Page last updated: 2024-09-27

Lateral Sinus Thrombophlebitis

Formation or presence of a blood clot (THROMBUS) in the LATERAL SINUSES. This condition is often associated with ear infections (OTITIS MEDIA or MASTOIDITIS) without antibiotic treatment. In developed nations, lateral sinus thrombosis can result from CRANIOCEREBRAL TRAUMA; BRAIN NEOPLASMS; NEUROSURGICAL PROCEDURES; THROMBOPHILIA; and other conditions. Clinical features include HEADACHE; VERTIGO; and increased intracranial pressure.

Synonyms(6)

Synonym
Septic Phlebitis, Lateral Sinus
Phlebitis, Lateral Sinus, Septic
Transverse Sinus Thrombosis
Lateral Sinus Thrombosis
Thrombosis, Lateral Sinus
Lateral Sinus Thrombophlebitis

Research Excerpts

Overview

ExcerptReference
"Lateral sinus thrombosis is a rare but known complication of otitis media."( Lannigan, F; Sim, G, 2013)
"Lateral sinus thrombosis is a rare but potentially life-threatening complication."( Lannigan, F; Sim, G, 2013)
"Otogenic lateral sinus thrombosis is a rare complication of acute otitis media whose clinical presentation has changed with the early use of antibiotics."( Csákányi, Z; Katona, G; Kollár, K; Kovács, É; Kulcsár, A; Mellár, M; Móser, J; Rosdy, B; Várallyay, G, 2014)

Research

Studies (22)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's1 (4.55)12.5806
2000's11 (50.00)18.1394
2010's8 (36.36)28.8240
2020's2 (9.09)9.53
DrugIndicatedRelationship StrengthStudiesTrials
lactic acid0low10
dalteparin0low30
pyrazinamide0low10
acetazolamide0low10
antipyrine0low10
cefuroxime0low10
isoniazid0low10
edaravone0low10
metronidazole0low20
potassium iodide0low10
chloramphenicol0low10
mannitol0low20
levonorgestrel0low10
streptomycin0low10
gadolinium0low10
ethinyl estradiol-norgestrel combination0low10
cefadroxil anhydrous0low10
cephalosporin c0low10
drospirenone0low10
homocysteine0low10
dabigatran0low10
cefotaxime0low10
acenocoumarol0low10
oxyntomodulin0low10
exudates0low10
rifampin0low10

