metronidazole has been researched along with Genital Herpes in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole (MTZ) has been the treatment of choice for women for decades, and single dose has been considered the first line of therapy." | 2.52 | Trichomonas vaginalis: a review of epidemiologic, clinical and treatment issues. ( Kissinger, P, 2015) |
| "The multifactorial etiology of bacterial vaginosis (BV) impedes development of effective treatment and prevention strategies." | 1.38 | Recalcitrance of bacterial vaginosis among herpes-simplex-virus-type-2-seropositive women. ( Cherpes, TL; Cosentino, LA; Kant, JA; Landsittel, D; Reighard, SD; Stoner, KA; Vicetti Miguel, RD, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kissinger, P | 1 |
| Stoner, KA | 1 |
| Reighard, SD | 1 |
| Vicetti Miguel, RD | 1 |
| Landsittel, D | 1 |
| Cosentino, LA | 1 |
| Kant, JA | 1 |
| Cherpes, TL | 1 |
| Schwebke, JR | 1 |
| Desmond, R | 1 |
| Schneider, GT | 1 |
| Martien, K | 1 |
| Emans, SJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Trichomonas Vaginalis Repeat Infections Among HIV Negative Women[NCT01832480] | Phase 3 | 623 participants (Actual) | Interventional | 2014-10-06 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Presence of TV is assessed by nucleic acid amplification test (NAAT) of vaginal swab collected 4 weeks post treatment completion. (NCT01832480)
Timeframe: 4 weeks post treatment completion
| Intervention | Participants (Count of Participants) |
|---|---|
| Trichomonas (TV) Positive After 2 g Dose | 58 |
| Trichomonas (TV) Positive After Metronidazole (MTZ) Multi Dose | 34 |
2 reviews available for metronidazole and Genital Herpes
| Article | Year |
|---|---|
Trichomonas vaginalis: a review of epidemiologic, clinical and treatment issues.
Topics: Drug Resistance; Female; Herpes Genitalis; HIV Infections; Humans; Metronidazole; Recurrence; Treatm | 2015 |
Treatment of common genital infections in adolescents.
Topics: Adolescent; Anti-Bacterial Agents; Antifungal Agents; Candidiasis, Vulvovaginal; Condylomata Acumina | 1987 |
1 trial available for metronidazole and Genital Herpes
| Article | Year |
|---|---|
A randomized trial of metronidazole in asymptomatic bacterial vaginosis to prevent the acquisition of sexually transmitted diseases.
Topics: Administration, Intravaginal; Adult; Alabama; Anti-Infective Agents; Chlamydia Infections; Female; G | 2007 |
2 other studies available for metronidazole and Genital Herpes
| Article | Year |
|---|---|
Recalcitrance of bacterial vaginosis among herpes-simplex-virus-type-2-seropositive women.
Topics: Adolescent; Adult; Anti-Infective Agents; Female; Herpes Genitalis; Herpesvirus 2, Human; Humans; Me | 2012 |
Vaginal infections. How to identify and treat them.
Topics: Adolescent; Adult; Candidiasis; Child; Chlamydia Infections; Female; Haemophilus Infections; Herpes | 1983 |