Page last updated: 2024-09-27

Histiocytic Sarcoma

Malignant neoplasms composed of MACROPHAGES or DENDRITIC CELLS. Most histiocytic sarcomas present as localized tumor masses without a leukemic phase. Though the biological behavior of these neoplasms resemble lymphomas, their cell lineage is histiocytic not lymphoid.

Synonyms(5)

Synonym
True Malignant Histiocytosis
Histiocytic Sarcoma
Histiocytosis, Malignant
Malignant Histiocytosis
True Histiocytic Lymphoma

Research Excerpts

Overview

ExcerptReference
"Histiocytic sarcoma is the most frequent hematopoietic tumor in rats."( Bauchet, AL; Belluco, S; Château-Joubert, S; Elies, L; Fontaine, JJ; Fouque, MC; Maliver, P; Schorsch, F, 2008)
"Histiocytic sarcoma is a malignant proliferation of cells showing morphologic and immunophenotypic features similar to those of mature tissue histiocytes and is known for its rapid progression and poor prognosis."( Chi, HS; Huh, JR; Jang, S; Jang, YH; Park, CJ, 2009)
"Histiocytic sarcoma is a rare malignant neoplasm that originates from a histiocytic hematopoietic lineage characterized by histiocytic differentiation and its corresponding immunophenotypic features."( Bae, JH; Chung, SM; Eun, CS; Han, DS; Kim, SM; Oh, YH; Paik, SS; Yoo, KD, 2010)
"Histiocytic sarcoma is a rare, aggressive neoplasm that responds poorly to therapy."( Abrahante, JE; Been, RA; DeCoursin, KJ; Hager, CJ; Landman, SR; Largaespada, DA; Linden, MA; Sarver, AL; Starr, TK; Steinbach, M, 2014)
"Histiocytic sarcoma is an extremely rare and aggressive malignant neoplasm of presumed hematopoietic origin."( Cui, Y; Dong, A; Wang, Y; Zuo, C, 2016)
"Histiocytic sarcoma is a rare disorder in humans, however it is seen with appreciable frequency in certain breeds of dogs, such as Bernese mountain dog."( Gregory-Bryson, E; Kiupel, M; Parys, M; Takada, M; Vilar Saavedra, P; Yuzbasiyan-Gurkan, V, 2018)
"Histiocytic sarcoma is a rare lymphohematopoietic malignancy with aggressive clinical course and poor therapy response."( Guenova, ML; Hristoskova, RG; Petkova, NY; Raynov, JI, 2018)
"Canine histiocytic sarcoma is a highly aggressive and metastatic hematopoietic neoplasm that responds poorly to currently available treatment regimens."( Corner, SM; Hix, JM; Kiupel, M; Smyth, LA; Takada, M; Yuzbasiyan-Gurkan, V, 2019)

Treatment

ExcerptReference
"A 66-year-old woman with malignant histiocytosis was treated with a combination of recombinant gamma interferon (GI-3) and etoposide."( Furugori, N; Morimoto, S; Sakata, Y; Suzuki, H; Takemori, H; Yamaya, T; Yoshida, Y, 1990)
"A case of malignant histiocytosis successfully treated with splenectomy and chemotherapy is presented."( Gergely, P; Kónya, L; Tóth, M, 1990)
"A 21-year-old female presenting with malignant histiocytosis was initially treated with conventional aggressive chemotherapy resulting in complete remission (CR) but relapsed within 6 months of discontinuation."( Berry, J; Russell, JA, 1989)
"The incidences of histiocytic sarcoma were increased in dosed groups of males and in females administered 50 mg/kg or greater, and the incidences in 50 and 200 mg/kg males were significantly greater than that in the vehicle control group."( , 2007)
"Canine histiocytic sarcoma is a highly aggressive and metastatic hematopoietic neoplasm that responds poorly to currently available treatment regimens."( Corner, SM; Hix, JM; Kiupel, M; Smyth, LA; Takada, M; Yuzbasiyan-Gurkan, V, 2019)
"The ideal treatment for intracranial histiocytic sarcoma (HS) remains unclear."( Ito, D; Kagawa, Y; Takahashi, T, 2021)
"We describe a unique case of a histiocytic sarcoma that transdifferentiated from blastoid mantle cell lymphoma after extensive therapy."( Al-Kawaaz, M; Gratzinger, D; Hegazi, MM; Kumar, J; Martin, BA; Tan, B, 2022)

Research

Studies (152)

TimeframeStudies, This Condition (%)All Conditions %
pre-199025 (16.45)23.3326
1990's34 (22.37)12.5806
2000's14 (9.21)18.1394
2010's56 (36.84)28.8240
2020's23 (15.13)9.53
DrugIndicatedRelationship StrengthStudiesTrials
adenine0low10
salicylic acid0low20
pteridines0low10
phenytoin0low10
atenolol0low10
ifosfamide0low20
lomustine0low120
mechlorethamine0low30
metronidazole0low10
mitoxantrone0low20
pioglitazone0medium11
procarbazine0low20
rofecoxib0medium11
sodium fluoride0medium11
thalidomide0low40
thiotepa0low10
triclosan0medium11
prednisolone0low110
thyroxine0low10
prednisone0medium181
tyrosine0low10
phenylalanine0low20
cytarabine0low90
thiophenes0low10
thiazoles0low10
nitroblue tetrazolium0low10
podophyllotoxin0low10
glycidol0low10
cladribine0low40
vidarabine0low10
neon0low10
clodronic acid0low10
cephalexin0low10
tetradecanoylphorbol acetate0low20
daunorubicin0medium21
paclitaxel0low10
etoposide0medium132
nimustine0low20
epirubicin0low10
2,5-bis(1-aziridinyl)-3,6-bis(2-methoxyethoxy)-4-benzoquinone0low10
trofosfamide0medium11
delphinidin0low10
fluorodeoxyglucose f180low80
zoledronic acid0low10
bendamustine hydrochloride0low10
artesunic acid0low10
imatinib mesylate0low20
methotrexate0low100
carboplatin0low10
resveratrol0low10
melphalan0low20
bromochloroacetic acid0low10
stilbenes0low10
fludarabine0low10
mercaptopurine0low20
thioguanine anhydrous0low10
digoxin0low10
quinine0low10
dasatinib0low40
naphthoquinones0low20
phenylephrine hydrochloride0low10
sirolimus0low20
morphine0low10
palbociclib0low10
sepantronium0low20
artenimol0low10
trametinib0low80
acid phosphatase0low10
pci 327650low10
plx40320low10
piperidines0low30
dabrafenib0low20
heme0low10
transforming growth factor beta0low10
cyclin d10low10
lewis x antigen0low10
cyclosporine0low20
muramidase0low220
acyclovir0low10
levoleucovorin0low20
guanine0low10
dacarbazine0low20
pemetrexed0low10
hopeaphenol0low10
pyrimidinones0low70

Protein Targets (1,419)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein5005
Chain B, HADH2 protein5005
Chain A, ATP-DEPENDENT DNA HELICASE Q14004
Chain A, Ferritin light chain5005
Thymidine kinase 0101
thioredoxin reductase140014
phosphopantetheinyl transferase9009
GLS protein9009
TDP1 protein370037
Smad3120012
thyroid stimulating hormone receptor4004
EWS/FLI fusion protein320032
arylsulfatase A6006
euchromatic histone-lysine N-methyltransferase 2190019
activating transcription factor 6100010
Histone H2A.x150015
Bloom syndrome protein isoform 19009
hemoglobin subunit beta4004
atrial natriuretic peptide receptor 1 precursor3003
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
lamin isoform A-delta10230023
Solute carrier family 22 member 1 0405
ATP-binding cassette sub-family C member 3020020
Multidrug resistance-associated protein 4020021
Solute carrier family 22 member 60304
Bile salt export pump0404
Bile salt export pump027027
Purine nucleoside phosphorylase0303
Thymidine kinase, cytosolic0103
POU domain, class 2, transcription factor 20001
Cytochrome P450 2C9 09010
Cytochrome P450 2J20202
Disintegrin and metalloproteinase domain-containing protein 171001
Purine nucleoside phosphorylase0022
Solute carrier family 22 member 60103
