
| Chakrabarty, M | 1 |
| Halder, D | 1 |
| Islam, MA | 1 |
| Shennan, A | 1 |
| Crawshaw, S | 1 |
| Briley, A | 1 |
| Hawken, J | 1 |
| Seed, P | 1 |
| Jones, G | 1 |
| Poston, L | 1 |
| Ross, SM | 1 |
| van Middelkoop, A | 1 |
| Norman, K | 1 |
| Pattinson, RC | 1 |
| de Souza, J | 1 |
| de Jong, P | 1 |
| Moller, G | 1 |
| Kirsten, G | 1 |
| Gray, RH | 1 |
| Wabwire-Mangen, F | 1 |
| Kigozi, G | 1 |
| Sewankambo, NK | 1 |
| Serwadda, D | 1 |
| Moulton, LH | 1 |
| Quinn, TC | 1 |
| O'Brien, KL | 1 |
| Meehan, M | 1 |
| Abramowsky, C | 1 |
| Robb, M | 1 |
| Wawer, MJ | 1 |
5 trials available for metronidazole and Birth Weight
| Article | Year |
|---|---|
Routine use of antimicrobials by pregnant Indian women does not improve birth outcome: a randomized controlled trial.
Topics: Adult; Anti-Bacterial Agents; Birth Weight; Cephalexin; Female; Genital Diseases, Female; Gestationa | 2005 |
A randomised controlled trial of metronidazole for the prevention of preterm birth in women positive for cervicovaginal fetal fibronectin: the PREMET Study.
Topics: Administration, Oral; Adult; Anti-Infective Agents; Biomarkers; Birth Weight; Cervix Uteri; Double-B | 2006 |
Trichomonas infection in pregnancy--does it affect perinatal outcome?
Topics: Antitrichomonal Agents; Birth Weight; Female; Humans; Infant, Newborn; Metronidazole; Pregnancy; Pre | 1983 |
Ampicillin and metronidazole treatment in preterm labour: a multicentre, randomised controlled trial.
Topics: Adult; Ampicillin; Birth Weight; Drug Therapy, Combination; Female; Gestational Age; Humans; Metroni | 1994 |
Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda.
Topics: Azithromycin; Birth Weight; Cefixime; Drug Therapy, Combination; Endophthalmitis; Female; Folic Acid | 2001 |
5 other studies available for metronidazole and Birth Weight
| Article | Year |
|---|---|
Dosing antibiotics in neonates: review of the pharmacokinetic data.
Topics: Adult; Aminoglycosides; Anti-Bacterial Agents; beta-Lactams; Birth Weight; Body Size; Cephalosporins | 2017 |
Treatment of bacterial vaginosis does not reduce preterm birth among high-risk asymptomatic women in fetal fibronectin positive patients.
Topics: Adult; Anti-Infective Agents; Apgar Score; Birth Weight; Chi-Square Distribution; Enzyme-Linked Immu | 2011 |
Population pharmacokinetics of metronidazole evaluated using scavenged samples from preterm infants.
Topics: Anti-Infective Agents; Bayes Theorem; Birth Weight; Chromatography, High Pressure Liquid; Creatinine | 2012 |
Gestational age and prevalence of preterm birth after vaginal metronidazole treatment during pregnancy.
Topics: Administration, Intravaginal; Anti-Infective Agents; Birth Weight; Case-Control Studies; Female; Ges | 2004 |
Effect of vaginal metronidazole + miconazole treatment during pregnancy for gestational age and birth weight in a population-based study.
Topics: Administration, Intravaginal; Adult; Antifungal Agents; Birth Weight; Case-Control Studies; Female; | 2005 |