metronidazole has been researched along with Genital Diseases, Male in 13 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Genital Diseases, Male: Pathological processes involving the male reproductive tract (GENITALIA, MALE).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fournier gangrene is a necrotizing fasciitis of the perineal and genital region, which almost exclusively affects men." | 1.33 | [Extensive Fournier gangrene. A dermatologic emergency]. ( Aschoff, R; Baldauf, A; Leike, S; Meurer, M; Wirth, MP, 2006) |
| "metronidazole in the treatment of urogenital trichomoniasis." | 1.33 | [Clinical and microbiological efficacy of metronidazole and ornidazole in the treatment of urogenital trichomoniasis in men]. ( Khrianin, AA; Reshetnikov, OV, 2006) |
| "Necrotising fasciitis of the genitalia still carries a high risk of mortality and morbidity, frequently necessitating long periods of hospitalisation and repeated surgical procedures." | 1.27 | Fournier's gangrene: necrotising fasciitis of the male genitalia. ( Arndt, TC; Bahlmann, JC; Fourie, IJ, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (76.92) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| SCHAPIRA, HE | 1 |
| Hoque, SR | 1 |
| Mortimer, P | 1 |
| Cliff, S | 1 |
| Aschoff, R | 1 |
| Baldauf, A | 1 |
| Leike, S | 1 |
| Wirth, MP | 1 |
| Meurer, M | 1 |
| Khrianin, AA | 1 |
| Reshetnikov, OV | 1 |
| Bahlmann, JC | 1 |
| Fourie, IJ | 1 |
| Arndt, TC | 1 |
| Bruce, M | 1 |
| Whitehead, SM | 1 |
| Leach, RD | 1 |
| Eykyn, SJ | 1 |
| Phillips, I | 1 |
| Simon, J | 1 |
| Kiss, L | 1 |
| Kovács, A | 1 |
| Hegyi, J | 1 |
| Watson, RA | 1 |
| Summers, JL | 1 |
| Ford, ML | 1 |
| Catterall, RD | 1 |
| Breier, M | 1 |
| Marberger, H | 1 |
| Decristoforo, A | 1 |
| Swoboda, HP | 1 |
1 review available for metronidazole and Genital Diseases, Male
| Article | Year |
|---|---|
Gardnerella vaginalis: genitourinary pathogen in men.
Topics: Adult; Bacteriuria; Balanitis; Child; Culture Media; Cystitis; Female; Gardnerella vaginalis; Genita | 1985 |
1 trial available for metronidazole and Genital Diseases, Male
| Article | Year |
|---|---|
Treatment of urogenital trichomoniasis with klion.
Topics: Clinical Trials as Topic; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Male; Me | 1972 |
11 other studies available for metronidazole and Genital Diseases, Male
| Article | Year |
|---|---|
STUDIES ON METRONIDAZOLE (FLAGYL) IN THE THERAPY OF UROGENITAL TRICHOMONIASIS IN THE MALE PATIENT.
Topics: Drug Therapy; Genital Diseases, Male; Humans; Inflammation; Male; Metronidazole; Toxicology; Trichom | 1965 |
Penile and scrotal swelling in a child.
Topics: Anti-Infective Agents; Biopsy; Child; Crohn Disease; Genital Diseases, Male; Humans; Lymphedema; Mal | 2005 |
[Extensive Fournier gangrene. A dermatologic emergency].
Topics: Adult; Cefotaxime; Combined Modality Therapy; Drug Therapy, Combination; Emergencies; Follow-Up Stud | 2006 |
[Clinical and microbiological efficacy of metronidazole and ornidazole in the treatment of urogenital trichomoniasis in men].
Topics: Adult; Antitrichomonal Agents; Genital Diseases, Male; Humans; Male; Male Urogenital Diseases; Metro | 2006 |
Fournier's gangrene: necrotising fasciitis of the male genitalia.
Topics: Adult; Aged; Chloramphenicol; Fasciitis; Gangrene; Genital Diseases, Male; Humans; Male; Metronidazo | 1983 |
A case of Fournier's gangrene.
Topics: Gangrene; Genital Diseases, Male; Gentamicins; Humans; Male; Metronidazole; Middle Aged; Penicillin | 1980 |
The aetiology of scrotal sepsis.
Topics: Abscess; Adult; Aged; Bacteria; Genital Diseases, Male; Humans; Male; Metronidazole; Middle Aged; Po | 1982 |
[Massive metronidazole (Klion) therapy of urogenital trichomonas infection].
Topics: Adolescent; Adult; Aged; Female; Genital Diseases, Male; Humans; Male; Metronidazole; Middle Aged; T | 1980 |
The Papanicolaou smear as a diagnostic tool in male trichomoniasis.
Topics: Cytodiagnosis; Genital Diseases, Male; Humans; Male; Methods; Metronidazole; Prostate; Prostatic Dis | 1972 |
Trichomonal infections of the genital tract.
Topics: Coitus; Female; Genital Diseases, Male; Humans; Male; Metronidazole; Pregnancy; Prostatitis; Trichom | 1972 |
[Fertility disorders due to inflammatory male adnexal diseases].
Topics: Abscess; Adult; Fructose; Genital Diseases, Male; Humans; Infertility, Male; Male; Metronidazole; Mi | 1972 |