metronidazole has been researched along with HIV in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In areas with a high prevalence of trichomoniasis, the addition of metronidazole to the syndromic management of male urethritis can eliminate infection with T vaginalis and may help to reduce the transmission of HIV." | 5.10 | Addition of treatment for trichomoniasis to syndromic management of urethritis in Malawi: a randomized clinical trial. ( Chilongozi, D; Cohen, MS; Hobbs, MM; Hoffman, IF; Kaydos-Daniels, SC; Kazembe, P; Kip, E; Martinson, F; Miller, WC; Msowoya, E; Price, MA; Zimba, D, 2003) |
| "Both factors are modulated by bacterial vaginosis (BV) and, to some extent, by Lactobacillus iners, the genital Lactobacillus spp." | 1.51 | Impact of Standard Bacterial Vaginosis Treatment on the Genital Microbiota, Immune Milieu, and Ex Vivo Human Immunodeficiency Virus Susceptibility. ( Anzala, O; Dizzell, S; Gajer, P; Huibner, S; Humphrys, M; Joag, V; Kaul, R; Kaushic, C; Kimani, J; Mureithi, M; Obila, O; Oyugi, J; Ravel, J; Scott, MC; Shahabi, K; Shannon, B; Tharao, W, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Joag, V | 1 |
| Obila, O | 1 |
| Gajer, P | 1 |
| Scott, MC | 1 |
| Dizzell, S | 1 |
| Humphrys, M | 1 |
| Shahabi, K | 1 |
| Huibner, S | 1 |
| Shannon, B | 1 |
| Tharao, W | 1 |
| Mureithi, M | 1 |
| Oyugi, J | 1 |
| Kimani, J | 1 |
| Kaushic, C | 1 |
| Ravel, J | 1 |
| Anzala, O | 1 |
| Kaul, R | 1 |
| Pérez-Chacón, G | 1 |
| Pocaterra, LA | 1 |
| Rojas, E | 1 |
| Hernán, A | 1 |
| Jiménez, JC | 1 |
| Núñez, L | 1 |
| Price, MA | 1 |
| Zimba, D | 1 |
| Hoffman, IF | 1 |
| Kaydos-Daniels, SC | 1 |
| Miller, WC | 1 |
| Martinson, F | 1 |
| Chilongozi, D | 1 |
| Kip, E | 1 |
| Msowoya, E | 1 |
| Hobbs, MM | 1 |
| Kazembe, P | 1 |
| Cohen, MS | 1 |
1 trial available for metronidazole and HIV
| Article | Year |
|---|---|
Addition of treatment for trichomoniasis to syndromic management of urethritis in Malawi: a randomized clinical trial.
Topics: Administration, Oral; Adult; Animals; Doxycycline; Drug Therapy, Combination; Gentamicins; HIV; HIV | 2003 |
2 other studies available for metronidazole and HIV
| Article | Year |
|---|---|
Impact of Standard Bacterial Vaginosis Treatment on the Genital Microbiota, Immune Milieu, and Ex Vivo Human Immunodeficiency Virus Susceptibility.
Topics: Administration, Oral; Adult; CD4-Positive T-Lymphocytes; Cells, Cultured; Cervix Uteri; Cytokines; D | 2019 |
Coinfection with
Topics: Adult; Animals; Anthelmintics; Anti-HIV Agents; Antiprotozoal Agents; Coinfection; Diarrhea; Giardia | 2017 |