metronidazole has been researched along with Carcinoma, Hepatocellular in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Broad-spectrum antibiotics, including piperacillin/tazobactam and metronidazole, were administered, and a percutaneous 10-French pigtail catheter for pus drainage and culture was inserted in the liver abscess." | 4.98 | Liver abscess caused by Clostridium haemolyticum infection after transarterial chemoembolization for hepatocellular carcinoma: A case report. ( Cho, SB; Hong, JY; Jeong, YH; Joo, YE; Kang, YJ; Kim, JW; Kim, KH; Lee, WS; Myung, DS; Son, DJ, 2018) |
| " difficile may contributed to the recurrent CDB episodes and liver abscess formation in necrotic liver tissue following TACE, and long-term metronidazole therapy was considered to be effective to C." | 3.85 | Recurrent bacteremia and liver abscess caused by Clostridium difficile: A case report. ( Iguchi, M; Kuzuya, T; Mikamo, H; Morioka, H; Yagi, T, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morioka, H | 1 |
| Iguchi, M | 1 |
| Kuzuya, T | 1 |
| Mikamo, H | 1 |
| Yagi, T | 1 |
| Son, DJ | 1 |
| Hong, JY | 1 |
| Kim, KH | 1 |
| Jeong, YH | 1 |
| Myung, DS | 1 |
| Cho, SB | 1 |
| Lee, WS | 1 |
| Kang, YJ | 1 |
| Kim, JW | 1 |
| Joo, YE | 1 |
| Izumiya, M | 1 |
| Yajima, T | 1 |
| Serizawa, H | 1 |
| Watanabe, N | 1 |
| Hamada, Y | 1 |
| Tsunematsu, S | 1 |
| Kumagai, N | 1 |
| Tsuchimoto, K | 1 |
| Toyoda, H | 1 |
| Hibi, T | 1 |
| Ishii, H | 1 |
| Castells, A | 1 |
| Bruix, J | 1 |
| Ayuso, C | 1 |
| Brú, C | 1 |
| Montanyà, X | 1 |
| Boix, L | 1 |
| Rodès, J | 1 |
| Archampong, EQ | 1 |
2 reviews available for metronidazole and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Liver abscess caused by Clostridium haemolyticum infection after transarterial chemoembolization for hepatocellular carcinoma: A case report.
Topics: Aged; Anti-Bacterial Agents; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Clostridium | 2018 |
[A case of Crohn's disease complicated with hepatocellular carcinoma].
Topics: Adult; Anti-Inflammatory Agents; Carcinoma, Hepatocellular; Crohn Disease; Drug Combinations; Drug T | 2003 |
1 trial available for metronidazole and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Transarterial embolization for hepatocellular carcinoma. Antibiotic prophylaxis and clinical meaning of postembolization fever.
Topics: Aged; Anti-Bacterial Agents; Arteries; Carcinoma, Hepatocellular; Cefotaxime; Drug Therapy, Combinat | 1995 |
2 other studies available for metronidazole and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Recurrent bacteremia and liver abscess caused by Clostridium difficile: A case report.
Topics: Aged; Anti-Bacterial Agents; Bacteremia; Bacterial Translocation; Carcinoma, Hepatocellular; Chemoem | 2017 |
Amoebic liver disease.
Topics: Adolescent; Adult; Carcinoma, Hepatocellular; Child; Diagnosis, Differential; Female; Hepatomegaly; | 1977 |