Osteoradionecrosis

Synonym
Osteoradionecrosis

Excerpt	Reference
"Extablished osteoradionecrosis is not a "true" necrosis of these bones but a particularly severe osteitis which evolves in bone, which is pathological because it has been irradiated, and is surrounded by tissues which are also pathological for the same reason."	( Gola, R; Lachard, J; Nerini, A; Zattara, H, 1979)
"Osteoradionecrosis is one of the most serious oral complications of head and neck cancer treatment."	( Chrcanovic, BR; Harris, M; Reher, P; Sousa, AA, 2010)
"Osteoradionecrosis is a complication of head and neck radiotherapy, with a difficult resolution and no well-established treatment."	( Bohn, JC; Sassi, LM; Schussel, JL; Stramandinoli-Zanicotti, RT, 2016)
"Osteoradionecrosis is a relatively rare but potentially morbid and costly complication of radiation therapy for head and neck cancer."	( Cervenka, B; Frankart, AJ; Frankart, MJ; Krishnan, DG; Takiar, V; Tang, AL, 2021)

Excerpt	Reference
"The incidence of osteoradionecrosis has declined since the introduction of preventive oral hygiene programs and meticulous dental evaluations before and after irradiation."	( Driver, N; Levendag, PC; Visch, LL, 1990)

Excerpt	Reference
"Conventional treatment of osteoradionecrosis of mandible is by antibiotics combined if necessary with a hemimandibulectomy."	( Blanc, JL; Cheynet, F; Lachard, A; Lachard, J; Lagier, JP; Rakotobe, P, 1986)
"Most patients were being treated for osteoradionecrosis after radiotherapy of ENT cancers, and drop-outs for the eye exam were common."	( Fledelius, HC; Jansen, EC; Thorn, J, 2002)
"For the surgical treatment of osteoradionecrosis after multimodal therapy of head-and-neck cancers, free vascular bone grafts are used to reconstruct osseous structures in the previously irradiated graft bed."	( Amann, K; Grabenbauer, G; Kopp, J; Lehner, B; Nkenke, E; Rödel, F; Schultze-Mosgau, S; Thorwarth, M; Wehrhan, F, 2005)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	86 (25.52)	23.3326
1990's	45 (13.35)	12.5806
2000's	60 (17.80)	18.1394
2010's	89 (26.41)	28.8240
2020's	57 (16.91)	9.53

Drug	Relationship Strength	Studies	Trials
salicylic acid	low	12	0
lactic acid	low	1	0
hydrogen	low	1	0
pyruvic acid	low	1	0
thymine	low	1	0
alendronate	low	4	0
amifostine anhydrous	low	2	0
cilostazol	low	1	0
ciprofloxacin	medium	1	1
fluorouracil	low	4	0
gentamicin	low	1	0
hydroxyurea	low	1	0
metronidazole	low	3	0
oxyphenbutazone	low	3	0
pamidronate	low	2	0
pentoxifylline	medium	49	3
prilocaine	low	1	0
sodium fluoride	low	1	0
mitomycin	low	1	0
prednisone	medium	1	1
penicillin g	medium	2	1
pilocarpine	low	1	0
phenylalanine	medium	1	1
ampicillin	low	1	0
methylmethacrylate	low	1	0
tolonium chloride	low	1	0
caprolactam	low	1	0
meglumine	low	1	0
hematoxylin	low	1	0
eosine yellowish-(ys)	low	1	0
deoxycytidine	low	1	0
durapatite	low	4	0
d-alpha tocopherol	low	9	0
tocopherols	medium	40	3
iridium	low	2	0
rhenium	low	1	0
tantalum	low	1	0
technetium	low	1	0
titanium	medium	12	1
cadmium	low	1	0
erbium	low	1	0
gold	low	1	0
camptothecin	low	1	0
barium sulfate	low	1	0
calcium phosphate, dibasic, anhydrous	low	1	0
calcium phosphate, monobasic, anhydrous	low	1	0
tricalcium phosphate	medium	3	1
fluorine	low	1	0
ozone	low	3	0
radon	low	3	0
trolamine salicylate	low	6	0
clodronic acid	medium	19	3
cephalexin	low	2	0
tetradecanoylphorbol acetate	low	1	0
fluorides	medium	7	2
amoxicillin	low	1	0
paclitaxel	low	3	0
epirubicin	medium	1	1
propiconazole	low	4	0
pefloxacin	low	1	0
simvastatin	low	1	0
gemcitabine	low	1	0
irinotecan	low	1	0
iridium radioisotopes	low	4	0
fluorodeoxyglucose f18	low	14	0
zoledronic acid	low	1	0
cobalt	low	1	0
deoxyglucose	low	1	0
technetium tc 99m hydroxymethylene diphosphonate	low	2	0
methotrexate	low	4	0
sulbactam	low	1	0
calcium pyrophosphate	low	1	0
cortisone	low	1	0
carboplatin	low	2	0
inositol 3-phosphate	low	3	0
n-formylmethionine leucyl-phenylalanine	low	1	0
sultamicillin	low	1	0
lincomycin	low	1	0
lithium	low	1	0
amphotericin b	low	1	0
mitolactol	low	1	0
phenylephrine hydrochloride	low	4	0
lead	low	3	0
tin	low	1	0
bismuth	low	1	0
radium	low	20	0
peplomycin	low	1	0
gadolinium dtpa	low	2	0
chlorhexidine	medium	5	1
jaw	low	99	0
technetium tc 99m sestamibi	low	1	0
sodium hypochlorite	low	1	0
sodium ethylxanthate	low	1	0
tetracycline	low	3	0
oxytetracycline, anhydrous	low	1	0
mobic	low	1	0
transforming growth factor beta	low	4	0
technetium tc 99m medronate	low	8	0
chondroitin sulfates	low	1	0
exudates	low	1	0
levoleucovorin	low	1	0
eye	medium	2	2

