Actinomycosis, Cervicofacial

A form of ACTINOMYCOSIS characterized by slow-growing inflammatory lesions of the lymph nodes that drain the mouth (lumpy jaw), reddening of the overlying skin, and intraperitoneal abscesses.

Synonym
Actinomycosis, Cervicofacial

Excerpt	Reference
"Cervicofacial actinomycosis is a disease that is currently encountered as a pseudotumor entity or cold abscess."	( Gleeson, RM; Leafstedt, SW, 1975)
"Cervicofacial actinomycosis is a unique polymicrobic infection of endogenous origin, displaying a highly variable clinical course, ranging from an acute, suppurative lesion to a chronic fibrotic process more suggestive of a malignancy."	( Lerner, PI, 1988)
"Although cervicofacial actinomycosis is known to be the most common type, intraorally and periodontally types occur rarely in a localized fashion."	( Açikgöz, G; Karagöz, F; Kirtiloğlu, T; Sakallioğlu, U, 2003)
"Cervicofacial actinomycosis is an uncommon and progressive infection caused by bacilli of the Actinomyces genus that typically involves intraoral soft tissues but may also involve bone."	( Aronoff, DM; Edwards, SP; Harms, PW; Lebar, B; Newton, DW; Smith, MH, 2011)
"Paediatric cervicofacial actinomycosis is a rare infectious disease caused by Actinomyces spp."	( Angwafo Iii, FF; Mbarga, JA; Mbarga, NF; Nfor, EK; Oben, CE; Sama, CB, 2016)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	54 (62.07)	23.3326
1990's	8 (9.20)	12.5806
2000's	13 (14.94)	18.1394
2010's	10 (11.49)	28.8240
2020's	2 (2.30)	9.53

Drug	Relationship Strength	Studies
bromide	low	1
iodine	low	1
niacin	low	2
azathioprine	low	1
ciprofloxacin	low	1
gentamicin	low	2
isoniazid	low	2
metronidazole	low	2
aminosalicylic acid	low	1
potassium iodide	low	2
probenecid	low	2
sulfadiazine	low	2
sulfamethoxazole	low	1
sulfamethoxypyridazine	low	1
sulfisoxazole	low	1
tetracaine	low	1
prednisone	low	2
penicillin g	low	17
chloramphenicol	low	5
cephalothin	low	1
ampicillin	low	4
penicillin v	low	8
thymol	low	1
framycetin	low	1
erythromycin	low	4
streptomycin	low	4
amoxicillin	low	7
propiconazole	low	1
nicorandil	low	1
cephalosporin c	low	1
beta-lactams	low	3
ertapenem	low	2
demecolcine	low	1
griseofulvin	low	1
clindamycin	low	11
mezlocillin	low	1
lincomycin	low	4
amphotericin b	low	1
clavulanic acid	low	1
sulfur	low	1
nitrofurantoin	low	1
chlorhexidine	low	1
amoxicillin-potassium clavulanate combination	low	8
nystatin a1	low	2
jaw	low	3
tetracycline	low	14
chlortetracycline	low	2
oxytetracycline, anhydrous	low	3
minocycline	low	1
demeclocycline	low	1
hyaluronoglucosaminidase	low	1
rifampin	low	1

