metronidazole and Acute Disease studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

Excerpt	Relevance	Reference
"In a 3-year study, 103 children with acute non-perforated appendicitis who underwent appendicectomy were randomized for either a single preoperative dose of gentamicin and metronidazole or three doses of gentamicin and metronidazole given before and after the operation."	10.17	Antibiotic prophylaxis in acute non-perforated appendicitis in children: single dose of metronidazole and gentamicin. ( Saing, H; Tam, PK; Tsang, TM, 1992)
"Among adults with uncomplicated acute appendicitis, treatment with 7 days of oral moxifloxacin compared with 2 days of intravenous ertapenem followed by 5 days of levofloxacin and metronidazole resulted in treatment success rates greater than 65% in both groups, but failed to demonstrate noninferiority for treatment success of oral antibiotics compared with intravenous followed by oral antibiotics."	9.41	Effect of Oral Moxifloxacin vs Intravenous Ertapenem Plus Oral Levofloxacin for Treatment of Uncomplicated Acute Appendicitis: The APPAC II Randomized Clinical Trial. ( Aarnio, M; Grönroos, J; Haijanen, J; Hurme, S; Ilves, I; Laukkarinen, J; Löyttyniemi, E; Marttila, H; Mattila, A; Meriläinen, S; Nordström, P; Paajanen, H; Pinta, T; Rantanen, T; Rautio, T; Rintala, J; Salminen, P; Sävelä, EL; Savolainen, H; Sippola, S; Sippola, T; Tammilehto, V, 2021)
"Metronidazole is commonly administered to dogs with acute diarrhea, but there is limited evidence to support this practice."	9.34	Metronidazole treatment of acute diarrhea in dogs: A randomized double blinded placebo-controlled clinical trial. ( Koenigshof, AM; Langlois, DK; Mani, R, 2020)
"This multicentre, double-blind study was undertaken to demonstrate non-inferiority of once-daily oral moxifloxacin compared with combination therapy in the management of acute, uncomplicated pelvic inflammatory disease (PID)."	9.14	A randomized double-blind comparison of moxifloxacin and doxycycline/metronidazole/ciprofloxacin in the treatment of acute, uncomplicated pelvic inflammatory disease. ( Heystek, M; Ross, JD, 2009)
"The clinical effect of Levofloxacin and Ceftriaxone in patients with acute cholangitis showed no significant differences."	9.10	[Ceftriaxone versus Levofloxacin for antibiotic therapy in patients with acute cholangitis]. ( Genitsariotis, R; Hahn, M; Jung, M; Kiesslich, R; Mäurer, M; Nafe, B; Will, D, 2003)
"To demonstrate the efficacy of oral metronidazole (OM) in simple or complicated appendicitis with localized peritonitis, a randomized prospective study was carried out in 1083 patients, ranging in age from 4 to 50 years (mean age, 21."	9.09	Can oral metronidazole substitute parenteral drug therapy in acute appendicitis? A new policy in the management of simple or complicated appendicitis with localized peritonitis: a randomized controlled clinical trial. ( Banani, SA; Talei, A, 1999)
"Metronidazole is effective for the treatment of acute pouchitis after ileal pouch-anal anastomosis, but it has not been directly compared with other antibiotics."	9.09	A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. ( Achkar, JP; Bambrick, ML; Bevins, CL; Brzezinski, A; Fazio, VW; Lashner, BA; Ormsby, AH; Remzi, FH; Seidner, DL; Shen, B, 2001)
"To investigate the efficacy of two omeprazole triple therapies for the eradication of Helicobacter pylori, ulcer healing and ulcer relapse during a 6-month treatment-free period in patients with active duodenal ulcer."	9.09	The DU-MACH study: eradication of Helicobacter pylori and ulcer healing in patients with acute duodenal ulcer using omeprazole based triple therapy. ( Bayerdörffer, E; Bradette, M; Farley, A; Leddin, D; Lind, T; O'Morain, C; Sinclair, P; Sipponen, P; Spiller, RC; Unge, P; Wrangstadh, M; Zanten, SJ; Zeijlon, L, 1999)
