metronidazole has been researched along with Chorioretinitis in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Chorioretinitis: Inflammation of the choroid in which the sensory retina becomes edematous and opaque. The inflammatory cells and exudate may burst through the sensory retina to cloud the vitreous body.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twelve patients with extremely severe uveitis and two patients with necrotizing (chorio-)retinitis were treated with a combination of antibiotics consisting of penicillin G, gentamicin and metronidazole." | 3.66 | [High-dosage combination antibiotic treatment in severe therapy-resistant uveitis and necrotizing (chorio)retinitis]. ( Dietze, U; Fricke, HJ; Heydenreich, A; Illéssy, A; Schröder, D, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DJABRI, SE | 1 |
| DIALLINAS, N | 1 |
| Fricke, HJ | 1 |
| Heydenreich, A | 1 |
| Dietze, U | 1 |
| Illéssy, A | 1 |
| Schröder, D | 1 |
2 other studies available for metronidazole and Chorioretinitis
| Article | Year |
|---|---|
[SIGNIFICANCE OF LAMBLIASIS AS AN ETIOLOGIC FACTOR IN SEROUS CENTRAL CHORIORETINITIS].
Topics: Adrenocorticotropic Hormone; Anti-Bacterial Agents; Chorioretinitis; Giardiasis; Humans; Imidazoles; | 1964 |
[High-dosage combination antibiotic treatment in severe therapy-resistant uveitis and necrotizing (chorio)retinitis].
Topics: Adolescent; Adult; Anti-Bacterial Agents; Chorioretinitis; Drug Therapy, Combination; Female; Gentam | 1983 |