Protein Targets (558)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
Microtubule-associated protein tau	7	0	0	7
thioredoxin glutathione reductase	5	0	0	5
Smad3	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	12	0	0	12
microphthalmia-associated transcription factor isoform 9	0	2	0	2
Carbonic anhydrase 1	0	8	0	8
Carbonic anhydrase 2	0	8	0	8
Tyrosine-protein phosphatase non-receptor type 1	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
Chain A, Beta-lactamase	6	0	0	6
Beta-lactamase	0	1	0	4
Beta-lactamase	0	1	0	4
Beta-lactamase	0	0	0	3
Beta-lactamase	0	1	0	4
AR protein	17	0	0	17
apical membrane antigen 1, AMA1	3	0	0	3
estrogen nuclear receptor alpha	23	0	0	23
Beta-lactamase	0	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
DNA polymerase eta isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	8	0	0	8
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
DNA polymerase kappa isoform 1	7	0	0	7
ATP-binding cassette sub-family C member 3	0	15	0	15
Multidrug resistance-associated protein 4	0	15	0	15
Bile salt export pump	0	9	0	9
Bile salt export pump	0	20	0	20
Beta-lactamase SHV-1	0	1	0	4
Beta-lactamase SHV-1	0	2	0	5
Cytochrome P450 2C9	0	6	1	7
Beta-lactamase	0	1	0	4
Kappa-type opioid receptor	0	0	0	3
Solute carrier family 15 member 1	0	6	0	6
Solute carrier family 15 member 1	0	2	0	2
Cytochrome P450 2J2	0	3	0	3
B2 metallo-beta-lactamase	0	0	0	3
Solute carrier family 15 member 2	0	4	0	4
Beta-lactamase	0	1	0	4
Beta-lactamase	0	1	0	4
Solute carrier family 15 member 2	0	4	0	4
Beta-lactamase	0	1	0	4
Beta-lactamase	0	0	0	3
Canalicular multispecific organic anion transporter 1	0	15	0	15
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, Cruzipain	6	0	0	6
interleukin 8	7	0	0	7
phosphopantetheinyl transferase	8	0	0	8
GLS protein	7	0	0	7
glucocorticoid receptor [Homo sapiens]	14	0	0	14
farnesoid X nuclear receptor	11	0	0	11
peroxisome proliferator-activated receptor delta	7	0	0	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
peripheral myelin protein 22	7	0	0	7
lamin isoform A-delta10	10	0	0	10
Cytochrome P450 1A2	0	3	0	3
Cytochrome P450 3A4	0	6	0	6
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2C19	0	3	0	3
Nuclear receptor ROR-gamma	6	0	0	6
Potassium voltage-gated channel subfamily H member 2	0	4	0	5
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Beta-lactamase	0	0	0	3
acid sphingomyelinase	3	0	0	3
GLI family zinc finger 3	14	0	0	14
retinoic acid nuclear receptor alpha variant 1	11	0	0	11
Beta-lactamase	0	1	0	4
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase type 2	0	0	0	3
Metallo-beta-lactamase VIM-11	0	0	0	3
Metallo-beta-lactamase VIM-2	0	0	0	3
Beta-lactamase	0	0	0	4
Metallo-beta-lactamase	0	0	0	3
Beta-lactamase	0	1	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
chromobox protein homolog 1	7	0	0	7
thyroid hormone receptor beta isoform 2	15	0	0	15
DNA polymerase beta	2	0	0	2
geminin	15	0	0	15
60 kDa heat shock protein, mitochondrial	0	3	0	3
Beta-lactamase OXA-7	0	0	0	3
Spike glycoprotein	6	0	0	6
10 kDa heat shock protein, mitochondrial	0	3	0	3
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	3
Thiosulfate sulfurtransferase	0	3	0	3
Metallo-beta-lactamase VIM-13	0	0	0	3
Efflux transporter	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase Toho-1	0	0	0	3
Beta-lactamase	0	0	0	3
Class D beta-lactamase	0	1	0	3
60 kDa chaperonin	0	4	0	4
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	2
10 kDa chaperonin	0	4	0	4
Metallo-b-lactamase	0	0	0	5
Carbapenem-hydrolyzing beta-lactamase KPC	0	2	0	5
Histamine H3 receptor	0	0	0	2
Beta-lactamase class B VIM-2	0	0	0	5
Beta-lactamase VIM-1	0	0	0	3
ATP-dependent phosphofructokinase	4	0	0	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Chain A, Ferritin light chain	2	0	0	2
acetylcholinesterase	4	0	0	4
thioredoxin reductase	5	0	0	5
RAR-related orphan receptor gamma	10	0	0	10
SMAD family member 2	6	0	0	6
