metronidazole and Graft-Versus-Host Disease
metronidazole has been researched along with Graft-Versus-Host Disease in 13 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Research Excerpts
Excerpt | Relevance | Reference |
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"In a single-center open-label prospective study, a total of 134 marrow transplant recipients with hematologic malignancies were randomly assigned to a bacterial decontamination medication using metronidazole and ciprofloxacin (n = 68) or ciprofloxacin alone (n = 66) during 5 weeks posttransplant." | 9.09 | Influence of intestinal bacterial decontamination using metronidazole and ciprofloxacin or ciprofloxacin alone on the development of acute graft-versus-host disease after marrow transplantation in patients with hematologic malignancies: final results and ( Beelen, DW; Elmaagacli, A; Hirche, H; Müller, KD; Schaefer, UW, 1999) |
"We present a case of intestinal amoebiasis unexpectedly revealed by colonoscopy after allogeneic bone marrow transplantation from a human leukocyte antigen-mismatched unrelated donor for acute myeloid leukemia arising from chronic myelomonocytic leukemia and successfully treated by metronidazole." | 5.42 | Intestinal amoebiasis in a patient with acute graft-versus-host disease after allogeneic bone marrow transplantation successfully treated by metronidazole. ( Chiba, S; Fujisawa, S; Hagihara, M; Itabashi, M; Kato, H; Kishimoto, K; Kunisaki, R; Kuwabara, H; Motohashi, K; Numata, A; Tanaka, M, 2015) |
"In a single-center open-label prospective study, a total of 134 marrow transplant recipients with hematologic malignancies were randomly assigned to a bacterial decontamination medication using metronidazole and ciprofloxacin (n = 68) or ciprofloxacin alone (n = 66) during 5 weeks posttransplant." | 5.09 | Influence of intestinal bacterial decontamination using metronidazole and ciprofloxacin or ciprofloxacin alone on the development of acute graft-versus-host disease after marrow transplantation in patients with hematologic malignancies: final results and ( Beelen, DW; Elmaagacli, A; Hirche, H; Müller, KD; Schaefer, UW, 1999) |
" Group A (n=5) received metronidazole as graft-versus-host disease prophylaxis during Bu treatment." | 3.72 | The effect of metronidazole on busulfan pharmacokinetics in patients undergoing hematopoietic stem cell transplantation. ( Aschan, J; Hassan, M; Hentschke, P; Ljungman, P; Nilsson, C; Ringdén, O, 2003) |
"Metronidazole (MTZ) is a nitroimidazole antibiotic used mainly for the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa." | 2.47 | Metronidazole and the immune system. ( Ashraf, M; Javeed, A; Riaz, A; Shakir, L, 2011) |
"We present a case of intestinal amoebiasis unexpectedly revealed by colonoscopy after allogeneic bone marrow transplantation from a human leukocyte antigen-mismatched unrelated donor for acute myeloid leukemia arising from chronic myelomonocytic leukemia and successfully treated by metronidazole." | 1.42 | Intestinal amoebiasis in a patient with acute graft-versus-host disease after allogeneic bone marrow transplantation successfully treated by metronidazole. ( Chiba, S; Fujisawa, S; Hagihara, M; Itabashi, M; Kato, H; Kishimoto, K; Kunisaki, R; Kuwabara, H; Motohashi, K; Numata, A; Tanaka, M, 2015) |
"Metronidazole was the primary treatment for 91 of 94 patients, 7 of 8 cases refractory to metronidazole had no response to vancomycin, and none was due to NAP1/027." | 1.40 | Clostridium difficile infection after allogeneic hematopoietic stem cell transplant: strain diversity and outcomes associated with NAP1/027. ( Chung, D; Huang, YT; Jakubowski, AA; Kaltsas, A; Kamboj, M; Papanicolaou, G; Sepkowitz, K; Sheahan, A; Sun, J; Wu, S; Xiao, K, 2014) |
Research
Studies (13)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 3 (23.08) | 18.2507 |
2000's | 3 (23.08) | 29.6817 |
2010's | 7 (53.85) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
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Sakemura, R | 1 |
Hayakawa, H | 1 |
Iida, H | 1 |
Ito, M | 1 |
Kajiguchi, T | 1 |
Gupta, NK | 1 |
Masia, R | 1 |
Kamboj, M | 1 |
Xiao, K | 1 |
Kaltsas, A | 1 |
Huang, YT | 1 |
Sun, J | 1 |
Chung, D | 1 |
Wu, S | 1 |
Sheahan, A | 1 |
Sepkowitz, K | 1 |
Jakubowski, AA | 1 |
Papanicolaou, G | 1 |
Numata, A | 1 |
Itabashi, M | 1 |
Kishimoto, K | 1 |
Motohashi, K | 1 |
Hagihara, M | 1 |
Kuwabara, H | 1 |
Tanaka, M | 1 |
Kato, H | 1 |
Chiba, S | 1 |
Kunisaki, R | 1 |
Fujisawa, S | 1 |
Brandon, JA | 1 |
