metronidazole has been researched along with Dermatoses in 31 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Anecdotal reports suggest that metronidazole may have disease modifying activity in the treatment of rheumatoid arthritis." | 9.07 | Double blind, placebo controlled study of metronidazole as a disease modifying agent in the treatment of rheumatoid arthritis. ( Capell, HA; Hunter, JA; Marshall, DA, 1992) |
| "To assess the effectiveness and tolerance of systemic metronidazole in the treatment of childhood ocular and cutaneous rosacea." | 7.77 | [Metronidazole: alternative treatment for ocular and cutaneous rosacea in the pediatric population]. ( Aitali, F; Boralevi, F; Chamaillard, M; Colin, J; Léauté-Labrèze, C; Léoni, S; Marques da Costa, C; Mesplié, N; Mortemousque, B; Taïeb, A, 2011) |
| " An evaluation of the different radiotherapy schedules used during this period allowed a dose-response curve to be constructed." | 5.27 | Pharyngo-cutaneous fistulae after laryngectomy. Influence of previous radiotherapy and prophylactic metronidazole. ( Elbrønd, O; Johansen, LV; Overgaard, J, 1988) |
| "Anecdotal reports suggest that metronidazole may have disease modifying activity in the treatment of rheumatoid arthritis." | 5.07 | Double blind, placebo controlled study of metronidazole as a disease modifying agent in the treatment of rheumatoid arthritis. ( Capell, HA; Hunter, JA; Marshall, DA, 1992) |
| "To assess the effectiveness and tolerance of systemic metronidazole in the treatment of childhood ocular and cutaneous rosacea." | 3.77 | [Metronidazole: alternative treatment for ocular and cutaneous rosacea in the pediatric population]. ( Aitali, F; Boralevi, F; Chamaillard, M; Colin, J; Léauté-Labrèze, C; Léoni, S; Marques da Costa, C; Mesplié, N; Mortemousque, B; Taïeb, A, 2011) |
| "Metronidazole was used in 14% of patients (n = 19/135), with a complete response being reported in 79% (n = 15/19) and partial response in 21% (n = 4/19)." | 3.01 | Treatment of pediatric ocular rosacea: A systematic review. ( Avraham, S; Kashetsky, N; Khaslavsky, S; Mukovozov, I; Starkey, SY, 2023) |
| "Myristyl nicotinate was found to be compatible with each of the drugs examined when formulated together and also was shown to be photocompatible with retinoic acid." | 1.34 | Formulation compatibility of myristyl nicotinate with drugs used to treat dermatological conditions involving an impaired skin barrier. ( Jacobson, EL; Jacobson, MK; Kim, H; Tashtoush, BM, 2007) |
| "Treatment with metronidazole (250 mg three times a day), prednisone (0." | 1.31 | Perianal Crohn's disease. ( Caglio, P; Caminero, M; Marini, M; Morales, MS, 2000) |
| "To report a case of necrotizing fasciitis after cosmetic blepharoplasty." | 1.30 | Necrotizing fasciitis after cosmetic blepharoplasty. ( Johnson, TE; Meldrum, ML; Suñer, IJ; Tse, DT, 1999) |
| "The mean age at diagnosis of Crohn's disease was 11." | 1.28 | Perianal complications of pediatric Crohn's disease. ( Bilik, R; Griffiths, AM; Palder, SB; Shandling, B; Sherman, P, 1991) |
| "Recurrent perineal Crohn's disease can be an extremely debilitating complication that may be difficult to treat." | 1.28 | Healing of severe perineal and cutaneous Crohn's disease with hyperbaric oxygen. ( Brady, CE; Cooley, BJ; Davis, JC, 1989) |
| " An evaluation of the different radiotherapy schedules used during this period allowed a dose-response curve to be constructed." | 1.27 | Pharyngo-cutaneous fistulae after laryngectomy. Influence of previous radiotherapy and prophylactic metronidazole. ( Elbrønd, O; Johansen, LV; Overgaard, J, 1988) |
| "The term "metastatic" Crohn's disease is used to define the cutaneous lesions, distant from the gastrointestinal tract and separated from other ulcerations by normal skin, showing granulomatous histology." | 1.27 | [Cutaneous Crohn disease]. ( Bakos, L; Kuhl, IC; Wissbluth, ML; Zampese, MS, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (48.39) | 18.7374 |
