metronidazole has been researched along with Gingival Diseases in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Gingival Diseases: Diseases involving the GINGIVA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This approach could be used to treat recurrent periodontitis or other diseases caused by intracellular-dwelling organisms." | 1.39 | Polymersome-mediated intracellular delivery of antibiotics to treat Porphyromonas gingivalis-infected oral epithelial cells. ( Armes, SP; Battaglia, G; Douglas, CW; Lewis, AL; Murdoch, C; Pinnock, A; Thornhill, MH; Warren, NJ; Wayakanon, K, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wayakanon, K | 1 |
| Thornhill, MH | 1 |
| Douglas, CW | 1 |
| Lewis, AL | 1 |
| Warren, NJ | 1 |
| Pinnock, A | 1 |
| Armes, SP | 1 |
| Battaglia, G | 1 |
| Murdoch, C | 1 |
| Hofstetter, HW | 1 |
| Lang, NP | 1 |
| Jones, JH | 1 |
| Lacour, M | 1 |
| Grappin, G | 1 |
1 review available for metronidazole and Gingival Diseases
| Article | Year |
|---|---|
[Metronidazole--an antibiotic for subgingival chemical plaque control?].
Topics: Animals; Clinical Trials as Topic; Dental Plaque; Drug Evaluation, Preclinical; Gingival Diseases; H | 1983 |
1 trial available for metronidazole and Gingival Diseases
| Article | Year |
|---|---|
[Metronidazole--an antibiotic for subgingival chemical plaque control?].
Topics: Animals; Clinical Trials as Topic; Dental Plaque; Drug Evaluation, Preclinical; Gingival Diseases; H | 1983 |
3 other studies available for metronidazole and Gingival Diseases
| Article | Year |
|---|---|
Polymersome-mediated intracellular delivery of antibiotics to treat Porphyromonas gingivalis-infected oral epithelial cells.
Topics: Anti-Bacterial Agents; Bacteroidaceae Infections; Cells, Cultured; Doxycycline; Gingiva; Gingival Di | 2013 |
Healthy and diseased gingiva.
Topics: Adult; Child; Chronic Disease; Dental Plaque; Diabetes Complications; Gingiva; Gingival Diseases; Gi | 1975 |
[Treatment of ulcerous gingivo-stomatitis by metronidazole].
Topics: Child, Preschool; Gingival Diseases; Humans; Infant; Male; Metronidazole; Stomatitis | 1968 |