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metronidazole and Infections, Microspora

metronidazole has been researched along with Infections, Microspora in 5 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
"Microsporidiosis is recognized as an increasingly important infection, particularly in patients with human immunodeficiency virus (HIV) infection."2.40Microsporidial disease in HIV-infected patients: a report of 42 patients and review of the literature. ( Crowe, SM; Leder, K; Ryan, N; Spelman, D, 1998)
"Treatment with albendazole led to clinical responses in six of 10 patients, and dietary manipulation resulted in clinical improvement in eight of nine patients."2.39Clinical features of microsporidiosis in patients with AIDS. ( Asmuth, DM; DeGirolami, PC; Desai, G; Ezratty, CR; Federman, M; Pleskow, DK; Wanke, CA, 1994)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's1 (20.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gisder, S1
Genersch, E1
Asmuth, DM1
DeGirolami, PC1
Federman, M1
Ezratty, CR1
Pleskow, DK1
Desai, G1
Wanke, CA1
Leder, K1
Ryan, N1
Spelman, D1
Crowe, SM1
Gumbo, T1
Hobbs, RE1
Carlyn, C1
Hall, G1
Isada, CM1
von Gottberg, AM1
Dini, LA1
Frean, JA1
Grimwood, AJ1

Reviews

3 reviews available for metronidazole and Infections, Microspora

ArticleYear
Clinical features of microsporidiosis in patients with AIDS.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1994, Volume: 18, Issue:5

    Topics: Adult; AIDS-Related Opportunistic Infections; Albendazole; Animals; Boston; CD4-Positive T-Lymphocyt

1994
Microsporidial disease in HIV-infected patients: a report of 42 patients and review of the literature.
    Scandinavian journal of infectious diseases, 1998, Volume: 30, Issue:4

    Topics: Adult; Aged; Albendazole; Animals; Anti-Infective Agents; Antiprotozoal Agents; Apansporoblastina; E

1998
Microsporidia infection in transplant patients.
    Transplantation, 1999, Feb-15, Volume: 67, Issue:3

    Topics: Animals; Anti-Infective Agents; Cyclosporine; Diarrhea; Feces; Graft Rejection; Heart Transplantatio

1999

Other Studies

2 other studies available for metronidazole and Infections, Microspora

ArticleYear
Identification of candidate agents active against N. ceranae infection in honey bees: establishment of a medium throughput screening assay based on N. ceranae infected cultured cells.
    PloS one, 2015, Volume: 10, Issue:2

    Topics: Animals; Antifungal Agents; Bees; Cyclohexanes; Drug Evaluation, Preclinical; Fatty Acids, Unsaturat

2015
Confirmation of transmission of the microsporidian parasite Enterocytozoon bieneusi in South Africa.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2000, Volume: 90, Issue:3

    Topics: Adult; AIDS-Related Opportunistic Infections; Albendazole; Animals; Anti-Bacterial Agents; Antinemat

2000