metronidazole has been researched along with Colonic Inertia in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Colonic Inertia: Symptom characterized by the passage of stool once a week or less.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with metronidazole reversed steatorrhea but exacerbated the gaseous distention of the small intestine, precipitating emergency surgical decompression and ileostomy." | 5.27 | Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin. ( Isaacs, P; Keshavarzian, A; McColl, I; Sladen, GE, 1983) |
| " Drug-related adverse events occurred in 18." | 2.71 | Safety and efficacy of sequential i.v. to p.o. moxifloxacin versus conventional combination therapies for the treatment of community-acquired pneumonia in patients requiring initial i.v. therapy. ( Choudhri, S; Fogarty, CM; Hamed, K; Katz, E; Larsen, LS; Song, J, 2004) |
| "To evaluate two triple-therapy (TT) regimens of colloidal bismuth subcitrate (CBS), metronidazole, and tetracycline HCl in eradicating Helicobacter pylori, with particular attention to the frequency of resulting adverse effects of the two therapies." | 2.67 | Use of high efficacy, lower dose triple therapy to reduce side effects of eradicating Helicobacter pylori. ( Andrews, P; Borody, TJ; Brandl, S; Ferch, N; Hyland, L; Jankiewicz, E, 1994) |
| "Treatment with metronidazole reversed steatorrhea but exacerbated the gaseous distention of the small intestine, precipitating emergency surgical decompression and ileostomy." | 1.27 | Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin. ( Isaacs, P; Keshavarzian, A; McColl, I; Sladen, GE, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sharifiaghdas, F | 1 |
| Simforoosh, N | 1 |
| Ozhand, A | 1 |
| Katz, E | 1 |
| Larsen, LS | 1 |
| Fogarty, CM | 1 |
| Hamed, K | 1 |
| Song, J | 1 |
| Choudhri, S | 1 |
| Keshavarzian, A | 1 |
| Isaacs, P | 1 |
| McColl, I | 1 |
| Sladen, GE | 1 |
| Borody, TJ | 1 |
| Brandl, S | 1 |
| Andrews, P | 1 |
| Ferch, N | 1 |
| Jankiewicz, E | 1 |
| Hyland, L | 1 |
| Hilmer, R | 1 |
| Goulston, K | 1 |
| Sweeney, JL | 1 |
| Hewett, P | 1 |
| Riddell, P | 1 |
| Hoffmann, DC | 1 |
2 trials available for metronidazole and Colonic Inertia
| Article | Year |
|---|---|
Safety and efficacy of sequential i.v. to p.o. moxifloxacin versus conventional combination therapies for the treatment of community-acquired pneumonia in patients requiring initial i.v. therapy.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Aza Compounds; Azithromycin; Ceftriaxone; Com | 2004 |
Use of high efficacy, lower dose triple therapy to reduce side effects of eradicating Helicobacter pylori.
Topics: Abdominal Pain; Anti-Bacterial Agents; Constipation; Diarrhea; Drug Administration Schedule; Drug Th | 1994 |
4 other studies available for metronidazole and Colonic Inertia
| Article | Year |
|---|---|
A complication after percutaneous nephrolithotomy.
Topics: Abdominal Pain; Adult; Anti-Infective Agents; Ceftriaxone; Constipation; Diagnosis, Differential; Fe | 2010 |
Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin.
Topics: Adult; Body Weight; Constipation; Humans; Ileostomy; Indomethacin; Intestinal Obstruction; Intestina | 1983 |
Drugs used in treatment of large bowel disease.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antidiarrheals; Azathioprine; Cathartics; Colitis, U | 1979 |
Rectal gangrene: a complication of phosphate enema.
Topics: Aged; Constipation; Debridement; Drug Therapy, Combination; Enema; Female; Gangrene; Gentamicins; He | 1986 |