"A double-blind, randomised study was conducted to compare the efficacy and safety of a combination of pefloxacin and metronidazole versus doxycycline and metronidazole in patients with pelvic inflammatory disease (PID)."	9.07	A comparison of pefloxacin/metronidazole and doxycycline/metronidazole in the treatment of laparoscopically confirmed acute pelvic inflammatory disease. ( Mouton, RP; Peters, AA; Smit, IB; van der Linden, MC; van der Meer, JW; van Erp, EJ; Witte, EH, 1993)
"Eighty-five patients were randomly allocated to receive either piperacillin (n = 38) or cefuroxime plus metronidazole (n = 45) after surgical treatment of diffuse peritonitis; 78 were evaluable."	9.07	Piperacillin compared with cefuroxime plus metronidazole in diffuse peritonitis. ( Alhava, EM; Huttunen, R; Karjalainen, K; Lahtinen, J; Miettinen, P; Paakkonen, M; Silvola, H; Viitanen, J, 1991)
"Metronidazole, 30 mg/kg per dose, once daily achieved AUC target attainment for B fragilis with an MIC of 2 mcg/mL or less in pediatric appendicitis patients."	7.91	Pharmacokinetic and Pharmacodynamic Properties of Metronidazole in Pediatric Patients With Acute Appendicitis: A Prospective Study. ( Anderson, PL; Chen, X; Child, J; Jones, RN; MacBrayne, C; Mistry, RD; Parker, SK; Somme, S, 2019)
"We present the first case of metronidazole-related acute pancreatitis during a relapse of ulcerative colitis."	7.74	Acute pancreatitis as a possible consequence of metronidazole during a relapse of ulcerative colitis. ( Ekonomou, IA; Giannoulis, EK; Giannoulis, KE; Savopoulos, CG; Tsesmeli, NE; Vretou, EE, 2007)
"The aim of this study was to test the effect of gut manipulation by either novel synbiotics or by metronidazole on either endotoxemia or the severity of liver damage in the course of acute pancreatitis from alcohol ingestion."	7.73	Experimental acute alcohol pancreatitis-related liver damage and endotoxemia: synbiotics but not metronidazole have a protective effect. ( Barreto, R; Fesce, E; Gelosa, F; Lorenzetti, A; Marotta, F; Naito, Y; Wu, CC; Yoshioka, M, 2005)
"Metronidazole may increase the risk of acute pancreatitis."	7.73	Metronidazole and risk of acute pancreatitis: a population-based case-control study. ( Jacobsen, J; Nørgaard, M; Pedersen, L; Ratanajamit, C; Skriver, MV; Sørensen, HT, 2005)
"A 45-year-old woman in the period 1988-1995 suffered three episodes of acute pancreatitis associated with the use of metronidazole."	7.69	[Acute pancreatitis caused by metronidazole]. ( de Jongh, FE; Ottervanger, JP; Stuiver, PC, 1996)
"The effect of metronidazole in experimental anaerobic pneumonia in guinea pigs infected with peptostreptococci has been studied."	7.67	[Effect of metronidazole on the course of experimental anaerobic streptococcal pneumonia]. ( Anisimova, LA; Bukova, VE; Khodyreva, GD; Kozliuk, AS; Shroĭt, IG, 1986)
"We present a case of a 22-yr-old female who developed acute pancreatitis coincident with metronidazole therapy, with documented recurrence when inadvertently rechallenged on two separate occasions."	7.67	Metronidazole-induced pancreatitis. ( Burakoff, R; Celifarco, A; Warschauer, C, 1989)
"Ciprofloxacin treatment was successful in all nine patients with chlamydial or gonococcal PID and in six of seven with nonchlamydial nongonococcal PID."	6.66	A comparison of ciprofloxacin with doxycycline plus metronidazole in the treatment of acute pelvic inflammatory disease. ( Aine, R; Grönroos, P; Heinonen, PK; Miettinen, A; Punnonen, R; Teisala, K, 1989)
