metronidazole has been researched along with Eye Disorders in 10 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the effectiveness and tolerance of systemic metronidazole in the treatment of childhood ocular and cutaneous rosacea." | 7.77 | [Metronidazole: alternative treatment for ocular and cutaneous rosacea in the pediatric population]. ( Aitali, F; Boralevi, F; Chamaillard, M; Colin, J; Léauté-Labrèze, C; Léoni, S; Marques da Costa, C; Mesplié, N; Mortemousque, B; Taïeb, A, 2011) |
| "To assess the effectiveness and tolerance of systemic metronidazole in the treatment of childhood ocular and cutaneous rosacea." | 3.77 | [Metronidazole: alternative treatment for ocular and cutaneous rosacea in the pediatric population]. ( Aitali, F; Boralevi, F; Chamaillard, M; Colin, J; Léauté-Labrèze, C; Léoni, S; Marques da Costa, C; Mesplié, N; Mortemousque, B; Taïeb, A, 2011) |
| "Rosacea is a chronic facial inflammatory dermatosis characterized by background facial erythema and flushing and may be accompanied by inflammatory papules and pustules, cutaneous fibrosis and hyperplasia known as phyma, and ocular involvement." | 2.53 | Canadian Clinical Practice Guidelines for Rosacea. ( Asai, Y; Baibergenova, A; Barankin, B; Cochrane, CL; Humphrey, S; Lynde, CW; Marcoux, D; Poulin, Y; Rivers, JK; Sapijaszko, M; Sibbald, RG; Tan, J; Toole, J; Ulmer, M; Zip, C, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Agrawal, R | 1 |
| De Salvo, G | 1 |
| Pavlidou, E | 1 |
| Smith, R | 1 |
| Pavesio, C | 1 |
| Cunningham, ET | 1 |
| Shields, CL | 1 |
| Asai, Y | 1 |
| Tan, J | 1 |
| Baibergenova, A | 1 |
| Barankin, B | 1 |
| Cochrane, CL | 1 |
| Humphrey, S | 1 |
| Lynde, CW | 1 |
| Marcoux, D | 1 |
| Poulin, Y | 1 |
| Rivers, JK | 1 |
| Sapijaszko, M | 1 |
| Sibbald, RG | 1 |
| Toole, J | 1 |
| Ulmer, M | 1 |
| Zip, C | 1 |
| Asensio-Sánchez, VM | 1 |
| Léoni, S | 1 |
| Mesplié, N | 1 |
| Aitali, F | 2 |
| Chamaillard, M | 2 |
| Boralevi, F | 2 |
| Marques da Costa, C | 2 |
| Taïeb, A | 2 |
| Léauté-Labrèze, C | 2 |
| Colin, J | 1 |
| Mortemousque, B | 2 |
| Kromberg, R | 1 |
| Mozet, C | 1 |
| Fritzsch, D | 1 |
| Dawczynski, J | 1 |
| Dietz, A | 1 |
| Subashini, K | 1 |
| Pushpa, G | 1 |
| Venugopal, V | 1 |
| Murali, N | 1 |
| Matuchansky, C | 1 |
| Renovanz, HD | 1 |
| Dralands, L | 1 |
1 review available for metronidazole and Eye Disorders
| Article | Year |
|---|---|
Canadian Clinical Practice Guidelines for Rosacea.
Topics: Anti-Infective Agents; Consensus; Dermatologic Agents; Dicarboxylic Acids; Doxycycline; Eye Diseases | 2016 |
9 other studies available for metronidazole and Eye Disorders
| Article | Year |
|---|---|
Diagnostic and therapeutic challenges.
Topics: Adult; Antiprotozoal Agents; Eye Diseases; Female; Fluorescein Angiography; Giardia; Giardiasis; Hum | 2015 |
[Toxic epidermal necrolysis following dorzolamide eyedrops].
Topics: Aged; Critical Care; Drug Therapy, Combination; Eye Diseases; Female; Glaucoma, Open-Angle; Humans; | 2008 |
[Metronidazole: alternative treatment for ocular and cutaneous rosacea in the pediatric population].
Topics: Adolescent; Anti-Infective Agents; Child; Child, Preschool; Disease Progression; Eye Diseases; Femal | 2011 |
[A rare complication of acute sinusitis].
Topics: Aged; Cavernous Sinus Thrombosis; Cefuroxime; Combined Modality Therapy; Decompression, Surgical; Di | 2012 |
Rosacea with severe ophthalmic involvement and blindness - a rare occurrence.
Topics: Administration, Ophthalmic; Adult; Anti-Bacterial Agents; Blindness; Clindamycin; Doxycycline; Eye D | 2012 |
Cutaneous and ocular signs of childhood rosacea.
Topics: Adolescent; Blepharitis; Chalazion; Child; Child, Preschool; Conjunctivitis; Corneal Ulcer; Eye Dise | 2008 |
Inflammatory bowel diseases 1977.
Topics: Azathioprine; Colitis, Ulcerative; Crohn Disease; Cromolyn Sodium; Diet; Eye Diseases; Humans; Joint | 1977 |
[Mycoses of the orbit and the eye].
Topics: Amphotericin B; Antifungal Agents; Aspergillus flavus; Aspergillus fumigatus; Aspergillus oryzae; Co | 1985 |
[Harmful effects of common drugs on the visual apparatus. Anti-infective drugs. D. Antiprotozoal agents].
Topics: Amidines; Antiprotozoal Agents; Blindness; Eye Diseases; Humans; Metronidazole; Papilledema; Photose | 1972 |