ATAD5 protein, partial	4	0	0	4
Fumarate hydratase	2	0	0	2
SMAD family member 3	6	0	0	6
TDP1 protein	13	0	0	13
nuclear receptor subfamily 1, group I, member 3	8	0	0	8
EWS/FLI fusion protein	9	0	0	9
retinoid X nuclear receptor alpha	8	0	0	8
estrogen-related nuclear receptor alpha	14	0	0	14
pregnane X nuclear receptor	13	0	0	13
G	3	0	0	3
polyprotein	2	0	0	2
P53	1	0	0	1
peroxisome proliferator activated receptor gamma	9	0	0	9
arylsulfatase A	3	0	0	3
IDH1	4	0	0	4
aryl hydrocarbon receptor	10	0	0	10
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	10	0	0	10
thyroid stimulating hormone receptor	4	0	0	4
activating transcription factor 6	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
Histone H2A.x	5	0	0	5
Bloom syndrome protein isoform 1	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	2	0	0	2
heat shock protein beta-1	6	0	0	6
survival motor neuron protein isoform d	5	0	0	5
cytochrome P450 3A4 isoform 1	5	0	0	5
M-phase phosphoprotein 8	2	0	0	2
muscleblind-like protein 1 isoform 1	4	0	0	4
muscarinic acetylcholine receptor M1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	5	1	0	7
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Interferon beta	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Cellular tumor antigen p53	11	0	0	11
Gamma-aminobutyric acid receptor subunit beta-1	5	1	0	7
Gamma-aminobutyric acid receptor subunit delta	5	1	0	7
Gamma-aminobutyric acid receptor subunit gamma-2	5	1	0	7
Glutamate receptor 2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	5	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	5	1	0	7
Gamma-aminobutyric acid receptor subunit gamma-1	5	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-2	5	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-4	5	1	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	5	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	5	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-1	5	1	0	7
Gamma-aminobutyric acid receptor subunit beta-3	5	1	0	7
Gamma-aminobutyric acid receptor subunit beta-2	5	1	0	7
GABA theta subunit	5	1	0	7
Inositol hexakisphosphate kinase 1	3	0	0	3
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit epsilon	5	1	0	7
Protein-arginine deiminase type-4	0	10	0	10
cytochrome P450 2C9, partial	3	0	0	3
Carbonic anhydrase 4	0	3	0	3
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 15	0	2	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Beta-lactamase	0	1	0	3
endonuclease IV	1	0	0	1
WRN	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	3
DNA (cytosine-5)-methyltransferase 1 isoform b	0	1	0	1
importin subunit beta-1 isoform 1	3	0	0	3
flap endonuclease 1	4	0	0	4
serine/threonine-protein kinase PLK1	3	0	0	3
snurportin-1	3	0	0	3
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1	0	1	0	1
Solute carrier family 22 member 6	0	3	0	3
Solute carrier family 22 member 8	0	4	0	5
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	3
Beta-lactamase OXA-1	0	1	0	2
Beta-lactamase TEM	0	3	0	6
Beta-lactamase	0	1	0	3
Metallo-beta-lactamase VIM-2	0	0	0	2
Solute carrier family 22 member 6	0	3	0	3
Solute carrier family 22 member 7	0	2	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 22 member 8	0	4	0	5
Solute carrier family 22 member 11	0	3	0	4
Solute carrier family 22 member 8	0	4	0	5
Solute carrier family 22 member 7	0	3	0	4
phosphoglycerate kinase	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	10	0	0	10
cytochrome P450 2D6	4	0	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
streptokinase A precursor	0	0	4	4
lethal factor (plasmid)	4	0	0	4
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
30S ribosomal protein S6	0	4	1	5
30S ribosomal protein S7	0	4	1	5
50S ribosomal protein L15	0	4	1	5
50S ribosomal protein L10	0	4	1	5
50S ribosomal protein L11	0	4	1	5
50S ribosomal protein L7/L12	0	4	1	5
50S ribosomal protein L19	0	4	1	5
50S ribosomal protein L1	0	4	1	5
50S ribosomal protein L20	0	4	1	5
