metronidazole has been researched along with Dracunculiasis in 16 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Dracunculiasis: Infection with nematodes of the genus Dracunculus. One or more worms may be seen at a time, with the legs and feet being the most commonly infected areas. Symptoms include pruritus, nausea, vomiting, diarrhea, or asthmatic attacks.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two-hundred and twenty-nine cases dracunculiasis were selected for a double-blind trial of metronidazole against placebo." | 9.04 | Metronidazole ("Flagyl") in dracunculiasis: a double blind study. ( Daulatram, J; Joshi, LG; Nandi, JS; Pardanani, DS; Trivedi, VD, 1977) |
| "In a clinical trial of metronidazole for dracunculiasis (75 cases), the drug was effective in giving symptomatic relief but had no preventive or vermicidal action." | 9.04 | Efficacy of metronidazole in dracunculiasis. A clinical trial. ( Rathore, HS; Sharma, MM; Sharma, VP, 1979) |
| "In a clinical trial of metronidazole for dracunculiasis (75 cases), the drug was effective in giving symptomatic relief but had no preventive or vermicidal action." | 5.04 | Efficacy of metronidazole in dracunculiasis. A clinical trial. ( Rathore, HS; Sharma, MM; Sharma, VP, 1979) |
| "Metronidazole was generally well tolerated but transient dose-related side-effects, mostly gastrointestinal, occurred in about 50% of patients treated with thiabendazole." | 2.65 | Controlled comparative trial of thiabendazole and metronidazole in the treatment of dracontiasis. ( Elemile, T; Enahoro, F; Kale, OO, 1983) |
| "Guinea worm disease is endemic in West Africa." | 2.64 | Failure of thiabendazole and metronidazole in the treatment and suppression of guinea worm disease. ( Belcher, DW; Ward, WB; Wunapa, FK, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kale, OO | 3 |
| Elemile, T | 1 |
| Enahoro, F | 1 |
| Paul, RC | 1 |
| Sahai, R | 1 |
| Gupta, SN | 1 |
| Simlot, LR | 1 |
| Singh, T | 1 |
| Kumar, S | 1 |
| Kulkarni, DR | 1 |
| Nagalotimath, SJ | 1 |
| Belcher, DW | 1 |
| Wunapa, FK | 1 |
| Ward, WB | 1 |
| Pardanani, DS | 2 |
| Trivedi, VD | 1 |
| Joshi, LG | 1 |
| Daulatram, J | 1 |
| Nandi, JS | 1 |
| Baines, EJ | 1 |
| Sharma, VP | 1 |
| Rathore, HS | 1 |
| Sharma, MM | 1 |
| Antani, J | 1 |
| Srinivas, HV | 2 |
| Krishnamurthy, KR | 2 |
| Jahagirdar, BR | 1 |
| Kothari, ML | 1 |
| Muller, R | 1 |
| Antani, JA | 1 |
| Borgaonkar, AN | 1 |
| Padonu, KO | 2 |
| Sastry, SC | 1 |
| Rao, YR | 1 |
| Narayana, DL | 1 |
1 review available for metronidazole and Dracunculiasis
| Article | Year |
|---|---|
Metronidazole: its past, present and future.
Topics: Anaerobiosis; Bacterial Infections; Crohn Disease; Dracunculiasis; Humans; Kinetics; Metronidazole; | 1978 |
8 trials available for metronidazole and Dracunculiasis
| Article | Year |
|---|---|
Controlled comparative trial of thiabendazole and metronidazole in the treatment of dracontiasis.
Topics: Adolescent; Adult; Aged; Anthelmintics; Child; Child, Preschool; Clinical Trials as Topic; Dose-Resp | 1983 |
Failure of thiabendazole and metronidazole in the treatment and suppression of guinea worm disease.
Topics: Adolescent; Adult; Africa, Western; Aged; Child; Child, Preschool; Clinical Trials as Topic; Dracunc | 1975 |
Metronidazole ("Flagyl") in dracunculiasis: a double blind study.
Topics: Clinical Trials as Topic; Dracunculiasis; Female; Humans; Male; Metronidazole; Time Factors | 1977 |
Efficacy of metronidazole in dracunculiasis. A clinical trial.
Topics: Dracunculiasis; Drug Evaluation; Humans; Metronidazole; Recurrence | 1979 |
Metronidazole in dracunculosis. A preliminary report of a therapeutic trial.
Topics: Clinical Trials as Topic; Dracunculiasis; Humans; Metronidazole | 1970 |
A controlled trial of metronidazole in the treatment of dracontiasis in Nigeria.
Topics: Administration, Oral; Bandages; Dracunculiasis; Encephalitis, Tick-Borne; Hexachlorophene; Humans; I | 1973 |
A controlled trial with metronidazole in the treatment of dracontiasis in Nigeria.
Topics: Dracunculiasis; Dracunculus Nematode; Humans; Metronidazole; Nigeria; Penicillins; Pilot Projects; T | 1973 |
A controlled field trial of the treatment of dracontiasis with metronidazole and niridazole.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Dracunculiasis; Gastrointestinal Diseases; Humans; | 1974 |
7 other studies available for metronidazole and Dracunculiasis
| Article | Year |
|---|---|
Fall in incidence of guinea-worm infection in western Nigeria after periodic treatment of infected persons.
Topics: Dracunculiasis; Dracunculus Nematode; Female; Humans; Longitudinal Studies; Male; Metronidazole; Nig | 1982 |
A note on the relative merits of metronidazole and mebendazole against dracunculiasis in the field.
Topics: Benzimidazoles; Dracunculiasis; Female; Humans; Male; Mebendazole; Metronidazole | 1983 |
Letter: Guinea-worms and metronidazole.
Topics: Animals; Dracunculiasis; Dracunculus Nematode; Drug Evaluation, Preclinical; Glucocorticoids; Haplor | 1975 |
Metronidazole in dracunculiasis. A preliminary report.
Topics: Dracunculiasis; Female; Humans; India; Inflammation; Male; Metronidazole; Time Factors | 1970 |
The possible mode of action of some chemotherapeutic agents in guinea worm disease.
Topics: Animals; Anthelmintics; Anti-Inflammatory Agents; Dracunculiasis; Dracunculus Nematode; Haplorhini; | 1971 |
Metronidazole in dracunculiasis. Report of further trials.
Topics: Antiparasitic Agents; Cellulitis; Dracunculiasis; Humans; India; Metronidazole | 1972 |
Metronidazole in the treatment of Dracunculosis.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Dracunculiasis; Female; Humans; Male; Metronidazol | 1974 |