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metronidazole and Graft-Versus-Host Disease

metronidazole has been researched along with Graft-Versus-Host Disease in 13 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
"In a single-center open-label prospective study, a total of 134 marrow transplant recipients with hematologic malignancies were randomly assigned to a bacterial decontamination medication using metronidazole and ciprofloxacin (n = 68) or ciprofloxacin alone (n = 66) during 5 weeks posttransplant."9.09Influence of intestinal bacterial decontamination using metronidazole and ciprofloxacin or ciprofloxacin alone on the development of acute graft-versus-host disease after marrow transplantation in patients with hematologic malignancies: final results and ( Beelen, DW; Elmaagacli, A; Hirche, H; Müller, KD; Schaefer, UW, 1999)
"We present a case of intestinal amoebiasis unexpectedly revealed by colonoscopy after allogeneic bone marrow transplantation from a human leukocyte antigen-mismatched unrelated donor for acute myeloid leukemia arising from chronic myelomonocytic leukemia and successfully treated by metronidazole."5.42Intestinal amoebiasis in a patient with acute graft-versus-host disease after allogeneic bone marrow transplantation successfully treated by metronidazole. ( Chiba, S; Fujisawa, S; Hagihara, M; Itabashi, M; Kato, H; Kishimoto, K; Kunisaki, R; Kuwabara, H; Motohashi, K; Numata, A; Tanaka, M, 2015)
"In a single-center open-label prospective study, a total of 134 marrow transplant recipients with hematologic malignancies were randomly assigned to a bacterial decontamination medication using metronidazole and ciprofloxacin (n = 68) or ciprofloxacin alone (n = 66) during 5 weeks posttransplant."5.09Influence of intestinal bacterial decontamination using metronidazole and ciprofloxacin or ciprofloxacin alone on the development of acute graft-versus-host disease after marrow transplantation in patients with hematologic malignancies: final results and ( Beelen, DW; Elmaagacli, A; Hirche, H; Müller, KD; Schaefer, UW, 1999)
" Group A (n=5) received metronidazole as graft-versus-host disease prophylaxis during Bu treatment."3.72The effect of metronidazole on busulfan pharmacokinetics in patients undergoing hematopoietic stem cell transplantation. ( Aschan, J; Hassan, M; Hentschke, P; Ljungman, P; Nilsson, C; Ringdén, O, 2003)
"Metronidazole (MTZ) is a nitroimidazole antibiotic used mainly for the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa."2.47Metronidazole and the immune system. ( Ashraf, M; Javeed, A; Riaz, A; Shakir, L, 2011)
"We present a case of intestinal amoebiasis unexpectedly revealed by colonoscopy after allogeneic bone marrow transplantation from a human leukocyte antigen-mismatched unrelated donor for acute myeloid leukemia arising from chronic myelomonocytic leukemia and successfully treated by metronidazole."1.42Intestinal amoebiasis in a patient with acute graft-versus-host disease after allogeneic bone marrow transplantation successfully treated by metronidazole. ( Chiba, S; Fujisawa, S; Hagihara, M; Itabashi, M; Kato, H; Kishimoto, K; Kunisaki, R; Kuwabara, H; Motohashi, K; Numata, A; Tanaka, M, 2015)
"Metronidazole was the primary treatment for 91 of 94 patients, 7 of 8 cases refractory to metronidazole had no response to vancomycin, and none was due to NAP1/027."1.40Clostridium difficile infection after allogeneic hematopoietic stem cell transplant: strain diversity and outcomes associated with NAP1/027. ( Chung, D; Huang, YT; Jakubowski, AA; Kaltsas, A; Kamboj, M; Papanicolaou, G; Sepkowitz, K; Sheahan, A; Sun, J; Wu, S; Xiao, K, 2014)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (23.08)18.2507
2000's3 (23.08)29.6817
2010's7 (53.85)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sakemura, R1
Hayakawa, H1
Iida, H1
Ito, M1
Kajiguchi, T1
Gupta, NK1
Masia, R1
Kamboj, M1
Xiao, K1
Kaltsas, A1
Huang, YT1
Sun, J1
Chung, D1
Wu, S1
Sheahan, A1
Sepkowitz, K1
Jakubowski, AA1
Papanicolaou, G1
Numata, A1
Itabashi, M1
Kishimoto, K1
Motohashi, K1
Hagihara, M1
Kuwabara, H1
Tanaka, M1
Kato, H1
Chiba, S1
Kunisaki, R1
Fujisawa, S1
Brandon, JA1
Jennings, CD1
Kaplan, AM1
Bryson, JS1
Shakir, L1
Javeed, A1
Ashraf, M1
Riaz, A1
Li, HW1
Sachs, J1
Pichardo, C1
Bronson, R1
Zhao, G1
Sykes, M1
Nilsson, C1
Aschan, J1
Hentschke, P1
Ringdén, O1
Ljungman, P1
Hassan, M1
Guthery, SL1
Heubi, JE1
Filipovich, A1
Ghosh, K1
Ayyaril, M1
Nirmala, V1
Beelen, DW1
Elmaagacli, A1
Müller, KD1
Hirche, H1
Schaefer, UW1
Zander, AR1
Zabelina, T1
Kröger, N1
Renges, H1
Krüger, W1
Löliger, C1
Dürken, M1
Stockschläder, M1
de Wit, M1
Wacker-Backhaus, G1
Bielack, S1
Jaburg, N1
Rüssmann, B1
Erttmann, R1
Kabisch, H1
Chakrabarti, S1
Lees, A1
Jones, SG1
Milligan, DW1

