metronidazole has been researched along with Acute Kidney Injury in 16 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Malaria has been associated with acute acalculous cholecystitis, a very uncommon complication in children." | 2.58 | Acalculous Cholecystitis in a Pediatric Patient With Plasmodium Falciparum Infection: A Case Report and Literature Review. ( Aguilera-Alonso, D; Del Rosal, T; Escosa-García, L; García-Hortelano, M; López Medina, EM; Villota Arrieta, J, 2018) |
| "Little is known about acute renal failure as a consequence of Clostridium difficile-associated diarrhea." | 2.43 | Clostridium difficile causing acute renal failure: case presentation and review. ( Arrich, J; Domanovits, H; Konnaris, C; Laggner, AN; Mullner, M; Sengolge, G; Sodeck, GH, 2005) |
| "The patient had a history of suspected hepatic amebiasis treated in Senegal in 1985 and has not traveled to endemic areas since 1990." | 1.42 | First case of amebic liver abscess 22 years after the first occurrence. ( Abou-Bacar, A; Betz, V; Brunet, J; Candolfi, E; Christmann, D; Filisetti, D; Gagnard, JC; Hannedouche, T; Hansmann, Y; Krummel, Y; Nespola, B; Pesson, B; Pfaff, AW, 2015) |
| "24 days after the onset of infectious mononucleosis, clinically and serologically confirmed, an otherwise healthy 18-year-old schoolboy developed a fulminant septicaemia with acute meningitis and loss of consciousness, consumptive coagulopathy and acute renal failure." | 1.29 | [Lemierre's post-tonsillitis sepsis with meningitis and intravascular consumption coagulopathy as complication of infectious mononucleosis with pansinusitis]. ( Busch, N; Haase, G; Kierdorf, H; Marschall, HU; Matern, S; Mertens, PR; Nguyen, H; Schönfelder, T; Sieberth, HG; Urhahn, R, 1996) |
| " In patients with acute renal disease under hemodialysis, there was no cumulation of metronidazole and its metabolites; hence there is no need for change in dosage regimen." | 1.27 | Metronidazole kinetics in patients with acute renal failure on dialysis: a cumulative study. ( Bonmarchand, GP; Delhotal, B; Flouvat, B; Humbert, G; Leroy, JA; Moirot, E; Roux, AF, 1984) |
| "), elimination half-life was 9." | 1.27 | Metronidazole pharmacokinetics in patients with acute renal failure. ( Gurr, FW; Kong, CB; McLean, AJ; Sabto, J; Somogyi, AA; Spicer, WJ, 1984) |
| " However, owing to the relatively wide therapeutic index of the drug, dosage supplementation may be necessary only in seriously ill patients to ensure therapeutic effect." | 1.27 | Hemodialysis clearance of metronidazole and its metabolites. ( Chang, CW; Lau, AH; Sabatini, S, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (31.25) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Liao, S | 1 |
| Yang, W | 1 |
| Yu, T | 1 |
| Dai, L | 1 |
| Liu, X | 1 |
| Zhang, J | 1 |
| Zhao, J | 1 |
| Liu, C | 1 |
| Aguilera-Alonso, D | 1 |
| López Medina, EM | 1 |
| Del Rosal, T | 1 |
| Villota Arrieta, J | 1 |
| Escosa-García, L | 1 |
| García-Hortelano, M | 1 |
| Nespola, B | 1 |
| Betz, V | 1 |
| Brunet, J | 1 |
| Gagnard, JC | 1 |
| Krummel, Y | 1 |
| Hansmann, Y | 1 |
| Hannedouche, T | 1 |
| Christmann, D | 1 |
| Pfaff, AW | 1 |
| Filisetti, D | 1 |
| Pesson, B | 1 |
| Abou-Bacar, A | 1 |
| Candolfi, E | 1 |
| Compain, F | 1 |
| Rossi, B | 1 |
| Richaud, C | 1 |
| Guerot, E | 1 |
| Rostane, H | 1 |
| Jarraud, S | 1 |
| Podglajen, I | 1 |
| Martínez, JG | 1 |
| Saus, C | 1 |
| Morey, A | 1 |
| Alarcón, A | 1 |
| Arrich, J | 1 |
| Sodeck, GH | 1 |
| Sengolge, G | 1 |
| Konnaris, C | 1 |
| Mullner, M | 1 |
| Laggner, AN | 1 |
| Domanovits, H | 1 |
| Georgopoulos, S | 1 |
| Korres, S | 1 |
| Riga, M | 1 |
| Balatsouras, D | 1 |
| Kotsis, G | 1 |
| Ferekidis, E | 1 |
| Roux, AF | 1 |
| Moirot, E | 1 |
| Delhotal, B | 1 |
| Leroy, JA | 1 |
| Bonmarchand, GP | 1 |
| Humbert, G | 1 |
| Flouvat, B | 1 |
| Somogyi, AA | 1 |
| Kong, CB | 1 |
| Gurr, FW | 1 |
| Sabto, J | 1 |
| Spicer, WJ | 1 |
| McLean, AJ | 1 |
| Kolko, A | 1 |
| Kiselman, R | 1 |
| Russ, G | 1 |
| Bacques, O | 1 |
| Kleinknecht, D | 1 |
| Busch, N | 1 |
| Mertens, PR | 1 |
| Schönfelder, T | 1 |
| Nguyen, H | 1 |
| Marschall, HU | 1 |
| Kierdorf, H | 1 |
| Haase, G | 1 |
| Urhahn, R | 1 |
| Sieberth, HG | 1 |
| Matern, S | 1 |
| Nakaya, Y | 1 |
| Shiota, S | 1 |
| Sakamoto, K | 1 |
| Iwase, A | 1 |
| Aoki, S | 1 |
| Matsuoka, R | 1 |
| Tei, Y | 1 |
| Okada, Y | 1 |
| Miyake, Y | 1 |
| West, SD | 1 |
| Brunskill, NJ | 1 |
| Moulin, B | 1 |
| Dhib, M | 1 |
| Heudes, AM | 1 |
| Godin, M | 1 |
| Fillastre, JP | 1 |
| Lau, AH | 1 |
| Chang, CW | 1 |
| Sabatini, S | 1 |
| Woodruff, AW | 1 |
2 reviews available for metronidazole and Acute Kidney Injury
| Article | Year |
|---|---|
Acalculous Cholecystitis in a Pediatric Patient With Plasmodium Falciparum Infection: A Case Report and Literature Review.
