metronidazole has been researched along with Infections, Spirochaetales in 24 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with metronidazole in most cases improved symptoms." | 1.28 | [Intestinal spirochetosis in HIV infection: prevalence, isolation and morphology of spirochetes]. ( Arasteh, K; Gelderblom, HR; Grosse, G; Heise, W; Käsbohrer, A; Koch, MA; L'age, M; Pauli, G; Schönberg, A, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (25.00) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 7 (29.17) | 29.6817 |
| 2010's | 7 (29.17) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Majid, Z | 2 |
| Abrar, G | 1 |
| Ismail, H | 1 |
| Danish, M | 1 |
| Mubarak, M | 1 |
| Luck, N | 1 |
| Garcia-Hernandez, D | 1 |
| Vall-Mayans, M | 1 |
| Coll-Estrada, S | 1 |
| Naranjo-Hans, L | 1 |
| Armengol, P | 1 |
| Iglesias, MA | 1 |
| Barberá, MJ | 1 |
| Arando, M | 1 |
| Kohli, DR | 1 |
| Lippman, HR | 1 |
| Shah, TU | 1 |
| Chandan, S | 1 |
| Braseth, A | 1 |
| Jha, LK | 1 |
| Lintel, NJ | 1 |
| Hewlett, AT | 1 |
| Khalid, MA | 1 |
| Khan, SA | 1 |
| Achakzai, IK | 1 |
| Soomro, GB | 1 |
| Luck, NH | 1 |
| Vipani, A | 1 |
| Yang, MX | 1 |
| Vinagre-Rodríguez, G | 1 |
| Fernandez-Gonzalez, N | 1 |
| Hernandez-Alonso, M | 1 |
| Martinez Quintana, E | 1 |
| Molina-Infante, J | 1 |
| Warren, S | 1 |
| Freedman, A | 1 |
| Lomax, N | 1 |
| Christian, A | 1 |
| Suarez-Peñaranda, JM | 1 |
| Macías-García, F | 1 |
| Llovo, J | 1 |
| Forteza, J | 1 |
| O'Donnell, S | 1 |
| Swan, N | 1 |
| Crotty, P | 1 |
| Sangster, D | 1 |
| O'Morain, C | 1 |
| Tunuguntla, A | 1 |
| Youngberg, G | 1 |
| Sibley, D | 1 |
| Thomas, E | 1 |
| van Mook, WN | 1 |
| Koek, GH | 1 |
| van der Ven, AJ | 1 |
| Ceelen, TL | 1 |
| Bos, RP | 1 |
| Martinez, MW | 1 |
| Petre, S | 1 |
| Wisinger, D | 1 |
| Temesgen, Z | 1 |
| Umeno, J | 1 |
| Matsumoto, T | 1 |
| Nakamura, S | 1 |
| Yoshino, S | 1 |
| Hirahashi, M | 1 |
| Yao, T | 1 |
| Iida, M | 1 |
| Calderaro, A | 1 |
| Bommezzadri, S | 1 |
| Gorrini, C | 1 |
| Piccolo, G | 1 |
| Peruzzi, S | 1 |
| Villanacci, V | 1 |
| Zambelli, C | 1 |
| Dettori, G | 1 |
| Chezzi, C | 1 |
| Douglas, JG | 1 |
| Crucioli, V | 1 |
| Lo, TC | 1 |
| Heading, RC | 1 |
| Gilmour, HM | 1 |
| Peghini, PL | 1 |
| Guccion, JG | 1 |
| Sharma, A | 1 |
| Yesudian, P | 1 |
| Thambiah, AS | 1 |
| Käsbohrer, A | 1 |
| Gelderblom, HR | 1 |
| Arasteh, K | 1 |
| Heise, W | 1 |
| Grosse, G | 1 |
| L'age, M | 1 |
| Schönberg, A | 1 |
| Koch, MA | 1 |
| Pauli, G | 1 |
| Aukrust, P | 1 |
| Abeler, V | 1 |
| Rodgers, FG | 1 |
| Rodgers, C | 1 |
| Shelton, AP | 1 |
| Hawkey, CJ | 1 |
| Burns, DG | 1 |
| Hayes, MM | 1 |
| Sirol, J | 1 |
| Vedy, J | 1 |
| Sabrié, A | 1 |
1 review available for metronidazole and Infections, Spirochaetales
| Article | Year |
|---|---|
Human intestinal spirochaetosis: any clinical significance?
Topics: Anti-Infective Agents; Brachyspira; Colon; Humans; Immunocompetence; Intestinal Diseases; Metronidaz | 2004 |
23 other studies available for metronidazole and Infections, Spirochaetales
| Article | Year |
|---|---|
Intestinal Spirochaetosis-A case series from the developing world.
Topics: Diarrhea; Endoscopy; Humans; Intestines; Metronidazole; Spirochaetales Infections | 2022 |
Human intestinal spirochetosis, a sexually transmissible infection? Review of six cases from two sexually transmitted infection centres in Barcelona.
