metronidazole has been researched along with Lichen Ruber Planus in 12 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral metronidazole has been reported to be effective in some patients with idiopathic lichen planus (LP) who did not have concomitant protozoal infections of the intestinal or genital tracts." | 9.09 | Oral metronidazole treatment of lichen planus. ( Büyük, AY; Kavala, M, 2000) |
| " Treatment with topical clobetasol and oral metronidazole led to partial resolution of the lesions with postinflammatory hyperpigmentation." | 7.96 | Lichen planus related to transforming growth factor beta inhibitor in a patient with metastatic chondrosarcoma: a case report. ( Aung, PP; Curry, JL; Farah, M; Nagarajan, P; Nelson, KC; Prieto, VG; Tetzlaff, MT; Torres-Cabala, CA, 2020) |
| "A 51-year-old woman with generalized lichen planus for 23 years experienced total involution of her lesions during metronidazole therapy." | 7.67 | Urinary tract infection as a cause of lichen planus: metronidazole therapy. ( Shelley, ED; Shelley, WB, 1984) |
| "Metronidazole was administered at 250 mg every eight hours daily without any concomitant therapy." | 5.36 | Efficacy of oral metronidazole in treatment of cutaneous and mucosal lichen planus. ( Behzadi, AH; Davoudi, S; Dehghan, N; Honarbakhsh, Y; Mehran, M; Piran, P; Rafizadeh, P; Rasi, A, 2010) |
| "Oral metronidazole has been reported to be effective in some patients with idiopathic lichen planus (LP) who did not have concomitant protozoal infections of the intestinal or genital tracts." | 5.09 | Oral metronidazole treatment of lichen planus. ( Büyük, AY; Kavala, M, 2000) |
| " Treatment with topical clobetasol and oral metronidazole led to partial resolution of the lesions with postinflammatory hyperpigmentation." | 3.96 | Lichen planus related to transforming growth factor beta inhibitor in a patient with metastatic chondrosarcoma: a case report. ( Aung, PP; Curry, JL; Farah, M; Nagarajan, P; Nelson, KC; Prieto, VG; Tetzlaff, MT; Torres-Cabala, CA, 2020) |
| "A 51-year-old woman with generalized lichen planus for 23 years experienced total involution of her lesions during metronidazole therapy." | 3.67 | Urinary tract infection as a cause of lichen planus: metronidazole therapy. ( Shelley, ED; Shelley, WB, 1984) |
| "Vaginitis is one of the most common causes of patient visits to gynecologists, primary care providers, and urgent care centers." | 2.66 | Noncandidal vaginitis: a comprehensive approach to diagnosis and management. ( Eckert, LO; Kus, LH; Neal, CM; Peipert, JF, 2020) |
| "Metronidazole was administered at 250 mg every eight hours daily without any concomitant therapy." | 1.36 | Efficacy of oral metronidazole in treatment of cutaneous and mucosal lichen planus. ( Behzadi, AH; Davoudi, S; Dehghan, N; Honarbakhsh, Y; Mehran, M; Piran, P; Rafizadeh, P; Rasi, A, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Neal, CM | 1 |
| Kus, LH | 1 |
| Eckert, LO | 1 |
| Peipert, JF | 1 |
| Farah, M | 1 |
| Nelson, KC | 1 |
| Tetzlaff, MT | 1 |
| Nagarajan, P | 1 |
| Torres-Cabala, CA | 1 |
| Prieto, VG | 1 |
| Curry, JL | 1 |
| Aung, PP | 1 |
| Massa, AF | 1 |
| Campos, MA | 1 |
| Baptista, A | 1 |
| Costa, C | 1 |
| Lima, O | 1 |
| Osório Ferreira, E | 1 |
| Rasi, A | 1 |
| Behzadi, AH | 1 |
| Davoudi, S | 1 |
| Rafizadeh, P | 1 |
| Honarbakhsh, Y | 1 |
| Mehran, M | 1 |
| Piran, P | 1 |
| Dehghan, N | 1 |
| Rose, AE | 1 |
| Patel, U | 1 |
| Chu, J | 1 |
| Patel, R | 1 |
| Meehan, S | 1 |
| Latkowski, JA | 1 |
| Criado, PR | 1 |
| de Oliveira Ramos, R | 1 |
| Vasconcellos, C | 1 |
| Jardim Criado, RF | 1 |
| Valente, NY | 1 |
| Shelley, WB | 1 |
| Shelley, ED | 1 |
| Wahba-Yahav, AV | 2 |
| Cribier, B | 1 |
| Chosidow, O | 1 |
| Büyük, AY | 1 |
| Kavala, M | 1 |
| Cekić-Arambasin, A | 1 |
| Durcević-matić, A | 1 |
3 reviews available for metronidazole and Lichen Ruber Planus
| Article | Year |
|---|---|
Noncandidal vaginitis: a comprehensive approach to diagnosis and management.
Topics: Administration, Intravaginal; Administration, Oral; Anti-Infective Agents; Anti-Inflammatory Agents; | 2020 |
Erythrodermic lichen planus.
Topics: Aged; Chills; Dermatitis, Exfoliative; Glucocorticoids; Humans; Immunologic Factors; Itraconazole; L | 2011 |
[Lichen].
Topics: Adrenal Cortex Hormones; Cyclosporine; Dapsone; Griseofulvin; Humans; Immunosuppressive Agents; Lich | 1997 |
1 trial available for metronidazole and Lichen Ruber Planus
| Article | Year |
|---|---|
Oral metronidazole treatment of lichen planus.
Topics: Administration, Oral; Adolescent; Adult; Female; Humans; Lichen Planus; Male; Metronidazole; Middle | 2000 |
8 other studies available for metronidazole and Lichen Ruber Planus
| Article | Year |
|---|---|
Lichen planus related to transforming growth factor beta inhibitor in a patient with metastatic chondrosarcoma: a case report.
Topics: Administration, Oral; Administration, Topical; Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents | 2020 |
Paediatric anogenital Crohn's disease 11 years after Lichen planus - same background for two different entities?
Topics: Anal Canal; Azathioprine; Child; Ciprofloxacin; Crohn Disease; Drug Therapy, Combination; Female; Ge | 2016 |
Efficacy of oral metronidazole in treatment of cutaneous and mucosal lichen planus.
Topics: Administration, Oral; Adult; Aged; Female; Humans; Lichen Planus; Male; Metronidazole; Middle Aged | 2010 |
Two case reports of cutaneous adverse reactions following hepatitis B vaccine: lichen planus and granuloma annulare.
Topics: Administration, Cutaneous; Administration, Oral; Adolescent; Anti-Inflammatory Agents; Desonide; Dia | 2004 |
Urinary tract infection as a cause of lichen planus: metronidazole therapy.
Topics: Cystitis; Drug Therapy, Combination; Female; Humans; Lichen Planus; Metronidazole; Middle Aged; Nitr | 1984 |
Idiopathic lichen planus: treatment with metronidazole.
Topics: Adult; Aged; Female; Humans; Lichen Planus; Male; Metronidazole; Treatment Outcome | 1995 |
Intestinal amebiasis, lichen planus, and treatment with metronidazole.
Topics: Chronic Disease; Dysentery, Amebic; Humans; Lichen Planus; Male; Metronidazole; Middle Aged | 1989 |
[The possibilities of drug therapy in oral lichen ruber].
Topics: Adrenal Cortex Hormones; Adult; Aged; Female; Humans; Lichen Planus; Male; Metronidazole; Middle Age | 1985 |