metronidazole has been researched along with Fungal Diseases in 20 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess whether treatment with metronidazole during pregnancy is associated with preterm birth, low birth weight, or major congenital anomalies, we conducted chart reviews and an analysis of electronic data from a cohort of women delivering at an urban New York State hospital." | 7.78 | Investigation of metronidazole use during pregnancy and adverse birth outcomes. ( Aubry, R; Baras, DC; Koss, CA; Koumans, EH; Lane, SD; Marcus, M; Markowitz, LE, 2012) |
| "To assess whether treatment with metronidazole during pregnancy is associated with preterm birth, low birth weight, or major congenital anomalies, we conducted chart reviews and an analysis of electronic data from a cohort of women delivering at an urban New York State hospital." | 3.78 | Investigation of metronidazole use during pregnancy and adverse birth outcomes. ( Aubry, R; Baras, DC; Koss, CA; Koumans, EH; Lane, SD; Marcus, M; Markowitz, LE, 2012) |
| "Anidulafungin was used to treat invasive candidiasis in seven patients (20%) and candidemia in 10 patients (29%); Candida albicans or Candida glabrata was isolated most frequently in these two infections combined (7 isolates each [41%]/17 infections)." | 1.35 | Early clinical experience with anidulafungin at a large tertiary care medical center. ( Brielmaier, BD; Casabar, E; Kurtzeborn, CM; McKinnon, PS; Ritchie, DJ, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (70.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koss, CA | 1 |
| Baras, DC | 1 |
| Lane, SD | 1 |
| Aubry, R | 1 |
| Marcus, M | 1 |
| Markowitz, LE | 1 |
| Koumans, EH | 1 |
| Brielmaier, BD | 1 |
| Casabar, E | 1 |
| Kurtzeborn, CM | 1 |
| McKinnon, PS | 1 |
| Ritchie, DJ | 1 |
| Gever, LN | 1 |
| Carruth, AK | 1 |
| Schulte, MJ | 1 |
| Vahlensieck, W | 1 |
| Trenschel, R | 1 |
| Peceny, R | 1 |
| Runde, V | 1 |
| Elmaagacli, A | 1 |
| Dermoumi, H | 1 |
| Heintschel von Heinegg, E | 1 |
| Müller, KD | 1 |
| Schaefer, UW | 1 |
| Beelen, DW | 1 |
| Willmott, FE | 1 |
| Josey, WE | 1 |
| Holt, RJ | 1 |
| Müller, HE | 1 |
| Guirges, SY | 1 |
| Al-Waili, NS | 1 |
| Szarmach, H | 1 |
| Małyszko, E | 1 |
| Wroński, A | 1 |
| Niczyporuk, W | 1 |
| Roszkiewicz, J | 1 |
| Renovanz, HD | 1 |
| Valent, M | 1 |
| Valentová, M | 1 |
| Klobusický, M | 1 |
| Tóth, B | 1 |
| Simon, J | 1 |
| Galgóczy, J | 1 |
| Kovács, E | 1 |
| Pálos, H | 1 |
| Luger, A | 1 |
| Girotti, M | 1 |
| Hauser, GA | 1 |
| Kurnatowska, A | 1 |
| Breinl, H | 1 |
| Gerteis, W | 1 |
2 reviews available for metronidazole and Fungal Diseases
| Article | Year |
|---|---|
[Sexually transmitted parasitoses and mycoses].
Topics: Adolescent; Adult; Antifungal Agents; Antitrichomonal Agents; Ectoparasitic Infestations; Female; Hu | 1999 |
[Blastocystis hominis, a largely unknown cause of diarrhea].
Topics: Animals; Apicomplexa; Diarrhea; Entomophthora; Feces; Guinea Pigs; Haplorhini; Humans; Metronidazole | 1987 |
2 trials available for metronidazole and Fungal Diseases
| Article | Year |
|---|---|
Fungal colonization and invasive fungal infections following allogeneic BMT using metronidazole, ciprofloxacin and fluconazole or ciprofloxacin and fluconazole as intestinal decontamination.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Antifungal Agents; Aspergillosis; | 2000 |
[Analysis of clinical and laboratory findings of Pimafucin treated colpitis caused by fungi and mixed infections].
