metronidazole has been researched along with Infant Malnutrition in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Infant Malnutrition: Malnutrition, occurring in infants ages 1 month to 24 months, which is due to insufficient intake of food, dietary nutrients, or a pathophysiologic condition which prevents the absorption and utilization of food. Growth and development are markedly affected.
| Excerpt | Relevance | Reference |
|---|---|---|
| "During the study period (6 months) upper respiratory tract infections (URTI) were the commonest illness in all groups; there were significantly more gastroenteric infections in the group given the supplement, but not the antibiotic, treatment; the children who received only the standard health service care were ill more often and for longer periods than children in the other groups." | 2.67 | The Kingston Project. III. The effects of high energy supplement and metronidazole on malnourished children rehabilitated in the community: morbidity and growth. ( Christie, CD; Dawson, S; Gernay, J; Heikens, GT; Schofield, WN, 1993) |
| " The biologic half-life of elimination was significantly longer (p less than 0." | 1.28 | Pharmacokinetics of metronidazole in severely malnourished and nutritionally rehabilitated children. ( Cravioto, J; Lares-Asseff, I; Pérez-Ortíz, B; Santiago, P, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Heikens, GT | 2 |
| Schofield, WN | 2 |
| Dawson, S | 2 |
| Christie, CD | 1 |
| Gernay, J | 1 |
| Diouf, S | 1 |
| Diagne, I | 1 |
| Moreira, C | 1 |
| Signate, SY | 1 |
| Faye, O | 1 |
| Ndiaye, O | 1 |
| Sylla, A | 1 |
| Diallo, I | 1 |
| Thiam, D | 1 |
| Diop, B | 1 |
| Thiam, I | 1 |
| Gaye, I | 1 |
| Sarr, M | 1 |
| Fall, M | 1 |
| Hocking, B | 1 |
| Lares-Asseff, I | 1 |
| Cravioto, J | 1 |
| Santiago, P | 1 |
| Pérez-Ortíz, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacokinetics of Antimicrobials and Carriage of Antimicrobial Resistance Amongst Hospitalised Children With Severe Acute Malnutrition[NCT02746276] | Phase 2 | 81 participants (Actual) | Interventional | 2016-04-01 | Active, not recruiting | ||
| First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition[NCT03174236] | Phase 3 | 2,000 participants (Anticipated) | Interventional | 2017-09-04 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for metronidazole and Infant Malnutrition
| Article | Year |
|---|---|
The Kingston Project. II. The effects of high energy supplement and metronidazole on malnourished children rehabilitated in the community: anthropometry.
Topics: Analysis of Variance; Anthropometry; Child, Preschool; Food, Fortified; Home Care Services; Hospital | 1993 |
The Kingston Project. III. The effects of high energy supplement and metronidazole on malnourished children rehabilitated in the community: morbidity and growth.
Topics: Child, Preschool; Data Interpretation, Statistical; Food, Fortified; Gastroenteritis; Growth; Humans | 1993 |
The Kingston Project. III. The effects of high energy supplement and metronidazole on malnourished children rehabilitated in the community: morbidity and growth.
Topics: Child, Preschool; Data Interpretation, Statistical; Food, Fortified; Gastroenteritis; Growth; Humans | 1993 |
The Kingston Project. III. The effects of high energy supplement and metronidazole on malnourished children rehabilitated in the community: morbidity and growth.
Topics: Child, Preschool; Data Interpretation, Statistical; Food, Fortified; Gastroenteritis; Growth; Humans | 1993 |
The Kingston Project. III. The effects of high energy supplement and metronidazole on malnourished children rehabilitated in the community: morbidity and growth.
Topics: Child, Preschool; Data Interpretation, Statistical; Food, Fortified; Gastroenteritis; Growth; Humans | 1993 |
3 other studies available for metronidazole and Infant Malnutrition
| Article | Year |
|---|---|
[Integrated treatment of iron deficiency, vitamin A deficiency and intestinal parasitic diseases: impact on Senegalese children's growth].
Topics: Anemia, Iron-Deficiency; Anti-Infective Agents; Antinematodal Agents; Child Nutrition Disorders; Chi | 2002 |
Metronidazole in recurrent diarrhoea of malnutrition.
Topics: Child, Preschool; Diarrhea, Infantile; Female; Humans; Infant; Infant Nutrition Disorders; Male; Met | 1976 |
Pharmacokinetics of metronidazole in severely malnourished and nutritionally rehabilitated children.
Topics: Child Nutrition Disorders; Child, Preschool; Female; Humans; Infant; Infant Nutrition Disorders; Mal | 1992 |