metronidazole has been researched along with Phlegmon in 31 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A multi-centre double-blind, placebo-controlled clinical trial was performed to determine the minimum number of doses of metronidazole required for effective prophylaxis of vaginal cuff abscess following hysterectomy." | 5.06 | A comparison of single-dose and multi-dose metronidazole prophylaxis for hysterectomy. ( Haverkorn, MJ, 1987) |
| "The use of topical metronidazole has been limited to the treatment of acne rosacea, infected foot ulcers associated with diabetes mellitus, varicose veins, postirradiation ulcers, and dental conditions since the Food and Drug Administration approved the drug in 1988." | 3.69 | Topical metronidazole for arterial insufficiency ulcers. ( Gibson, LB; Kaplan, B, 1995) |
| "Periorbital cellulitis is a potential sight-threatening complication of sinusitis." | 2.94 | The management of periorbital cellulitis secondary to sinonasal infection: a multicenter prospective study in the United Kingdom. ( Al-Lami, A; Grounds, R; Hone, R; Hopkins, C; Lloyd, G; Mahalingam, S; Pervez, A; Poon, JS; Riley, P; Rudd, J; Shamil, E; Wong, G, 2020) |
| "30 patients had severe acute pelvic inflammatory disease with peritonitis, 3 tubo-ovarian abscesses, 4 endomyometritis, and 2 posthysterectomy pelvic cellulitis." | 2.66 | Sulbactam/ampicillin versus metronidazole/gentamicin in the treatment of severe pelvic infections. ( Crombleholme, W; Dahrouge, D; DeKay, V; Hadley, WK; Landers, D; Ohm-Smith, M; Robbie, MO; Sweet, RL, 1986) |
| "Patients with confirmed Lemierre syndrome were included in our retrospective monocentric study." | 2.50 | Lemierre syndrome: study of 11 cases and literature review. ( Atallah, I; Karkas, A; N'Gouan, JM; Reyt, E; Righini, CA; Schmerber, S; Tourniaire, R, 2014) |
| "Lemierre's syndrome is a rare disease in young otherwise healthy people showing septic embolism in the lungs and peripheral vessels." | 1.36 | [Phlegmon of the palm of the hand as initial manifestation of the Lemierre syndrome]. ( Braunbeck, A; Daecke, W; Fiebig, C; Geiger, EV; Maier, M; Marzi, I; Weber, R, 2010) |
| "Pneumococcal cellulitis is an uncommon infection." | 1.34 | [Streptococcus pneumoniae cellulitis in a diabetic patient]. ( Bouzat, P; Broux, C; Croizé, J; Jacquot, C; Pavese, P; Soriano, E; Stahl, JP, 2007) |
| "Bacterial orbital cellulitis is an infection of the soft tissues behind the orbital septum." | 1.31 | The role of technetium-99m-HMPAO-labeled WBC scintigraphy in the diagnosis of orbital cellulitis. ( Ada, E; Capa, G; Durak, H; Durak, I; Sayit, E; Söylev, M; Yilmaz, M, 2001) |
| "Midline nasal dermoid cysts are congenital lesions resulting from aberrant embryological development." | 1.29 | Nasal dermoid sinus cysts: an unusual presentation, computed tomographic scan findings, and surgical results. ( Armstrong, DC; Bortoluzzi, P; Posnick, JC, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (29.03) | 18.7374 |
| 1990's | 9 (29.03) | 18.2507 |
| 2000's | 6 (19.35) | 29.6817 |
| 2010's | 5 (16.13) | 24.3611 |
| 2020's | 2 (6.45) | 2.80 |
| Authors | Studies |
|---|---|
| Tara, F | 2 |
| Danesteh, S | 2 |
| Rezaee, M | 2 |
| Geraylow, KR | 2 |
| Moodi Ghalibaf, A | 2 |
| Moeindarbari, S | 2 |
| Mahalingam, S | 1 |
| Hone, R | 1 |
| Lloyd, G | 1 |
| Grounds, R | 1 |
| Shamil, E | 1 |
| Wong, G | 1 |
| Al-Lami, A | 1 |
| Pervez, A | 1 |
| Rudd, J | 1 |
| Poon, JS | 1 |
| Riley, P | 1 |
| Hopkins, C | 1 |
| Edson, RS | 1 |
| Litin, SC | 1 |
| Bundrick, JB | 1 |
| Righini, CA | 1 |
| Karkas, A | 1 |
| Tourniaire, R | 1 |
| N'Gouan, JM | 1 |
| Schmerber, S | 1 |
| Reyt, E | 1 |
| Atallah, I | 1 |
| van Hulsteijn, LT | 1 |
| Mieog, JS | 1 |
| Zwartbol, MH | 1 |
| Merkus, JW | 1 |
| van Nieuwkoop, C | 1 |
| Evans, D | 1 |
| Shakur, R | 1 |
| Scott, D | 1 |
| Park, HC | 1 |
| Chang, MY | 1 |
| Lee, BH | 1 |
| Braunbeck, A | 1 |
| Geiger, EV | 1 |
| Weber, R | 1 |
| Maier, M | 1 |
| Daecke, W | 1 |
| Fiebig, C | 1 |
| Marzi, I | 1 |
| Kumar, V | 1 |
| Saunders, D | 1 |