Protein Targets (446)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Luciferase2002
RAR-related orphan receptor gamma9009
retinoid X nuclear receptor alpha8008
G7007
peroxisome proliferator activated receptor gamma6006
euchromatic histone-lysine N-methyltransferase 27007
thyroid stimulating hormone receptor3003
chromobox protein homolog 14004
parathyroid hormone/parathyroid hormone-related peptide receptor precursor3003
geminin100010
muscleblind-like protein 1 isoform 13003
Interferon beta8008
HLA class I histocompatibility antigen, B alpha chain 7007
Guanine nucleotide-binding protein G1001
Inositol hexakisphosphate kinase 17007
cytochrome P450 2C9, partial7007
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Beta-lactamase3003
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
thioredoxin reductase3003
GALC protein2002
GLI family zinc finger 3100010
nuclear receptor subfamily 1, group I, member 36006
cytochrome P450 family 3 subfamily A polypeptide 47007
glucocorticoid receptor [Homo sapiens]9009
retinoic acid nuclear receptor alpha variant 19009
estrogen-related nuclear receptor alpha9009
Carbonic anhydrase 0101
Carbonic anhydrase 0101
arylsulfatase A2002
Carbonic anhydrase0101
Bloom syndrome protein isoform 11001
thyroid hormone receptor beta isoform a5005
nuclear factor erythroid 2-related factor 2 isoform 1110011
peripheral myelin protein 222002
survival motor neuron protein isoform d2002
Gamma-aminobutyric acid receptor subunit pi2103
ATP-binding cassette sub-family C member 3011012
Multidrug resistance-associated protein 4011012
Carbonic anhydrase0101
Solute carrier family 22 member 60303
Carbonic anhydrase 120215
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110102
Bile salt export pump013013
Glycogen phosphorylase, muscle form0101
Renin0202
Carbonic anhydrase 10318
Carbonic anhydrase 20317
Carbonic anhydrase 20202
Cytochrome P450 1A20202
Carbonic anhydrase 30215
Cathepsin B0101
Cytochrome P450 3A40303
Steryl-sulfatase0101
5-hydroxytryptamine receptor 2C0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Cytochrome P450 2C80202
Cytochrome P450 2D60101
Cytochrome P450 2A60202
Cytochrome P450 2C9 0303
5-hydroxytryptamine receptor 2A0101
Androgen receptor0101
Gamma-aminobutyric acid receptor subunit beta-12103
Translocator protein0101
Gamma-aminobutyric acid receptor subunit delta2103
Gamma-aminobutyric acid receptor subunit gamma-22103
Gamma-aminobutyric acid receptor subunit alpha-52103
Gamma-aminobutyric acid receptor subunit alpha-32103
Cannabinoid receptor 10101
Arachidonate 5-lipoxygenase-activating protein0101
Cytochrome P450 2B60112
Carbonic anhydrase 40315
Carbonic anhydrase 60214
Gamma-aminobutyric acid receptor subunit gamma-12103
Gamma-aminobutyric acid receptor subunit alpha-22103
Carbonic anhydrase 5A, mitochondrial0101
Adenosine receptor A10101
Serum paraoxonase/arylesterase 10101
Dipeptidyl peptidase 40001
Gamma-aminobutyric acid receptor subunit alpha-42103
Gamma-aminobutyric acid receptor subunit gamma-32103
Endochitinase0101
Gamma-aminobutyric acid receptor subunit alpha-62103
Adenosine receptor A2a0101
5-hydroxytryptamine receptor 2B0101
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0101
Cytochrome P450 2C190202
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Carbonic anhydrase 5A, mitochondrial0316
Carbonic anhydrase0101
Kappa-type opioid receptor0102
Carbonic anhydrase 70214
Carbonic anhydrase0101
D(1A) dopamine receptor0101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase0101
D(2) dopamine receptor0101
Gamma-aminobutyric acid receptor subunit alpha-12103
Gamma-aminobutyric acid receptor subunit beta-32103
Gamma-aminobutyric acid receptor subunit beta-22103
Cholinesterase0101
Carbonic anhydrase 0101
Mu-type opioid receptor0101
Fatty-acid amide hydrolase 10101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Glutamate receptor ionotropic, NMDA 2B0101
Squalene synthase0101
Neuronal acetylcholine receptor subunit alpha-70101
Carbonic anhydrase 90316
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase 30101
Carbonic anhydrase0102
Carbonic anhydrase0102
Carbonic anhydrase 0101
Sigma intracellular receptor 20101
Delta carbonic anhydrase0101
Sigma non-opioid intracellular receptor 10101
Renin0101
Carbonic anhydrase 0101
Endochitinase A10101
Multidrug resistance-associated protein 10101
Carbonic anhydrase 130214
GABA theta subunit2103
Canalicular multispecific organic anion transporter 10909
Carbonic anhydrase 40202
Carbonic anhydrase 150102
Acidic mammalian chitinase0101
Carbonic anhydrase 130203
Carbonic anhydrase 70101
Gamma-aminobutyric acid receptor subunit epsilon2103
Carbonic anhydrase 0101
Carbonic anhydrase 140215
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
Carbonic anhydrase 5B, mitochondrial0215
ATAD5 protein, partial3003
USP1 protein, partial4004
estrogen nuclear receptor alpha120012
67.9K protein2002
peroxisome proliferator-activated receptor delta7007
nuclear factor erythroid 2-related factor 2 isoform 22002
Cytochrome P450 2J20101
Nicotinate phosphoribosyltransferase0101
apical membrane antigen 1, AMA11001
progesterone receptor4004
Cellular tumor antigen p536006
Multidrug resistance-associated protein 1 0001
Solute carrier family 15 member 10303
Solute carrier family 15 member 10101
Solute carrier family 15 member 20303
Solute carrier family 22 member 60202
Solute carrier family 15 member 20202
Solute carrier family 22 member 80202
Solute carrier family 22 member 80202
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0002
Beta-lactamase 0001
Beta-lactamase 0101
Beta-lactamase 0002
Metallo-beta-lactamase type 20013
Metallo-beta-lactamase VIM-11 0002
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20002
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0002
Beta-lactamase 0001
Beta-lactamase 0002
Metallo-beta-lactamase0002
Beta-lactamase 0101
