metronidazole has been researched along with Vaginal Neoplasms in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Vaginal Neoplasms: Tumors or cancer of the VAGINA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Four patients had had cervical cancer, five had uterine cancer, one had prostatic cancer, one had vesical cancer and one had vaginal cancer." | 1.37 | A novel treatment for haemorrhagic radiation proctitis using colonic irrigation and oral antibiotic administration. ( Atittharnsakul, P; Patiwongpaisarn, A; Rojanasakul, A; Sahakitrungruang, C; Thum-Umnuaysuk, S, 2011) |
| "Advanced vulvovaginal cancers have a survival of less than 25% in 5 years when treated with radiotherapy alone." | 1.27 | Metronidazole as a radiosensitizer and high-dose radiation in advanced vulvovaginal malignancies, a pilot study. ( Cain, JM; Hilaris, BS; Jones, WB; Lewis, JL; Nori, D, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sahakitrungruang, C | 1 |
| Thum-Umnuaysuk, S | 1 |
| Patiwongpaisarn, A | 1 |
| Atittharnsakul, P | 1 |
| Rojanasakul, A | 1 |
| Nori, D | 1 |
| Cain, JM | 1 |
| Hilaris, BS | 1 |
| Jones, WB | 1 |
| Lewis, JL | 1 |
| Rodgerson, EB | 1 |
3 other studies available for metronidazole and Vaginal Neoplasms
| Article | Year |
|---|---|
A novel treatment for haemorrhagic radiation proctitis using colonic irrigation and oral antibiotic administration.
Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Ciprofloxacin; Combined Modality Therapy; Female; Ga | 2011 |
Metronidazole as a radiosensitizer and high-dose radiation in advanced vulvovaginal malignancies, a pilot study.
Topics: Adult; Aged; Carcinoma; Female; Humans; Metronidazole; Middle Aged; Pilot Projects; Radiotherapy Dos | 1983 |
Vulvovaginal papillomas and trichomonas vaginalis.
Topics: Female; Humans; Metronidazole; Papilloma; Podophyllin; Trichomonas Vaginitis; Vaginal Neoplasms; Vul | 1972 |