metronidazole and methotrexate

metronidazole has been researched along with methotrexate in 34 studies

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19905 (14.71)18.7374
1990's4 (11.76)18.2507
2000's10 (29.41)29.6817
2010's15 (44.12)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Abaszadeh, M; AbdolahRamazani, S; Faghih-Mirzaei, E; Jafari, M; Khodadadi, A; Pirhadi, S; Sabouri, S; Shamsadinipour, M; Zeidabadinejad, L1
Jenkin, RD1
Giles, GR; Hannam, TW; Kelly, JP1
Cohen, SA; Daum, F; Glassman, M; Holmes, RD; Markowitz, J; Piccoli, D; Rossi, TM; Treem, WR; Ulshen, MH; Winter, HS1
Asanov, AA; Azhigaliev, NA; Fel'dman, SZ; Kusherbaev, SK; Sadykov, SS1
Carter, RF1
Tannock, IF1
van Hogezand, RA1
Bielack, S; de Wit, M; Dürken, M; Erttmann, R; Jaburg, N; Kabisch, H; Kröger, N; Krüger, W; Löliger, C; Renges, H; Rüssmann, B; Stockschläder, M; Wacker-Backhaus, G; Zabelina, T; Zander, AR1
Encke, J; Erb, G; Flosdorff, P; Ganten, M; Grüber-Hoffmann, B; Hansmann, J1
Beglinger, Ch1
Herrlinger, K; Stange, EF1
Koning, E; Lerebours, E; Michot, F; Savoye, G; Savoye-Collet, C; Tougeron, D1
Krämer, S; Maarouf, M; Müller-Lung, U1
Zhang, JC; Zhang, X1
Ahn, HJ; Choi, KY; Kim, NY; Kim, SW; Lee, HM; Lee, HN; Yu, JH1
Chaturvedi, A; Ishak, GE; Iyer, RS; Khanna, PC; Pruthi, S1
Fujita, Y; Ozeki, T1
Bull, J; Ebbers, MNB; Engelmann, R; Kneitz, S; Kreikemeyer, B; Lang, H; Lübcke, PM; Müller-Hilke, B; Volzke, J1
Chai, W; Cui, L; Gong, F; He, Z; Jia, G; Liu, X; Wen, Y1

Reviews

6 review(s) available for metronidazole and methotrexate

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Radiation sensitizers.
    Cancer, 1976, Volume: 37, Issue:4 Suppl

    Topics: Animals; Antineoplastic Agents; Bromodeoxycytidine; Bromodeoxyuridine; Carcinoma; Deoxyuridine; Dogs; Dose-Response Relationship, Radiation; Floxuridine; Humans; Hypoxia; Idoxuridine; Lung Neoplasms; Methotrexate; Metronidazole; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Research; Sarcoma, Experimental; Skin

1976
Medical management of patients with difficult-to-treat inflammatory bowel disease.
    The Netherlands journal of medicine, 1994, Volume: 45, Issue:2

    Topics: Adrenal Cortex Hormones; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Colitis, Ulcerative; Crohn Disease; Cyclosporine; Humans; Mercaptopurine; Mesalamine; Methotrexate; Metronidazole

1994
[Treatment of Crohn's disease].
    Therapeutische Umschau. Revue therapeutique, 2003, Volume: 60, Issue:3

    Topics: Acute Disease; Adjuvants, Immunologic; Adrenal Cortex Hormones; Algorithms; Aminosalicylic Acids; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Azathioprine; Budesonide; Case-Control Studies; Clinical Trials as Topic; Crohn Disease; Drug Therapy, Combination; Gastrointestinal Agents; Humans; Immunosuppressive Agents; Infliximab; Mesalamine; Methotrexate; Metronidazole; Osteoporosis; Prednisolone; Prednisone; Randomized Controlled Trials as Topic; Time Factors

2003
[Chronic inflammatory bowel diseases].
    Deutsche medizinische Wochenschrift (1946), 2004, Oct-15, Volume: 129, Issue:42

