metronidazole has been researched along with Dental Pulp Disease in 12 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Samples taken from carious dentin (17 cases) and infected pulpal tissues (14 cases) were cultured on control plates and plates containing the mixed drugs." | 1.29 | In vitro antimicrobial susceptibility to combinations of drugs on bacteria from carious and endodontic lesions of human deciduous teeth. ( Hoshino, E; Noda, T; Sato, T; Uematsu, H, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Ribeiro, JS | 1 |
| Münchow, EA | 1 |
| Bordini, EAF | 1 |
| Rodrigues, NS | 1 |
| Dubey, N | 1 |
| Sasaki, H | 1 |
| Fenno, JC | 1 |
| Schwendeman, S | 1 |
| Bottino, MC | 1 |
| Asl Aminabadi, N | 1 |
| Satrab, S | 1 |
| Najafpour, E | 1 |
| Samiei, M | 2 |
| Jamali, Z | 2 |
| Shirazi, S | 2 |
| Aminabadi, NA | 1 |
| Huang, B | 1 |
| Agheli, S | 1 |
| Kargül, B | 1 |
| Tanboga, I | 1 |
| Altinok, B | 1 |
| Velasco-Loera, N | 1 |
| De Alba-Vazquez, Y | 1 |
| Garrocho-Rangel, A | 1 |
| Gonzalez-Amaro, AM | 1 |
| Flores-Reyes, H | 1 |
| Pozos-Guillen, AJ | 1 |
| Khemaleelakul, S | 1 |
| Baumgartner, JC | 1 |
| Pruksakorn, S | 1 |
| Takushige, T | 1 |
| Cruz, EV | 1 |
| Asgor Moral, A | 1 |
| Hoshino, E | 2 |
| Sato, T | 1 |
| Uematsu, H | 1 |
| Noda, T | 1 |
| Dahlén, G | 1 |
| Samuelsson, W | 1 |
| Molander, A | 1 |
| Reit, C | 1 |
| Maros, E | 1 |
| Bartha, K | 1 |
| Langeland, K | 1 |
| Pascon, EA | 1 |
| Cros, P | 1 |
| Freidel, M | 1 |
| Jacquemard, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Comparative Clinical and Radiographic Study of 3Mixstatin vs Tri-Antibiotic Mix and Simvastatin in the Treatment of Primary Molars With Inflammatory Root Resorption A Randomized Clinical Trial[NCT03585751] | 45 participants (Anticipated) | Interventional | 2018-09-30 | Not yet recruiting | |||
| A Randomized Controlled Trial Comparing the Clinical and Radiographic Success of 3Mixtatin Versus Modified 3Mix in Lesion Sterilization and Tissue Repair (LSTR) for The Treatment of Necrotic Primary Molars[NCT05677945] | 24 participants (Anticipated) | Interventional | 2023-03-31 | Not yet recruiting | |||
| Clinical and Radiographic Evaluation of the Synergistic Effect of Nano Silver Particles and Calcium Hydroxide Versus Triple Antibiotic Paste as Antibacterial Agents for Lesion Sterilization and Tissue Repair (LSTR) in Necrotic Primary Molars: Randomized C[NCT05681221] | 22 participants (Anticipated) | Interventional | 2023-02-20 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Dental Pulp Disease
| Article | Year |
|---|---|
[Endodontic treatment of gangrenous teeth--literature review].
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Anti-Infective Agents; Calcium Hydroxide; Chloramphe | 2001 |
2 trials available for metronidazole and Dental Pulp Disease
| Article | Year |
|---|---|
A randomized trial of direct pulp capping in primary molars using MTA compared to 3Mixtatin: a novel pulp capping biomaterial.
Topics: Aluminum Compounds; Anti-Bacterial Agents; Biocompatible Materials; Calcium Compounds; Chi-Square Di | 2016 |
A Randomized Trial Using 3Mixtatin Compared to MTA in Primary Molars with Inflammatory Root Resorption: A Novel Endodontic Biomaterial.
Topics: Aluminum Compounds; Anti-Bacterial Agents; Calcium Compounds; Cefixime; Child; Child, Preschool; Cip | 2016 |
A Randomized Trial Using 3Mixtatin Compared to MTA in Primary Molars with Inflammatory Root Resorption: A Novel Endodontic Biomaterial.
Topics: Aluminum Compounds; Anti-Bacterial Agents; Calcium Compounds; Cefixime; Child; Child, Preschool; Cip | 2016 |
A Randomized Trial Using 3Mixtatin Compared to MTA in Primary Molars with Inflammatory Root Resorption: A Novel Endodontic Biomaterial.
