metronidazole has been researched along with Infections, Prosthesis-Related in 8 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Colwick, SE | 1 |
| Alkhoury, F | 1 |
| Martin, JT | 1 |
| Ferneini, AM | 1 |
| Rajendran, R | 1 |
| Sreekumar, S | 2 |
| Sudhakar, A | 1 |
| Martínez-Ramos, D | 1 |
| Molina-Martínez, J | 1 |
| Villalba-Munera, V | 1 |
| Salvador-Sanchís, JL | 1 |
| Sbordone, L | 1 |
| Barone, A | 1 |
| Ramaglia, L | 1 |
| Ciaglia, RN | 1 |
| Iacono, VJ | 1 |
| Ericsson, I | 1 |
| Persson, LG | 1 |
| Berglundh, T | 1 |
| Edlund, T | 1 |
| Lindhe, J | 1 |
| Wetzel, AC | 1 |
| Vlassis, J | 1 |
| Caffesse, RG | 1 |
| Hämmerle, CH | 1 |
| Lang, NP | 1 |
| Bellelli, G | 1 |
| Barbisoni, P | 1 |
| Rozzini, R | 1 |
| Trabucchi, M | 1 |
| Bunetel, L | 1 |
| Guérin, J | 1 |
| Agnani, G | 1 |
| Piel, S | 1 |
| Pinsard, H | 1 |
| Corbel, JC | 1 |
| Bonnaure-Mallet, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Surgical Treatment of Peri-implantitis With and Without Adjunctive Use of Antibiotics : a Controlled and Randomized Clinical Study[NCT01857804] | Phase 4 | 100 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 other studies available for metronidazole and Infections, Prosthesis-Related
| Article | Year |
|---|---|
Abdominal aortic aneurysm repair complicated by infection with Clostridium septicum.
Topics: Aged, 80 and over; Anti-Infective Agents; Aortic Aneurysm, Abdominal; Blood Vessel Prosthesis; Blood | 2011 |
Biodegradable tocopherol acetate as a drug carrier to prevent ureteral stent-associated infection.
Topics: Absorbable Implants; Anti-Infective Agents, Urinary; Bacterial Adhesion; Cross Infection; Drug Carri | 2011 |
[Linezolid as alternative treatment for vascular prosthesis infections].
Topics: Acetamides; Anti-Bacterial Agents; Aorta, Abdominal; Blood Vessel Prosthesis; Blood Vessel Prosthesi | 2007 |
Antimicrobial susceptibility of periodontopathic bacteria associated with failing implants.
Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bacteria, Anaerob | 1995 |
The effect of antimicrobial therapy on periimplantitis lesions. An experimental study in the dog.
Topics: Amoxicillin; Animals; Anti-Infective Agents; Dental Implants; Dental Plaque; Dogs; Equipment Contami | 1996 |
Attempts to obtain re-osseointegration following experimental peri-implantitis in dogs.
Topics: Alveolar Process; Animals; Anti-Infective Agents; Bone Regeneration; Chlorhexidine; Dental Implants; | 1999 |
A rare case of successful antibiotic therapy in an elderly man with a retarded aorto-bifemoral graft infection.
Topics: Aged; Ampicillin; Anti-Bacterial Agents; Aortic Aneurysm, Abdominal; Aortic Dissection; Humans; Male | 1999 |
In vitro study of the effect of titanium on porphyromonas gingivalis in the presence of metronidazole and spiramycin.
Topics: Anti-Bacterial Agents; Biocompatible Materials; Dental Implants; Drug Synergism; Humans; In Vitro Te | 2001 |