"In a 3-year study, 103 children with acute non-perforated appendicitis who underwent appendicectomy were randomized for either a single preoperative dose of gentamicin and metronidazole or three doses of gentamicin and metronidazole given before and after the operation."	6.17	Antibiotic prophylaxis in acute non-perforated appendicitis in children: single dose of metronidazole and gentamicin. ( Saing, H; Tam, PK; Tsang, TM, 1992)
"Among adults with uncomplicated acute appendicitis, treatment with 7 days of oral moxifloxacin compared with 2 days of intravenous ertapenem followed by 5 days of levofloxacin and metronidazole resulted in treatment success rates greater than 65% in both groups, but failed to demonstrate noninferiority for treatment success of oral antibiotics compared with intravenous followed by oral antibiotics."	5.41	Effect of Oral Moxifloxacin vs Intravenous Ertapenem Plus Oral Levofloxacin for Treatment of Uncomplicated Acute Appendicitis: The APPAC II Randomized Clinical Trial. ( Aarnio, M; Grönroos, J; Haijanen, J; Hurme, S; Ilves, I; Laukkarinen, J; Löyttyniemi, E; Marttila, H; Mattila, A; Meriläinen, S; Nordström, P; Paajanen, H; Pinta, T; Rantanen, T; Rautio, T; Rintala, J; Salminen, P; Sävelä, EL; Savolainen, H; Sippola, S; Sippola, T; Tammilehto, V, 2021)
"Metronidazole is commonly administered to dogs with acute diarrhea, but there is limited evidence to support this practice."	5.34	Metronidazole treatment of acute diarrhea in dogs: A randomized double blinded placebo-controlled clinical trial. ( Koenigshof, AM; Langlois, DK; Mani, R, 2020)
"He had a 50-day-history of amebic dysentery and had been treated with 1,500 mg metronidazole per day."	5.33	[MRI and SPECT findings in a case of metronidazole-induced reversible acute cerebellar ataxia]. ( Ohta, S; Santa, Y; Takase, K; Yoshimura, T, 2005)
"Metronidazole, P."	5.29	[The clinical experience in Panama with metronidazole in treating Chagas' disease in the acute and chronic phases]. ( Blandón, R; Guevara, JF; Johnson, CM; Leandro, I; Sousa, O, 1993)
"This multicentre, double-blind study was undertaken to demonstrate non-inferiority of once-daily oral moxifloxacin compared with combination therapy in the management of acute, uncomplicated pelvic inflammatory disease (PID)."	5.14	A randomized double-blind comparison of moxifloxacin and doxycycline/metronidazole/ciprofloxacin in the treatment of acute, uncomplicated pelvic inflammatory disease. ( Heystek, M; Ross, JD, 2009)
"The incidence of wound infection in patients who underwent surgery for colon disease and acute appendicitis was lower when they were treated with piperacillin-tazobactam (P< ."	5.12	[Controlled, open, parallel-group study of the clinical and microbiological efficacy of piperacillin-tazobactam versus metronidazole + gentamicin in urgent colorectal surgery]. ( Alvarez, G; Bombuy, E; Charco, R; Ferrer, J; Fondevila, C; Fuster, J; García-Valdecasas, JC, 2006)
"The clinical effect of Levofloxacin and Ceftriaxone in patients with acute cholangitis showed no significant differences."	5.10	[Ceftriaxone versus Levofloxacin for antibiotic therapy in patients with acute cholangitis]. ( Genitsariotis, R; Hahn, M; Jung, M; Kiesslich, R; Mäurer, M; Nafe, B; Will, D, 2003)
"To demonstrate the efficacy of oral metronidazole (OM) in simple or complicated appendicitis with localized peritonitis, a randomized prospective study was carried out in 1083 patients, ranging in age from 4 to 50 years (mean age, 21."	5.09	Can oral metronidazole substitute parenteral drug therapy in acute appendicitis? A new policy in the management of simple or complicated appendicitis with localized peritonitis: a randomized controlled clinical trial. ( Banani, SA; Talei, A, 1999)