Thymidine kinase 0101
Solute carrier family 22 member 80103
Canalicular multispecific organic anion transporter 1021022
Thymidine kinase0202
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE140014
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
RAR-related orphan receptor gamma240024
AR protein320032
nuclear receptor subfamily 1, group I, member 3260026
cytochrome P450 family 3 subfamily A polypeptide 4200020
glucocorticoid receptor [Homo sapiens]240024
estrogen-related nuclear receptor alpha260026
pregnane X nuclear receptor230023
estrogen nuclear receptor alpha340034
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a200020
nuclear factor erythroid 2-related factor 2 isoform 2130013
heat shock protein beta-14004
importin subunit beta-1 isoform 14004
snurportin-14004
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 12002
Voltage-dependent calcium channel gamma-2 subunit170017
Cyclin-dependent kinase 103710
Heat shock protein HSP 90-beta0101
Glutamate receptor 2170017
Xanthine dehydrogenase/oxidase0202
TAR DNA-binding protein 437108
Protein mono-ADP-ribosyltransferase PARP150101
Leucine-rich repeat serine/threonine-protein kinase 20213
ATPase family AAA domain-containing protein 5160016
Ataxin-2180018
Cytochrome P450 3A4010113
Cytochrome P450 2B60405
Chain A, TYROSYL-DNA PHOSPHODIESTERASE110011
regulator of G-protein signaling 47007
Beta-1 adrenergic receptor 0011
D(1A) dopamine receptor1001
DNA polymerase iota isoform a (long)100010
geminin270027
Gamma-aminobutyric acid receptor subunit pi7119
Fatty acid-binding protein, liver0202
Urease0101
Beta-2 adrenergic receptor0213
Beta-1 adrenergic receptor0213
Beta-3 adrenergic receptor0011
Gamma-aminobutyric acid receptor subunit beta-17119
Gamma-aminobutyric acid receptor subunit delta7119
Gamma-aminobutyric acid receptor subunit gamma-27119
5-hydroxytryptamine receptor 1A0214
Gamma-aminobutyric acid receptor subunit alpha-57119
Gamma-aminobutyric acid receptor subunit alpha-37119
Gamma-aminobutyric acid receptor subunit gamma-17119
Gamma-aminobutyric acid receptor subunit alpha-27119
Alpha-1D adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit alpha-47119
Gamma-aminobutyric acid receptor subunit gamma-37119
Gamma-aminobutyric acid receptor subunit alpha-67119
Alpha-1A adrenergic receptor0101
Alpha-1B adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit alpha-172110
Gamma-aminobutyric acid receptor subunit beta-37119
Gamma-aminobutyric acid receptor subunit beta-27119
Beta-2 adrenergic receptor0112
GABA theta subunit7119
Gamma-aminobutyric acid receptor subunit epsilon7119
ATP-dependent phosphofructokinase8008
Chain A, Integrase0101
Chain A, Integrase0101
Chain A, T4 LYSOZYME0011
Chain A, GCN4P10011
Chain B, GCN4P10011
Chain C, GCN4P10011
Chain A, T4 LYSOZYME0011
Chain A, T4 LYSOZYME0011
Chain A, Replicase polyprotein 1ab0101
Chain A, 3C-like proteinase0101
pregnane X receptor4004
progesterone receptor160016
retinoid X nuclear receptor alpha210021
peroxisome proliferator-activated receptor delta150015
cellular tumor antigen p53 isoform a100010
Endolysin0011
Cellular tumor antigen p53250025
Integrin beta-391010
Integrin alpha-IIb9009
aldehyde dehydrogenase 1 family, member A1190019
retinoic acid nuclear receptor alpha variant 1240024
thyroid stimulating hormone receptor150015
nuclear factor erythroid 2-related factor 2 isoform 1260026
Nuclear receptor ROR-gamma6118
Chain A, Putative fructose-1,6-bisphosphate aldolase6006
acetylcholinesterase8008
estrogen receptor 2 (ER beta)120012
G130013
cytochrome P450 2D6110011
vitamin D3 receptor isoform VDRA8008
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
DNA polymerase kappa isoform 17007
histone acetyltransferase KAT2A isoform 16006
Interferon beta260026
HLA class I histocompatibility antigen, B alpha chain 130013
Inositol hexakisphosphate kinase 1130013
cytochrome P450 2C9, partial130013
Microtubule-associated protein tau8008
bromodomain adjacent to zinc finger domain 2B2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 18008
mitogen-activated protein kinase 14004
Solute carrier family 15 member 10202
Solute carrier family 15 member 10101
B2 metallo-beta-lactamase 0001
Solute carrier family 15 member 20101
Solute carrier family 15 member 20102
Solute carrier family 22 member 80101
Chain A, BCL-2-RELATED PROTEIN A10011
glp-1 receptor, partial100010
Fumarate hydratase170017
GLI family zinc finger 3220022
farnesoid X nuclear receptor180018
polyprotein170017
67.9K protein170017
IDH1140014
thyroid hormone receptor beta isoform 2220022
huntingtin isoform 25005
tyrosine-protein kinase Yes8008
urokinase-type plasminogen activator precursor9009
plasminogen precursor9009
urokinase plasminogen activator surface receptor precursor9009
nuclear receptor ROR-gamma isoform 1110011
survival motor neuron protein isoform d120012
muscleblind-like protein 1 isoform 15005
relaxin receptor 1 isoform 11001
bcl-2-like protein 11 isoform 10011
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Deoxycytidine kinase00711
Adenosine receptor A30202
Rap guanine nucleotide exchange factor 42002
Type IV secretion-like conjugative transfer relaxase protein TraI 0101
72 kDa type IV collagenase0303
Stromelysin-10112
Matrix metalloproteinase-90303
Macrophage metalloelastase0101
interleukin 84004
ATAD5 protein, partial6006
USP1 protein, partial130013
PPM1D protein130013
P532002
peroxisome proliferator activated receptor gamma170017
vitamin D (1,25- dihydroxyvitamin D3) receptor150015
RPL19A0011
aryl hydrocarbon receptor140014
v-jun sarcoma virus 17 oncogene homolog (avian)110011
Spike glycoprotein0033
Replicase polyprotein 1ab0033
NPC intracellular cholesterol transporter 1 precursor6006
chromobox protein homolog 1130013
thyroid hormone receptor beta isoform a110011
nuclear factor NF-kappa-B p105 subunit isoform 11012
ras-related protein Rab-9A5005
heat shock protein HSP 90-alpha isoform 20002
transactivating tegument protein VP16 [Human herpesvirus 1]0404
cytochrome P450 3A4 isoform 17007
COUP transcription factor 2 isoform a0101
lethal factor (plasmid)5005
Transmembrane protease serine 20033
Glucose transporter0101
Hexose transporter 1 0101
Procathepsin L0033
Polyunsaturated fatty acid 5-lipoxygenase0404
Replicase polyprotein 1a0033
Replicase polyprotein 1ab0033
Replicase polyprotein 1ab0235
Replicase polyprotein 1ab0437
Solute carrier family 2, facilitated glucose transporter member 10101
Alpha-synuclein3104
Spike glycoprotein130316
Eukaryotic initiation factor 4A-I0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0415
Peptidyl-prolyl cis-trans isomerase FKBP30101
Peptidyl-prolyl cis-trans isomerase FKBP40101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10101
Hypoxia-inducible factor 1-alpha0101
Endothelial PAS domain-containing protein 10101
Angiotensin-converting enzyme 2 0033
Peptidyl-prolyl cis-trans isomerase FKBP140101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 40101
heat shock protein 90, putative0002
