metronidazole has been researched along with Bewilderment in 8 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Acute reversible cerebellar ataxia with confusion secondary to prolonged metronidazole use has been reported rarely as a cause of encephalopathy in patients with ALD." | 3.83 | Metronidazole-Induced Encephalopathy in Alcoholic Liver Disease: A Diagnostic and Therapeutic Challenge. ( Contractor, Q; Jain, SS; Mohite, AR; Pawar, SV; Rathi, PM; Sonthalia, N; Surude, RG, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cowdell, JC | 1 |
| Burton, MC | 1 |
| Harris, D | 1 |
| Holmes-Maybank, K | 1 |
| Harte, BJ | 1 |
| Josephson, SA | 1 |
| Rizvi, I | 1 |
| Garg, RK | 1 |
| Kumar, N | 1 |
| Pandey, S | 1 |
| Malhotra, HS | 1 |
| Sonthalia, N | 1 |
| Pawar, SV | 1 |
| Mohite, AR | 1 |
| Jain, SS | 1 |
| Surude, RG | 1 |
| Rathi, PM | 1 |
| Contractor, Q | 1 |
| Manek, K | 1 |
| Williams, V | 1 |
| Callery, S | 1 |
| Daneman, N | 1 |
| Mahl, TC | 1 |
| Ummadi, S | 1 |
| Rohatgi, A | 1 |
| Monga, R | 1 |
| Goyal, D | 1 |
| Giannini, AJ | 1 |
| Moulin, B | 1 |
| Dhib, M | 1 |
| Heudes, AM | 1 |
| Godin, M | 1 |
| Fillastre, JP | 1 |
1 review available for metronidazole and Bewilderment
| Article | Year |
|---|---|
Rendered Speechless.
Topics: Anti-Infective Agents; Cerebellum; Confusion; Humans; Male; Metronidazole; Middle Aged; Speech Disor | 2017 |
7 other studies available for metronidazole and Bewilderment
| Article | Year |
|---|---|
Metronidazole-associated encephalopathy: a reversible condition.
Topics: Anti-Bacterial Agents; Ataxia; Brain Diseases; Confusion; Humans; Magnetic Resonance Imaging; Male; | 2018 |
Metronidazole-Induced Encephalopathy in Alcoholic Liver Disease: A Diagnostic and Therapeutic Challenge.
Topics: Anti-Infective Agents; Cerebellar Ataxia; Confusion; Dysarthria; Humans; Liver Diseases, Alcoholic; | 2016 |
Reducing the risk of severe complications among patients with Clostridium difficile infection.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Antiprotozoal Agents; Comorbidity; Confusion; Entero | 2011 |
Metronidazole and mental confusion.
Topics: Administration, Oral; Aged; Colitis; Confusion; Diarrhea; Dose-Response Relationship, Drug; Follow-U | 2003 |
Metronidazole induced acute confusional agitated state.
Topics: Antitrichomonal Agents; Confusion; Humans; Male; Metronidazole; Middle Aged; Psychomotor Agitation | 2000 |
Side effects of metronidazole.
Topics: Adult; Cognition Disorders; Confusion; Depression; Female; Humans; Metronidazole | 1977 |
[Neurotoxic risk of metronidazole in severe renal insufficiency].
Topics: Acute Kidney Injury; Adult; Confusion; Female; Humans; Metronidazole; Renal Dialysis; Seizures | 1988 |