metronidazole has been researched along with Granulocytic Leukemia, Chronic in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present a 70-year-old female with a medical history of CML, diabetes, hypertension, and hypercholesterolemia who presented to our dermatology clinic for chief complaint of worsening edematous facial rash beginning after initiation of dasatinib." | 8.12 | Facial Edema Associated with Dasatinib: Case Report with Successful Treatment. ( Ambur, A; Nathoo, R; Nyckowski, T; Vinokurov, A, 2022) |
| "We present a 70-year-old female with a medical history of CML, diabetes, hypertension, and hypercholesterolemia who presented to our dermatology clinic for chief complaint of worsening edematous facial rash beginning after initiation of dasatinib." | 4.12 | Facial Edema Associated with Dasatinib: Case Report with Successful Treatment. ( Ambur, A; Nathoo, R; Nyckowski, T; Vinokurov, A, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nyckowski, T | 1 |
| Ambur, A | 1 |
| Vinokurov, A | 1 |
| Nathoo, R | 1 |
| Ghosh, K | 1 |
| Ayyaril, M | 1 |
| Nirmala, V | 1 |
2 other studies available for metronidazole and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
Facial Edema Associated with Dasatinib: Case Report with Successful Treatment.
Topics: Aged; Antineoplastic Agents; Dasatinib; Edema; Exanthema; Face; Female; Gels; Humans; Leukemia, Myel | 2022 |
Acute GVHD involving the gastrointestinal tract and infestation with Blastocystis hominis in a patient with chronic myeloid leukaemia following allogeneic bone marrow transplantation.
Topics: Acute Disease; Adult; Animals; Antiprotozoal Agents; Blastocystis hominis; Blastocystis Infections; | 1998 |