endonuclease IV2002
LMP1 [Human herpesvirus 4]0003
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0303
serine/threonine-protein kinase mTOR isoform 15005
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
peripheral myelin protein 22110011
nuclear receptor coactivator 3 isoform a0303
Thymidine kinase 2, mitochondrial0101
Thymidine kinase0101
Thymidylate synthase0304
Thymidine kinase0101
Probable deoxycytidylate deaminase0002
Cytidine deaminase0104
D(1A) dopamine receptor2002
E3 ubiquitin-protein ligase Mdm20101
Enoyl-[acyl-carrier-protein] reductase [NADH] 0303
Deoxynucleoside kinase0101
Bone morphogenetic protein receptor type-1B0077
Membrane-associated progesterone receptor component 10055
Cell division cycle 7-related protein kinase0055
Serine/threonine-protein kinase PLK40077
ATP-dependent RNA helicase DDX3X0077
Pirin0202
Pyridoxal kinase0077
Citron Rho-interacting kinase0077
Serine/threonine-protein kinase Chk10077
Aurora kinase A0178
Cyclin-G-associated kinase0077
Ephrin type-B receptor 60077
Peroxisomal acyl-coenzyme A oxidase 30077
Receptor-interacting serine/threonine-protein kinase 203710
Mitotic checkpoint serine/threonine-protein kinase BUB10077
Dynamin-like 120 kDa protein, mitochondrial0077
Tyrosine-protein kinase JAK20257
Eukaryotic translation initiation factor 5B0044
Rho-associated protein kinase 20077
Serine/threonine-protein kinase ULK10077
Serine/threonine-protein kinase/endoribonuclease IRE10077
Nuclear receptor subfamily 1 group I member 20033
Ribosomal protein S6 kinase alpha-50077
U5 small nuclear ribonucleoprotein 200 kDa helicase0077
Ribosomal protein S6 kinase alpha-40077
Serine/threonine-protein kinase 160077
Cyclin-dependent kinase-like 50055
Serine/threonine-protein kinase 100077
Serine/threonine-protein kinase D30088
Structural maintenance of chromosomes protein 20077
Mitogen-activated protein kinase kinase kinase 60077
Mitogen-activated protein kinase kinase kinase kinase 40077
Serine/threonine-protein kinase LATS10077
Serine/threonine-protein kinase PAK 40077
Tyrosine-protein kinase ABL1071019
Epidermal growth factor receptor07815
GTPase KRas0202
RAF proto-oncogene serine/threonine-protein kinase0327
High affinity nerve growth factor receptor0077
Guanine nucleotide-binding protein G(i) subunit alpha-20066
ADP/ATP translocase 20077
Protein kinase C beta type0189
Insulin receptor0178
Tyrosine-protein kinase Lck05712
Tyrosine-protein kinase Fyn07714
Glycogen phosphorylase, liver form0077
Tyrosine-protein kinase Fes/Fps0077
Adenine phosphoribosyltransferase0066
Tyrosine-protein kinase Yes0279
Tyrosine-protein kinase Lyn0279
Proto-oncogene tyrosine-protein kinase receptor Ret0279
Insulin-like growth factor 1 receptor0178
Signal recognition particle receptor subunit alpha0066
Cytochrome c1, heme protein, mitochondrial0077
Hepatocyte growth factor receptor0077
Tyrosine-protein kinase HCK03710
Platelet-derived growth factor receptor beta04711
Tyrosine-protein kinase Fgr0156
Serine/threonine-protein kinase A-Raf0279
Glycogen phosphorylase, brain form0077
Breakpoint cluster region protein03914
Serine/threonine-protein kinase pim-10077
Fibroblast growth factor receptor 103710
DNA topoisomerase 2-alpha02716
Cyclin-dependent kinase 40279
ADP/ATP translocase 30077
Inosine-5'-monophosphate dehydrogenase 20066
Proto-oncogene tyrosine-protein kinase Src05712
cAMP-dependent protein kinase type II-alpha regulatory subunit0077
Serine/threonine-protein kinase B-raf02913
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0077
Ribosyldihydronicotinamide dehydrogenase [quinone]02810
Tyrosine-protein kinase Fer0077
Protein kinase C alpha type02911
cAMP-dependent protein kinase catalytic subunit alpha0077
General transcription and DNA repair factor IIH helicase subunit XPD0077
Casein kinase II subunit alpha'0178
Ras-related protein Rab-6A0077
Ephrin type-A receptor 10066
Multifunctional protein ADE20077
cAMP-dependent protein kinase catalytic subunit gamma0055
cAMP-dependent protein kinase catalytic subunit beta0077
Ferrochelatase, mitochondrial0088
Ribosomal protein S6 kinase beta-10077
Tyrosine-protein kinase JAK10279
Cyclin-dependent kinase 204812
Beta-adrenergic receptor kinase 10077
Probable ATP-dependent RNA helicase DDX60077
Mitogen-activated protein kinase 3 0178
MAP/microtubule affinity-regulating kinase 30077
Mitogen-activated protein kinase 10077
Ephrin type-A receptor 20279
Ephrin type-B receptor 20178
Non-receptor tyrosine-protein kinase TYK20077
UMP-CMP kinase 0055
Phosphatidylethanolamine-binding protein 10066
Wee1-like protein kinase0077
Heme oxygenase 20077
S-adenosylmethionine synthase isoform type-20077
DnaJ homolog subfamily A member 10077
RAC-alpha serine/threonine-protein kinase0178
RAC-beta serine/threonine-protein kinase0178
Dual specificity protein kinase TTK0055
DNA replication licensing factor MCM40077
Myosin-100066
Dual specificity mitogen-activated protein kinase kinase 205712
Receptor-type tyrosine-protein kinase FLT304711
Bone morphogenetic protein receptor type-1A0077
Activin receptor type-1B0077
TGF-beta receptor type-10178
Serine/threonine-protein kinase receptor R30044
TGF-beta receptor type-20077
Electron transfer flavoprotein subunit beta0055
Tyrosine-protein kinase CSK0279
Glycine--tRNA ligase0077
Protein kinase C iota type0088
Exosome RNA helicase MTR40077
Tyrosine-protein kinase Tec0279
Tyrosine-protein kinase ABL20077
Tyrosine-protein kinase FRK0178
Tyrosine-protein kinase SYK0279
26S proteasome regulatory subunit 6B0077
Mitogen-activated protein kinase 80077
Mitogen-activated protein kinase 90077
Dual specificity mitogen-activated protein kinase kinase 40055
Dual specificity mitogen-activated protein kinase kinase 30077
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0066
Casein kinase I isoform alpha0167
Casein kinase I isoform delta0077
MAP kinase-activated protein kinase 20178
Elongation factor Tu, mitochondrial0077
Choline-phosphate cytidylyltransferase A0066
Cysteine--tRNA ligase, cytoplasmic0055
Casein kinase I isoform epsilon0077
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0077
Dual specificity protein kinase CLK10077
Dual specificity protein kinase CLK20077
Dual specificity protein kinase CLK30055
Glycogen synthase kinase-3 alpha0077
Glycogen synthase kinase-3 beta0077
Cyclin-dependent kinase 70279
Cyclin-dependent kinase 90279
Ras-related protein Rab-27A0077
Interleukin-1 receptor-associated kinase 10077
Ribosomal protein S6 kinase alpha-30178
Serine/threonine-protein kinase Nek20077
Serine/threonine-protein kinase Nek30077
Dual specificity mitogen-activated protein kinase kinase 60077
Serine/threonine-protein kinase PLK10066
LIM domain kinase 10178
LIM domain kinase 20178
Mitogen-activated protein kinase 100077
Tyrosine--tRNA ligase, cytoplasmic0077
5'-AMP-activated protein kinase subunit gamma-10078
Ephrin type-B receptor 30077
Ephrin type-A receptor 50077
Ephrin type-B receptor 40178
Ephrin type-A receptor 40077
Adenylate kinase 2, mitochondrial0077
