metronidazole has been researched along with Infection Reactivation in 1 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The standard treatment for bacterial vaginosis (BV) with oral metronidazole is often ineffective, and recurrence rates are high among African women." | 1.62 | Temporal Changes in Vaginal Microbiota and Genital Tract Cytokines Among South African Women Treated for Bacterial Vaginosis. ( Abdool Karim, Q; Abdool Karim, SS; Balle, C; de Oliveira, T; Garrett, N; Giandhari, J; Jaspan, HB; Liebenberg, LJP; Mindel, A; Mngomezulu, K; Mtshali, A; Mzobe, G; Ngcapu, S; Onywera, H; Osman, F; Passmore, JS; Ravel, J; Rompalo, A; San, JE, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mtshali, A | 1 |
| San, JE | 1 |
| Osman, F | 1 |
| Garrett, N | 1 |
| Balle, C | 1 |
| Giandhari, J | 1 |
| Onywera, H | 1 |
| Mngomezulu, K | 1 |
| Mzobe, G | 1 |
| de Oliveira, T | 1 |
| Rompalo, A | 1 |
| Mindel, A | 1 |
| Abdool Karim, SS | 1 |
| Ravel, J | 1 |
| Passmore, JS | 1 |
| Abdool Karim, Q | 1 |
| Jaspan, HB | 1 |
| Liebenberg, LJP | 1 |
| Ngcapu, S | 1 |
1 other study available for metronidazole and Infection Reactivation
| Article | Year |
|---|---|
Temporal Changes in Vaginal Microbiota and Genital Tract Cytokines Among South African Women Treated for Bacterial Vaginosis.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Bacteria; Cytokines; Dysbiosis; Female; Host-Pat | 2021 |