| 1990's | 6 (19.35) | 18.2507 |
| 2000's | 5 (16.13) | 29.6817 |
| 2010's | 3 (9.68) | 24.3611 |
| 2020's | 2 (6.45) | 2.80 |
| Authors | Studies |
|---|---|
| Khaslavsky, S | 1 |
| Starkey, SY | 1 |
| Avraham, S | 1 |
| Kashetsky, N | 1 |
| Mukovozov, I | 1 |
| Hedberg, ML | 1 |
| Chibnall, RJ | 1 |
| Compton, LA | 1 |
| Melhorn, A | 1 |
| Abide, JM | 1 |
| Léoni, S | 1 |
| Mesplié, N | 1 |
| Aitali, F | 1 |
| Chamaillard, M | 1 |
| Boralevi, F | 1 |
| Marques da Costa, C | 1 |
| Taïeb, A | 1 |
| Léauté-Labrèze, C | 1 |
| Colin, J | 1 |
| Mortemousque, B | 1 |
| Nguyen, V | 1 |
| Eichenfield, LF | 1 |
| Wollina, U | 1 |
| Hansel, G | 1 |
| Köstler, E | 1 |
| Schönlebe, J | 1 |
| Tashtoush, BM | 1 |
| Kim, H | 1 |
| Jacobson, EL | 1 |
| Jacobson, MK | 1 |
| Geary, RJ | 1 |
| Long, LL | 1 |
| Mutasim, DF | 1 |
| Lehrnbecher, T | 1 |
| Kontny, HU | 1 |
| Jeschke, R | 1 |
| Suñer, IJ | 1 |
| Meldrum, ML | 1 |
| Johnson, TE | 1 |
| Tse, DT | 1 |
| Simpson-Dent, S | 1 |
| Fearfield, LA | 1 |
| Staughton, RC | 1 |
| Morales, MS | 1 |
| Marini, M | 1 |
| Caminero, M | 1 |
| Caglio, P | 1 |
| Shiotani, A | 1 |
| Okada, K | 1 |
| Yanaoka, K | 1 |
| Itoh, H | 1 |
| Nishioka, S | 1 |
| Sakurane, M | 1 |
| Matsunaka, M | 1 |
| Matuchansky, C | 1 |
| Willson, RL | 1 |
| Lee, DJ | 1 |
| Wharam, MD | 1 |
| Kashima, H | 1 |
| Order, SE | 1 |
| Brückner, V | 1 |
| Marshall, DA | 1 |
| Hunter, JA | 1 |
| Capell, HA | 1 |
| Palder, SB | 1 |
| Shandling, B | 1 |
| Bilik, R | 1 |
| Griffiths, AM | 1 |
| Sherman, P | 1 |
| Brady, CE | 1 |
| Cooley, BJ | 1 |
| Davis, JC | 1 |
| Asorey Carballeira, A | 1 |
| Alguacil Muñoz, A | 1 |
| Guerra Vales, JM | 1 |
| Vilalta Castel, E | 1 |
| Brook, I | 1 |
| Johansen, LV | 1 |
| Overgaard, J | 1 |
| Elbrønd, O | 1 |
| Khanna, AK | 1 |
| Khanna, A | 1 |
| Asthana, AK | 1 |
| Su, WP | 1 |
| Liu, HN | 1 |
| Zampese, MS | 1 |
| Bakos, L | 1 |
| Kuhl, IC | 1 |
| Wissbluth, ML | 1 |
| Milich, MV | 1 |
| Korsunskaia, IM | 1 |
| Pershin, GN | 1 |
| Okinshevich, OV | 1 |
| Halvorson, GD | 1 |
| Halvorson, JE | 1 |
| Iserson, KV | 1 |
| Archampong, EQ | 1 |
| Clark, CG | 1 |
| Long, PI | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Trimethoprim-sulfamethoxazole Versus Placebo in the Treatment of Cutaneous Abscesses in the Emergency Department[NCT00867789] | 140 participants (Actual) | Interventional | 2009-03-31 | Terminated (stopped due to Slow enrollment due to subjects not meeting inclusion/exclusion criteria) | |||
| A Randomized Trial of Intranasal Fentanyl Versus Placebo as an Adjunct to Lidocaine Infiltration in Adults Undergoing Abscess Incision and Drainage in the Emergency[NCT03872700] | Phase 3 | 49 participants (Actual) | Interventional | 2019-08-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00867789)
Timeframe: two years
| Intervention | Percentage of outcomes assessed (Number) |
|---|---|
| Trimethoprim-sulfamethaxazole | 0 |
| Sugar Pill | 0 |
Patient reported NRS pain scores after Blunt Dissection. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once anytime up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 4.1 |
| Placebo | 4.4 |
Patient reported NRS pain scores after Irrigation. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once anytime up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 3.4 |
| Placebo | 2.6 |
Patient reported NRS pain scores after Lidocaine injection. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Following Lidocaine injection measured once anytime up to 12 minutes after intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 8.4 |
| Placebo | 8.0 |