Adenosine kinase0077
Ras-related protein Rab-100077
Actin-related protein 30077
Actin-related protein 20077
GTP-binding nuclear protein Ran0077
Casein kinase I isoform gamma-20077
Cyclin-dependent kinase 30066
Cyclin-dependent kinase 60279
Cyclin-dependent-like kinase 5 0178
Cyclin-dependent kinase 160077
Cyclin-dependent kinase 170077
Heat shock factor protein 10202
ATP-dependent 6-phosphofructokinase, platelet type0077
Dual specificity mitogen-activated protein kinase kinase 104711
DNA topoisomerase 2-beta01816
Protein kinase C theta type0088
Activin receptor type-10077
Macrophage-stimulating protein receptor0077
Focal adhesion kinase 10178
Protein kinase C zeta type0156
Protein kinase C delta type02810
Tyrosine-protein kinase BTK05813
Activated CDC42 kinase 10178
Epithelial discoidin domain-containing receptor 103710
Mitogen-activated protein kinase kinase kinase kinase 20077
Tyrosine-protein kinase Mer0167
Serine/threonine-protein kinase 40077
5'-AMP-activated protein kinase catalytic subunit alpha-10078
Dual specificity mitogen-activated protein kinase kinase 50077
Mitogen-activated protein kinase 70077
Serine/threonine-protein kinase PAK 20066
Serine/threonine-protein kinase 30077
Mitogen-activated protein kinase kinase kinase 10077
Integrin-linked protein kinase0077
Rho-associated protein kinase 10077
Non-receptor tyrosine-protein kinase TNK10077
Receptor-interacting serine/threonine-protein kinase 10112
Calcium/calmodulin-dependent protein kinase type II subunit gamma0077
Calcium/calmodulin-dependent protein kinase type II subunit delta0077
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0077
Activin receptor type-2B0077
Bone morphogenetic protein receptor type-20077
Protein-tyrosine kinase 60279
cGMP-dependent protein kinase 1 0077
Cyclin-dependent kinase 130077
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0077
Protein-tyrosine kinase 2-beta0077
Maternal embryonic leucine zipper kinase0077
Structural maintenance of chromosomes protein 1A0066
Chromodomain-helicase-DNA-binding protein 40066
Peroxisomal acyl-coenzyme A oxidase 10055
Cyclin-dependent kinase 100033
Ephrin type-A receptor 70055
Delta(24)-sterol reductase0077
Ribosomal protein S6 kinase alpha-10279
Dual specificity testis-specific protein kinase 10055
Myosin light chain kinase, smooth muscle0077
Mitogen-activated protein kinase 110178
Serine/threonine-protein kinase STK110077
Serine/threonine-protein kinase N10077
Serine/threonine-protein kinase N20077
Mitogen-activated protein kinase 140189
Calcium/calmodulin-dependent protein kinase type IV0077
Mitogen-activated protein kinase kinase kinase 110077
MAP kinase-activated protein kinase 30033
Discoidin domain-containing receptor 20279
AP2-associated protein kinase 10077
Myosin light chain kinase 30077
Uncharacterized aarF domain-containing protein kinase 50066
Putative heat shock protein HSP 90-beta 20077
Rab-like protein 30055
Serine/threonine-protein kinase MRCK alpha0077
Serine/threonine-protein kinase MRCK gamma0077
Acyl-CoA dehydrogenase family member 100077
Serine/threonine-protein kinase N30066
Serine/threonine-protein kinase ULK30077
Dual serine/threonine and tyrosine protein kinase0112
Uncharacterized protein FLJ452520077
Acyl-CoA dehydrogenase family member 110077
Serine/threonine-protein kinase/endoribonuclease IRE20077
Serine/threonine-protein kinase MARK20077
ATP-dependent RNA helicase DHX300044
Serine/threonine-protein kinase TAO10077
STE20-related kinase adapter protein alpha0077
Myosin-140077
AarF domain-containing protein kinase 10077
ATP-dependent RNA helicase DDX420066
Mitogen-activated protein kinase kinase kinase kinase 30077
MAP kinase-activated protein kinase 50077
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B0044
Misshapen-like kinase 10066
Atypical kinase COQ8A, mitochondrial0077
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0077
Mitogen-activated protein kinase 150077
Serine/threonine-protein kinase Nek90077
ATP-dependent RNA helicase DDX10077
Mitogen-activated protein kinase kinase kinase kinase 10077
Aurora kinase B0178
MAP/microtubule affinity-regulating kinase 40077
Serine/threonine-protein kinase Nek10077
PAS domain-containing serine/threonine-protein kinase0066
Calcium/calmodulin-dependent protein kinase kinase 20077
EKC/KEOPS complex subunit TP53RK0077
Dual specificity testis-specific protein kinase 20066
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0279
Mitogen-activated protein kinase kinase kinase 50077
Mitogen-activated protein kinase kinase kinase 30077
Eukaryotic translation initiation factor 2-alpha kinase 10077
Nucleolar GTP-binding protein 10077
Serine/threonine-protein kinase D20077
NUAK family SNF1-like kinase 20066
RNA cytidine acetyltransferase0077
Serine/threonine-protein kinase SIK20178
STE20-like serine/threonine-protein kinase 0077
Serine/threonine-protein kinase TAO30077
dCTP pyrophosphatase 10077
Dual specificity protein kinase CLK40077
Casein kinase I isoform gamma-10077
Serine/threonine-protein kinase PAK 60055
Phenylalanine--tRNA ligase beta subunit0077
Isoleucine--tRNA ligase, mitochondrial0055
BMP-2-inducible protein kinase0077
Obg-like ATPase 10066
Midasin0077
Interleukin-1 receptor-associated kinase 40077
Mitogen-activated protein kinase kinase kinase 200178
Cyclin-dependent kinase 120077
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130066
Serine/threonine-protein kinase pim-20055
Serine/threonine-protein kinase 260077
Serine/threonine-protein kinase NLK0077
5'-AMP-activated protein kinase subunit gamma-20078
Serine/threonine-protein kinase TBK10077
Septin-90077
Ribosomal protein S6 kinase alpha-60077
TRAF2 and NCK-interacting protein kinase0077
Serine/threonine-protein kinase TAO20077
Serine/threonine-protein kinase ICK0077
RAC-gamma serine/threonine-protein kinase0178
Serine/threonine-protein kinase SIK30178
Mitogen-activated protein kinase kinase kinase 20077
Thyroid hormone receptor-associated protein 30066
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0077
Mitogen-activated protein kinase kinase kinase kinase 50077
Receptor-interacting serine/threonine-protein kinase 30178
Serine/threonine-protein kinase MRCK beta0077
Interleukin-1 receptor-associated kinase 30077
Serine/threonine-protein kinase 240066
Casein kinase I isoform gamma-30077
Mitogen-activated protein kinase kinase kinase 40077
Chain A, 2-oxoglutarate Oxygenase7007
hypoxia-inducible factor 1 alpha subunit7007
Inositol monophosphatase 16006
Isocitrate lyase0101
Leukotriene C4 synthase0011
GALC protein4004
caspase 7, apoptosis-related cysteine protease7007
caspase-37007
nuclear receptor subfamily 1, group I, member 25005
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0213
Serine/threonine-protein kinase 250011
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta0011
Serine/threonine-protein kinase RIO30011
Dual specificity mitogen-activated protein kinase kinase 70011
Inhibitor of nuclear factor kappa-B kinase subunit beta0113
