metronidazole has been researched along with Liver Neoplasms in 16 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifteen to 25% of patients with colorectal cancer have combined liver metastases at the time of diagnosis, whereas an additional 15 to 25% will develop liver metastases after curative resection of primary colorectal cancer, with the vast majority (80-90%) of liver metastases unresponsive to curative resection at first." | 7.30 | A prospective, single-centre, randomized, double-blind controlled study protocol to study whether long-term oral metronidazole can effectively reduce the incidence of postoperative liver metastasis in patients with colorectal cancer. ( Dong, DH; Gao, RQ; Ji, G; Li, XH; Mo, ZC; Wang, WD; Yang, XS; Yu, PF; Zhou, HK, 2023) |
| "Broad-spectrum antibiotics, including piperacillin/tazobactam and metronidazole, were administered, and a percutaneous 10-French pigtail catheter for pus drainage and culture was inserted in the liver abscess." | 4.98 | Liver abscess caused by Clostridium haemolyticum infection after transarterial chemoembolization for hepatocellular carcinoma: A case report. ( Cho, SB; Hong, JY; Jeong, YH; Joo, YE; Kang, YJ; Kim, JW; Kim, KH; Lee, WS; Myung, DS; Son, DJ, 2018) |
| " difficile may contributed to the recurrent CDB episodes and liver abscess formation in necrotic liver tissue following TACE, and long-term metronidazole therapy was considered to be effective to C." | 3.85 | Recurrent bacteremia and liver abscess caused by Clostridium difficile: A case report. ( Iguchi, M; Kuzuya, T; Mikamo, H; Morioka, H; Yagi, T, 2017) |
| "Fifteen to 25% of patients with colorectal cancer have combined liver metastases at the time of diagnosis, whereas an additional 15 to 25% will develop liver metastases after curative resection of primary colorectal cancer, with the vast majority (80-90%) of liver metastases unresponsive to curative resection at first." | 3.30 | A prospective, single-centre, randomized, double-blind controlled study protocol to study whether long-term oral metronidazole can effectively reduce the incidence of postoperative liver metastasis in patients with colorectal cancer. ( Dong, DH; Gao, RQ; Ji, G; Li, XH; Mo, ZC; Wang, WD; Yang, XS; Yu, PF; Zhou, HK, 2023) |
| "Ameboma are ulcerative, exophytic, inflammatory masses up to 15 cm in diameter in patients with long standing colonic amoebic infections containing granulation tissue with pseudotumor appearance." | 1.72 | Cecal ameboma and a liver abscess mimicking metastatic colonic cancer. An autochthonous infectious disease in Spain? ( Carbajo, AY; Fernández-Prada, SJ; Fuentes-Valenzuela, E; García-Pajares, F; Martínez Lara, C, 2022) |
| "Treatment with metronidazole successfully eliminated the protozoa and cured the pyothorax." | 1.30 | Trichomonas tenax empyema in an immunocompromised patient with advanced cancer. ( Arizono, N; Morimoto, T; Nakao, K; Shimatsu, A; Shiota, T, 1998) |
