metronidazole has been researched along with Primate Diseases in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Primate Diseases: Diseases of animals within the order PRIMATES. This term includes diseases of Haplorhini and Strepsirhini.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diarrhea is the gastrointestinal disease most frequently encountered in captive rhesus macaques." | 5.35 | Effects of the macrolide drug tylosin on chronic diarrhea in rhesus macaques (Macaca mulatta). ( Blackwood, RS; Christe, KL; Lerche, NW; Spinner, A; Tarara, RP, 2008) |
| "Diarrhea is the gastrointestinal disease most frequently encountered in captive rhesus macaques." | 1.35 | Effects of the macrolide drug tylosin on chronic diarrhea in rhesus macaques (Macaca mulatta). ( Blackwood, RS; Christe, KL; Lerche, NW; Spinner, A; Tarara, RP, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blackwood, RS | 1 |
| Tarara, RP | 1 |
| Christe, KL | 1 |
| Spinner, A | 1 |
| Lerche, NW | 1 |
| Gracenea, M | 1 |
| Gómez, MS | 1 |
| Fernández, J | 1 |
| Feliu, C | 1 |
2 other studies available for metronidazole and Primate Diseases
| Article | Year |
|---|---|
Effects of the macrolide drug tylosin on chronic diarrhea in rhesus macaques (Macaca mulatta).
Topics: Animals; Anti-Bacterial Agents; C-Reactive Protein; Chronic Disease; Colonoscopy; Cytokines; Diarrhe | 2008 |
Secnidazole vs. paromomycin: comparative antiprotozoan treatment in captive primates.
Topics: Animals; Antiprotozoal Agents; Cercopithecidae; Entamoeba; Entamoebiasis; Hominidae; Metronidazole; | 1998 |