"Metronidazole is effective for the treatment of acute pouchitis after ileal pouch-anal anastomosis, but it has not been directly compared with other antibiotics."	5.09	A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. ( Achkar, JP; Bambrick, ML; Bevins, CL; Brzezinski, A; Fazio, VW; Lashner, BA; Ormsby, AH; Remzi, FH; Seidner, DL; Shen, B, 2001)
"To investigate the efficacy of two omeprazole triple therapies for the eradication of Helicobacter pylori, ulcer healing and ulcer relapse during a 6-month treatment-free period in patients with active duodenal ulcer."	5.09	The DU-MACH study: eradication of Helicobacter pylori and ulcer healing in patients with acute duodenal ulcer using omeprazole based triple therapy. ( Bayerdörffer, E; Bradette, M; Farley, A; Leddin, D; Lind, T; O'Morain, C; Sinclair, P; Sipponen, P; Spiller, RC; Unge, P; Wrangstadh, M; Zanten, SJ; Zeijlon, L, 1999)
" Twenty-three consecutive patients suffering from acute alcoholic pancreatitis with computed tomography demonstrating two or more fluid collections were randomly assigned to one of two groups receiving either nonantibiotic treatment or prophylactic antibiotics (ceftazidime, amikacine, and metronidazole for 10 days)."	5.08	Prophylactic antibiotics in treatment of severe acute alcoholic pancreatitis. ( Delcenserie, R; Ducroix, JP; Yzet, T, 1996)
"Eighty-five patients were randomly allocated to receive either piperacillin (n = 38) or cefuroxime plus metronidazole (n = 45) after surgical treatment of diffuse peritonitis; 78 were evaluable."	5.07	Piperacillin compared with cefuroxime plus metronidazole in diffuse peritonitis. ( Alhava, EM; Huttunen, R; Karjalainen, K; Lahtinen, J; Miettinen, P; Paakkonen, M; Silvola, H; Viitanen, J, 1991)
"A double-blind, randomised study was conducted to compare the efficacy and safety of a combination of pefloxacin and metronidazole versus doxycycline and metronidazole in patients with pelvic inflammatory disease (PID)."	5.07	A comparison of pefloxacin/metronidazole and doxycycline/metronidazole in the treatment of laparoscopically confirmed acute pelvic inflammatory disease. ( Mouton, RP; Peters, AA; Smit, IB; van der Linden, MC; van der Meer, JW; van Erp, EJ; Witte, EH, 1993)
"An open randomised comparative trial of the efficacy and safety of Augmentin as against the triple therapy of penicillin-gentamicin-metronidazole in acute salpingitis was conducted in forty women admitted to hospital."	5.06	[Treatment of acute non-chlamydial salpingitis. Study of the efficacy and tolerance of a single-therapy antibiotic: Augmentin]. ( Barrat, J; Marpeau, L; Pigné, A; Tessier, F; Tison, E, 1988)
"One hundred forty-six consecutive inpatients with acute pelvic inflammatory disease (PID) were randomly treated either with the combination of doxycycline and metronidazole or with the combination of penicillin G/amoxicillin and metronidazole."	5.05	Factors predicting abnormal hysterosalpingographic findings in patients treated for acute pelvic inflammatory disease. ( Aantaa, K; Paavonen, J; Räsänen, J; Vesterinen, E, 1985)
" Metronidazole treatment of acute diarrhea in dogs: A randomized double blinded placebo-controlled clinical trial."	3.96	( , 2020)
"Metronidazole, 30 mg/kg per dose, once daily achieved AUC target attainment for B fragilis with an MIC of 2 mcg/mL or less in pediatric appendicitis patients."	3.91	Pharmacokinetic and Pharmacodynamic Properties of Metronidazole in Pediatric Patients With Acute Appendicitis: A Prospective Study. ( Anderson, PL; Chen, X; Child, J; Jones, RN; MacBrayne, C; Mistry, RD; Parker, SK; Somme, S, 2019)