50S ribosomal protein L27	0	4	1	5
50S ribosomal protein L28	0	4	1	5
50S ribosomal protein L29	0	4	1	5
50S ribosomal protein L31	0	4	1	5
50S ribosomal protein L31 type B	0	4	1	5
50S ribosomal protein L32	0	4	1	5
50S ribosomal protein L33	0	4	1	5
50S ribosomal protein L34	0	4	1	5
50S ribosomal protein L35	0	4	1	5
50S ribosomal protein L36	0	4	1	5
30S ribosomal protein S10	0	4	1	5
30S ribosomal protein S11	0	4	1	5
30S ribosomal protein S12	0	4	1	5
30S ribosomal protein S13	0	4	1	5
30S ribosomal protein S16	0	4	1	5
30S ribosomal protein S18	0	4	1	5
30S ribosomal protein S19	0	4	1	5
30S ribosomal protein S20	0	4	1	5
30S ribosomal protein S2	0	4	1	5
30S ribosomal protein S3	0	4	1	5
30S ribosomal protein S4	0	4	1	5
30S ribosomal protein S5	0	4	1	5
30S ribosomal protein S8	0	4	1	5
30S ribosomal protein S9	0	4	1	5
50S ribosomal protein L13	0	4	1	5
50S ribosomal protein L14	0	4	1	5
50S ribosomal protein L16	0	4	1	5
50S ribosomal protein L23	0	4	1	5
30S ribosomal protein S15	0	4	1	5
50S ribosomal protein L17	0	4	1	5
50S ribosomal protein L21	0	4	1	5
50S ribosomal protein L30	0	4	1	5
50S ribosomal protein L6	0	4	1	5
30S ribosomal protein S14	0	4	1	5
30S ribosomal protein S17	0	4	1	5
30S ribosomal protein S1	0	4	1	5
50S ribosomal protein L18	0	4	1	5
50S ribosomal protein L2	0	4	1	5
50S ribosomal protein L3	0	4	1	5
50S ribosomal protein L24	0	4	1	5
50S ribosomal protein L4	0	4	1	5
50S ribosomal protein L22	0	4	1	5
50S ribosomal protein L5	0	4	1	5
30S ribosomal protein S21	0	4	1	5
50S ribosomal protein L25	0	4	1	5
50S ribosomal protein L36 2	0	4	1	5
Methionine--tRNA ligase, mitochondrial	0	0	1	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
Luciferase	4	0	0	4
PAX8	0	0	0	2
glp-1 receptor, partial	4	0	0	4
15-lipoxygenase, partial	3	0	0	3
pregnane X receptor	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
USP1 protein, partial	4	0	0	4
caspase 7, apoptosis-related cysteine protease	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
PINK1	1	0	0	1
thyroid stimulating hormone receptor	7	0	0	7
estrogen receptor 2 (ER beta)	5	0	0	5
progesterone receptor	7	0	0	7
67.9K protein	4	0	0	4
glucocerebrosidase	2	0	0	2
Parkin	1	0	0	1
heat shock protein 90	0	0	1	1
caspase-3	2	0	0	2
calcineurin A1, putative	0	0	1	1
cytochrome P450 2D6 isoform 1	2	0	0	2
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cytochrome P450 2C19 precursor	4	0	0	4
cytochrome P450 2C9 precursor	4	0	0	4
perilipin-5	0	1	0	1
thyroid hormone receptor beta isoform a	5	0	0	5
perilipin-1	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
transcriptional regulator ERG isoform 3	3	0	0	3
huntingtin isoform 2	1	0	0	1
mitogen-activated protein kinase 1	3	0	0	3
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
protein AF-9 isoform a	0	0	0	1
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
bcl-2-related protein A1	0	1	0	1
nuclear receptor ROR-gamma isoform 1	5	0	0	5
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	2
Integrin beta-3	1	0	0	1
72 kDa type IV collagenase	0	2	0	2
Integrin alpha-IIb	1	0	0	1
Matrix metalloproteinase-9	0	2	0	2
Trypanothione reductase	0	1	0	1
Alpha-synuclein	1	2	0	3
Histamine H2 receptor	6	0	0	6
TAR DNA-binding protein 43	3	0	0	3
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Multidrug and toxin extrusion protein 1	0	3	0	3
Spermine oxidase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
P2Y purinoceptor 12	0	2	0	2
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	2	0	4
DNA gyrase subunit B	0	2	0	4
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA topoisomerase 2-alpha	0	1	0	4
DNA gyrase subunit A	0	1	0	2
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	3	0	3
DNA gyrase subunit A	0	3	0	3
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	5
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Neutrophil elastase	0	1	0	1
Cytochrome P450 2B6	0	1	1	2
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	2