    Topics: Adrenal Cortex Hormones; Adult; Aminosalicylic Acids; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Azathioprine; Budesonide; Colitis, Ulcerative; Colonoscopy; Controlled Clinical Trials as Topic; Crohn Disease; Diagnosis, Differential; Female; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Magnetic Resonance Imaging; Mercaptopurine; Methotrexate; Metronidazole; Pouchitis; Remission Induction; Tacrolimus; Time Factors; Tomography, X-Ray Computed; Ultrasonography

2004
Low-dose methotrexate-induced vulvar edema: A case report.
    Medicine, 2019, Volume: 98, Issue:35

    Topics: Abdominal Pain; Administration, Oral; Adult; China; Female; Glycyrrhizic Acid; Humans; Injections, Intramuscular; Materia Medica; Methotrexate; Metronidazole; Pregnancy; Pregnancy, Ectopic; Treatment Outcome; Trichomonas Vaginitis; Uterine Hemorrhage; Vulvar Diseases

2019

Trials

1 trial(s) available for metronidazole and methotrexate

ArticleYear
Use of a five-agent GVHD prevention regimen in recipients of unrelated donor marrow.
    Bone marrow transplantation, 1999, Volume: 23, Issue:9

    Topics: Adolescent; Adult; Anti-Infective Agents; Antilymphocyte Serum; Bone Marrow Transplantation; Child; Child, Preschool; Cyclosporine; Drug Therapy, Combination; Female; Graft vs Host Disease; Hematologic Diseases; Histocompatibility Testing; Humans; Immunoglobulin A; Immunoglobulin M; Immunosuppressive Agents; Infant; Male; Methotrexate; Metronidazole; Middle Aged; Transplantation, Homologous; Treatment Outcome

1999

Other Studies

27 other study(ies) available for metronidazole and methotrexate

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Metronidazole aryloxy, carboxy and azole derivatives: Synthesis, anti-tumor activity, QSAR, molecular docking and dynamics studies.
    Bioorganic & medicinal chemistry, 2019, 01-15, Volume: 27, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Catalytic Domain; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Focal Adhesion Kinase 1; Humans; Hydrogen Bonding; Metronidazole; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Protein Kinase Inhibitors; Quantitative Structure-Activity Relationship

2019
Radiation treatment of Ewing's sarcoma and osteogenic sarcoma.
    Canadian journal of surgery. Journal canadien de chirurgie, 1977, Volume: 20, Issue:6

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Doxorubicin; Female; Humans; Lung Neoplasms; Methotrexate; Metronidazole; Neoplasm Metastasis; Osteosarcoma; Radiotherapy Dosage; Sarcoma, Ewing

1977
The cytocidal action of metronidazole in combination with other antineoplastic agents.
    Cancer treatment reviews, 1979, Volume: 6 Suppl

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Hypoxia; Methotrexate; Metronidazole; Mice; Neoplasms, Experimental

1979
Immunology of inflammatory bowel disease: summary of the proceedings of the Subcommittee on Immunosuppressive Use in IBD.
    Journal of pediatric gastroenterology and nutrition, 1991, Volume: 12, Issue:4

    Topics: Aminosalicylic Acids; Anti-Inflammatory Agents; Humans; Immunologic Factors; Immunosuppressive Agents; Inflammatory Bowel Diseases; Lipoxygenase Inhibitors; Mercaptopurine; Mesalamine; Methotrexate; Metronidazole; Steroids

1991
[Results of radiation and chemoradiation therapy in esophageal cancer].
    Meditsinskaia radiologiia, 1990, Volume: 35, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Dactinomycin; Doxorubicin; Esophageal Neoplasms; Gamma Rays; Humans; Methotrexate; Metronidazole; Prospidium; Radiotherapy Dosage; Remission Induction; Time Factors

1990
Sensitivity to amphotericin B of a Naegleria sp. isolated from a case of primary amoebic meningoencephalitis.
    Journal of clinical pathology, 1969, Volume: 22, Issue:4

    Topics: Amebiasis; Amoeba; Amphotericin B; Animals; Chloramphenicol; Emetine; Humans; Meningoencephalitis; Methotrexate; Metronidazole; Mice; Oxytetracycline; Penicillins; Quinine; Streptomycin; Sulfadiazine

1969
In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: methotrexate, 5-fluorouracil and adriamycin.
    British journal of cancer, 1980, Volume: 42, Issue:6