" Historically, a triple-antibiotic therapy consisted of ampicillin, gentamicin, and clindamycin has been used postoperatively for perforated appendicitis."	3.88	Dual versus Triple Antibiotics Regimen in Children with Perforated Acute Appendicitis. ( Baazov, A; Dreznik, Y; Feigin, E; Freud, E; Kravarusic, D; Levy, I; Livni, G; Samuk, I, 2018)
"All patients with acute appendicitis at Sahlgrenska University Hospital (May 2009 and February 2010) were offered intravenous piperacillin plus tazobactam according to our previous experience, followed by 9 days out-hospital oral ciprofloxacin plus metronidazole."	3.78	Antibiotics as first-line therapy for acute appendicitis: evidence for a change in clinical practice. ( Hansson, J; Johnsson, E; Jönsson, C; Körner, U; Ludwigs, K; Lundholm, K, 2012)
"We present the first case of metronidazole-related acute pancreatitis during a relapse of ulcerative colitis."	3.74	Acute pancreatitis as a possible consequence of metronidazole during a relapse of ulcerative colitis. ( Ekonomou, IA; Giannoulis, EK; Giannoulis, KE; Savopoulos, CG; Tsesmeli, NE; Vretou, EE, 2007)
"Metronidazole may increase the risk of acute pancreatitis."	3.73	Metronidazole and risk of acute pancreatitis: a population-based case-control study. ( Jacobsen, J; Nørgaard, M; Pedersen, L; Ratanajamit, C; Skriver, MV; Sørensen, HT, 2005)
"The aim of this study was to test the effect of gut manipulation by either novel synbiotics or by metronidazole on either endotoxemia or the severity of liver damage in the course of acute pancreatitis from alcohol ingestion."	3.73	Experimental acute alcohol pancreatitis-related liver damage and endotoxemia: synbiotics but not metronidazole have a protective effect. ( Barreto, R; Fesce, E; Gelosa, F; Lorenzetti, A; Marotta, F; Naito, Y; Wu, CC; Yoshioka, M, 2005)
"To study the long-term curative effects of suture plus proximal gastric vagotomy (PGV) and suture plus triad-therapy (omeprazole, amoxycillin and flagyl taken orally) for the treatment of duodenal ulcer with acute perforation."	3.71	[Long-term curative effects of suture plus proximal gastric vagotomy or triad-therapy for duodenal ulcer with acute perforation]. ( Fang, L; Huang, S; Jiang, K; Jiang, X; Lin, N; Pan, W; Wan, Y; Xu, R, 2002)
" Amoxicillin was the most frequently prescribed antibiotic used for most clinical conditions apart from pericoronitis, acute ulcerative gingivitis and dry sockets where metronidazole was the drug of choice."	3.70	A study of therapeutic antibiotic prescribing in National Health Service general dental practice in England. ( Ireland, RS; Martin, MV; Palmer, NA; Pealing, R, 2000)
"A 45-year-old woman in the period 1988-1995 suffered three episodes of acute pancreatitis associated with the use of metronidazole."	3.69	[Acute pancreatitis caused by metronidazole]. ( de Jongh, FE; Ottervanger, JP; Stuiver, PC, 1996)
"The penetrance of mezlocillin, metronidazole and trimethoprim-sulfamethoxazole into the pancreatic juice of humans was measured in ten patients convalescing from acute pancreatitis at the time of endoscopic retrograde cholangiopancreatography."	3.67	Assessment of antimicrobial penetrance into the pancreatic juice in humans. ( Bawdon, RE; Cushing, RD; Ledgerwood, AM; Lucas, CE; Sugawa, C; Wallace, JR, 1986)
"The effect of metronidazole in experimental anaerobic pneumonia in guinea pigs infected with peptostreptococci has been studied."	3.67	[Effect of metronidazole on the course of experimental anaerobic streptococcal pneumonia]. ( Anisimova, LA; Bukova, VE; Khodyreva, GD; Kozliuk, AS; Shroĭt, IG, 1986)