Albumin0033
Beta-lactamase SHV-10001
Beta-lactamase SHV-10002
Beta-lactamase0002
B2 metallo-beta-lactamase 0002
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-130002
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20002
Beta-lactamase 0002
Beta-lactamase Toho-10001
Beta-lactamase 0001
Solute carrier family 22 member 70101
Metallo-beta-lactamase0002
Beta-lactamase 0001
Beta-lactamase 0002
Metallo-b-lactamase 0002
BlaVIM-1 0002
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0002
Carbapenem-hydrolyzing beta-lactamase KPC0002
Histamine H3 receptor0002
Beta-lactamase class B VIM-2 0013
Solute carrier family 22 member 110101
Beta-lactamase VIM-1 0002
Solute carrier family 22 member 70101
interleukin 82002
TDP1 protein4004
AR protein8008
aldehyde dehydrogenase 1 family, member A16006
EWS/FLI fusion protein5005
farnesoid X nuclear receptor2002
pregnane X nuclear receptor8008
cytochrome P450 2D65005
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
aryl hydrocarbon receptor4004
activating transcription factor 62002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
thyroid hormone receptor beta isoform 25005
heat shock protein beta-11001
DNA polymerase iota isoform a (long)3003
streptokinase A precursor0022
lethal factor (plasmid)3003
Dihydroxyacetone phosphate acyltransferase0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Methionine--tRNA ligase, mitochondrial0011
Solute carrier family 22 member 20101
Prothrombin0202
Coagulation factor X0101
Plasminogen0101
Coagulation factor XII0101
Tissue-type plasminogen activator0101
Vitamin K-dependent protein C0101
Serine protease hepsin0101
Trypsin-10101
Trypsin-20101
Muscarinic acetylcholine receptor M10101
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Trypsin-30101
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
SMAD family member 23003
PPM1D protein2002
SMAD family member 33003
nuclear receptor subfamily 1, group I, member 21001
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Chain A, 2-oxoglutarate Oxygenase3003
acetylcholinesterase2002
Microtubule-associated protein tau2002
caspase 7, apoptosis-related cysteine protease1001
thyroid stimulating hormone receptor4004
glucocerebrosidase1001
caspase-31001
IDH11001
Histone H2A.x3003
lysosomal alpha-glucosidase preproprotein1001
vitamin D3 receptor isoform VDRA3003
flap endonuclease 11001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
nuclear receptor ROR-gamma isoform 12002
cytochrome P450 3A4 isoform 12002
replicative DNA helicase0001
recombinase A0011
UDP-glucuronosyltransferase 1A90002
UDP-glucuronosyltransferase 2B170001
Amyloid-beta precursor protein0101
UDP-glucuronosyltransferase 2B70001
UDP-glucuronosyltransferase 1-60001
UDP-glucuronosyltransferase 1A1 0001
UDP-glucuronosyltransferase 1A70001
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
phosphopantetheinyl transferase1001
GLS protein1001
bromodomain adjacent to zinc finger domain 2B1001
3-oxoacyl-[acyl-carrier-protein] synthase 3 0101
cytochrome P450 2D6 isoform 11001
potassium voltage-gated channel subfamily H member 2 isoform d2002
histone acetyltransferase KAT2A isoform 11001
N-glycosylase/DNA lyase0101
Polyphenol oxidase 20101
Bile salt export pump0404
Myeloperoxidase0101
Formamidopyrimidine-DNA glycosylase0101
DNA gyrase subunit A0101
DNA gyrase subunit B0101
Macrophage migration inhibitory factor0101
Endonuclease III-like protein 10101
DNA gyrase subunit B0202
DNA gyrase subunit A0202
Enoyl-[acyl-carrier-protein] reductase [NADH]0205
Pantothenate synthetase0101
Isocitrate lyase0101
Putative FAD-containing monooxygenase MymA0101
Dihydrofolate reductase0101
Endonuclease 8-like 10101
estrogen receptor 2 (ER beta)4004
v-jun sarcoma virus 17 oncogene homolog (avian)2002
cellular tumor antigen p53 isoform a1001
Integrin beta-31001
Integrin alpha-IIb1001
hypoxia-inducible factor 1 alpha subunit1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
transcriptional regulator ERG isoform 31001
DNA polymerase beta1001
lamin isoform A-delta103003
Voltage-dependent calcium channel gamma-2 subunit1001
Progesterone receptor0011
Glutamate receptor 21001
lethal(3)malignant brain tumor-like protein 1 isoform I1001
TAR DNA-binding protein 432002
Beta-lactamase0001
Beta-lactamase TEM0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0012
Beta-lactamase IMP-1 0001
Beta-lactamase 0001
Thioredoxin reductase 0101
mitogen-activated protein kinase 11001
Flavodoxin0001
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Lanosterol 14-alpha demethylase0202
dopamine D1 receptor1001
thioredoxin glutathione reductase1001
NAD-dependent protein deacetylase sirtuin-60101
Chain A, Cruzipain1001
15-lipoxygenase, partial1001
DNA-directed RNA polymerase subunit beta0101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Solute carrier organic anion transporter family member 1A40101
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 2B1 0202
NH(3)-dependent NAD(+) synthetase0101
60 kDa heat shock protein, mitochondrial0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Arylacetamide deacetylase0102
Caspase-10101
Alpha-synuclein0101
Solute carrier organic anion transporter family member 1A10101
Solute carrier organic anion transporter family member 1A20101
Histamine H2 receptor1001
10 kDa heat shock protein, mitochondrial0101
Glutathione S-transferase omega-10101
DNA-directed RNA polymerase subunit beta0101
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Solute carrier organic anion transporter family member 1B30203
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Solute carrier organic anion transporter family member 1B10203
Protein-arginine deiminase type-40202
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Albumin0011
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Protease 0101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]