dopamine D1 receptor	1	0	0	1
regulator of G-protein signaling 4	3	0	0	3
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
PPM1D protein	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
nuclear receptor subfamily 0 group B member 1	0	1	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
steroidogenic factor 1	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Tubulin beta-2B chain	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Metallo-beta-lactamase VIM-19	0	0	0	2
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
Albumin	0	0	4	4
ATP-dependent translocase ABCB1	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
60 kDa chaperonin	0	1	0	1
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Lanosterol 14-alpha demethylase	0	4	0	4
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
Lethal factor	0	1	0	1
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
Heme oxygenase 1	0	1	0	1
Heme oxygenase 2	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
histone acetyltransferase KAT2A isoform 1	3	0	0	3
N-glycosylase/DNA lyase	0	1	0	1
Polyphenol oxidase 2	0	3	0	3
Myeloperoxidase	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Endonuclease 8-like 1	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Serum paraoxonase/arylesterase 1	0	2	0	2
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Stromelysin-1	0	2	0	2
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	2	0	2
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
Amyloid-beta precursor protein	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	2	0	0	2
Cholesteryl ester transfer protein	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	2	0	0	2
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
beta-2 adrenergic receptor	1	0	0	1
Estrogen receptor	0	0	1	1
Caspase-7	1	0	0	1
Estrogen receptor beta	0	0	1	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Valosin-containing protein	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Replicase polyprotein 1ab	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 9	0	2	0	2
Glucocorticoid receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
alpha-galactosidase	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	2
Carbonic anhydrase 12	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
UDP-glucuronosyltransferase 1-6	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	2
Solute carrier family 22 member 1	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Pannexin-1	0	1	0	1
Solute carrier family 22 member 12	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Pannexin-1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Low molecular weight protein-tyrosine phosphatase A	0	1	0	1
nonstructural protein 1	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
heat shock protein 90, putative	0	0	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	2	0	3
Aurora kinase A	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Dihydropteroate synthase	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Endothelin-1 receptor	0	2	0	2
Protease	0	1	1	2
Endothelin-1 receptor	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
cGMP-gated cation channel alpha-1	0	0	1	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain B, Odorant-binding Protein	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Acetylcholinesterase	0	1	0	1
Cholinesterase	0	1	0	1
Secreted chorismate mutase	0	1	0	1
Heat sensitive channel TRPV3	0	0	1	1
Transient receptor potential cation channel subfamily A member 1	0	1	1	2
Transient receptor potential cation channel subfamily M member 8	0	1	1	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Actinomycosis, Cervicofacial

Synonyms(1)

Research Excerpts

Overview

Research

Studies (87)

Protein Targets (558)

Actinomycosis, Cervicofacial

Synonyms(1)

Research Excerpts

Overview

Research

Studies (87)

Drugs Studied (56)

Protein Targets (558)