metronidazole has been researched along with Erosive Duodenitis in 19 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the efficacy of either omeprazole or ranitidine in a second-line quadruple regimen in patients with duodenal ulcer or erosive duodenitis." | 5.09 | Randomized study comparing omeprazole with ranitidine as anti-secretory agents combined in quadruple second-line Helicobacter pylori eradication regimens. ( Balta, A; Bouzakis, H; Broutet, N; Kralios, N; Michopoulos, S; Tsibouris, P; Vougadiotis, J, 2000) |
| "In patients with persisting symptoms after metronidazole treated Giardia infection we commonly found chronic Giardia infection and microscopic duodenal inflammation, especially in illness duration less than 7 months." | 3.74 | Persisting symptoms and duodenal inflammation related to Giardia duodenalis infection. ( Coll, P; Hanevik, K; Hausken, T; Helgeland, L; Langeland, N; Morken, MH; Mørch, K; Strand, EA, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 10 (52.63) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 2 (10.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Makobongo, MO | 1 |
| Einck, L | 1 |
| Peek, RM | 1 |
| Merrell, DS | 1 |
| Kampitak, T | 1 |
| Olafsson, S | 1 |
| Hatlebakk, JG | 1 |
| Berstad, A | 1 |
| Crone, J | 1 |
| Granditsch, G | 1 |
| Huber, WD | 1 |
| Binder, C | 1 |
| Innerhofer, A | 1 |
| Amann, G | 1 |
| Hirschl, AM | 1 |
| Li, XB | 1 |
| Ge, ZZ | 1 |
| Chen, XY | 1 |
| Liu, WZ | 1 |
| Hanevik, K | 1 |
| Hausken, T | 1 |
| Morken, MH | 1 |
| Strand, EA | 1 |
| Mørch, K | 1 |
| Coll, P | 1 |
| Helgeland, L | 1 |
| Langeland, N | 1 |
| Adamek, RJ | 2 |
| Opferkuch, W | 2 |
| Wegener, M | 2 |
| Szymanski, C | 1 |
| Pfaffenbach, B | 1 |
| Ricken, D | 1 |
| Rebora, A | 1 |
| Drago, F | 1 |
| Picciotto, A | 1 |
| Gatto, M | 1 |
| Fernandez Pardal, M | 1 |
| Melero, M | 1 |
| Zurru, C | 1 |
| Scorticati, C | 1 |
| Micheli, F | 1 |
| Khulusi, S | 1 |
| Badve, S | 1 |
| Patel, P | 1 |
| Lloyd, R | 1 |
| Marrero, JM | 1 |
| Finlayson, C | 1 |
| Mendall, MA | 1 |
| Northfield, TC | 1 |
| Cilleruelo Pascual, ML | 1 |
| Urruzuno Tellería, P | 1 |
| Román Riechman, E | 1 |
| Medina Benítez, E | 1 |
| Manzanares López-Manzanares, J | 1 |
| Echávarri Olavarría, F | 1 |
| Molina Arias, M | 1 |
| Tan, WC | 1 |
| Hogan, J | 1 |
| Purkayastha, SK | 1 |
| Lombard, M | 1 |
| Krasner, N | 1 |
| Brieva, L | 1 |
| Ara, JR | 1 |
| Bertol, V | 1 |
| Canellas, A | 1 |
| del Agua, C | 1 |
| Michopoulos, S | 1 |
| Tsibouris, P | 1 |
| Bouzakis, H | 1 |
| Balta, A | 1 |
| Vougadiotis, J | 1 |
| Broutet, N | 1 |
| Kralios, N | 1 |
| Vichev, E | 1 |
| Krŭstev, N | 1 |
| Krŭstev, D | 1 |
| Baeva, N | 1 |
| Kiselova, A | 1 |
| Ianev, N | 1 |
| George, LL | 1 |
| Borody, TJ | 1 |
| Andrews, P | 1 |
| Devine, M | 1 |
| Moore-Jones, D | 1 |
| Walton, M | 1 |
| Brandl, S | 1 |
| Korovina, NA | 1 |
| Levitskaia, SV | 1 |
| Bokser, GV | 1 |
| Spirina, TS | 1 |
| Taranenko, LA | 1 |
| Safonova, TB | 1 |
| Elta, GH | 1 |
| Murphy, R | 1 |
| Behler, EM | 1 |
| Barnett, JL | 1 |
| Nostrant, TT | 1 |
| Kern, S | 1 |
| Appelman, H | 1 |
7 trials available for metronidazole and Erosive Duodenitis
| Article | Year |
|---|---|
Patients with endoscopic gastritis and/or duodenitis improve markedly following eradication of Helicobacter pylori, although less so than patients with ulcers.