Peripheral plasma membrane protein CASK0011
Serine/threonine-protein kinase DCLK10011
Inhibitor of nuclear factor kappa-B kinase subunit alpha0112
Muscle, skeletal receptor tyrosine-protein kinase0011
Mitogen-activated protein kinase 130112
3-phosphoinositide-dependent protein kinase 10011
Mitogen-activated protein kinase kinase kinase 130011
Death-associated protein kinase 30011
Mitogen-activated protein kinase kinase kinase 70011
NUAK family SNF1-like kinase 10112
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma0011
Voltage-dependent L-type calcium channel subunit alpha-1F0404
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma0011
Serine/threonine-protein kinase PAK 30011
Serine/threonine-protein kinase 17B0011
Cyclin-dependent kinase 140011
Serine/threonine-protein kinase OSR10011
Serine/threonine-protein kinase Chk20011
Tyrosine-protein kinase ABL10101
Proto-oncogene tyrosine-protein kinase Src0112
Transthyretin0337
Receptor tyrosine-protein kinase erbB-20426
Cytochrome P450 1A20404
Neuronal proto-oncogene tyrosine-protein kinase Src 0001
Proto-oncogene tyrosine-protein kinase LCK 0202
Macrophage colony-stimulating factor 1 receptor0415
Proto-oncogene tyrosine-protein kinase ROS0112
Quinolone resistance protein NorA0101
Wee1-like protein kinase 20011
Uncharacterized serine/threonine-protein kinase SBK30011
Cytochrome P450 2D60606
Mast/stem cell growth factor receptor Kit0224
Cytochrome P450 2A60101
Myosin light chain kinase, smooth muscle0011
Angiotensin-converting enzyme 0101
Insulin receptor-related protein0011
Potassium voltage-gated channel subfamily E member 10101
Platelet-derived growth factor receptor alpha0325
Tyrosine-protein kinase Blk0101
Vascular endothelial growth factor receptor 1 0011
Interferon-induced, double-stranded RNA-activated protein kinase0011
Serine/threonine-protein kinase MAK0011
Cyclin-dependent kinase 11B0011
Fibroblast growth factor receptor 20011
Receptor tyrosine-protein kinase erbB-30112
Fibroblast growth factor receptor 40011
Fibroblast growth factor receptor 30011
Protein kinase C eta type0022
Activin receptor type-2A0011
Ephrin type-A receptor 30011
Ephrin type-A receptor 80011
Leukocyte tyrosine kinase receptor0011
Tyrosine-protein kinase receptor UFO0011
Mitogen-activated protein kinase 40011
G protein-coupled receptor kinase 40011
Cytochrome P450 2C190607
Prostaglandin G/H synthase 20415
Tyrosine-protein kinase receptor Tie-10011
Vascular endothelial growth factor receptor 30011
Vascular endothelial growth factor receptor 20314
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0112
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0112
Serine/threonine-protein kinase mTOR0224
Megakaryocyte-associated tyrosine-protein kinase0011
Tyrosine-protein kinase TXK0224
G protein-coupled receptor kinase 60066
Tyrosine-protein kinase ZAP-700011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0112
Cyclin-dependent kinase 80011
Tyrosine-protein kinase Blk0224
Potassium voltage-gated channel subfamily KQT member 10101
Cytoplasmic tyrosine-protein kinase BMX0224
cAMP-dependent protein kinase catalytic subunit PRKX0022
Serine/threonine-protein kinase Nek40011
Tyrosine-protein kinase JAK30224
Death-associated protein kinase 10011
Mitogen-activated protein kinase 120112
5'-AMP-activated protein kinase catalytic subunit alpha-20012
Ephrin type-B receptor 10011
Hormonally up-regulated neu tumor-associated kinase0011
Serine/threonine-protein kinase SIK10213
Receptor-interacting serine/threonine-protein kinase 40011
Cell division control protein 2 homolog0011
Calcium-dependent protein kinase 10011
Tubulin alpha-1A chain0011
Casein kinase II subunit alpha0112
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta0011
SRSF protein kinase 20011
DNA-dependent protein kinase catalytic subunit0101
Mitogen-activated protein kinase kinase kinase 90011
Serine/threonine-protein kinase PknB0011
Cyclin-dependent kinase-like 10011
Myelin transcription factor 10101
Voltage-dependent L-type calcium channel subunit alpha-1D 0404
Protein kinase C epsilon type0123
Angiopoietin-1 receptor0011
Mitogen-activated protein kinase kinase kinase 100011
Tyrosine-protein kinase receptor TYRO30011
Cyclin-dependent kinase 180044
Tyrosine-protein kinase ITK/TSK0224
Myotonin-protein kinase0011
Potassium voltage-gated channel subfamily H member 20707
Mitogen-activated protein kinase kinase kinase 120011
Serine/threonine-protein kinase PAK 10112
cGMP-dependent protein kinase 20011
Serine/threonine-protein kinase PRP4 homolog0011
Calcium/calmodulin-dependent protein kinase type II subunit beta0011
Voltage-dependent L-type calcium channel subunit alpha-1S0404
Voltage-dependent L-type calcium channel subunit alpha-1C0404
Calcium/calmodulin-dependent protein kinase type 10011
Sodium channel protein type 5 subunit alpha0202
Serine/threonine-protein kinase D10022
Serine/threonine-protein kinase 380033
Receptor tyrosine-protein kinase erbB-40123
Ribosomal protein S6 kinase alpha-20011
Rhodopsin kinase GRK10011
NT-3 growth factor receptor0011
BDNF/NT-3 growth factors receptor0011
Mitogen-activated protein kinase 60011
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform0011
Serine/threonine-protein kinase SBK10011
Mitogen-activated protein kinase kinase kinase 190011
Serine/threonine-protein kinase TNNI3K0011
Serine/threonine-protein kinase Nek50011
Breakpoint cluster region protein0101
Mitogen-activated protein kinase kinase kinase 150011
Serine/threonine-protein kinase tousled-like 20011
Serine/threonine-protein kinase 32C0011
Serine/threonine-protein kinase pim-30011
Serine/threonine-protein kinase VRK20011
Myosin light chain kinase family member 40011
Homeodomain-interacting protein kinase 10011
Calcium/calmodulin-dependent protein kinase type 1D0011
Cyclin-dependent kinase-like 30011
Serine/threonine-protein kinase BRSK20011
Serine/threonine-protein kinase NIM10011
Serine/threonine-protein kinase ULK20011
Serine/threonine-protein kinase DCLK20011
Calcium/calmodulin-dependent protein kinase kinase 10011
Casein kinase I isoform alpha-like0011
Homeodomain-interacting protein kinase 40011
Myosin-IIIa0011
Ankyrin repeat and protein kinase domain-containing protein 10011
Serine/threonine-protein kinase Nek110011
Serine/threonine-protein kinase BRSK10011
Serine/threonine-protein kinase 350011
Serine/threonine-protein kinase Nek70033
Rhodopsin kinase GRK70011
Serine/threonine-protein kinase 32A0011
Myosin-IIIb0011
Dual specificity tyrosine-phosphorylation-regulated kinase 20011
Cyclin-dependent kinase-like 20011
Serine/threonine-protein kinase Sgk30011
Atypical kinase COQ8B, mitochondrial0011
Calcium/calmodulin-dependent protein kinase type 1G0033
Cyclin-dependent kinase 150011
SRSF protein kinase 10011
Protein cereblon0226
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha0011
Serine/threonine-protein kinase RIO10011
MAP kinase-interacting serine/threonine-protein kinase 10011
Serine/threonine-protein kinase RIO20011