| Conscience, I | 1 |
| Perceau, G | 1 |
| Le Berruyer, PY | 1 |
| Bernard, P | 1 |
| Bouzat, P | 1 |
| Broux, C | 1 |
| Soriano, E | 1 |
| Pavese, P | 1 |
| Croizé, J | 1 |
| Stahl, JP | 1 |
| Jacquot, C | 1 |
| Cullen, KW | 1 |
| MacBain, GC | 1 |
| Feki, A | 1 |
| Gehanno, P | 1 |
| Saint-Guily, JL | 1 |
| Régnier, B | 1 |
| Vachon, F | 1 |
| Kaplan, B | 1 |
| Gibson, LB | 1 |
| Wong, VY | 1 |
| Duncan, NO | 1 |
| Edwards, MS | 1 |
| Posnick, JC | 1 |
| Bortoluzzi, P | 1 |
| Armstrong, DC | 1 |
| McRae, D | 1 |
| Dilkes, M | 1 |
| Jacob-Hood, J | 1 |
| Ghufoor, K | 1 |
| Tsarev, VN | 1 |
| Ushakov, RV | 1 |
| Rose, C | 1 |
| Tellion, C | 1 |
| Ferri, F | 1 |
| Donazzan, M | 1 |
| Desiaterik, VI | 1 |
| Krivitskiĭ, IuM | 1 |
| Svetlovskiĭ, AA | 1 |
| Shapovaliuk, VV | 1 |
| Dellamonica, P | 1 |
| Bernard, E | 1 |
| Sayit, E | 1 |
| Söylev, M | 1 |
| Capa, G | 1 |
| Durak, I | 1 |
| Ada, E | 1 |
| Yilmaz, M | 1 |
| Durak, H | 1 |
| Dancer, SJ | 1 |
| McNAIR, D | 1 |
| Finn, P | 1 |
| Kolsto, AB | 1 |
| Beaune, J | 1 |
| Llorca, G | 1 |
| Gonin, A | 1 |
| Brun, Y | 1 |
| Fleurette, J | 1 |
| Neidhart, JP | 1 |
| Haverkorn, MJ | 1 |
| Crombleholme, W | 1 |
| Landers, D | 1 |
| Ohm-Smith, M | 1 |
| Robbie, MO | 1 |
| Hadley, WK | 1 |
| DeKay, V | 1 |
| Dahrouge, D | 1 |
| Sweet, RL | 1 |
| Halvorson, GD | 1 |
| Halvorson, JE | 1 |
| Iserson, KV | 1 |
| Antani, JA | 1 |
| Srinivas, HV | 1 |
| Krishnamurthy, KR | 1 |
| Borgaonkar, AN | 1 |
| Finegold, SM | 1 |
| Rosenblatt, JE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Trimethoprim-sulfamethoxazole Versus Placebo in the Treatment of Cutaneous Abscesses in the Emergency Department[NCT00867789] | 140 participants (Actual) | Interventional | 2009-03-31 | Terminated (stopped due to Slow enrollment due to subjects not meeting inclusion/exclusion criteria) | |||
| A Randomized Trial of Intranasal Fentanyl Versus Placebo as an Adjunct to Lidocaine Infiltration in Adults Undergoing Abscess Incision and Drainage in the Emergency[NCT03872700] | Phase 3 | 49 participants (Actual) | Interventional | 2019-08-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00867789)
Timeframe: two years
| Intervention | Percentage of outcomes assessed (Number) |
|---|---|
| Trimethoprim-sulfamethaxazole | 0 |
| Sugar Pill | 0 |
Patient reported NRS pain scores after Blunt Dissection. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once anytime up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 4.1 |
| Placebo | 4.4 |
Patient reported NRS pain scores after Irrigation. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once anytime up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 3.4 |
| Placebo | 2.6 |
Patient reported NRS pain scores after Lidocaine injection. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Following Lidocaine injection measured once anytime up to 12 minutes after intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 8.4 |
| Placebo | 8.0 |
Patient reported pain after Packing of abscess. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once at the time of completion of application of the bandage, up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 4.5 |
| Placebo | 3.9 |
Patient reported NRS pain scores following Incision. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once anytime up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 3.9 |
| Placebo | 3.9 |
Patient reported pain scores at baseline. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Baseline
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 8.3 |
| Placebo | 8.1 |
Patient reported pain scores for overall Procedure assessed immediately after placement of dressing at the end of procedure. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once following placement of dressing at completion of procedure, up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 6.2 |
| Placebo | 7.0 |
1 review available for metronidazole and Phlegmon
| Article | Year |
|---|---|
Lemierre syndrome: study of 11 cases and literature review.