Protein Targets (835)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, farnesyl pyrophosphate synthase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	4	0	5
Farnesyl pyrophosphate synthase	0	6	0	6
Acetylcholinesterase	0	5	0	5
Hypoxanthine-guanine phosphoribosyltransferase	0	2	0	2
Farnesyl pyrophosphate synthase	0	4	0	4
Farnesyl pyrophosphate synthase	0	2	0	2
regulator of G-protein signaling 4	8	0	0	8
arylsulfatase A	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	18	0	0	18
Bloom syndrome protein isoform 1	6	0	0	6
muscarinic acetylcholine receptor M1	3	0	0	3
Cellular tumor antigen p53	16	0	0	16
D(3) dopamine receptor	0	2	0	2
Spike glycoprotein	13	0	1	14
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	13	0	0	13
Chain A, Beta-lactamase	9	0	0	9
Chain A, 2-oxoglutarate Oxygenase	9	0	0	9
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	3
AR protein	23	0	0	23
apical membrane antigen 1, AMA1	4	0	0	4
estrogen nuclear receptor alpha	27	0	0	27
Beta-lactamase	0	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
DNA polymerase eta isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	10	0	0	10
urokinase-type plasminogen activator precursor	7	0	0	7
plasminogen precursor	7	0	0	7
urokinase plasminogen activator surface receptor precursor	7	0	0	7
DNA polymerase kappa isoform 1	8	0	0	8
ATP-binding cassette sub-family C member 3	0	16	0	16
Multidrug resistance-associated protein 4	0	16	0	17
Bile salt export pump	0	3	0	3
Bile salt export pump	0	19	0	19
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase SHV-1	0	1	0	3
Cytochrome P450 2C9	0	4	0	4
Beta-lactamase	0	1	0	3
Kappa-type opioid receptor	0	0	0	2
Solute carrier family 15 member 1	0	6	0	6
Solute carrier family 15 member 1	0	3	0	3
Cytochrome P450 2J2	0	1	0	1
B2 metallo-beta-lactamase	0	0	0	3
Solute carrier family 15 member 2	0	4	0	4
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	4	0	5
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Canalicular multispecific organic anion transporter 1	0	15	0	15
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
Chain A, Cruzipain	5	0	0	5
interleukin 8	3	0	0	3
phosphopantetheinyl transferase	9	0	0	9
GLS protein	8	0	0	8
glucocorticoid receptor [Homo sapiens]	20	0	0	20
farnesoid X nuclear receptor	13	0	0	13
peroxisome proliferator-activated receptor delta	14	0	0	14
vitamin D (1,25- dihydroxyvitamin D3) receptor	14	0	0	14
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	12	0	0	12
nuclear factor erythroid 2-related factor 2 isoform 1	21	0	0	21
peripheral myelin protein 22	8	0	0	8
lamin isoform A-delta10	16	0	0	16
Cytochrome P450 1A2	0	2	0	2
Cytochrome P450 3A4	0	4	0	4
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2C19	0	2	0	2
Nuclear receptor ROR-gamma	4	0	0	4
Potassium voltage-gated channel subfamily H member 2	0	3	0	4
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	2
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Beta-lactamase	0	0	0	2
acid sphingomyelinase	3	0	0	3
GLI family zinc finger 3	16	0	0	16
retinoic acid nuclear receptor alpha variant 1	18	0	0	18
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	1	0	3
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
chromobox protein homolog 1	14	0	0	14
thyroid hormone receptor beta isoform 2	14	0	0	14
DNA polymerase beta	4	0	0	4
geminin	20	0	0	20
Carbonic anhydrase 1	0	6	0	7
Carbonic anhydrase 2	0	7	1	10
60 kDa heat shock protein, mitochondrial	0	2	0	2
Beta-lactamase OXA-7	0	0	0	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Thiosulfate sulfurtransferase	0	2	0	2
Metallo-beta-lactamase VIM-13	0	0	0	2
Efflux transporter	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	0	0	2
Class D beta-lactamase	0	1	0	3
60 kDa chaperonin	0	2	0	2
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	2
10 kDa chaperonin	0	2	0	2
Metallo-b-lactamase	0	0	0	3
Carbapenem-hydrolyzing beta-lactamase KPC	0	1	0	3
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	3
Beta-lactamase VIM-1	0	0	0	2
ATP-dependent phosphofructokinase	8	0	0	8
