metronidazole has been researched along with Infections, Microspora in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Microsporidiosis is recognized as an increasingly important infection, particularly in patients with human immunodeficiency virus (HIV) infection." | 2.40 | Microsporidial disease in HIV-infected patients: a report of 42 patients and review of the literature. ( Crowe, SM; Leder, K; Ryan, N; Spelman, D, 1998) |
| "Treatment with albendazole led to clinical responses in six of 10 patients, and dietary manipulation resulted in clinical improvement in eight of nine patients." | 2.39 | Clinical features of microsporidiosis in patients with AIDS. ( Asmuth, DM; DeGirolami, PC; Desai, G; Ezratty, CR; Federman, M; Pleskow, DK; Wanke, CA, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gisder, S | 1 |
| Genersch, E | 1 |
| Asmuth, DM | 1 |
| DeGirolami, PC | 1 |
| Federman, M | 1 |
| Ezratty, CR | 1 |
| Pleskow, DK | 1 |
| Desai, G | 1 |
| Wanke, CA | 1 |
| Leder, K | 1 |
| Ryan, N | 1 |
| Spelman, D | 1 |
| Crowe, SM | 1 |
| Gumbo, T | 1 |
| Hobbs, RE | 1 |
| Carlyn, C | 1 |
| Hall, G | 1 |
| Isada, CM | 1 |
| von Gottberg, AM | 1 |
| Dini, LA | 1 |
| Frean, JA | 1 |
| Grimwood, AJ | 1 |
3 reviews available for metronidazole and Infections, Microspora
| Article | Year |
|---|---|
Clinical features of microsporidiosis in patients with AIDS.
Topics: Adult; AIDS-Related Opportunistic Infections; Albendazole; Animals; Boston; CD4-Positive T-Lymphocyt | 1994 |
Microsporidial disease in HIV-infected patients: a report of 42 patients and review of the literature.
Topics: Adult; Aged; Albendazole; Animals; Anti-Infective Agents; Antiprotozoal Agents; Apansporoblastina; E | 1998 |
Microsporidia infection in transplant patients.
Topics: Animals; Anti-Infective Agents; Cyclosporine; Diarrhea; Feces; Graft Rejection; Heart Transplantatio | 1999 |
2 other studies available for metronidazole and Infections, Microspora
| Article | Year |
|---|---|
Identification of candidate agents active against N. ceranae infection in honey bees: establishment of a medium throughput screening assay based on N. ceranae infected cultured cells.
Topics: Animals; Antifungal Agents; Bees; Cyclohexanes; Drug Evaluation, Preclinical; Fatty Acids, Unsaturat | 2015 |
Confirmation of transmission of the microsporidian parasite Enterocytozoon bieneusi in South Africa.
Topics: Adult; AIDS-Related Opportunistic Infections; Albendazole; Animals; Anti-Bacterial Agents; Antinemat | 2000 |