metronidazole has been researched along with Surgical Incision in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dry socket was the most common complication in the antibiotics group (six subjects), while acutely inflamed sockets was the most common in the placebo group (five subjects)." | 2.82 | Are systemic antibiotics necessary in the prevention of wound healing complications after intra-alveolar dental extraction? ( Adetoye, JO; Dipo-Fagbemi, IM; Ebigwei, S; Gbotolorun, OM; Olojede, AO, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghahramani, L | 1 |
| Minaie, MR | 1 |
| Arasteh, P | 1 |
| Hosseini, SV | 1 |
| Izadpanah, A | 1 |
| Bananzadeh, AM | 1 |
| Ahmadbeigi, M | 1 |
| Hooshanginejad, Z | 1 |
| Gbotolorun, OM | 1 |
| Dipo-Fagbemi, IM | 1 |
| Olojede, AO | 1 |
| Ebigwei, S | 1 |
| Adetoye, JO | 1 |
2 trials available for metronidazole and Surgical Incision
| Article | Year |
|---|---|
Antibiotic therapy for prevention of fistula in-ano after incision and drainage of simple perianal abscess: A randomized single blind clinical trial.
Topics: Abscess; Anti-Bacterial Agents; Antibiotic Prophylaxis; Anus Diseases; Ciprofloxacin; Drainage; Huma | 2017 |
Are systemic antibiotics necessary in the prevention of wound healing complications after intra-alveolar dental extraction?
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Double-Blind Method; Dry Socket; Female; Humans; Male; Me | 2016 |