Chain A, Ferritin light chain	4	0	0	4
DNA topoisomerase	0	1	0	1
thioredoxin reductase	16	0	0	16
15-lipoxygenase, partial	4	0	0	4
ATAD5 protein, partial	6	0	0	6
Fumarate hydratase	8	0	0	8
NFKB1 protein, partial	3	0	0	3
PPM1D protein	4	0	0	4
TDP1 protein	21	0	0	21
Thrombopoietin	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	15	0	0	15
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
thyroid stimulating hormone receptor	7	0	0	7
EWS/FLI fusion protein	13	0	0	13
estrogen-related nuclear receptor alpha	20	0	0	20
polyprotein	8	0	0	8
67.9K protein	8	0	0	8
glucocerebrosidase	4	0	0	4
putative alpha-glucosidase	1	0	0	1
alpha-galactosidase	3	0	0	3
lysosomal alpha-glucosidase preproprotein	4	0	0	4
peripheral myelin protein 22 isoform 1	6	0	0	6
hemoglobin subunit beta	2	0	0	2
cellular tumor antigen p53 isoform a	6	0	0	6
cytochrome P450 2C19 precursor	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	10	0	0	10
huntingtin isoform 2	3	0	0	3
ras-related protein Rab-9A	2	0	0	2
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	8	0	0	8
survival motor neuron protein isoform d	8	0	0	8
cytochrome P450 3A4 isoform 1	8	0	0	8
M-phase phosphoprotein 8	4	0	0	4
muscleblind-like protein 1 isoform 1	5	0	0	5
histone acetyltransferase KAT2A isoform 1	8	0	0	8
relaxin receptor 1 isoform 1	2	0	0	2
lethal factor (plasmid)	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	8	1	0	9
Telomerase reverse transcriptase	0	1	0	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Histone deacetylase 3	0	1	0	1
Type-2 restriction enzyme ScaI	0	1	0	1
Deoxyribonuclease-2-alpha	0	1	0	1
Tyrosyl-DNA phosphodiesterase 2	0	1	0	1
Deoxyribonuclease-1	0	1	0	1
Type-2 restriction enzyme PstI	0	1	0	1
Type-2 restriction enzyme EcoRI	0	1	0	1
Prothrombin	0	0	0	1
DNA ligase	0	1	0	1
Interferon beta	13	0	0	13
Integrin beta-3	5	1	0	6
Integrin alpha-IIb	5	0	0	5
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
DNA topoisomerase 1	0	1	1	7
DNA topoisomerase 2-alpha	0	2	0	5
Gamma-aminobutyric acid receptor subunit beta-1	8	1	0	9
Gamma-aminobutyric acid receptor subunit delta	8	1	0	9
Gamma-aminobutyric acid receptor subunit gamma-2	8	1	0	9
Gamma-aminobutyric acid receptor subunit alpha-5	8	1	0	9
Gamma-aminobutyric acid receptor subunit alpha-3	8	1	0	9
Gamma-aminobutyric acid receptor subunit gamma-1	8	1	0	9
Gamma-aminobutyric acid receptor subunit alpha-2	8	1	0	9
Type-2 restriction enzyme BamHI	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	8	1	0	9
Gamma-aminobutyric acid receptor subunit gamma-3	8	1	0	9
Gamma-aminobutyric acid receptor subunit alpha-6	8	1	0	9
Somatostatin receptor type 1	0	1	0	1
Somatostatin receptor type 2	0	1	0	1
Somatostatin receptor type 4	0	1	0	1
Somatostatin receptor type 3	0	1	0	1
Somatostatin receptor type 5	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Type-2 restriction enzyme HindIII	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
Histone deacetylase 4	0	1	0	1
Ribonuclease pancreatic	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	8	1	0	9
Gamma-aminobutyric acid receptor subunit beta-3	8	1	0	9
Gamma-aminobutyric acid receptor subunit beta-2	8	1	0	9
Inositol monophosphatase 1	4	0	0	4
DNA topoisomerase 2-beta	0	0	0	1
DNA topoisomerase 1	0	1	0	2
Histone deacetylase 1	0	1	0	1
DNA topoisomerase 1	0	1	0	1
Integrase	0	3	0	3
Histone deacetylase 7	0	1	0	1
GABA theta subunit	8	1	0	9
Histone deacetylase 2	0	1	0	1
DNA topoisomerase type IB small subunit	0	0	1	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	8	1	0	9
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
RAR-related orphan receptor gamma	15	0	0	15
SMAD family member 2	8	0	0	8
SMAD family member 3	8	0	0	8
caspase 7, apoptosis-related cysteine protease	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	13	0	0	13
retinoid X nuclear receptor alpha	15	0	0	15
caspase-3	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	13	0	0	13
Histone H2A.x	14	0	0	14
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
