metronidazole has been researched along with Gas Gangrene in 20 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Gas Gangrene: A severe condition resulting from bacteria invading healthy muscle from adjacent traumatized muscle or soft tissue. The infection originates in a wound contaminated with bacteria of the genus CLOSTRIDIUM. C. perfringens accounts for the majority of cases (over eighty percent), while C. noyvi, C. septicum, and C. histolyticum cause most of the other cases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In contrast, clindamycin was highly effective over a broad dosing range (8." | 5.27 | Comparison of clindamycin, rifampin, tetracycline, metronidazole, and penicillin for efficacy in prevention of experimental gas gangrene due to Clostridium perfringens. ( Laine, BM; Maier, KA; Mitten, JE; Stevens, DL, 1987) |
| " However, vancomycin and fosfomycin, which revealed suboptimal in vitro bactericidal activity, proved as efficacious as penicillin G and imipenem in an experimental mode of murine gas gangrene." | 3.67 | Clostridium perfringens type A. Comparison of in vitro and in vivo activity of twelve antimicrobial drugs. ( Traub, WH, 1986) |
| "The efficacy of hyperbaric oxygen (HBO) alone and in combination with several antimicrobial agents was evaluated in a lethal model of gas gangrene in mice." | 1.29 | Evaluation of antimicrobials combined with hyperbaric oxygen in a mouse model of clostridial myonecrosis. ( Anderson, LH; Mehm, WJ; Muhvich, KH, 1994) |
| " In contrast, clindamycin was highly effective over a broad dosing range (8." | 1.27 | Comparison of clindamycin, rifampin, tetracycline, metronidazole, and penicillin for efficacy in prevention of experimental gas gangrene due to Clostridium perfringens. ( Laine, BM; Maier, KA; Mitten, JE; Stevens, DL, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (55.00) | 18.7374 |
| 1990's | 6 (30.00) | 18.2507 |
| 2000's | 3 (15.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yildiz, T | 1 |
| Gündeş, S | 1 |
| Willke, A | 1 |
| Solak, M | 1 |
| Toker, K | 1 |
| Delotte, J | 1 |
| Karimdjee, BS | 1 |
| Cua, E | 1 |
| Pop, D | 1 |
| Bernard, JL | 1 |
| Bongain, A | 1 |
| Benchimol, D | 1 |
| Willis, AT | 1 |
| Gehanno, P | 1 |
| Saint-Guily, JL | 1 |
| Régnier, B | 1 |
| Vachon, F | 1 |
| Vutskits, Z | 1 |
| Pashby, NL | 1 |
| Muhvich, KH | 1 |
| Anderson, LH | 1 |
| Mehm, WJ | 1 |
| Stevens, DL | 3 |
| Bryant, AE | 1 |
| Adams, K | 1 |
| Mader, JT | 1 |
| Thom, S | 1 |
| Heimbach, D | 1 |
| Chowdhury, PS | 1 |
| Timmis, SB | 1 |
| Marcovitz, PA | 1 |
| Rouquette-Vincenti, I | 1 |
| Petitjeans, F | 1 |
| Villevieille, T | 1 |
| Szymczyszyn, P | 1 |
| Fangio, P | 1 |
| Baranger, B | 1 |
| Brinquin, L | 1 |
| Welsch, H | 1 |
| Martens, F | 1 |
| Van Velthofen, V | 1 |
| Calliauw, L | 1 |
| Traub, WH | 1 |
| Maier, KA | 1 |
| Laine, BM | 2 |
| Mitten, JE | 2 |
| Bignardi, GE | 1 |
| Freeman, WA | 1 |
| McFadzean, JA | 1 |
| Whelan, JP | 1 |
1 review available for metronidazole and Gas Gangrene
| Article | Year |
|---|---|
A role for hyperbaric oxygen in clostridial myonecrosis.
Topics: Animals; Combined Modality Therapy; Gas Gangrene; Hyperbaric Oxygenation; Metronidazole; Mice; Myosi | 1993 |
19 other studies available for metronidazole and Gas Gangrene
| Article | Year |
|---|---|
Spontaneous, nontraumatic gas gangrene due to Clostridium perfringens.
