metronidazole has been researched along with Atherogenesis in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, M | 1 |
| Tang, Q | 1 |
| Nie, J | 1 |
| Zhang, C | 1 |
| Zhou, X | 1 |
| Yu, S | 1 |
| Sun, J | 1 |
| Cheng, X | 1 |
| Dong, N | 1 |
| Hu, Y | 1 |
| Chen, L | 1 |
| Amar, S | 1 |
| Wu, SC | 1 |
| Madan, M | 1 |
| López, NJ | 1 |
| Quintero, A | 1 |
| Casanova, PA | 1 |
| Ibieta, CI | 1 |
| Baelum, V | 1 |
| López, R | 1 |
1 trial available for metronidazole and Atherogenesis
| Article | Year |
|---|---|
Effects of periodontal therapy on systemic markers of inflammation in patients with metabolic syndrome: a controlled clinical trial.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Atherosclerosis; Biomarkers; Blood Glucose; Body Ma | 2012 |
2 other studies available for metronidazole and Atherogenesis
| Article | Year |
|---|---|
BMAL1-Downregulation Aggravates
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Apolipoproteins E; ARNTL Transcription Factors; Athero | 2020 |
Is Porphyromonas gingivalis cell invasion required for atherogenesis? Pharmacotherapeutic implications.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Bacteroidaceae Infections; Cell Line; Cholesterol; Diet | 2009 |