metronidazole has been researched along with Abscess, Periapical in 20 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "No statistically significant difference is observed between both the groups and a combination of Ciprofloxacin, Minocycline and Tinidazole antibacterial drugs can be used on teeth pulpally involved with physiologic root resorption." | 5.16 | In vivo evaluation of lesion sterilization and tissue repair in primary teeth pulp therapy using two antibiotic drug combinations. ( Anantharaj, A; Jaya, AR; Praveen, P; Rani, PS; Venkataraghavan, K, 2012) |
| "Metronidazole gel (3% w/v) was more effective than metronidazole solution (0." | 2.79 | Clinical evaluation of sustained-release metronidazole gel versus metronidazole solution as an intracanal medicament in abscessed primary molars. ( Bhangdia, MB; Kulkarni, PK; Nandlal, B; Shanbhog, R; Vijaykumar, GS, 2014) |
| " Despite this there remains little evidence-based literature on what should be prescribed for any given clinical situation, at what dosage and for how long." | 2.45 | The role of phenoxymethylpenicillin, amoxicillin, metronidazole and clindamycin in the management of acute dentoalveolar abscesses--a review. ( Ellison, SJ, 2009) |
| "Subsequently, #8 developed pulp necrosis and an acute apical abscess and #7 symptomatic apical periodontitis." | 1.40 | Treatment of a large cystlike inflammatory periapical lesion associated with mature necrotic teeth using regenerative endodontic therapy. ( Lin, LM; Ricucci, D; Rosenberg, PA; Saoud, TM; Sigurdsson, A, 2014) |
| "Cerebral actinomycosis is rare and difficult to diagnose." | 1.37 | [Cerebral actinomycosis pseudotumor: a case report]. ( Battikh, R; Ben Abdelhafidh, N; Bougrine, F; Bouziani, A; M'Sadek, F; Madhi, W; Othmani, S; Yedeas, M, 2011) |
| "Necrotizing fasciitis is a potentially fatal, acute bacterial infection characterized by extensive fascial and subcutaneous tissue necrosis." | 1.28 | Fatal necrotizing fasciitis of dental origin. ( Beecroft, WA; Cogan, AG; Stoykewych, AA, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (30.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 8 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jaya, AR | 1 |
| Praveen, P | 1 |
| Anantharaj, A | 1 |
| Venkataraghavan, K | 1 |
| Rani, PS | 1 |
| Bhangdia, MB | 1 |
| Nandlal, B | 1 |
| Vijaykumar, GS | 1 |
| Kulkarni, PK | 1 |
| Shanbhog, R | 1 |
| Sönmez, IS | 1 |
| Akbay Oba, A | 1 |
| Erkmen Almaz, M | 1 |
| Becerra, P | 1 |
| Ricucci, D | 2 |
| Loghin, S | 1 |
| Gibbs, JL | 1 |
| Lin, LM | 2 |
| Saoud, TM | 1 |
| Sigurdsson, A | 1 |
| Rosenberg, PA | 1 |
| Ertaş, U | 1 |
| Yalçin, E | 1 |
| Ellison, SJ | 1 |
| Battikh, R | 1 |
| M'Sadek, F | 1 |
| Bougrine, F | 1 |
| Madhi, W | 1 |
| Ben Abdelhafidh, N | 1 |
| Bouziani, A | 1 |
| Yedeas, M | 1 |
| Othmani, S | 1 |
| Thomson, A | 1 |
| Kahler, B | 1 |
| Nosrat, A | 1 |
| Seifi, A | 1 |
| Asgary, S | 1 |
| Baumgartner, JC | 1 |
| Xia, T | 1 |
| Marchiori, C | 1 |
| Tonon, E | 1 |
| Boscolo Rizzo, P | 1 |
| Vaglia, A | 1 |
| Meyding-Lamadé, U | 1 |
| Levorato, M | 1 |
| Da Mosto, MC | 1 |
| Dietz, A | 1 |
| Dickens, CW | 1 |
| Roche, Y | 1 |
| Yoshimori, RN | 1 |
| Hood, FJ | 1 |
| Stoykewych, AA | 1 |
| Beecroft, WA | 1 |
| Cogan, AG | 1 |
| Lewis, MA | 1 |
| MacFarlane, TW | 1 |
| McGowan, DA | 1 |
| Schein, B | 1 |
| Haapasalo, M | 1 |
| Ranta, K | 1 |
| Ranta, H | 1 |
| Urai, A | 1 |
| Aoki, H | 1 |
| Shinoda, N | 1 |
| Kimura, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effectiveness of Regenerative Endodontics Therapy for Single-rooted Mature Permanent Tooth With Pulp Necrosis: a Multicenter Randomized Controlled Clinical Trial.[NCT04313010] | 346 participants (Anticipated) | Interventional | 2020-03-16 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for metronidazole and Abscess, Periapical
| Article | Year |
|---|---|
The role of phenoxymethylpenicillin, amoxicillin, metronidazole and clindamycin in the management of acute dentoalveolar abscesses--a review.