| "A reported excess of liver tumors in rats exposed to metronidazole can be explained by the fact that the authors failed to age standardize their data despite a big and highly significant beneficial effect of the drug on survival." | 1.27 | Toxicologic evaluation of metronidazole with particular reference to carcinogenic, mutagenic, and teratogenic potential. ( Roe, FJ, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (37.50) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 3 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| Fuentes-Valenzuela, E | 1 |
| Carbajo, AY | 1 |
| Fernández-Prada, SJ | 1 |
| Martínez Lara, C | 1 |
| García-Pajares, F | 1 |
| Wang, M | 1 |
| Li, Y | 1 |
| Yang, X | 1 |
| Liu, Z | 1 |
| Wang, K | 1 |
| Gong, D | 1 |
| Li, J | 1 |
| Gao, RQ | 1 |
| Mo, ZC | 1 |
| Zhou, HK | 1 |
| Yu, PF | 1 |
| Wang, WD | 1 |
| Dong, DH | 1 |
| Yang, XS | 1 |
| Li, XH | 1 |
| Ji, G | 1 |
| Morioka, H | 1 |
| Iguchi, M | 1 |
| Kuzuya, T | 1 |
| Mikamo, H | 1 |
| Yagi, T | 1 |
| Bullman, S | 1 |
| Pedamallu, CS | 1 |
| Sicinska, E | 1 |
| Clancy, TE | 1 |
| Zhang, X | 1 |
| Cai, D | 1 |
| Neuberg, D | 1 |
| Huang, K | 1 |
| Guevara, F | 1 |
| Nelson, T | 1 |
| Chipashvili, O | 1 |
| Hagan, T | 1 |
| Walker, M | 1 |
| Ramachandran, A | 1 |
| Diosdado, B | 1 |
| Serna, G | 1 |
| Mulet, N | 1 |
| Landolfi, S | 1 |
| Ramon Y Cajal, S | 1 |
| Fasani, R | 1 |
| Aguirre, AJ | 1 |
| Ng, K | 1 |
| Élez, E | 1 |
| Ogino, S | 1 |
| Tabernero, J | 1 |
| Fuchs, CS | 1 |
| Hahn, WC | 1 |
| Nuciforo, P | 1 |
| Meyerson, M | 1 |
| Son, DJ | 1 |
| Hong, JY | 1 |
| Kim, KH | 1 |
| Jeong, YH | 1 |
| Myung, DS | 1 |
| Cho, SB | 1 |
| Lee, WS | 1 |
| Kang, YJ | 1 |
| Kim, JW | 1 |
| Joo, YE | 1 |
| Heil, TC | 1 |
| Dercksen, MW | 1 |
| Blank, SN | 1 |
| Izumiya, M | 1 |
| Yajima, T | 1 |
| Serizawa, H | 1 |
| Watanabe, N | 1 |
| Hamada, Y | 1 |
| Tsunematsu, S | 1 |
| Kumagai, N | 1 |
| Tsuchimoto, K | 1 |
| Toyoda, H | 1 |
| Hibi, T | 1 |
| Ishii, H | 1 |
| Roe, FJ | 1 |
| Moffat, FL | 2 |
| Falk, RE | 1 |
| Calhoun, K | 2 |
| Langer, JC | 1 |
| Dreznik, Z | 1 |
| Makowka, L | 2 |
| Rotstein, LE | 2 |
| Ambus, U | 1 |
| Howard, V | 2 |
| Campbell, A | 1 |
| Castells, A | 1 |
| Bruix, J | 1 |
| Ayuso, C | 1 |
| Brú, C | 1 |
| Montanyà, X | 1 |
| Boix, L | 1 |
| Rodès, J | 1 |
| Shiota, T | 1 |
| Arizono, N | 1 |
| Morimoto, T | 1 |
| Shimatsu, A | 1 |
| Nakao, K | 1 |
| Archampong, EQ | 1 |
| Ettinger, DS | 1 |
| Dragon, LH | 1 |
| Klein, J | 1 |
| Sgagias, M | 1 |
| Order, SE | 1 |
| Gilas, T | 1 |
| Falk, M | 1 |
| Dalfen, R | 1 |
| Laing, D | 1 |
| Venturi, D | 1 |
| Hammer, B | 1 |
| Reutter, FW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Rectal Microbiome Variability Among Rectal Cancer Cohorts Including Complete Clinical Responders, Pathologic Responders, and Early Recurrence[NCT04223102] | 40 participants (Anticipated) | Interventional | 2020-02-18 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for metronidazole and Liver Neoplasms
| Article | Year |
|---|---|
Liver abscess caused by Clostridium haemolyticum infection after transarterial chemoembolization for hepatocellular carcinoma: A case report.