Topics: Abscess; Adolescent; Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agen | 2014 |
6 trials available for metronidazole and Phlegmon
| Article | Year |
|---|---|
Effectiveness of postoperative oral administration of cephalexin and metronidazole on surgical site infection among obese women undergoing cesarean section: a randomized, double-blind, placebo-controlled, parallel-group study-phase III.
Topics: Administration, Oral; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cellulitis; Cephalexin; Cesarea | 2022 |
Effectiveness of postoperative oral administration of cephalexin and metronidazole on surgical site infection among obese women undergoing cesarean section: a randomized, double-blind, placebo-controlled, parallel-group study-phase III.
Topics: Administration, Oral; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cellulitis; Cephalexin; Cesarea | 2022 |
Effectiveness of postoperative oral administration of cephalexin and metronidazole on surgical site infection among obese women undergoing cesarean section: a randomized, double-blind, placebo-controlled, parallel-group study-phase III.
Topics: Administration, Oral; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cellulitis; Cephalexin; Cesarea | 2022 |
Effectiveness of postoperative oral administration of cephalexin and metronidazole on surgical site infection among obese women undergoing cesarean section: a randomized, double-blind, placebo-controlled, parallel-group study-phase III.
Topics: Administration, Oral; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cellulitis; Cephalexin; Cesarea | 2022 |
The management of periorbital cellulitis secondary to sinonasal infection: a multicenter prospective study in the United Kingdom.
Topics: Adult; Anti-Bacterial Agents; Ceftriaxone; Cellulitis; Child; Drug Therapy, Combination; Humans; Len | 2020 |
Computerized tomography of acute, tender peritonsillar swellings.
Topics: Biopsy, Needle; Cellulitis; Cost-Benefit Analysis; Humans; Metronidazole; Palatine Tonsil; Penicilli | 1993 |
[Open, noncomparative multicenter study of the efficacy and tolerance of a spiramycin-metronidazole combination used in infectious oral pathology].
Topics: Bacterial Infections; Cellulitis; Drug Combinations; Dry Socket; Edema; Humans; Metronidazole; Mouth | 1991 |
A comparison of single-dose and multi-dose metronidazole prophylaxis for hysterectomy.
Topics: Abscess; Adolescent; Adult; Aged; Aged, 80 and over; Cellulitis; Clinical Trials as Topic; Double-Bl | 1987 |
Sulbactam/ampicillin versus metronidazole/gentamicin in the treatment of severe pelvic infections.
Topics: Ampicillin; beta-Lactamase Inhibitors; Cellulitis; Drug Therapy, Combination; Endometritis; Female; | 1986 |
24 other studies available for metronidazole and Phlegmon
| Article | Year |
|---|---|
Clinical Pearls in Infectious Diseases 2017.
Topics: Administration, Intravaginal; Adult; Aged; Anti-Bacterial Agents; Body Piercing; Campylobacter Infec | 2017 |
Appendicitis Presenting As Cellulitis of the Right Leg.
Topics: Aged; Anti-Bacterial Agents; Appendicitis; Cefuroxime; Cellulitis; Emergency Service, Hospital; Esch | 2017 |
Antibiotic prescribing.
Topics: Anti-Bacterial Agents; Cellulitis; Clindamycin; Clostridioides difficile; Diarrhea; Humans; Medical | 2008 |
Nonoperative management of right colonic diverticulitis using radiologic evaluation.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Cellulitis; Cephalosporins; Colon, Ascending; Divert | 2010 |
[Phlegmon of the palm of the hand as initial manifestation of the Lemierre syndrome].
Topics: Abscess; Acromioclavicular Joint; Anti-Bacterial Agents; Cellulitis; Combined Modality Therapy; Diag | 2010 |
Orbital cellulitis after phacoemulsification and intraocular lens implantation.
Topics: Anti-Infective Agents; Cellulitis; Erythromycin; Female; Humans; Lens Implantation, Intraocular; Met | 2004 |
[Bilateral breast bacterial cellulite secondary to Streptococcus agalactiae septicemia].