Topics: Acute Disease; Adult; Amoxicillin; Anti-Bacterial Agents; Clindamycin; Drainage; Drug Resistance, Ba | 2009 |
Regenerative endodontics--biologically-based treatment for immature permanent teeth: a case report and review of the literature.
Topics: Amoxicillin; Anti-Bacterial Agents; Bicuspid; Blood Coagulation; Child; Ciprofloxacin; Dental Pulp; | 2010 |
Regenerative endodontic treatment (revascularization) for necrotic immature permanent molars: a review and report of two cases with a new biomaterial.
Topics: Anti-Bacterial Agents; Apexification; Biocompatible Materials; Calcium; Child; Ciprofloxacin; Dental | 2011 |
3 trials available for metronidazole and Abscess, Periapical
| Article | Year |
|---|---|
In vivo evaluation of lesion sterilization and tissue repair in primary teeth pulp therapy using two antibiotic drug combinations.
Topics: Anti-Bacterial Agents; Child; Ciprofloxacin; Dental Pulp Necrosis; Double-Blind Method; Drug Combina | 2012 |
Clinical evaluation of sustained-release metronidazole gel versus metronidazole solution as an intracanal medicament in abscessed primary molars.
Topics: Anti-Infective Agents; Bacterial Load; Child; Delayed-Action Preparations; Dental Pulp Cavity; Denta | 2014 |
The place of metronidazole in the treatment of acute oro-facial infection.
Topics: Acute Disease; Anaerobiosis; Clinical Trials as Topic; Humans; Metronidazole; Microbial Sensitivity | 1978 |
14 other studies available for metronidazole and Abscess, Periapical
| Article | Year |
|---|---|
Revascularization/Regeneration performed in immature molars: case reports.
Topics: Aluminum Compounds; Anti-Bacterial Agents; Apexification; Calcium Compounds; Child; Ciprofloxacin; D | 2013 |
Histologic study of a human immature permanent premolar with chronic apical abscess after revascularization/revitalization.
Topics: Aluminum Compounds; Anti-Bacterial Agents; Apexification; Bicuspid; Blood Coagulation; Calcification | 2014 |
Treatment of a large cystlike inflammatory periapical lesion associated with mature necrotic teeth using regenerative endodontic therapy.
Topics: Anti-Bacterial Agents; Apexification; Blood Coagulation; Ciprofloxacin; Dental Pulp Necrosis; Female | 2014 |
Chronic temporal abscess resulting from a periapical abscess of the upper right first molar.
Topics: Abscess; Anti-Bacterial Agents; Ceftriaxone; Drainage; Female; Focal Infection, Dental; Humans; Inje | 2009 |
[Cerebral actinomycosis pseudotumor: a case report].
Topics: Actinomycosis; Adrenal Cortex Hormones; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacteria | 2011 |
Antibiotic susceptibility of bacteria associated with endodontic abscesses.
Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bacteria, Anaerob | 2003 |
[Brain abscesses after extracranial infections of the head and neck area].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic | 2003 |
Metronidazole in the treatment of chronic periapical abscess.
Topics: Adult; Chronic Disease; Female; Humans; Metronidazole; Periapical Abscess | 1981 |
In-vitro activity of spiramycin and metronidazole alone or in combination against clinical isolates from odontogenic abscesses.
Topics: Anti-Bacterial Agents; Bacteria, Aerobic; Bacteria, Anaerobic; Drug Combinations; Female; Humans; Ma | 1997 |
Fatal necrotizing fasciitis of dental origin.
Topics: Adult; Bacteroides Infections; Candidiasis; Cefotaxime; Clindamycin; Cloxacillin; Fasciitis; Female; | 1992 |
Antibiotic susceptibilities of bacteria isolated from acute dentoalveolar abscesses.
Topics: Acute Disease; Amoxicillin; Anti-Bacterial Agents; Bacteria; Clindamycin; Drug Resistance, Microbial | 1989 |
Microbiological considerations in selecting a drug for endodontic abscesses.
Topics: Adult; Bacteria, Anaerobic; Humans; Male; Metronidazole; Periapical Abscess; Root Canal Therapy | 1986 |
Mixed anaerobic periapical infection with sinus tract.
Topics: Adult; Bacteria; Dental Fistula; Humans; Incisor; Male; Maxilla; Metronidazole; Periapical Abscess | 1987 |
[Clinical study of (Flagyl) metronidazole in halitosis due to periapical abscess].
Topics: Adult; Female; Halitosis; Humans; Male; Metronidazole; Middle Aged; Periapical Abscess | 1970 |