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metronidazole and Ear Neoplasms

metronidazole has been researched along with Ear Neoplasms in 2 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Ear Neoplasms: Tumors or cancer of any part of the hearing and equilibrium system of the body (the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR).

Research Excerpts

ExcerptRelevanceReference
"He had had recent chemotherapy for Merkel cell carcinoma of the right ear."1.34Use of intravenous immunoglobulin for the treatment of severe Clostridium difficile colitis. ( Hassoun, A; Ibrahim, F, 2007)
"Anaerobic bacterial meningitis due to this pathogen is rarely diagnosed and if present, a predisposing source of infection should be actively sought for."1.29Bacteroides fragilis meningitis. ( Ngan, CC; Tan, AL, 1994)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hassoun, A1
Ibrahim, F1
Ngan, CC1
Tan, AL1

Other Studies

2 other studies available for metronidazole and Ear Neoplasms

ArticleYear
Use of intravenous immunoglobulin for the treatment of severe Clostridium difficile colitis.
    The American journal of geriatric pharmacotherapy, 2007, Volume: 5, Issue:1

    Topics: Aged; Anti-Bacterial Agents; Carcinoma, Merkel Cell; Clostridioides difficile; Cytotoxins; Diarrhea;

2007
Bacteroides fragilis meningitis.
    Singapore medical journal, 1994, Volume: 35, Issue:3

    Topics: Adult; Bacteroides fragilis; Bacteroides Infections; Cholesteatoma, Middle Ear; Ear Neoplasms; Human

1994