Topics: Aged; Anti-Bacterial Agents; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Clostridium | 2018 |
[A case of Crohn's disease complicated with hepatocellular carcinoma].
Topics: Adult; Anti-Inflammatory Agents; Carcinoma, Hepatocellular; Crohn Disease; Drug Combinations; Drug T | 2003 |
2 trials available for metronidazole and Liver Neoplasms
| Article | Year |
|---|---|
A prospective, single-centre, randomized, double-blind controlled study protocol to study whether long-term oral metronidazole can effectively reduce the incidence of postoperative liver metastasis in patients with colorectal cancer.
Topics: Colorectal Neoplasms; Double-Blind Method; Humans; Incidence; Liver Neoplasms; Metronidazole; Prospe | 2023 |
Transarterial embolization for hepatocellular carcinoma. Antibiotic prophylaxis and clinical meaning of postembolization fever.
Topics: Aged; Anti-Bacterial Agents; Arteries; Carcinoma, Hepatocellular; Cefotaxime; Drug Therapy, Combinat | 1995 |
12 other studies available for metronidazole and Liver Neoplasms
| Article | Year |
|---|---|
Cecal ameboma and a liver abscess mimicking metastatic colonic cancer. An autochthonous infectious disease in Spain?
Topics: Amebiasis; Cecum; Colonic Neoplasms; Communicable Diseases; Entamoeba histolytica; Humans; Liver Abs | 2022 |
Effects of metronidazole on colorectal cancer occurrence and colorectal cancer liver metastases by regulating Fusobacterium nucleatum in mice.
Topics: Animals; Colorectal Neoplasms; DNA; Fusobacterium Infections; Fusobacterium nucleatum; Ki-67 Antigen | 2023 |
Recurrent bacteremia and liver abscess caused by Clostridium difficile: A case report.
Topics: Aged; Anti-Bacterial Agents; Bacteremia; Bacterial Translocation; Carcinoma, Hepatocellular; Chemoem | 2017 |
Analysis of
Topics: Adenocarcinoma; Animals; Anti-Bacterial Agents; Bacteroides; Carcinogenesis; Colorectal Neoplasms; F | 2017 |
[Infection or metastases? The amoebic abscess].
Topics: Abdominal Pain; Antiprotozoal Agents; Diagnosis, Differential; Entamoeba histolytica; Fever; Humans; | 2018 |
Toxicologic evaluation of metronidazole with particular reference to carcinogenic, mutagenic, and teratogenic potential.
Topics: Abnormalities, Drug-Induced; Animals; Cricetinae; Crohn Disease; Female; Follow-Up Studies; Humans; | 1983 |
Effect of radiofrequency hyperthermia and chemotherapy on primary and secondary hepatic malignancies when used with metronidazole.
Topics: Adult; Aged; Combined Modality Therapy; Female; Humans; Hyperthermia, Induced; Liver Neoplasms; Male | 1983 |
Trichomonas tenax empyema in an immunocompromised patient with advanced cancer.
Topics: Acromegaly; Adenocarcinoma; Animals; Antitrichomonal Agents; Bone Marrow Neoplasms; Brain Neoplasms; | 1998 |
Amoebic liver disease.
Topics: Adolescent; Adult; Carcinoma, Hepatocellular; Child; Diagnosis, Differential; Female; Hepatomegaly; | 1977 |
Isotopic immunoglobulin in an integrated multimodal treatment program for a primary liver cancer: a case report.
Topics: Adenoma, Bile Duct; Adult; Carcinoembryonic Antigen; Doxorubicin; Drug Therapy, Combination; Female; | 1979 |
Further experience with regional radiofrequency hyperthermia and cytotoxic chemotherapy for unresectable hepatic neoplasia.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Body Temperature; Combined Modality Therapy; Fem | 1985 |
[Amebic liver abscess].
Topics: Adult; Ampicillin; Antibodies; Cloxacillin; Diagnosis, Differential; Doxycycline; Drainage; Fluoresc | 1973 |