Topics: Anti-Bacterial Agents; Anti-Ulcer Agents; Bismuth; Drug Therapy, Combination; Duodenitis; Female; Fo | 2002 |
Modified short-term triple therapy--ranitidine, clarithromycin, and metronidazole--for cure of Helicobacter pylori infection.
Topics: Adult; Aged; Clarithromycin; Drug Therapy, Combination; Duodenitis; Female; Gastritis; Helicobacter | 1995 |
[Short-term triple therapy with pantoprazole, clarithromycin and metronidazole for the healing of Helicobacter pylori infection].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Benzimidazoles; Biopsy; Clarithrom | 1995 |
Pathogenesis of gastric metaplasia of the human duodenum: role of Helicobacter pylori, gastric acid, and ulceration.
Topics: Adult; Aged; Amoxicillin; Antacids; Anti-Ulcer Agents; Drug Therapy, Combination; Duodenal Ulcer; Du | 1996 |
Helicobacter pylori eradication--comparison of three drug regimens and symptomatic assessment in duodenitis and antral gastritis.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Bismuth; Clarithromycin; Drug Therapy, Combination; | 1997 |
Randomized study comparing omeprazole with ranitidine as anti-secretory agents combined in quadruple second-line Helicobacter pylori eradication regimens.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Anti-Ulcer Agents; Drug Administration Schedule; | 2000 |
[Comparative evaluation of the effectiveness of the treatment of gastroduodenal Campylobacter infection in children].
Topics: Anti-Infective Agents; Campylobacter Infections; Duodenitis; Furazolidone; Gastroenteritis; Humans; | 1991 |
12 other studies available for metronidazole and Erosive Duodenitis
| Article | Year |
|---|---|
In vitro characterization of the anti-bacterial activity of SQ109 against Helicobacter pylori.
Topics: Adamantane; Amoxicillin; Antitubercular Agents; Cell Membrane; Chloramphenicol; Clarithromycin; Drug | 2013 |
Selective immunoglobulin M deficiency in a patient with refractory giardiasis.
Topics: Adolescent; Antiprotozoal Agents; Diarrhea; Duodenitis; Giardia lamblia; Giardiasis; Humans; Immunog | 2010 |
Helicobacter pylori in children and adolescents: increase of primary clarithromycin resistance, 1997-2000.
Topics: Adolescent; Amoxicillin; Anti-Bacterial Agents; Child; Child, Preschool; Clarithromycin; Drug Resist | 2003 |
Duodenal gastric metaplasia and Helicobacter pylori infection in patients with diffuse nodular duodenitis.
Topics: Adult; Aged; Case-Control Studies; Chronic Disease; Clarithromycin; Drug Therapy, Combination; Duode | 2007 |
Persisting symptoms and duodenal inflammation related to Giardia duodenalis infection.
Topics: Animals; Biopsy; Cohort Studies; Disease Outbreaks; Duodenitis; Duodenoscopy; Duodenum; Feces; Giard | 2007 |
Helicobacter pylori in patients with rosacea.
Topics: Antibodies, Bacterial; Duodenitis; Female; Gastritis; Helicobacter Infections; Helicobacter pylori; | 1994 |
L-dopa malabsorption in a parkinsonian patient with Strongyloides stercoralis duodenitis.
Topics: Aged; Animals; Duodenitis; Humans; Intestinal Diseases, Parasitic; Levodopa; Male; Mebendazole; Metr | 1994 |
[Triple-therapy treatment during 1 month versus 2 weeks in gastroduodenal disease due to Helicobacter pylori in children].
Topics: Adolescent; Amoxicillin; Anti-Bacterial Agents; Bismuth; Child; Child, Preschool; Drug Evaluation; D | 1996 |
[Polyneuropathy caused by vitamin B12 deficiency secondary to chronic atrophic gastritis and giardiasis].
Topics: Amoxicillin; Anemia, Pernicious; Anti-Bacterial Agents; Antiprotozoal Agents; Bismuth; Duodenitis; E | 1998 |
[Gastroduodenitis and ulcers--statistical study for 1998].
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Anti-Ulcer Agents; Bulgaria; Clarithromycin; Drug Ther | 2000 |
Cure of duodenal ulcer after eradication of Helicobacter pylori.
Topics: Adult; Aged; Anti-Ulcer Agents; Campylobacter Infections; Duodenal Ulcer; Duodenitis; Duodenum; Fema | 1990 |
Campylobacter pylori in patients with dyspeptic symptoms and endoscopic evidence of erosion(s).
Topics: Adolescent; Adult; Aged; Bismuth; Campylobacter; Duodenitis; Dyspepsia; Endoscopy; Gastric Mucosa; G | 1989 |