Page last updated: 2024-10-31

metronidazole and Constriction, Pathological

metronidazole has been researched along with Constriction, Pathological in 5 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
"Whilst colonic amoebiasis and its complications are well-documented, ileal amoebiasis has not been described in the literature."1.30Ileal amoebiasis. ( Haffejee, AA; Moodley, J; Ramdial, P; Singh, B, 1997)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's2 (40.00)18.2507
2000's1 (20.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aebischer, B1
Elsig, S1
Taeymans, J1
Pomp, S1
Kuhness, D1
Barcaro, G1
Sementa, L1
Mankad, V1
Fortunelli, A1
Sterrer, M1
Netzer, FP1
Surnev, S1
Schmieder, AH1
Caruthers, SD1
Keupp, J1
Wickline, SA1
Lanza, GM1
Lowe, J1
Wodarcyk, AJ1
Floyd, KT1
Rastogi, N1
Schultz, EJ1
Swager, SA1
Chadwick, JA1
Tran, T1
Raman, SV1
Janssen, PM1
Rafael-Fortney, JA1
Alcalay, RN1
Levy, OA1
Wolf, P1
Oliva, P1
Zhang, XK1
Waters, CH1
Fahn, S1
Kang, U1
Liong, C1
Ford, B1
Mazzoni, P1
Kuo, S1
Johnson, A1
Xiong, L1
Rouleau, GA1
Chung, W1
Marder, KS1
Gan-Or, Z1
Kamei, K1
Terao, T1
Katayama, Y1
Hatano, K1
Kodama, K1
Shirahama, M1
Sakai, A1
Hirakawa, H1
Mizokami, Y1
Shiotsuki, I1
Ishii, N1
Inoue, Y1
Akboga, MK1
Yayla, C1
Balci, KG1
Ozeke, O1
Maden, O1
Kisacik, H1
Temizhan, A1
Aydogdu, S1
Zhu, J2
Ying, SH1
Feng, MG1
Zhang, XG1
Li, H1
Wang, L1
Hao, YY1
Liang, GD1
Ma, YH1
Yang, GS1
Hu, JH1
Pfeifer, L1
Goertz, RS1
Neurath, MF1
Strobel, D1
Wildner, D1
Lin, JT1
Yang, XN1
Zhong, WZ1
Liao, RQ1
Dong, S1
Nie, Q1
Weng, SX1
Fang, XJ1
Zheng, JY1
Wu, YL1
Řezanka, T1
Kaineder, K1
Mezricky, D1
Řezanka, M1
Bišová, K1
Zachleder, V1
Vítová, M1
Rinker, JA1
Marshall, SA1
Mazzone, CM1
Lowery-Gionta, EG1
Gulati, V1
Pleil, KE1
Kash, TL1
Navarro, M1
Thiele, TE1
Zhang, Y1
Huang, Y1
Jin, Z1
Li, X1
Li, B1
Xu, P1
Huang, P1
Liu, C1
Fokdal, L1
Sturdza, A1
Mazeron, R1
Haie-Meder, C1
Tan, LT1
Gillham, C1
Šegedin, B1
Jürgenliemk-Schultz, I1
Kirisits, C1
Hoskin, P1
Pötter, R1
Lindegaard, JC1
Tanderup, K1
Levin, DE1
Schmitz, AJ1
Hines, SM1
Hines, KJ1
Tucker, MJ1
Brewer, SH1
Fenlon, EE1
Álvarez-Pérez, S1
Blanco, JL1
Peláez, T1
Martínez-Nevado, E1
García, ME1
Puckerin, AA1
Chang, DD1
Subramanyam, P1
Colecraft, HM1
Dogan, H1
Coteli, E1
Karatas, F1
Ceylan, O1
Sahin, MD1
Akdamar, G1
Kryczyk, A1
Żmudzki, P1
Hubicka, U1
Giovannelli, D1
Chung, M1
Staley, J1
Starovoytov, V1
Le Bris, N1
Vetriani, C1
Chen, W1
Wu, L1
Liu, X1
Shen, Y1
Liang, Y1
Tan, H1
Yang, Y1
Liu, Q1
Wang, M1
Liu, L1
Wang, X1
Liu, B1
Liu, GH1
Zhu, YJ1
Wang, JP1
Che, JM1
Chen, QQ1
Chen, Z1
Maucksch, U1
Runge, R1
Wunderlich, G1
Freudenberg, R1
Naumann, A1
Kotzerke, J1
Reese, GE1
Bicknell, CD1
Elton, C1
Schmid, BD1
Lalyre, Y1
Sigel, B1
Kiani, R1
Layden, TJ1
Singh, B1
Moodley, J1
Ramdial, P1
Haffejee, AA1
Jan, IA1
Hazir, T1
Qazi, A1
Khan, MA1
Khan, NA1

Reviews

1 review available for metronidazole and Constriction, Pathological

ArticleYear
    Hand therapy, 2016, Volume: 21, Issue:1

    Topics: AC133 Antigen; Acenaphthenes; Acer; Acrosome Reaction; Adult; Agaricales; Aged; Aged, 80 and over; A

2016

Other Studies

4 other studies available for metronidazole and Constriction, Pathological

ArticleYear
Pseudomembranous colitis presenting as an isolated colonic stricture.
    International journal of colorectal disease, 2007, Volume: 22, Issue:10

    Topics: Aged; Anti-Bacterial Agents; Colonic Diseases; Constriction, Pathologic; Enterocolitis, Pseudomembra

2007
Inferior vena cava obstruction complicating amebic liver abscess.
    Digestive diseases and sciences, 1982, Volume: 27, Issue:6

    Topics: Adult; Constriction, Pathologic; Drainage; Humans; Liver Abscess, Amebic; Male; Metronidazole; Radio

1982
Ileal amoebiasis.
    Journal of the Royal College of Surgeons of Edinburgh, 1997, Volume: 42, Issue:3

    Topics: Adult; Amebiasis; Amebicides; Colitis; Constriction, Pathologic; Female; Humans; Ileal Diseases; Int

1997
Fulminant pseudomembranous colitis leading to total colonic stricture.
    JPMA. The Journal of the Pakistan Medical Association, 1997, Volume: 47, Issue:11

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Child; Colectomy; Colonic Diseases; Constriction, Path

1997