metronidazole has been researched along with Cholangitis in 8 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Cholangitis: Inflammation of the biliary ductal system (BILE DUCTS); intrahepatic, extrahepatic, or both.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The clinical effect of Levofloxacin and Ceftriaxone in patients with acute cholangitis showed no significant differences." | 9.10 | [Ceftriaxone versus Levofloxacin for antibiotic therapy in patients with acute cholangitis]. ( Genitsariotis, R; Hahn, M; Jung, M; Kiesslich, R; Mäurer, M; Nafe, B; Will, D, 2003) |
| "The clinical effect of Levofloxacin and Ceftriaxone in patients with acute cholangitis showed no significant differences." | 5.10 | [Ceftriaxone versus Levofloxacin for antibiotic therapy in patients with acute cholangitis]. ( Genitsariotis, R; Hahn, M; Jung, M; Kiesslich, R; Mäurer, M; Nafe, B; Will, D, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, WJ | 1 |
| Wu, ZR | 1 |
| Yang, Q | 1 |
| Hu, HJ | 1 |
| Wang, JK | 1 |
| Shi, YJ | 1 |
| Li, FY | 1 |
| Cheng, NS | 1 |
| Lee, JK | 1 |
| Park, CW | 1 |
| Lee, SH | 1 |
| Kang, HW | 1 |
| Kwon, JH | 1 |
| Kim, JH | 1 |
| Lim, YJ | 1 |
| Kim, ES | 1 |
| Koh, MS | 1 |
| Lee, JH | 1 |
| Crook, EK | 1 |
| Carpenter, NA | 1 |
| van Bunderen, CC | 1 |
| Bomers, MK | 1 |
| Wesdorp, E | 1 |
| Peerbooms, P | 1 |
| Veenstra, J | 1 |
| Kiesslich, R | 1 |
| Will, D | 1 |
| Hahn, M | 1 |
| Nafe, B | 1 |
| Genitsariotis, R | 1 |
| Mäurer, M | 1 |
| Jung, M | 1 |
| Okada, T | 1 |
| Sasaki, F | 1 |
| Honda, S | 1 |
| Naito, S | 1 |
| Todo, S | 1 |
| Kocherovets, VI | 1 |
| Stolbovoĭ, AV | 1 |
| Dzhalashev, IaKh | 1 |
| Mathew, KK | 1 |
2 reviews available for metronidazole and Cholangitis
| Article | Year |
|---|---|
Clostridium perfringens septicaemia with massive intravascular haemolysis: a case report and review of the literature.
Topics: Aged; Amoxicillin; Anti-Bacterial Agents; Cholangitis; Clostridium Infections; Clostridium perfringe | 2010 |
[Non-clostridial anaerobic infection in diseases of the liver and biliary tract (review of the Soviet and foreign literature)].
Topics: Age Factors; Aged; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Infections; Biliary Tract D | 1984 |
2 trials available for metronidazole and Cholangitis
| Article | Year |
|---|---|
Updates in bacteriological epidemiology of community-acquired severe acute cholangitis and the effectiveness of metronidazole added routinely to the first-line antimicrobial regimen.
Topics: Aged; Anti-Infective Agents; Cholangitis; Cohort Studies; Community-Acquired Infections; Female; Hum | 2013 |
[Ceftriaxone versus Levofloxacin for antibiotic therapy in patients with acute cholangitis].
Topics: Acute Disease; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Bact | 2003 |
4 other studies available for metronidazole and Cholangitis
| Article | Year |
|---|---|
Biliary antibiotics irrigation for E. coli-induced chronic proliferative cholangitis and hepatolithiasis: A pathophysiological study in rabbits.
Topics: Animals; Anti-Bacterial Agents; Bacitracin; Chlorhexidine; Cholangitis; Chronic Disease; Collagen Ty | 2020 |
Acute lymphocytic cholangitis and liver failure in an Amur tiger (Panthera tigris altaica).
Topics: Animals; Animals, Zoo; Anti-Infective Agents; Cholagogues and Choleretics; Cholangitis; Glucocortico | 2014 |
Microbial flora alterations in jejunum and colon after chemical bowel preparation before Kasai hepatoportojejunostomy.
Topics: Anti-Infective Agents; Biliary Atresia; Cholangitis; Colon; Colony Count, Microbial; Drug Therapy, C | 2007 |
Metronidazole in primary cholangitis.
Topics: Adult; Cholangitis; Female; Humans; Metronidazole | 1983 |