metronidazole has been researched along with Acid Aspiration Syndrome in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To report a case of acute reversible pancreatitis associated with metronidazole-treated aspiration pneumonia." | 7.70 | Metronidazole-associated pancreatitis. ( Heinrich, KA; Sura, ME; Suseno, M, 2000) |
| "To report a case of acute reversible pancreatitis associated with metronidazole-treated aspiration pneumonia." | 3.70 | Metronidazole-associated pancreatitis. ( Heinrich, KA; Sura, ME; Suseno, M, 2000) |
| "Metronidazole has adverse side effects, and widespread use where not indicated can promote carriage of multiresistant intestinal flora such as vancomycin-resistant enterococci." | 1.37 | New aspirations: the debate on aspiration pneumonia treatment guidelines. ( Charles, PG; Howden, BP; Kwong, JC, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Joundi, RA | 1 |
| Wong, BM | 1 |
| Leis, JA | 1 |
| Daoud, E | 1 |
| Guzman, J | 1 |
| Kwong, JC | 1 |
| Howden, BP | 1 |
| Charles, PG | 1 |
| Sura, ME | 1 |
| Heinrich, KA | 1 |
| Suseno, M | 1 |
| Brook, I | 1 |
5 other studies available for metronidazole and Acid Aspiration Syndrome
| Article | Year |
|---|---|
Antibiotics "just-in-case" in a patient with aspiration pneumonitis.
Topics: Anti-Bacterial Agents; Cerebral Palsy; Clostridioides difficile; Enterocolitis, Pseudomembranous; Ep | 2015 |
Q: Are antibiotics indicated for the treatment of aspiration pneumonia?
Topics: Anti-Bacterial Agents; beta-Lactams; Clindamycin; Humans; Metronidazole; Pneumonia; Pneumonia, Aspir | 2010 |
New aspirations: the debate on aspiration pneumonia treatment guidelines.
Topics: Anti-Infective Agents; Australia; Humans; Metronidazole; Pneumonia, Aspiration; Practice Guidelines | 2011 |
Metronidazole-associated pancreatitis.
Topics: Anti-Infective Agents; Female; Humans; Metronidazole; Middle Aged; Oxidation-Reduction; Pancreatitis | 2000 |
Anaerobic infections in childhood.
Topics: Bacteria, Anaerobic; Bacterial Infections; Bacteroides fragilis; Brain Abscess; Cephalosporins; Chil | 1986 |