Patient reported pain after Packing of abscess. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once at the time of completion of application of the bandage, up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 4.5 |
| Placebo | 3.9 |
Patient reported NRS pain scores following Incision. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once anytime up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 3.9 |
| Placebo | 3.9 |
Patient reported pain scores at baseline. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Baseline
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 8.3 |
| Placebo | 8.1 |
Patient reported pain scores for overall Procedure assessed immediately after placement of dressing at the end of procedure. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once following placement of dressing at completion of procedure, up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 6.2 |
| Placebo | 7.0 |
4 reviews available for metronidazole and Dermatoses
| Article | Year |
|---|---|
Treatment of pediatric ocular rosacea: A systematic review.
Topics: Anti-Bacterial Agents; Child; Child, Preschool; Doxycycline; Female; Humans; Male; Metronidazole; Ro | 2023 |
Symptomatic vulvar demodicosis: A case report and review of the literature.
Topics: Administration, Oral; Administration, Topical; Adult; Animals; Antiparasitic Agents; Antiprotozoal A | 2020 |
[Invasive amebiasis (II): Extra-intestinal forms and complications. Parasitological and serological diagnosis. Treatment].
Topics: Amebiasis; Amebicides; Animals; Anti-Bacterial Agents; Brain Abscess; Digestive System Diseases; Eme | 1985 |
Surgical problems in amoebiasis.
Topics: Abscess; Amebiasis; Amebicides; Anti-Bacterial Agents; Appendicitis; Colonic Diseases; Dysentery, Am | 1973 |
1 trial available for metronidazole and Dermatoses
| Article | Year |
|---|---|
Double blind, placebo controlled study of metronidazole as a disease modifying agent in the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Male; Metronidazole; Middle | 1992 |
26 other studies available for metronidazole and Dermatoses
| Article | Year |
|---|---|
[Metronidazole in extemporaneous prescriptions].
Topics: Anti-Infective Agents; Dermatology; Dose-Response Relationship, Drug; Drug Administration Schedule; | 2016 |
Metastatic Crohn disease: clearance with metronidazole.
Topics: Crohn Disease; Humans; Male; Metronidazole; Middle Aged; Skin Diseases | 2011 |
[Metronidazole: alternative treatment for ocular and cutaneous rosacea in the pediatric population].
Topics: Adolescent; Anti-Infective Agents; Child; Child, Preschool; Disease Progression; Eye Diseases; Femal | 2011 |
Periorificial dermatitis in children and adolescents.
Topics: Administration, Oral; Administration, Topical; Adolescent; Adrenal Cortex Hormones; Anti-Infective A | 2006 |
Glabellar pomade crust mimicking dyskeratosis follicularis.
Topics: Aged; Darier Disease; Dermatologic Agents; Diagnosis, Differential; Female; Hair Diseases; Hair Foll | 2006 |
Formulation compatibility of myristyl nicotinate with drugs used to treat dermatological conditions involving an impaired skin barrier.
Topics: Chemistry, Pharmaceutical; Dermatologic Agents; Humans; Hydrocortisone; Ketoconazole; Metronidazole; | 2007 |
Bowel bypass syndrome without bowel bypass.
Topics: Adult; Anti-Infective Agents; Anti-Inflammatory Agents; Biopsy; Ciprofloxacin; Erythema Nodosum; Fem | 1999 |
Metastatic Crohn's disease in a 9-year-old boy.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Azathioprine; Child; Crohn Disease; Erythema; Human | 1999 |
Necrotizing fasciitis after cosmetic blepharoplasty.
Topics: Aged; Blepharoplasty; Debridement; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Eyelids; Fa | 1999 |
HIV associated eosinophilic folliculitis--differential diagnosis and management.