Topics: Acalculous Cholecystitis; Acute Kidney Injury; Administration, Intravenous; Anti-Bacterial Agents; A | 2018 |
Clostridium difficile causing acute renal failure: case presentation and review.
Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Anti-Infective Agents; Clostridioides difficile; Enter | 2005 |
14 other studies available for metronidazole and Acute Kidney Injury
| Article | Year |
|---|---|
Establishment of a Drug Screening Model for Cardiac Complications of Acute Renal Failure.
Topics: Acute Kidney Injury; Animals; Animals, Genetically Modified; Cardio-Renal Syndrome; Cardiovascular D | 2021 |
First case of amebic liver abscess 22 years after the first occurrence.
Topics: Acute Kidney Injury; Aged; Antibodies, Protozoan; Antiprotozoal Agents; Bacterial Infections; Diagno | 2015 |
Photo Quiz: A 44-Year-Old Kidney Transplant Patient with Pneumonia.
Topics: Acute Kidney Injury; Adult; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Toxins; beta-Lactam | 2017 |
[Crohn's disease and renal amyloidosis. Acute renal failure].
Topics: Acetaminophen; Acute Kidney Injury; Adrenal Cortex Hormones; Adult; Amyloidosis; Analgesics, Non-Nar | 2002 |
Lemierre's syndrome associated with consumption coagulopathy and acute renal failure: a case report.
Topics: Acute Kidney Injury; Adult; Anti-Bacterial Agents; Disseminated Intravascular Coagulation; Drug Ther | 2008 |
Metronidazole kinetics in patients with acute renal failure on dialysis: a cumulative study.
Topics: Acute Kidney Injury; Adult; Aged; Chromatography, High Pressure Liquid; Creatinine; Female; Half-Lif | 1984 |
Metronidazole pharmacokinetics in patients with acute renal failure.
Topics: Acute Kidney Injury; Adult; Aged; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; K | 1984 |
Acute renal failure due to bilateral ureteral hematomas complicating anticoagulant therapy.
Topics: Acute Kidney Injury; Aged; Female; Hematoma; Hemorrhage; Humans; Metronidazole; Ureteral Diseases; W | 1993 |
[Lemierre's post-tonsillitis sepsis with meningitis and intravascular consumption coagulopathy as complication of infectious mononucleosis with pansinusitis].
Topics: Acute Kidney Injury; Adolescent; Anti-Bacterial Agents; Bacteremia; Chloramphenicol; Disseminated In | 1996 |
Double infection with Giardia lamblia and Salmonella paratyphi A associated with acute renal failure.
Topics: Acute Kidney Injury; Adult; Animals; Anti-Infective Agents; Antiprotozoal Agents; Antitrichomonal Ag | 1998 |
Complications associated with influenza infection.
Topics: Acute Kidney Injury; Alphainfluenzavirus; Drug Therapy, Combination; Humans; Imipenem; Influenza, Hu | 2002 |
[Neurotoxic risk of metronidazole in severe renal insufficiency].
Topics: Acute Kidney Injury; Adult; Confusion; Female; Humans; Metronidazole; Renal Dialysis; Seizures | 1988 |
Hemodialysis clearance of metronidazole and its metabolites.
Topics: Acute Kidney Injury; Adult; Cellulose; Female; Humans; Kidney Failure, Chronic; Kinetics; Male; Memb | 1986 |
Current practice in tropical medicine.
Topics: Acute Kidney Injury; Amebiasis; Amebicides; Chloroquine; Cholera; Drug Resistance, Microbial; Hepati | 1969 |