    Topics: Animals; Body Weight; Doxorubicin; Drug Therapy, Combination; Fibrosarcoma; Fluorouracil; Leukocyte Count; Male; Mammary Neoplasms, Experimental; Methotrexate; Metronidazole; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental

1980
[Follow up of Crohn's disease under therapy with hydro-MRI].
    Der Radiologe, 2003, Volume: 43, Issue:1

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Azathioprine; Crohn Disease; Cyclosporins; Enema; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Male; Methotrexate; Metronidazole; Middle Aged; Recurrence; Retrospective Studies; Sulfonamides; Time Factors

2003
Predicting factors of fistula healing and clinical remission after infliximab-based combined therapy for perianal fistulizing Crohn's disease.
    Digestive diseases and sciences, 2009, Volume: 54, Issue:8

    Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; Azathioprine; Ciprofloxacin; Crohn Disease; Drainage; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Infliximab; Intestinal Fistula; Magnetic Resonance Imaging; Male; Methotrexate; Metronidazole; Middle Aged; Predictive Value of Tests; Remission Induction; Retrospective Studies

2009
[Prolonged fever and monocytosis after hemorrhoidectomy and treatment with methotrexate--listeriosis with cerebral abscess].
    Deutsche medizinische Wochenschrift (1946), 2009, Volume: 134, Issue:23

    Topics: Anti-Infective Agents; Biopsy, Needle; Brain; Brain Abscess; Diagnosis, Differential; Drug Therapy, Combination; Fever; Hemorrhoids; Humans; Immunosuppressive Agents; Leukocytosis; Listeriosis; Magnetic Resonance Imaging; Male; Methotrexate; Metronidazole; Middle Aged; Monocytes; Penicillins; Psoriasis; Stereotaxic Techniques; Tomography, X-Ray Computed

2009
[Combined therapy in a patient with generalized aggressive periodontitis and rheumatoid arthritis: a 15-year follow up case].
    Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology, 2010, Volume: 45, Issue:5

    Topics: Adult; Aggressive Periodontitis; Anti-Infective Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Dental Scaling; Female; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Methotrexate; Metronidazole; Periodontal Splints; Root Canal Therapy; Spiramycin

2010
[A case of pseudomembranous colitis in a juvenile rheumatoid arthritis patient taking methotrexate].
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2010, Volume: 56, Issue:6

    Topics: Abdominal Pain; Adolescent; Anti-Infective Agents; Antirheumatic Agents; Arthritis, Juvenile; Diagnosis, Differential; Diarrhea; Enterocolitis, Pseudomembranous; Humans; Male; Methotrexate; Metronidazole; Sigmoidoscopy; Tomography, X-Ray Computed

2010
Medication neurotoxicity in children.
    Pediatric radiology, 2011, Volume: 41, Issue:11

    Topics: Adolescent; Angiogenesis Inhibitors; Anti-Infective Agents; Antibodies, Monoclonal, Humanized; Bevacizumab; Child, Preschool; Cyclosporine; Female; Humans; Immunosuppressive Agents; Infant; Magnetic Resonance Imaging; Male; Methotrexate; Metronidazole; Neurotoxicity Syndromes; Posterior Leukoencephalopathy Syndrome; Tacrolimus; Young Adult

2011
Asymptomatic colitis induced by low-dose methotrexate.
    BMJ case reports, 2016, Nov-25, Volume: 2016

    Topics: Aged; Anti-Infective Agents; Antibodies, Monoclonal, Humanized; Antidotes; Antirheumatic Agents; Arthritis, Rheumatoid; Colitis; Colonoscopy; Drug Therapy, Combination; Female; Humans; Incidental Findings; Leucovorin; Methotrexate; Metronidazole

2016
Periodontal treatment prevents arthritis in mice and methotrexate ameliorates periodontal bone loss.
    Scientific reports, 2019, 05-31, Volume: 9, Issue:1

    Topics: Alveolar Bone Loss; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Chlorhexidine; Collagen; Disease Progression; Injections, Intraperitoneal; Male; Methotrexate; Metronidazole; Mice; Mice, Inbred DBA; Periodontitis; Porphyromonas gingivalis; X-Ray Microtomography

2019