Cyclin-dependent kinase 190011
Transient receptor potential cation channel subfamily M member 60011
Testis-specific serine/threonine-protein kinase 10011
Serine/threonine-protein kinase 330011
Serine/threonine-protein kinase DCLK30011
Myosin light chain kinase 2, skeletal/cardiac muscle0011
Homeodomain-interacting protein kinase 20011
Tyrosine-protein kinase Srms0011
Homeodomain-interacting protein kinase 30011
Serine/threonine-protein kinase PLK30011
MAP kinase-interacting serine/threonine-protein kinase 20011
Serine/threonine-protein kinase Nek60011
SNF-related serine/threonine-protein kinase0011
Serine/threonine-protein kinase LATS20011
Serine/threonine-protein kinase 360011
Serine/threonine-protein kinase 32B0011
Serine/threonine-protein kinase PLK20011
Serine/threonine-protein kinase MARK10011
Serine/threonine-protein kinase PAK 50011
eIF-2-alpha kinase GCN20011
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0066
Phosphatidylinositol 4-kinase beta0011
Serine/threonine-protein kinase 17A0011
STE20/SPS1-related proline-alanine-rich protein kinase0011
Ephrin type-A receptor 60011
Death-associated protein kinase 20011
Potassium voltage-gated channel subfamily D member 30101
Serine/threonine-protein kinase tousled-like 10011
Long-chain-fatty-acid--CoA ligase 50033
ALK tyrosine kinase receptor0011
Broad substrate specificity ATP-binding cassette transporter ABCG20306
SRSF protein kinase 30011
Cyclin-dependent kinase 11A0011
Aurora kinase C0011
Calcium/calmodulin-dependent protein kinase type II subunit alpha0011
Serine/threonine-protein kinase 38-like0033
Microtubule-associated serine/threonine-protein kinase 10011
NF-kappa-B essential modulator0101
Chain A, Breast cancer type 1 susceptibility protein1001
Luciferase8008
Caspase-73003
runt-related transcription factor 1 isoform AML1b1001
caspase-33003
core-binding factor subunit beta isoform 21001
Polyunsaturated fatty acid lipoxygenase ALOX15B3003
NADH-ubiquinone oxidoreductase chain 40001
ATP-dependent translocase ABCB1011119
Carbonyl reductase [NADPH] 10203
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
Platelet-activating factor receptor1001
Multidrug resistance-associated protein 1 0305
Histamine H2 receptor4004
Histone deacetylase 10101
Reverse transcriptase/RNaseH 0112
Histone deacetylase 80101
Histone deacetylase 60101
Lactoylglutathione lyase0101
Histone acetyltransferase p3000101
CREB-binding protein0101
Thymidine kinase 2 0101
AAA family ATPase 0002
Chain A, Beta-lactamase7007
Chain A, Cruzipain2002
PAX80003
SMAD family member 26006
SMAD family member 36006
STAT3, partial0101
thioredoxin glutathione reductase4004
alpha-galactosidase3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a5005
tumor necrosis factor1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor5005
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
Solute carrier organic anion transporter family member 1A40204
Sodium/potassium-transporting ATPase subunit alpha-1 0202
Sodium/potassium-transporting ATPase subunit beta-10202
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-3 0101
ATP-dependent translocase ABCB10303
Sodium/potassium-transporting ATPase subunit beta-1 0101
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
ATP-dependent translocase ABCB10404
Sodium/potassium-transporting ATPase subunit alpha-20202
Sodium/potassium-transporting ATPase subunit alpha-10101
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10102
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1B30708
Solute carrier organic anion transporter family member 1B10405
Serum paraoxonase/arylesterase 10404
Kinesin-like protein KIF110101
Nucleotide-binding oligomerization domain-containing protein 20202
Genome polyprotein 0202
UDP-glucuronosyltransferase 2B70102
Prothrombin0001
Regulatory protein E20022
DNA topoisomerase 10102
Polyunsaturated fatty acid lipoxygenase ALOX150303
DNA topoisomerase 20002
UDP-glucuronosyltransferase 1A1 0203
Glutamate receptor ionotropic, NMDA 1 0003
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0003
Glutamate receptor ionotropic, NMDA 2B0003
Glutamate receptor ionotropic, NMDA 2C0003
DNA topoisomerase 2-alpha 0001
Glutamate receptor ionotropic, NMDA 2D0003
Tubulin beta-2B chain0316
Integrase 0202
Similar to alpha-tubulin isoform 1 0316
Similar to alpha-tubulin isoform 1 0305
Glutamate receptor ionotropic, NMDA 3B0003
Glutamate receptor ionotropic, NMDA 3A0003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)7007
corticotropin-releasing hormone receptor 20112
corticotropin releasing factor-binding protein0112
glycogen synthase kinase-3 beta isoform 10022
5'-nucleotidase0101
Adenosine deaminase 0002
Chain A, DEOXYNUCLEOSIDE KINASE0101
Equilibrative nucleoside transporter 10101
Hypoxanthine-guanine phosphoribosyltransferase0003
Ricin0101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0022
Purine nucleoside phosphorylase 0012
Shiga toxin subunit A0101
Guanine deaminase0001
DNA repair protein RAD52 homolog isoform a0002
Cytochrome P450 2C80103
Cytochrome P450 3A50001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)5005
15-lipoxygenase, partial4004
glucocerebrosidase1001
potassium voltage-gated channel subfamily H member 2 isoform d2002
Large neutral amino acids transporter small subunit 1 0202
Chain A, JmjC domain-containing histone demethylation protein 3A3003
apical membrane antigen 1, AMA14004
transcriptional regulator ERG isoform 34004
UDP-glucose 6-dehydrogenase0101
Solute carrier family 22 member 80001
UDP-glucose 6-dehydrogenase0101
Prostaglandin G/H synthase 10505
UDP-glucuronosyltransferase 1A1 0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
acid sphingomyelinase1001
dopamine D1 receptor2002
ClpP2002
Thymidylate synthase 0202
Thymidylate synthase 0202
polyunsaturated fatty acid lipoxygenase ALOX121001
DNA polymerase beta2002
flap endonuclease 13003
DNA polymerase eta isoform 13003
M-phase phosphoprotein 83003
caspase-1 isoform alpha precursor1001
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0405
Dihydrofolate reductase0304
Dihydrofolate reductase 0202
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0304
Thymidylate synthase0303
Carbonic anhydrase 20619
Thymidylate synthase0404
Bifunctional dihydrofolate reductase-thymidylate synthase0101
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10022
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0325
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0202
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0202
Dihydrofolate reductase0303
Histidine decarboxylase0112
Trifunctional purine biosynthetic protein adenosine-30303
Bifunctional purine biosynthesis protein ATIC0404
Delta-type opioid receptor0315
Mu-type opioid receptor0418
Kappa-type opioid receptor0315
Reduced folate transporter0303
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Solute carrier organic anion transporter family member 1A30002
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30202