acetylcholinesterase	7	0	0	7
estrogen receptor 2 (ER beta)	15	0	0	15
G	8	0	0	8
cytochrome P450 2D6	9	0	0	9
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	8	0	0	8
Inositol hexakisphosphate kinase 1	8	0	0	8
cytochrome P450 2C9, partial	8	0	0	8
Microtubule-associated protein tau	8	0	0	8
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
mitogen-activated protein kinase 1	6	0	0	6
Solute carrier family 22 member 6	0	5	0	5
Solute carrier family 22 member 8	0	2	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	7	0	0	7
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
Luciferase	10	0	0	10
PAX8	0	0	0	1
glp-1 receptor, partial	5	0	0	5
pregnane X receptor	6	0	0	6
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
USP1 protein, partial	6	0	0	6
PINK1	2	0	0	2
progesterone receptor	14	0	0	14
cytochrome P450 family 3 subfamily A polypeptide 4	13	0	0	13
pregnane X nuclear receptor	14	0	0	14
Parkin	2	0	0	2
peroxisome proliferator activated receptor gamma	14	0	0	14
heat shock protein 90	0	0	1	1
IDH1	7	0	0	7
calcineurin A1, putative	0	0	1	1
aryl hydrocarbon receptor	6	0	0	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
thyroid stimulating hormone receptor	6	0	0	6
activating transcription factor 6	4	0	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
cytochrome P450 2D6 isoform 1	1	0	0	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cytochrome P450 2C9 precursor	4	0	0	4
perilipin-5	0	1	0	1
thyroid hormone receptor beta isoform a	6	0	0	6
perilipin-1	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
transcriptional regulator ERG isoform 3	3	0	0	3
heat shock protein beta-1	7	0	0	7
importin subunit beta-1 isoform 1	4	0	0	4
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
flap endonuclease 1	6	0	0	6
protein AF-9 isoform a	0	0	0	1
snurportin-1	4	0	0	4
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
bcl-2-related protein A1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
Solute carrier family 22 member 1	0	3	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Glutathione reductase, mitochondrial	0	2	0	3
72 kDa type IV collagenase	0	4	0	4
Matrix metalloproteinase-9	0	3	0	3
Glutamate receptor 2	8	0	0	8
Trypanothione reductase	0	1	0	1
Alpha-synuclein	1	1	0	2
Histamine H2 receptor	6	0	0	6
TAR DNA-binding protein 43	8	0	0	8
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
Multidrug and toxin extrusion protein 1	0	3	0	3
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	6	0	0	6
Spermine oxidase	0	1	0	1
endonuclease IV	4	0	0	4
neuropeptide S receptor isoform A	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Guanine nucleotide-binding protein G	4	0	0	4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	3
DNA gyrase subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA gyrase subunit A	0	1	0	2
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
Stromelysin-1	0	2	2	4
Macrophage metalloelastase	0	1	0	1
dopamine D1 receptor	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Glucocorticoid receptor	0	4	1	5
Sex hormone-binding globulin	0	0	2	2
Glycine receptor subunit alpha-1	0	4	0	4
Corticosteroid-binding globulin	0	2	0	2
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	4	0	0	4
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Thymidine kinase 2	0	1	0	1
Deoxycytidine kinase	0	0	0	2
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	2
AAA family ATPase	0	0	0	2
Reverse transcriptase/RNaseH	0	0	1	1
Genome polyprotein	0	2	0	2
Tyrosine-protein kinase Fyn	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	2
Carbonic anhydrase 4	0	3	0	4
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase 15	0	2	0	3
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
nonstructural protein 1	2	0	0	2
Vpr	2	0	0	2
Solute carrier family 22 member 8	0	1	0	3
Epidermal growth factor receptor	0	2	0	2
Amyloid-beta precursor protein	1	0	0	1
Thymidylate synthase	0	3	0	3
