metronidazole has been researched along with Amino Acid Metabolism Disorders, Inborn in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (83.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nashabat, M | 1 |
| Obaid, A | 1 |
| Al Mutairi, F | 1 |
| Saleh, M | 1 |
| Elamin, M | 1 |
| Ahmed, H | 1 |
| Ababneh, F | 1 |
| Eyaid, W | 1 |
| Alswaid, A | 1 |
| Alohali, L | 1 |
| Faqeih, E | 1 |
| Aljeraisy, M | 1 |
| Hussein, MA | 1 |
| Alasmari, A | 1 |
| Alfadhel, M | 1 |
| Sanjurjo Crespo, P | 1 |
| Labayru Echeverría, M | 1 |
| Ingunza Aguirre, N | 1 |
| Sasieta Altuna, M | 1 |
| Vallo Boado, A | 1 |
| Burns, SP | 1 |
| Iles, RA | 1 |
| Saudubray, JM | 3 |
| Chalmers, RA | 2 |
| van der Meer, SB | 1 |
| Poggi, F | 1 |
| Spada, M | 1 |
| Bonnefont, JP | 1 |
| Ogier, H | 1 |
| Hubert, P | 1 |
| Depondt, E | 1 |
| Rapoport, D | 1 |
| Rabier, D | 1 |
| Charpentier, C | 1 |
| Parvy, P | 1 |
| Bardet, J | 1 |
| Kamoun, P | 1 |
| Thompson, GN | 1 |
| Walter, JH | 1 |
| Bresson, JL | 1 |
| Lyonnet, SL | 1 |
| Reed, PJ | 1 |
| Leonard, JV | 1 |
| Halliday, D | 1 |
| Koletzko, B | 1 |
| Bachmann, C | 1 |
| Wendel, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Multicentre Comparative Trial to Evaluate the Long Term Effectiveness of the Use of Carbaglu® in Patients With Propionic Acidemia (PA) or Methylmalonic Acidemia (MMA)[NCT02426775] | Phase 3 | 33 participants (Actual) | Interventional | 2015-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for metronidazole and Amino Acid Metabolism Disorders, Inborn
| Article | Year |
|---|---|
Evaluation of long-term effectiveness of the use of carglumic acid in patients with propionic acidemia (PA) or methylmalonic acidemia (MMA): study protocol for a randomized controlled trial.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Carnitine; Child; Clinical Trials, Phase III as To | 2019 |
Propionylcarnitine excretion is not affected by metronidazole administration to patients with disorders of propionate metabolism.
Topics: Amino Acid Metabolism, Inborn Errors; Antitrichomonal Agents; Carnitine; Child, Preschool; Humans; I | 1996 |
The use of metronidazole in management of methylmalonic and propionic acidaemias.
Topics: Amino Acid Metabolism, Inborn Errors; Breath Tests; Child, Preschool; Feces; Humans; Hydrogen; Infan | 1990 |
3 other studies available for metronidazole and Amino Acid Metabolism Disorders, Inborn
| Article | Year |
|---|---|
[Use of metronidazole in four cases of methyl-malonic acidemia].
Topics: Amino Acid Metabolism, Inborn Errors; Female; Humans; Infant; Infant, Newborn; Male; Methylmalonic A | 1993 |
Clinical outcome and long-term management of 17 patients with propionic acidaemia.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Carnitine; Child; Child, Preschool; Diet, P | 1996 |
Antibiotic therapy for improvement of metabolic control in methylmalonic aciduria.
Topics: Amino Acid Metabolism, Inborn Errors; Child; Fatty Acids; Humans; Lincomycin; Male; Malonates; Methy | 1990 |