metronidazole has been researched along with Cancer of Nasopharynx in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We performed this meta-analysis to assess the metronidazole amino acidum natrium combined with radiation in the treatment of nasopharyngeal carcinoma." | 8.91 | Metronidazole amino acidum natrium combined with radiation in the treatment of nasopharyngeal carcinoma: A meta-analysis based on randomized controlled trials. ( Liu, J; Niu, L; Song, F; Wang, L; Wei, S; Wu, F; Xing, Y; Yang, C; Yang, X; Yang, Y, 2015) |
| "We performed this meta-analysis to assess the metronidazole amino acidum natrium combined with radiation in the treatment of nasopharyngeal carcinoma." | 4.91 | Metronidazole amino acidum natrium combined with radiation in the treatment of nasopharyngeal carcinoma: A meta-analysis based on randomized controlled trials. ( Liu, J; Niu, L; Song, F; Wang, L; Wei, S; Wu, F; Xing, Y; Yang, C; Yang, X; Yang, Y, 2015) |
| "To evaluate efficacy and side effects of glycididazole sodium (CMNa) combined with chemotherapy (cisplatin plus 5-FU/folic acid, PLF) and radiotherapy in treating patients with locally advanced nasopharyngeal carcinoma." | 2.79 | Glycididazole sodium combined with radiochemotherapy for locally advanced nasopharyngeal carcinoma. ( Chen, DP; Li, MY; Liang, YY; Liu, JQ; Qi, B; Yin, WJ, 2014) |
| " The type, procession and dosage of radiotherapy were identical in both groups." | 2.72 | [Effect of hypoxic radiosensitizer sodium glycididazole on long-term result of radiotherapy for nasopharyngeal carcinoma]. ( Bao, YH; Cai, Y; Chen, LH; Chen, YY; Cui, NJ; Gao, HJ; Gao, L; He, LR; Hu, YH; Li, DM; Liu, MZ; Lu, TX; Sheng, G; Sun, Q; Wang, FY; Xiao, GL; Xu, GZ; Zhang, SW; Zhu, L, 2006) |
| "Anaerobic bacterial meningitis due to this pathogen is rarely diagnosed and if present, a predisposing source of infection should be actively sought for." | 1.29 | Bacteroides fragilis meningitis. ( Ngan, CC; Tan, AL, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, MY | 1 |
| Liu, JQ | 1 |
| Chen, DP | 1 |
| Qi, B | 1 |
| Liang, YY | 1 |
| Yin, WJ | 1 |
| Wei, S | 1 |
| Xing, Y | 1 |
| Liu, J | 1 |
| Wang, L | 1 |
| Yang, X | 1 |
| Song, F | 1 |
| Yang, C | 1 |
| Niu, L | 1 |
| Yang, Y | 1 |
| Wu, F | 1 |
| He, ZY | 1 |
| Li, FY | 1 |
| Tong, Q | 1 |
| Liao, ZW | 1 |
| Guan, XX | 1 |
| Wang, Y | 1 |
| Liu, MZ | 1 |
| He, LR | 1 |
| Lu, TX | 1 |
| Chen, YY | 1 |
| Hu, YH | 1 |
| Cui, NJ | 1 |
| Xu, GZ | 1 |
| Gao, L | 1 |
| Xiao, GL | 1 |
| Zhang, SW | 1 |
| Cai, Y | 1 |
| Li, DM | 1 |
| Chen, LH | 1 |
| Wang, FY | 1 |
| Sun, Q | 1 |
| Zhu, L | 1 |
| Sheng, G | 1 |
| Gao, HJ | 1 |
| Bao, YH | 1 |
| Ngan, CC | 1 |
| Tan, AL | 1 |
1 review available for metronidazole and Cancer of Nasopharynx
| Article | Year |
|---|---|
Metronidazole amino acidum natrium combined with radiation in the treatment of nasopharyngeal carcinoma: A meta-analysis based on randomized controlled trials.
Topics: Antineoplastic Agents; Carcinoma; Combined Modality Therapy; Humans; Metronidazole; Nasopharyngeal C | 2015 |
3 trials available for metronidazole and Cancer of Nasopharynx
| Article | Year |
|---|---|
Glycididazole sodium combined with radiochemotherapy for locally advanced nasopharyngeal carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Case-Control Studies; Chem | 2014 |
[Concurrent chemoradiotherapy with sodium glycididazole and cisplatin for local advanced nasopharyngeal carcinoma].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplatin; Cobalt Radioisotopes; C | 2008 |
[Effect of hypoxic radiosensitizer sodium glycididazole on long-term result of radiotherapy for nasopharyngeal carcinoma].
Topics: Adolescent; Adult; Aged; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Metronidazo | 2006 |
1 other study available for metronidazole and Cancer of Nasopharynx
| Article | Year |
|---|---|
Bacteroides fragilis meningitis.
Topics: Adult; Bacteroides fragilis; Bacteroides Infections; Cholesteatoma, Middle Ear; Ear Neoplasms; Human | 1994 |