Topics: Adenocarcinoma; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Breast Diseases; Ce | 2006 |
[Streptococcus pneumoniae cellulitis in a diabetic patient].
Topics: Aged; Ceftriaxone; Cellulitis; Ciprofloxacin; Diabetes Complications; Humans; Male; Metronidazole; M | 2007 |
An unusual case of cellulitis associated with Bacteroides fragilis septicaemia.
Topics: Bacteroides fragilis; Bacteroides Infections; Cellulitis; Humans; Male; Metronidazole; Middle Aged; | 1982 |
[Significance of a spiramycin-metronidazole combination in the treatment of acute, circumscribed perimaxillary cellulitis].
Topics: Acute Disease; Adult; Cellulitis; Drug Combinations; Drug Tolerance; Female; Humans; Jaw Diseases; L | 1981 |
[Cellulitis of the neck due to anaerobic germs: report of 10 cases (author's transl)].
Topics: Anaerobiosis; Cellulitis; Gas Gangrene; Humans; Metronidazole; Neck; Penicillin G | 1982 |
Topical metronidazole for arterial insufficiency ulcers.
Topics: Administration, Topical; Adult; Arterial Occlusive Diseases; Cellulitis; Foot Ulcer; Humans; Leg; Ma | 1995 |
Medical management of orbital infection.
Topics: Ceftazidime; Cellulitis; Child; Female; Humans; Metronidazole; Nafcillin; Orbital Diseases | 1994 |
Nasal dermoid sinus cysts: an unusual presentation, computed tomographic scan findings, and surgical results.
Topics: Bone Transplantation; Cellulitis; Child, Preschool; Cloxacillin; Combined Modality Therapy; Coronary | 1994 |
[The immunomodulating therapy of odontogenic phlegmons with complexes of antibacterial preparations and water-soluble polymers for medical use].
Topics: Adjuvants, Immunologic; Anti-Infective Agents, Local; Cellulitis; Colloids; Dextrans; Drug Evaluatio | 1996 |
[Severe diffuse facial cellulitis].
Topics: Adolescent; Amikacin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Bacter | 1997 |
[Surgical treatment of putrid neck phlegmon].
Topics: Adult; Anti-Bacterial Agents; Antitrichomonal Agents; Cellulitis; Female; Humans; Hyperbaric Oxygena | 1998 |
'Deep throat' cellulitis.
Topics: Anti-Bacterial Agents; Cefoxitin; Cellulitis; Cephamycins; Female; Fusobacterium Infections; Fusobac | 1999 |
The role of technetium-99m-HMPAO-labeled WBC scintigraphy in the diagnosis of orbital cellulitis.
Topics: Cefotaxime; Cellulitis; Eye Infections, Bacterial; Female; Humans; Leukocytes; Magnetic Resonance Im | 2001 |
Bacillus cereus cellulitis from contaminated heroin.
Topics: Adult; Anti-Bacterial Agents; Bacillus cereus; Cellulitis; Forearm; Genotype; Gentamicins; Heroin; H | 2002 |
[Necrotic phlegmon of the hand, starting point for a septicemia caused by Aeromonas hydrophila. Demonstration of the ichthyological origin of the infection].
Topics: Aeromonas; Animals; Bacterial Infections; Cellulitis; Chloramphenicol; Doxycycline; Drug Therapy, Co | 1978 |
Abscess incision and drainage in the emergency department--Part I.
Topics: Abscess; Bacteria, Aerobic; Bacteria, Anaerobic; Cellulitis; Clindamycin; Drainage; Emergency Servic | 1985 |
Abscess incision and drainage in the emergency department--Part I.
Topics: Abscess; Bacteria, Aerobic; Bacteria, Anaerobic; Cellulitis; Clindamycin; Drainage; Emergency Servic | 1985 |
Abscess incision and drainage in the emergency department--Part I.
Topics: Abscess; Bacteria, Aerobic; Bacteria, Anaerobic; Cellulitis; Clindamycin; Drainage; Emergency Servic | 1985 |
Abscess incision and drainage in the emergency department--Part I.
Topics: Abscess; Bacteria, Aerobic; Bacteria, Anaerobic; Cellulitis; Clindamycin; Drainage; Emergency Servic | 1985 |
Metronidazole in dracunculiasis. Report of further trials.
Topics: Antiparasitic Agents; Cellulitis; Dracunculiasis; Humans; India; Metronidazole | 1972 |
Practical aspects of anaerobic sepsis.
Topics: Abscess; Anaerobiosis; Arthritis, Infectious; Bacterial Infections; Bacteroides; Bone Diseases; Brai | 1973 |