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, DEOXYNUCLEOSIDE KINASE	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Procathepsin L	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	1	1	2
Equilibrative nucleoside transporter 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
WRN	2	0	0	2
Mcl-1	0	1	0	1
MPI protein	0	1	0	1
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0	0	0	1
alkaline phosphatase, intestinal	0	0	1	1
thioredoxin glutathione reductase	5	0	0	5
hypothetical protein, conserved	2	0	0	2
luciferase	1	0	0	1
pyruvate kinase	1	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	2	0	2
CDK5	0	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
major prion protein preproprotein Prp precursor	0	1	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	0	1	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	2	0	2
intestinal alkaline phosphatase precursor	0	0	1	1
serine/threonine-protein kinase PLK1	4	0	0	4
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Vif	0	1	0	1
Tat	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	3	1	0	4
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
endoribonuclease toxin MazF	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Pyruvate kinase PKM	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
phosphoglycerate kinase	2	0	0	2
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	1	0	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Amino acid transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Urease subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Urease subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Carbonic anhydrase 9	0	3	0	5
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Chain A, Acetylcholinesterase	0	1	0	1
interferon gamma precursor	0	0	0	1
Interstitial collagenase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Muscarinic acetylcholine receptor M4	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Liver carboxylesterase 1	0	0	0	1
Chymotrypsinogen A	0	1	0	1
Albumin	0	1	1	2
Serum paraoxonase/arylesterase 1	0	3	0	3
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	1	2
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	3	0	3
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	4
Solute carrier family 22 member 6	0	3	0	3
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier family 22 member 11	0	0	0	2
Protein-arginine deiminase type-4	0	2	0	2
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	3
Prostaglandin G/H synthase 2	0	1	0	1
Formyl peptide receptor-related sequence 1	0	0	1	1
fMet-Leu-Phe receptor	0	2	2	4
N-formyl peptide receptor 2	0	0	2	2
FML2_HUMAN	0	0	1	1
Androgen receptor	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	0	1	0	1
Nrf2	1	0	0	1
Microphthalmia-associated transcription factor	0	0	0	1
Smad3	2	0	0	2
caspase recruitment domain family, member 15	0	1	0	1
Caspase-7	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
caspase-3	2	0	0	2
histone deacetylase 9 isoform 3	2	0	0	2
receptor-interacting serine/threonine-protein kinase 2 isoform 1	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Beta lactamase (plasmid)	0	1	0	1
Valosin-containing protein	0	1	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	2	0	0	2
Neuronal acetylcholine receptor subunit beta-2	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
Tubulin alpha-1A chain	0	0	1	2
Tubulin beta chain	0	0	1	1
Tubulin beta-4A chain	0	1	1	3
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Integrin alpha-V	0	1	0	1
Tubulin beta chain	0	1	1	3
ATP-dependent translocase ABCB1	0	2	0	4
60 kDa chaperonin	0	1	0	1
Tubulin alpha-3C chain	0	1	1	3
Botulinum neurotoxin type A	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
Fibroblast growth factor receptor 1	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Substance-K receptor	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
Cholecystokinin receptor type A	0	2	0	2
Melanocortin receptor 5	0	2	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Tubulin alpha-1B chain	0	1	1	3
Tubulin alpha-4A chain	0	1	1	3
Tubulin beta-4B chain	0	1	1	3
