metronidazole has been researched along with Ear Neoplasms in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Ear Neoplasms: Tumors or cancer of any part of the hearing and equilibrium system of the body (the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR).
| Excerpt | Relevance | Reference |
|---|---|---|
| "He had had recent chemotherapy for Merkel cell carcinoma of the right ear." | 1.34 | Use of intravenous immunoglobulin for the treatment of severe Clostridium difficile colitis. ( Hassoun, A; Ibrahim, F, 2007) |
| "Anaerobic bacterial meningitis due to this pathogen is rarely diagnosed and if present, a predisposing source of infection should be actively sought for." | 1.29 | Bacteroides fragilis meningitis. ( Ngan, CC; Tan, AL, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hassoun, A | 1 |
| Ibrahim, F | 1 |
| Ngan, CC | 1 |
| Tan, AL | 1 |
2 other studies available for metronidazole and Ear Neoplasms
| Article | Year |
|---|---|
Use of intravenous immunoglobulin for the treatment of severe Clostridium difficile colitis.
Topics: Aged; Anti-Bacterial Agents; Carcinoma, Merkel Cell; Clostridioides difficile; Cytotoxins; Diarrhea; | 2007 |
Bacteroides fragilis meningitis.
Topics: Adult; Bacteroides fragilis; Bacteroides Infections; Cholesteatoma, Middle Ear; Ear Neoplasms; Human | 1994 |