Topics: Aluminum Compounds; Anti-Bacterial Agents; Calcium Compounds; Cefixime; Child; Child, Preschool; Cip | 2016 |
A Randomized Trial Using 3Mixtatin Compared to MTA in Primary Molars with Inflammatory Root Resorption: A Novel Endodontic Biomaterial.
Topics: Aluminum Compounds; Anti-Bacterial Agents; Calcium Compounds; Cefixime; Child; Child, Preschool; Cip | 2016 |
9 other studies available for metronidazole and Dental Pulp Disease
| Article | Year |
|---|---|
Engineering of Injectable Antibiotic-laden Fibrous Microparticles Gelatin Methacryloyl Hydrogel for Endodontic Infection Ablation.
Topics: Anti-Bacterial Agents; Biofilms; Cells, Cultured; Clindamycin; Dental Pulp Diseases; Gelatin; Humans | 2022 |
Conventional endodontic treatment of primary molars using metronidazole as an intra-canal medicament: a pilot study.
Topics: Abscess; Alveolar Bone Loss; Anti-Infective Agents; Child; Dental Fistula; Dental Pulp Diseases; Fem | 2010 |
Comparison of the antibacterial effect of modified 3-mix paste versus Ultrapex over anaerobic microorganisms from infected root canals of primary teeth: an in vitro study.
Topics: Actinomyces; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Infections; Bacteroides; Bifidoba | 2012 |
Identification of bacteria in acute endodontic infections and their antimicrobial susceptibility.
Topics: Abscess; Adolescent; Adult; Amoxicillin; Anti-Bacterial Agents; Bacteria, Anaerobic; Child; Clavulan | 2002 |
Endodontic treatment of primary teeth using a combination of antibacterial drugs.
Topics: Adolescent; Anti-Infective Agents, Local; Bacterial Infections; Child; Child, Preschool; Ciprofloxac | 2004 |
Endodontic treatment of primary teeth using a combination of antibacterial drugs.
Topics: Adolescent; Anti-Infective Agents, Local; Bacterial Infections; Child; Child, Preschool; Ciprofloxac | 2004 |
Endodontic treatment of primary teeth using a combination of antibacterial drugs.
Topics: Adolescent; Anti-Infective Agents, Local; Bacterial Infections; Child; Child, Preschool; Ciprofloxac | 2004 |
Endodontic treatment of primary teeth using a combination of antibacterial drugs.
Topics: Adolescent; Anti-Infective Agents, Local; Bacterial Infections; Child; Child, Preschool; Ciprofloxac | 2004 |
Endodontic treatment of primary teeth using a combination of antibacterial drugs.
Topics: Adolescent; Anti-Infective Agents, Local; Bacterial Infections; Child; Child, Preschool; Ciprofloxac | 2004 |
Endodontic treatment of primary teeth using a combination of antibacterial drugs.
Topics: Adolescent; Anti-Infective Agents, Local; Bacterial Infections; Child; Child, Preschool; Ciprofloxac | 2004 |
Endodontic treatment of primary teeth using a combination of antibacterial drugs.
Topics: Adolescent; Anti-Infective Agents, Local; Bacterial Infections; Child; Child, Preschool; Ciprofloxac | 2004 |
Endodontic treatment of primary teeth using a combination of antibacterial drugs.
Topics: Adolescent; Anti-Infective Agents, Local; Bacterial Infections; Child; Child, Preschool; Ciprofloxac | 2004 |
Endodontic treatment of primary teeth using a combination of antibacterial drugs.
Topics: Adolescent; Anti-Infective Agents, Local; Bacterial Infections; Child; Child, Preschool; Ciprofloxac | 2004 |
In vitro antimicrobial susceptibility to combinations of drugs on bacteria from carious and endodontic lesions of human deciduous teeth.
Topics: Amoxicillin; Bacteria, Anaerobic; Cefaclor; Child; Child, Preschool; Ciprofloxacin; Dental Caries; D | 1993 |
Identification and antimicrobial susceptibility of enterococci isolated from the root canal.
Topics: Ampicillin; Ampicillin Resistance; Anti-Bacterial Agents; Calcium Hydroxide; Clindamycin; Dental Pul | 2000 |
[Local tolerance testing of grinazole implanted in bone].
Topics: Animals; Dental Pulp Diseases; Drug Evaluation, Preclinical; Drug Tolerance; Guinea Pigs; Mandible; | 1985 |
[Value of the synergic association metronidazole-spiramycin in current dental practice. Report of 63 cases].
Topics: Adolescent; Adult; Aged; Child; Dental Pulp Diseases; Drug Synergism; Female; Humans; Leucomycins; M | 1971 |