Bcl-2-like protein 1	0	1	0	1
Tyrosine-protein kinase Mer	0	1	0	1
Tubulin beta-3 chain	0	2	1	4
Tubulin beta-2A chain	0	1	1	3
Beta-tubulin	0	1	0	1
Tubulin beta-8 chain	0	1	1	3
Tubulin beta-2B chain	0	0	1	3
Tubulin alpha-3E chain	0	1	1	3
Tubulin alpha-1A chain	0	1	1	3
Similar to alpha-tubulin isoform 1	0	0	1	3
Similar to alpha-tubulin isoform 1	0	0	0	2
Tubulin alpha-1C chain	0	1	1	3
Tubulin beta-6 chain	0	1	1	3
Tubulin beta-2B chain	0	1	1	3
Tubulin beta-1 chain	0	1	1	3
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	3	0	3
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	2
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	1	0	2
streptokinase A precursor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase TEM	0	3	0	4
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	2
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
vasopressin V1b receptor	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Tumor necrosis factor	0	1	0	1
Cholinesterase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Adenosine receptor A2b	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chitotriosidase-1	0	2	1	3
Endochitinase B1	0	2	1	3
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Carbonic anhydrase 12	0	2	0	3
Plasma kallikrein	0	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Carbonic anhydrase 3	0	1	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Carbonic anhydrase 6	0	1	0	2
Adenosine receptor A1	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Carbonic anhydrase 7	0	1	0	2
Carbonic anhydrase	0	0	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	2
SLC16A10 protein	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 13	0	1	0	2
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Carbonic anhydrase 14	0	2	0	3
Phospholipase A-2-activating protein	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
GALC protein	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Muscarinic acetylcholine receptor M2	0	2	1	3
Muscarinic acetylcholine receptor M1	0	2	0	3
Muscarinic acetylcholine receptor M3	0	2	0	3
Muscarinic acetylcholine receptor M4	0	2	0	3
Muscarinic acetylcholine receptor M5	0	2	0	3
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	0	3
Muscarinic acetylcholine receptor M1	0	1	2	3
Cytochrome P450 2A6	0	1	1	2
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Cytochrome P450 2A13	0	1	1	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
heat shock protein 90, putative	0	0	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Prolyl 4-hydroxylase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
photoreceptor-specific nuclear receptor	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Insulin receptor	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Carbonic anhydrase	0	1	0	1
Eyes absent homolog 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase OXA-1	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Metallo-beta-lactamase type 2	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Neutrophil collagenase	0	2	0	2
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Serine/threonine-protein kinase D3	0	0	1	1
Protein kinase C gamma type	0	1	1	2
Protein kinase C beta type	0	1	1	2
Luciferin 4-monooxygenase	0	0	1	1
Protein kinase C alpha type	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Protein kinase C eta type	0	0	1	1
Protein kinase C iota type	0	0	1	1
Protein kinase C epsilon type	0	1	1	2
Protein kinase C theta type	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	1	1	2
Serine/threonine-protein kinase D1	0	0	1	1
Ras guanyl-releasing protein 3	0	0	1	1
Thymidine phosphorylase	0	1	0	1
Microtubule-associated protein tau	0	2	0	2
Butyrophilin subfamily 3 member A1	0	0	1	2
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	2	0	2
H	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (337)

Protein Targets (835)

Osteoradionecrosis

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (337)

Drugs Studied (119)

Protein Targets (835)