Jennings, CD | 1 |
Kaplan, AM | 1 |
Bryson, JS | 1 |
Shakir, L | 1 |
Javeed, A | 1 |
Ashraf, M | 1 |
Riaz, A | 1 |
Li, HW | 1 |
Sachs, J | 1 |
Pichardo, C | 1 |
Bronson, R | 1 |
Zhao, G | 1 |
Sykes, M | 1 |
Nilsson, C | 1 |
Aschan, J | 1 |
Hentschke, P | 1 |
Ringdén, O | 1 |
Ljungman, P | 1 |
Hassan, M | 1 |
Guthery, SL | 1 |
Heubi, JE | 1 |
Filipovich, A | 1 |
Ghosh, K | 1 |
Ayyaril, M | 1 |
Nirmala, V | 1 |
Beelen, DW | 1 |
Elmaagacli, A | 1 |
Müller, KD | 1 |
Hirche, H | 1 |
Schaefer, UW | 1 |
Zander, AR | 1 |
Zabelina, T | 1 |
Kröger, N | 1 |
Renges, H | 1 |
Krüger, W | 1 |
Löliger, C | 1 |
Dürken, M | 1 |
Stockschläder, M | 1 |
de Wit, M | 1 |
Wacker-Backhaus, G | 1 |
Bielack, S | 1 |
Jaburg, N | 1 |
Rüssmann, B | 1 |
Erttmann, R | 1 |
Kabisch, H | 1 |
Chakrabarti, S | 1 |
Lees, A | 1 |
Jones, SG | 1 |
Milligan, DW | 1 |
Reviews
2 reviews available for metronidazole and Graft-Versus-Host Disease
Article | Year |
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Successful Treatment of a Case of Late-onset Colitis after Umbilical Cord Transplantation with Metronidazole: A Case Report and Literature Review.
Topics: Colitis; Cord Blood Stem Cell Transplantation; Diarrhea; Graft vs Host Disease; Hematopoietic Stem C | 2017 |
Metronidazole and the immune system.
Topics: Adaptive Immunity; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antiprotozoal Agents; Graf | 2011 |
Trials
3 trials available for metronidazole and Graft-Versus-Host Disease
Article | Year |
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Enteral metronidazole for the prevention of graft versus host disease in pediatric marrow transplant recipients: results of a pilot study.
Topics: Anti-Infective Agents; Bone Marrow Transplantation; Child; Child, Preschool; Female; Graft vs Host D | 2004 |
Influence of intestinal bacterial decontamination using metronidazole and ciprofloxacin or ciprofloxacin alone on the development of acute graft-versus-host disease after marrow transplantation in patients with hematologic malignancies: final results and
Topics: Adolescent; Adult; Anti-Bacterial Agents; Bone Marrow Transplantation; Ciprofloxacin; Drug Therapy, | 1999 |
Use of a five-agent GVHD prevention regimen in recipients of unrelated donor marrow.
Topics: Adolescent; Adult; Anti-Infective Agents; Antilymphocyte Serum; Bone Marrow Transplantation; Child; | 1999 |
Other Studies
8 other studies available for metronidazole and Graft-Versus-Host Disease
Article | Year |
---|---|
Cord colitis syndrome: a cause of granulomatous inflammation in the upper and lower gastrointestinal tract.
Topics: Adult; Anti-Bacterial Agents; Ciprofloxacin; Colitis; Cord Blood Stem Cell Transplantation; Crohn Di | 2013 |
Clostridium difficile infection after allogeneic hematopoietic stem cell transplant: strain diversity and outcomes associated with NAP1/027.
Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Child; Child, Preschool; Clostridioides difficile; C | 2014 |
Intestinal amoebiasis in a patient with acute graft-versus-host disease after allogeneic bone marrow transplantation successfully treated by metronidazole.
Topics: Antiprotozoal Agents; Bone Marrow Transplantation; Dysentery, Amebic; Graft vs Host Disease; Humans; | 2015 |
Murine syngeneic graft-versus-host disease is responsive to broad-spectrum antibiotic therapy.
Topics: Animals; Anti-Bacterial Agents; Bone Marrow Transplantation; CD4-Positive T-Lymphocytes; Cell Line; | 2011 |
Nonalloreactive T cells prevent donor lymphocyte infusion-induced graft-versus-host disease by controlling microbial stimuli.
Topics: Animals; Ciprofloxacin; Graft vs Host Disease; Inflammation; Lymphocyte Transfusion; Lymphopenia; Me | 2012 |
The effect of metronidazole on busulfan pharmacokinetics in patients undergoing hematopoietic stem cell transplantation.
Topics: Adolescent; Adult; Busulfan; Drug Interactions; Female; Graft vs Host Disease; Hematopoietic Stem Ce | 2003 |
Acute GVHD involving the gastrointestinal tract and infestation with Blastocystis hominis in a patient with chronic myeloid leukaemia following allogeneic bone marrow transplantation.
Topics: Acute Disease; Adult; Animals; Antiprotozoal Agents; Blastocystis hominis; Blastocystis Infections; | 1998 |
Clostridium difficile infection in allogeneic stem cell transplant recipients is associated with severe graft-versus-host disease and non-relapse mortality.
Topics: Adolescent; Adult; Cytomegalovirus Infections; Enterocolitis, Pseudomembranous; Graft vs Host Diseas | 2000 |