metronidazole has been researched along with Ludwig's Angina in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Ludwig's Angina: Severe cellulitis of the submaxillary space with secondary involvement of the perimandibular spaces. It usually results from infection in the lower molar area or from an infection following a penetrating injury to the MOUTH FLOOR.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ludwig's angina is an uncommon but potentially fatal condition which presents as a hard swelling of the floor of the mouth." | 1.28 | Ludwig's angina: a place for steroid therapy in its management? ( Freund, B; Timon, C, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van Kuilenburg, JT | 1 |
| van Niekerk, J | 1 |
| Sinnige, H | 1 |
| de Jager, CP | 1 |
| Rao, DD | 1 |
| Desai, A | 1 |
| Kulkarni, RD | 1 |
| Gopalkrishnan, K | 1 |
| Rao, CB | 1 |
| Zeitoun, IM | 1 |
| Dhanarajani, PJ | 1 |
| Freund, B | 1 |
| Timon, C | 1 |
1 review available for metronidazole and Ludwig's Angina
| Article | Year |
|---|---|
Cervical cellulitis and mediastinitis caused by odontogenic infections: report of two cases and review of literature.
Topics: Adult; Amikacin; Fatal Outcome; Focal Infection, Dental; Humans; Ludwig's Angina; Male; Mediastinal | 1995 |
3 other studies available for metronidazole and Ludwig's Angina
| Article | Year |
|---|---|
A woman with a swollen neck.
Topics: Aged; Anti-Bacterial Agents; Cefuroxime; Female; Humans; Ludwig's Angina; Metronidazole; Neck; Neck | 2009 |
Comparison of maxillofacial space infection in diabetic and nondiabetic patients.
Topics: Adolescent; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Case-Control Studi | 2010 |
Ludwig's angina: a place for steroid therapy in its management?
Topics: Humans; Injections, Intravenous; Ludwig's Angina; Male; Methylprednisolone; Metronidazole; Middle Ag | 1992 |