Reviews

2 reviews available for metronidazole and Graft-Versus-Host Disease

ArticleYear
Successful Treatment of a Case of Late-onset Colitis after Umbilical Cord Transplantation with Metronidazole: A Case Report and Literature Review.
    Internal medicine (Tokyo, Japan), 2017, Dec-01, Volume: 56, Issue:23

    Topics: Colitis; Cord Blood Stem Cell Transplantation; Diarrhea; Graft vs Host Disease; Hematopoietic Stem C

2017
Metronidazole and the immune system.
    Die Pharmazie, 2011, Volume: 66, Issue:6

    Topics: Adaptive Immunity; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antiprotozoal Agents; Graf

2011

Trials

3 trials available for metronidazole and Graft-Versus-Host Disease

ArticleYear
Enteral metronidazole for the prevention of graft versus host disease in pediatric marrow transplant recipients: results of a pilot study.
    Bone marrow transplantation, 2004, Volume: 33, Issue:12

    Topics: Anti-Infective Agents; Bone Marrow Transplantation; Child; Child, Preschool; Female; Graft vs Host D

2004
Influence of intestinal bacterial decontamination using metronidazole and ciprofloxacin or ciprofloxacin alone on the development of acute graft-versus-host disease after marrow transplantation in patients with hematologic malignancies: final results and
    Blood, 1999, May-15, Volume: 93, Issue:10

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Bone Marrow Transplantation; Ciprofloxacin; Drug Therapy,

1999
Use of a five-agent GVHD prevention regimen in recipients of unrelated donor marrow.
    Bone marrow transplantation, 1999, Volume: 23, Issue:9

    Topics: Adolescent; Adult; Anti-Infective Agents; Antilymphocyte Serum; Bone Marrow Transplantation; Child;

1999

Other Studies

8 other studies available for metronidazole and Graft-Versus-Host Disease

ArticleYear
Cord colitis syndrome: a cause of granulomatous inflammation in the upper and lower gastrointestinal tract.
    The American journal of surgical pathology, 2013, Volume: 37, Issue:7

    Topics: Adult; Anti-Bacterial Agents; Ciprofloxacin; Colitis; Cord Blood Stem Cell Transplantation; Crohn Di

2013
Clostridium difficile infection after allogeneic hematopoietic stem cell transplant: strain diversity and outcomes associated with NAP1/027.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2014, Volume: 20, Issue:10

    Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Child; Child, Preschool; Clostridioides difficile; C

2014
Intestinal amoebiasis in a patient with acute graft-versus-host disease after allogeneic bone marrow transplantation successfully treated by metronidazole.
    Transplant infectious disease : an official journal of the Transplantation Society, 2015, Volume: 17, Issue:6

    Topics: Antiprotozoal Agents; Bone Marrow Transplantation; Dysentery, Amebic; Graft vs Host Disease; Humans;

2015
Murine syngeneic graft-versus-host disease is responsive to broad-spectrum antibiotic therapy.
    Journal of immunology (Baltimore, Md. : 1950), 2011, Mar-15, Volume: 186, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Bone Marrow Transplantation; CD4-Positive T-Lymphocytes; Cell Line;

2011
Nonalloreactive T cells prevent donor lymphocyte infusion-induced graft-versus-host disease by controlling microbial stimuli.
    Journal of immunology (Baltimore, Md. : 1950), 2012, Dec-15, Volume: 189, Issue:12

    Topics: Animals; Ciprofloxacin; Graft vs Host Disease; Inflammation; Lymphocyte Transfusion; Lymphopenia; Me

2012
The effect of metronidazole on busulfan pharmacokinetics in patients undergoing hematopoietic stem cell transplantation.
    Bone marrow transplantation, 2003, Volume: 31, Issue:6

    Topics: Adolescent; Adult; Busulfan; Drug Interactions; Female; Graft vs Host Disease; Hematopoietic Stem Ce

2003
Acute GVHD involving the gastrointestinal tract and infestation with Blastocystis hominis in a patient with chronic myeloid leukaemia following allogeneic bone marrow transplantation.
    Bone marrow transplantation, 1998, Volume: 22, Issue:11

    Topics: Acute Disease; Adult; Animals; Antiprotozoal Agents; Blastocystis hominis; Blastocystis Infections;

1998
Clostridium difficile infection in allogeneic stem cell transplant recipients is associated with severe graft-versus-host disease and non-relapse mortality.
    Bone marrow transplantation, 2000, Volume: 26, Issue:8

    Topics: Adolescent; Adult; Cytomegalovirus Infections; Enterocolitis, Pseudomembranous; Graft vs Host Diseas

2000
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