Topics: Administration, Topical; Anti-Infective Agents; Anti-Inflammatory Agents; Antifungal Agents; Eosinop | 1999 |
Perianal Crohn's disease.
Topics: Adolescent; Anti-Infective Agents; Anti-Inflammatory Agents; Crohn Disease; Diagnosis, Differential; | 2000 |
Beneficial effect of Helicobacter pylori eradication in dermatologic diseases.
Topics: Anti-Bacterial Agents; Antigens, Bacterial; Bacterial Proteins; Blotting, Western; Clarithromycin; D | 2001 |
Inflammatory bowel diseases 1977.
Topics: Azathioprine; Colitis, Ulcerative; Crohn Disease; Cromolyn Sodium; Diet; Eye Diseases; Humans; Joint | 1977 |
Letter: Metronidazole and tissue zinc/iron ratio in cancer therapy.
Topics: Humans; Iron; Metronidazole; Neoplasms; Nervous System Diseases; Skin Diseases; Zinc | 1976 |
Short course high fractional dose irradiation in advanced and recurrent head and neck cancer.
Topics: Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Male; Metronidazole; Mucous Membr | 1979 |
Photosensitizers and radiosensitizers in dermatology and oncology.
Topics: Brain Neoplasms; DNA; Humans; Methoxsalen; Metronidazole; Misonidazole; Mycosis Fungoides; Photochem | 1979 |
Perianal complications of pediatric Crohn's disease.
Topics: Abscess; Adolescent; Anus Diseases; Child; Child, Preschool; Crohn Disease; Female; Fissure in Ano; | 1991 |
Healing of severe perineal and cutaneous Crohn's disease with hyperbaric oxygen.
Topics: Combined Modality Therapy; Crohn Disease; Female; Humans; Hyperbaric Oxygenation; Metronidazole; Mid | 1989 |
Pathogenicity of capsulate and non-capsulate members of Bacteroides fragilis and B. melaninogenicus groups in mixed infection with Escherichia coli and Streptococcus pyogenes.
Topics: Abscess; Aerobiosis; Anaerobiosis; Animals; Bacteroides; Bacteroides fragilis; Bacteroides Infection | 1988 |
Pharyngo-cutaneous fistulae after laryngectomy. Influence of previous radiotherapy and prophylactic metronidazole.
Topics: Fistula; Humans; Laryngeal Neoplasms; Laryngectomy; Metronidazole; Pharyngeal Diseases; Radiation In | 1988 |
Postirradiation ulcer and topical metronidazole.
Topics: Breast Neoplasms; Carcinoma, Squamous Cell; Female; Humans; Metronidazole; Middle Aged; Radiation In | 1988 |
Diagnostic criteria for Sweet's syndrome.
Topics: Administration, Oral; Aged; Female; Fluorescent Antibody Technique; Humans; Male; Metronidazole; Mid | 1986 |
[Cutaneous Crohn disease].
Topics: Aged; Crohn Disease; Female; Humans; Metronidazole; Skin Diseases; Vaginal Diseases; Vulvar Diseases | 1986 |
[Metronidazole in the treatment of various dermatoses and dermatophytoses].
Topics: Adolescent; Adult; Dermatomycoses; Female; Humans; Male; Metronidazole; Middle Aged; Ointments; Skin | 1985 |
Abscess incision and drainage in the emergency department--Part I.
Topics: Abscess; Bacteria, Aerobic; Bacteria, Anaerobic; Cellulitis; Clindamycin; Drainage; Emergency Servic | 1985 |
Abscess incision and drainage in the emergency department--Part I.
Topics: Abscess; Bacteria, Aerobic; Bacteria, Anaerobic; Cellulitis; Clindamycin; Drainage; Emergency Servic | 1985 |
Abscess incision and drainage in the emergency department--Part I.
Topics: Abscess; Bacteria, Aerobic; Bacteria, Anaerobic; Cellulitis; Clindamycin; Drainage; Emergency Servic | 1985 |
Abscess incision and drainage in the emergency department--Part I.
Topics: Abscess; Bacteria, Aerobic; Bacteria, Anaerobic; Cellulitis; Clindamycin; Drainage; Emergency Servic | 1985 |
Cutaneous leishmaniasis treated with metronidazole.
Topics: Adult; Evaluation Studies as Topic; Humans; Leishmaniasis; Male; Metronidazole; Remission, Spontaneo | 1973 |