Solute carrier family 22 member 200202
Dihydrofolate reductase 0101
Solute carrier family 22 member 60202
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0304
Multidrug resistance associated protein0102
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Thioredoxin reductase 0101
Flavodoxin0001
Lanosterol 14-alpha demethylase0101
Chain A, Probable serine/threonine-protein kinase pknB0101
WRN1001
NFKB1 protein, partial2002
Thrombopoietin1001
DNA polymerase III, partial1001
hypothetical protein, conserved2002
nonstructural protein 10101
LANA0001
Parkin3003
pyruvate kinase2002
phospholipase A2, group III0101
cytochrome P450 2D6 isoform 11001
interferon gamma precursor0001
histone-lysine N-methyltransferase NSD2 isoform 10001
atrial natriuretic peptide receptor 2 precursor2002
protein AF-9 isoform a0001
dual specificity tyrosine-phosphorylation-regulated kinase 1A0001
rac GTPase-activating protein 1 isoform a0101
Vpr3003
muscarinic acetylcholine receptor M13003
pyruvate kinase PKM isoform b1001
Solute carrier family 22 member 20203
5-hydroxytryptamine receptor 40202
Solute carrier family 22 member 30202
Glycoprotein hormones alpha chain1001
Amyloid-beta precursor protein1113
Aldo-keto reductase family 1 member B10404
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Ornithine decarboxylase1001
Muscarinic acetylcholine receptor M10202
Angiotensin-converting enzyme0202
Sodium-dependent noradrenaline transporter 0415
5-hydroxytryptamine receptor 2C0202
Guanine nucleotide-binding protein G1001
Casein kinase II subunit beta0101
NEDD8-activating enzyme E1 regulatory subunit0011
Nuclear receptor subfamily 3 group C member 3 0202
Multidrug and toxin extrusion protein 20101
Casein kinase II subunit alpha 30101
NEDD8-activating enzyme E1 catalytic subunit0011
Multidrug and toxin extrusion protein 10101
Single-stranded DNA cytosine deaminase1001
P2Y purinoceptor 120101
phosphoglycerate kinase1001
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
Opioid receptor, delta 1b 0101
Acetylcholinesterase0202
Opioid receptor homologue0101
Acyl-CoA desaturase 10101
Muscarinic acetylcholine receptor M10112
Muscarinic acetylcholine receptor M30112
Muscarinic acetylcholine receptor M40112
Muscarinic acetylcholine receptor M50112
Alpha-2A adrenergic receptor0011
Muscarinic acetylcholine receptor M20112
Translocator protein0011
Proteinase-activated receptor 10112
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0102
Kappa-type opioid receptor0214
Mu-type opioid receptor0214
UDP-glucuronosyltransferase 1A30001
Delta-type opioid receptor0416
Kappa-type opioid receptor0202
Kappa-type opioid receptor0214
Mu-type opioid receptor0215
Nociceptin receptor0101
5-hydroxytryptamine receptor 70202
Mu-type opioid receptor0101
Mu-type opioid receptor0303
Mas-related G-protein coupled receptor member X20011
Mu-type opioid receptor0101
Sigma non-opioid intracellular receptor 10101
peripheral myelin protein 22 isoform 13003
Tubulin alpha-1A chain0225
Tubulin beta chain0224
Tubulin beta-4A chain0226
Integrin alpha-V 0101
Tubulin beta chain0226
60 kDa chaperonin0101
Tubulin alpha-3C chain0226
Botulinum neurotoxin type A 0101
Apoptosis regulator Bcl-20202
60 kDa heat shock protein, mitochondrial0101
UDP-glucuronosyltransferase 1-60101
Substance-K receptor0202
UDP-glucuronosyltransferase 1A40101
Cholecystokinin receptor type A0202
Melanocortin receptor 50202
UDP-glucuronosyltransferase 2B10 0101
10 kDa heat shock protein, mitochondrial0101
Tubulin alpha-1B chain0226
Tubulin alpha-4A chain0226
Tubulin beta-4B chain0226
Bcl-2-like protein 10303
Tubulin beta-3 chain0327
Tubulin beta-2A chain0226
Thiosulfate sulfurtransferase0101
Beta-tubulin 0101
Tubulin beta-8 chain0226
60 kDa chaperonin 0101
Tubulin alpha-3E chain0226
Tubulin alpha-1A chain0226
10 kDa chaperonin 0101
Tubulin alpha-1C chain0226
Tubulin beta-6 chain0226
Tubulin beta-2B chain0226
Tubulin beta-1 chain0226
Chain B, Cell division protein kinase 60101
Chain B, Cell division protein kinase 60101
Cyclin-T10202
Cyclin-K0101
G2/mitotic-specific cyclin-B10202
Cyclin-A20202
Acetylcholinesterase0101
G1/S-specific cyclin-D10202
G1/S-specific cyclin-E10202
G1/S-specific cyclin-D20101
G1/S-specific cyclin-D30202
Cyclin-H0202
CDK-activating kinase assembly factor MAT10101
Cyclin-A10101
Cyclin-dependent kinase 5 activator 10101
Testosterone 17-beta-dehydrogenase 30101
Putative nucleoside diphosphate kinase0011
Nucleoside diphosphate kinase B0011
Sigma intracellular receptor 20101
Nuclear receptor subfamily 4 group A member 30101
Peroxiredoxin-like 2A0101
Platelet glycoprotein VI0101
Chain A, Thymidylate Synthase0101
Chain A, Thymidylate Synthase0101
Chain A, Thymidylate Synthase0101
Serine hydroxymethyltransferase, cytosolic0112
Thymidylate synthase 0101
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Carbonic anhydrase 120305
Carbonic anhydrase 10507
Plasma kallikrein0002
Alkaline phosphatase, tissue-nonspecific isozyme0101
Carbonic anhydrase 30204
Alkaline phosphatase, tissue-nonspecific isozyme 0101
Intestinal-type alkaline phosphatase0101
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
Carbonic anhydrase 40204
Carbonic anhydrase 60204
Adenosine receptor A10002
Adenosine receptor A2a0002
Carbonic anhydrase 5A, mitochondrial0204
Carbonic anhydrase0103
Carbonic anhydrase 70204
Carbonic anhydrase0002
E3 ubiquitin-protein ligase XIAP0101
Large neutral amino acids transporter small subunit 10203
SLC16A10 protein0002
Carbonic anhydrase 90305
Carbonic anhydrase 0002
Carbonic anhydrase-like protein, putative0002
Carbonic anhydrase0002
Carbonic anhydrase0002
Carbonic anhydrase 0002
Carbonic anhydrase 130102
Monocarboxylate transporter 100002
Carbonic anhydrase 150204
Carbonic anhydrase 130102
Carbonic anhydrase 140305
Phospholipase A-2-activating protein0101
Carbonic anhydrase 5B, mitochondrial0204
beta-2 adrenergic receptor1001
lysosomal alpha-glucosidase preproprotein2002
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41102
Neuronal acetylcholine receptor subunit beta-21102
Gamma-aminobutyric acid 0101
cytochrome P450 2C9 precursor1001
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 2 subunit alpha0101
Gamma-aminobutyric acid receptor subunit alpha-10101
Aldo-keto reductase family 1 member B10101
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0102
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit epsilon0101
Sodium channel protein type 9 subunit alpha0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0101
Sodium channel protein type 2 subunit alpha0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit theta0101
Sodium channel protein type 3 subunit alpha0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit theta0101
CDGSH iron-sulfur domain-containing protein 10101
Free fatty acid receptor 10011
Peroxisome proliferator-activated receptor gamma0101
Steryl-sulfatase0101
Tyrosine-protein phosphatase non-receptor type 10305
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] A 0101