Topics: Amikacin; Anti-Bacterial Agents; Anti-Infective Agents; Blister; Ceftazidime; Clostridium perfringen | 2006 |
Gas gangrene of the breast: management of a potential life-threatening infection.
Topics: Abscess; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Breast Diseases; Fema | 2009 |
Treatment of anaerobic infections.
Topics: Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Infections; Clostridium Infections; Clostridiu | 1984 |
[Cellulitis of the neck due to anaerobic germs: report of 10 cases (author's transl)].
Topics: Anaerobiosis; Cellulitis; Gas Gangrene; Humans; Metronidazole; Neck; Penicillin G | 1982 |
[The role of metronidazole (Klion) in the prevention of anaerobic wound infection in vascular diseases].
Topics: Amputation Stumps; Arterial Occlusive Diseases; Gas Gangrene; Humans; Leg; Metronidazole; Surgical W | 1982 |
Metronidazole in the treatment of gas gangrene following lower limb amputation.
Topics: Aged; Amputation, Surgical; Gas Gangrene; Humans; Male; Metronidazole | 1981 |
Evaluation of antimicrobials combined with hyperbaric oxygen in a mouse model of clostridial myonecrosis.
Topics: Animals; Clindamycin; Combined Modality Therapy; Disease Models, Animal; Female; Gas Gangrene; Hyper | 1994 |
Evaluation of therapy with hyperbaric oxygen for experimental infection with Clostridium perfringens.
Topics: Animals; Clindamycin; Clostridium perfringens; Dose-Response Relationship, Immunologic; Female; Gas | 1993 |
Use of hyperbaric oxygen.
Topics: Animals; Clindamycin; Combined Modality Therapy; Gas Gangrene; Hyperbaric Oxygenation; Metronidazole | 1993 |
Clostridium perfringens within intracardiac thrombus: a case of intracardiac gas gangrene.
Topics: Aged; Anti-Bacterial Agents; Cardiomyopathy, Dilated; Clostridium perfringens; Echocardiography, Tra | 1999 |
[Obesity, diabetes mellitus, and gas gangrene: a major therapeutic challenge].
Topics: Abscess; Amikacin; Anus Diseases; Buttocks; Candidiasis; Ceftazidime; Colostomy; Combined Modality T | 2001 |
[Fournier gangrene].
Topics: Ceftazidime; Chloramphenicol; Combined Modality Therapy; Drainage; Drug Therapy, Combination; Gas Ga | 1992 |
Post-traumatic brain abscess with Clostridium perfringens.
Topics: Adolescent; Brain Abscess; Combined Modality Therapy; Frontal Bone; Gas Gangrene; Humans; Male; Metr | 1989 |
Clostridium perfringens type A. Comparison of in vitro and in vivo activity of twelve antimicrobial drugs.
Topics: Animals; Anti-Bacterial Agents; Cephalosporins; Clostridium perfringens; Fosfomycin; Gas Gangrene; I | 1986 |
Comparison of clindamycin, rifampin, tetracycline, metronidazole, and penicillin for efficacy in prevention of experimental gas gangrene due to Clostridium perfringens.
Topics: Animals; Anti-Bacterial Agents; Clindamycin; Clostridium perfringens; Female; Gas Gangrene; Male; Me | 1987 |
Comparison of single and combination antimicrobial agents for prevention of experimental gas gangrene caused by Clostridium perfringens.
Topics: Animals; Clindamycin; Clostridium perfringens; Drug Therapy, Combination; Female; Gas Gangrene; Male | 1987 |
Gas gangrene.
Topics: Drug Hypersensitivity; Gas Gangrene; Humans; Metronidazole; Penicillins | 1988 |
Gas gangrene.
Topics: Anti-Bacterial Agents; Gas Gangrene; Humans; Male; Metronidazole | 1988 |
Activity of metronidazole against experimental tetanus and gas gangrene.
Topics: Animals; Clostridium; Clostridium perfringens; Clostridium tetani; Gas Gangrene; Metronidazole; Mice | 1968 |