Topics: Adult; Biopsy; Colon; Diarrhea; Homosexuality, Male; Humans; Male; Metronidazole; Penicillin G Benza | 2021 |
An Unusual Appearance of the Colon Wall.
Topics: Anti-Bacterial Agents; Biopsy; Colon; Colonoscopy; Humans; Intestinal Mucosa; Male; Metronidazole; M | 2017 |
Colonic spirochetosis: an unusual cause of chronic diarrhea.
Topics: Anti-Bacterial Agents; Colonic Diseases; Diarrhea; Humans; Male; Metronidazole; Middle Aged; Spiroch | 2019 |
Intestinal Spirocheteosis in a Patient with Celiac Disease.
Topics: Adolescent; Biopsy, Needle; Celiac Disease; Chronic Disease; Diarrhea; Diet, Gluten-Free; Endoscopy, | 2019 |
Intestinal Spirochetosis Masquerading as Inflammatory Bowel Disease.
Topics: Adult; Anemia; Anti-Bacterial Agents; Brachyspira; Delayed Diagnosis; Diagnosis, Differential; Gastr | 2019 |
[Intestinal spirochetosis: A rare cause of chronic diarrhea].
Topics: Adult; Anti-Bacterial Agents; Chronic Disease; Colitis; Diarrhea; Homosexuality, Male; Humans; Intes | 2015 |
Intestinal spirochaetosis causing chronic diarrhoea in a patient with HIV infection.
Topics: Adult; Anti-Infective Agents; Biopsy; Chronic Disease; Colonoscopy; Diarrhea; HIV Infections; Homose | 2017 |
Histopathological diagnosis of intestinal spirochetosis in a nonimmunocompromised patient.
Topics: Aged; Anti-Infective Agents; Colonoscopy; Diarrhea; Feces; Humans; Immunocompetence; Intestinal Dise | 2010 |
Assessment of the clinical significance of intestinal spirochaetosis.
Topics: Abdominal Pain; Aminosalicylic Acid; Colon; Diarrhea; Female; Humans; Ileum; Intestinal Mucosa; Male | 2008 |
Intestinal spirochetosis: a poorly understood infection causing chronic diarrhea.
Topics: Anti-Infective Agents; Chronic Disease; Diagnosis, Differential; Diarrhea; Humans; Male; Metronidazo | 2004 |
Intestinal spirochetosis and diarrhea, commensal or causal.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Biopsy; Colitis, Microscopic; D | 2004 |
Intestinal spirochetosis due to Brachyspira pilosicoli: endoscopic and radiographic features.
Topics: Adult; Antiprotozoal Agents; Colon; Humans; Intestinal Mucosa; Male; Metronidazole; Polymerase Chain | 2007 |
Infective colitis associated with human intestinal spirochetosis.
Topics: Adult; Aged; Anti-Bacterial Agents; Brachyspira; Child, Preschool; Colitis; Colon; Colonoscopy; DNA, | 2007 |
Spirochaetosis: a remediable cause of diarrhoea and rectal bleeding?
Topics: Diarrhea; Gastrointestinal Hemorrhage; Humans; Male; Metronidazole; Middle Aged; Rectal Diseases; Sp | 1981 |
Intestinal spirochaetosis.
Topics: Adolescent; Adult; Colon; Colonic Diseases; Female; Humans; Male; Metronidazole; Rectal Diseases; Re | 1994 |
Improvement of chronic diarrhea after treatment for intestinal spirochetosis.
Topics: Adult; Chronic Disease; Diagnosis, Differential; Diarrhea; Goblet Cells; Humans; Intestinal Mucosa; | 2000 |
Metronidazole in the treatment of tropical phagedenic ulcers.
Topics: Fusobacterium Infections; Humans; Leg Ulcer; Metronidazole; Spirochaetales Infections | 1979 |
[Intestinal spirochetosis in HIV infection: prevalence, isolation and morphology of spirochetes].
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; AIDS-Related Complex; Endoscopy; Homosexuality; Hum | 1990 |
[Intestinal spirochaetosis].
Topics: Adult; Homosexuality; Humans; Intestinal Mucosa; Male; Metronidazole; Proctitis; Spirochaetales Infe | 1989 |
Proposed pathogenic mechanism for the diarrhea associated with human intestinal spirochetes.
Topics: Adolescent; Diarrhea; Feces; Female; Humans; Metronidazole; Microscopy, Electron; Rectum; Spirochaet | 1986 |
Rectal spirochaetosis--symptomatic response to metronidazole and mebendazole. A case report.
Topics: Benzimidazoles; Homosexuality; Humans; Male; Mebendazole; Metronidazole; Middle Aged; Rectal Disease | 1985 |
[Noma or forgotten ugliness. Clinical study and pathogenesis apropos of 6 cases at Fort-Lamy (Chad)].
Topics: Anti-Bacterial Agents; Chad; Child; Child, Preschool; Female; Humans; Leishmaniasis, Mucocutaneous; | 1972 |