Topics: Antifungal Agents; Clinical Trials as Topic; Female; Humans; Hydrogen-Ion Concentration; Metronidazo | 1971 |
16 other studies available for metronidazole and Fungal Diseases
| Article | Year |
|---|---|
Investigation of metronidazole use during pregnancy and adverse birth outcomes.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Antifungal Agents; Cohort Studies; Female; Fungi; Hu | 2012 |
Early clinical experience with anidulafungin at a large tertiary care medical center.
Topics: Academic Medical Centers; Alanine Transaminase; Anidulafungin; Antifungal Agents; Aspartate Aminotra | 2008 |
Flagyl I.V., a new form for metronidazole.
Topics: Humans; Infusions, Parenteral; Metronidazole; Mycoses | 1981 |
Antifungal agent used topically to control odor.
Topics: Humans; Male; Metronidazole; Mycoses; Odorants; Solutions; Wound Infection | 1993 |
Yogurt helps to control wound odor.
Topics: Administration, Topical; Combined Modality Therapy; Humans; Metronidazole; Mycoses; Odorants; Thorac | 1993 |
Genital yeasts in female patients attending a VD clinic.
Topics: Adolescent; Adult; Age Factors; Anti-Bacterial Agents; Candida albicans; Candidiasis, Vulvovaginal; | 1975 |
Vaginitis. Reducing the number of refractory cases.
Topics: Ampicillin; Candidiasis, Vulvovaginal; Contraception; Corynebacterium Infections; Female; Humans; Me | 1977 |
New antifungal drugs.
Topics: Amphotericin B; Antifungal Agents; Chlorobenzenes; Clotrimazole; Flucytosine; Humans; Imidazoles; Me | 1975 |
Blastocystis hominis: evidence for human pathogenicity and effectiveness of metronidazole therapy.
Topics: Adolescent; Adult; Aged; Child; Entomophthora; Female; Fungi; Gastrointestinal Diseases; Humans; Int | 1987 |
[Trichomoniasis of the urogenital tract in patients hospitalized in 1976-1983].
Topics: Adolescent; Adult; Age Factors; Drug Resistance, Microbial; Female; Humans; Male; Metronidazole; Mid | 1985 |
[Mycoses of the orbit and the eye].
Topics: Amphotericin B; Antifungal Agents; Aspergillus flavus; Aspergillus fumigatus; Aspergillus oryzae; Co | 1985 |
Incidence of trichomonadosis and vaginal mycosis.
Topics: Czechoslovakia; Female; Humans; Metronidazole; Mycoses; Trichomonas Vaginitis; Vaginal Diseases | 1973 |
[Syphilis diagnosis in the age of antibiotics].
Topics: Adult; Aged; Alopecia; Anti-Bacterial Agents; Balanitis; Biopsy; Child; Child, Preschool; Chloramphe | 1971 |
[Clinical features of vaginal discharge].
Topics: Antifungal Agents; Female; Humans; Leukorrhea; Metronidazole; Mycoses; Trichomonas Vaginitis; Vagini | 1968 |
[The effect of new halogensulfonamides on vaginal microorganisms in women with trichomoniasis complicated by mycosis. Clinical part].
Topics: Candidiasis, Vulvovaginal; Female; Humans; Metronidazole; Mycoses; Sulfonamides; Vulvovaginitis | 1969 |
[Results of microscopic germ diagnosis of vaginal smears of a non-selective gynecologic collective (A contribution to the problem of leukorrhea)].
Topics: Colposcopy; Female; Humans; Leukorrhea; Metronidazole; Microscopy; Mycoses; Trichomonas Vaginitis; V | 1966 |