Amine oxidase [flavin-containing] A0202
Peroxisome proliferator-activated receptor alpha0101
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Amine oxidase [flavin-containing] B0303
Peroxisome proliferator-activated receptor gamma0247
Peroxisome proliferator-activated receptor gamma0112
Carnitine O-palmitoyltransferase 1, liver isoform0101
Peroxisome proliferator-activated receptor alpha0112
CDGSH iron-sulfur domain-containing protein 20101
CDGSH iron-sulfur domain-containing protein 10202
Chain A, AKAP9-BRAF fusion protein0101
Serine/threonine-protein kinase B-raf 0101
Dual specificity mitogen-activated protein kinase kinase 40011
Aspartyl/asparaginyl beta-hydroxylase0101
Serine/threonine-protein kinase ATR0011
nuclear receptor subfamily 0 group B member 10101
steroidogenic factor 10101
Regulatory protein E20011
Regulatory protein E20011
Glucocorticoid receptor05212
Prostaglandin G/H synthase 10415
Prostaglandin G/H synthase 20202
Calcium-activated potassium channel subunit alpha-10101
luciferase0001
Estrogen receptor0303
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10404
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Androgen receptor0101
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Histamine H1 receptor0022
Nociceptin receptor0011
Estrogen receptor beta0202
cytochrome P450 2C19 precursor1001
Solute carrier family 22 member 10101
Solute carrier family 22 member 20101
Potassium channel subfamily K member 20101
Albumin0112
Histidine-rich protein PFHRP-II0101
Cytochrome P450 2D10101
Cytochrome P450 2D260101
Cytochrome P450 2D30101
Solute carrier organic anion transporter family member 1A10101
Solute carrier family 22 member 10203
Cytochrome P450 2D40101
Solute carrier family 22 member 20202
Chain A, Troponin C, slow skeletal and cardiac muscles0011
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
BRCA11001
M18 aspartyl aminopeptidase0101
cathepsin L10101
hexokinase-4 isoform 11001
histone deacetylase 9 isoform 32002
glucokinase regulatory protein1001
FAD-linked sulfhydryl oxidase ALR0001
Vif0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 10101
transcription factor p65 isoform 10011
serine/threonine-protein kinase 33 isoform a0011
POsterior Segregation0011
Aryl hydrocarbon receptor0101
Estrogen receptor beta0012
Polyphenol oxidase 20204
Lysine-specific histone demethylase 1A0101
Transient receptor potential cation channel subfamily A member 10112
Myc proto-oncogene protein0102
Cytochrome P450 1A10101
Cholinesterase0101
Cathepsin D0101
Luciferin 4-monooxygenase0112
DNA polymerase alpha catalytic subunit0101
Leukotriene A-4 hydrolase0101
Tyrosinase0303
Aromatase0202
Ornithine decarboxylase0101
Tyrosinase0101
Estrogen receptor0012
Nuclear factor NF-kappa-B p105 subunit0101
Endothelin receptor type B1001
Acetylcholinesterase0202
Sucrase-isomaltase, intestinal0101
Endothelin-1 receptor1001
Dipeptidyl peptidase 40202
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 10101
Nitric oxide synthase, inducible0101
Cannabinoid receptor 10101
Alpha-glucosidase MAL120101
Prostaglandin G/H synthase 20303
Cholinesterase0101
Nuclear factor NF-kappa-B p100 subunit 0101
Squalene synthase0101
Transcription factor p650101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0102
Nuclear factor erythroid 2-related factor 20012
Cytochrome P450 1B10202
N1L 0101
NAD(P)H dehydrogenase [quinone] 10003
Lysosomal alpha-glucosidase0101
Transient receptor potential cation channel subfamily A member 10101
NAD-dependent protein deacetylase sirtuin-20011
NAD-dependent protein deacetylase sirtuin-10013
Prenyltransferase homolog0001
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0011
Zinc finger protein mex-50011
large T antigen0101
inositol monophosphatase 11001
Prostaglandin G/H synthase 20101
Prostaglandin G/H synthase 2 0101
Cytochrome c oxidase subunit 10101
Cytochrome c oxidase subunit 20101
Seed linoleate 13S-lipoxygenase-10101
Calpain-2 catalytic subunit0101
Prostaglandin G/H synthase 10101
Bifunctional epoxide hydrolase 20101
Prostaglandin G/H synthase 2 0101
C-X-C chemokine receptor type 30101
Prostaglandin G/H synthase 1 0101
Transporter0101
Sodium-dependent serotonin transporter0101
chaperonin-containing TCP-1 beta subunit homolog1001
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Tyrosine-protein phosphatase YopH0101
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Cystathionine gamma-lyase0101
Xanthine dehydrogenase/oxidase0101
Carbonic anhydrase0101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit beta-10001
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Eukaryotic translation initiation factor 4E0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Peptidyl-prolyl cis-trans isomerase FKBP50101
Programmed cell death protein 40011
Regulatory-associated protein of mTOR0101
Target of rapamycin complex subunit LST80101
Serine/threonine-protein kinase mTOR 0101
Carbonic anhydrase 0101
Eyes absent homolog 20101
Carbonic anhydrase 0101
Protein kinase C gamma type0112
Beta-1 adrenergic receptor0101
Ras guanyl-releasing protein 30011
Cereblon isoform 40202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Adenosine receptor A30202
Alpha-1B adrenergic receptor0202
Alpha-1A adrenergic receptor0202
serine/threonine-protein kinase PLK12002
Cytochrome P450 2B10101
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
Solute carrier organic anion transporter family member 1A50001
Rap guanine nucleotide exchange factor 31001
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Chain A, enoyl-acyl carrier reductase0101
Chain C, enoyl-acyl carrier reductase0101
Chain A, enoyl-acyl carrier reductase0101
Chain C, enoyl-acyl carrier reductase0101
Chain A, enoyl-acyl carrier reductase0101
Chain C, enoyl-acyl carrier reductase0101
Chain A, Repressor0011
PINK11001
3-oxoacyl-[acyl-carrier-protein] synthase 3 0101
thyrotropin-releasing hormone receptor1001
twin arginine protein translocation system - TatA protein0001
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI0101
DNA gyrase subunit A0101
DNA gyrase subunit B0101
Endoplasmic reticulum chaperone BiP0101
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI0101
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0202
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI0202
Enoyl-acyl carrier reductase0101
Enoyl-acyl-carrier protein reductase 0202
Enoyl-ACP reductase II 0101
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Tubulin--tyrosine ligase0101
Taste receptor type 2 member 140001
Adenosylhomocysteinase0101
RNA-directed RNA polymerase 0112
Butyrophilin subfamily 3 member A10012
Geranylgeranyl pyrophosphate synthase0203
Farnesyl pyrophosphate synthase0202
Neutrophil collagenase0101
Farnesyl diphosphate synthase0101
Matrix metalloproteinase-140101
Farnesyl pyrophosphate synthase 0202
Geranylgeranyl pyrophosphate synthase0202
Farnesyl pyrophosphate synthase 0101
H0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]