"We present a case of a 22-yr-old female who developed acute pancreatitis coincident with metronidazole therapy, with documented recurrence when inadvertently rechallenged on two separate occasions."	3.67	Metronidazole-induced pancreatitis. ( Burakoff, R; Celifarco, A; Warschauer, C, 1989)
"12."	2.90	One-day versus four-day antibiotic treatment for acute right colonic uncomplicated diverticulitis: A randomized clinical trial. ( Lee, BH; Park, HC; Park, JH, 2019)
"To determine the late recurrence rate of appendicitis after antibiotic therapy for the treatment of uncomplicated acute appendicitis."	2.87	Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial. ( Aarnio, M; Grönroos, JM; Hurme, S; Jartti, A; Mecklin, JP; Nordström, P; Paajanen, H; Rantanen, T; Rautio, T; Salminen, P; Sand, J; Tuominen, R; Virtanen, J, 2018)
"The learning point of this case is that intestinal amoebiasis should be considered a differential diagnosis for patients around fifty years old with bowel symptoms and travel history or living in tight quarters."	2.82	Fulminant necrotizing amoebic colitis presenting as acute appendicitis: a case report and comprehensive literature review. ( Habiburrahman, M; Handjari, DR; Krisnuhoni, E; Putranto, AS; Rahadiani, N; Stephanie, M, 2022)
"Of these 22, only 1 patient (5%) had recurrence of acute appendicitis during follow-up."	2.80	Nonoperative treatment with antibiotics versus surgery for acute nonperforated appendicitis in children: a pilot randomized controlled trial. ( Almström, M; Eaton, S; Hall, NJ; Naji, H; Patkova, B; Pierro, A; Svensson, JF; Wester, T, 2015)
"In most of the patients studied, ambulatory conservative management was safe and effective in the treatment of uncomplicated acute diverticulitis."	2.74	[Safety and efficiency of ambulatory treatment of acute diverticulitis]. ( García Marín, A; Martín Gil, J; Pérez Díaz, MD; Rey Valcárcel, C; Sanz Sánchez, M; Serralta De Colsa, D; Turégano Fuentes, F; Vaquero Rodríguez, A, 2009)
"Ciprofloxacin treatment was successful in all nine patients with chlamydial or gonococcal PID and in six of seven with nonchlamydial nongonococcal PID."	2.66	A comparison of ciprofloxacin with doxycycline plus metronidazole in the treatment of acute pelvic inflammatory disease. ( Aine, R; Grönroos, P; Heinonen, PK; Miettinen, A; Punnonen, R; Teisala, K, 1989)
" Despite this there remains little evidence-based literature on what should be prescribed for any given clinical situation, at what dosage and for how long."	2.45	The role of phenoxymethylpenicillin, amoxicillin, metronidazole and clindamycin in the management of acute dentoalveolar abscesses--a review. ( Ellison, SJ, 2009)
"Pouchitis is a common and long-term complication of ileal pouch-anal anastomosis in patients with underlying ulcerative colitis."	2.43	[Diagnosis and medical treatment of pouchitis in ileal pouch-anal anastomosis in patients with ulcerative colitis]. ( Fujii, T; Kawamata, S; Matsushita, M; Okazaki, K; Shimatani, M, 2005)
"One of them also had primary sclerosing cholangitis."	2.42	[Pancreatitis accompanying inflammatory bowel diseases, and our observations]. ( Aleksandrova, A; Nedin, D, 2004)
"Periodontal diseases are common oral diseases that afflict all humans to some degree."	2.37	Current concepts in periodontal diseases. ( Higgins, TJ; Hunter, N; Knox, KW, 1985)
"Acute appendicitis is the most frequent surgical emergency in the paediatric population."	1.72	Evidence-based optimisation of empirical antibiotic regimens in paediatric complicated appendicitis: a retrospective study of 94 patients. ( Andrey, V; Crisinel, PA; Gerber, F; Joseph, JM, 2022)
"The elective treatment for acute pouchitis is antibiotics."	1.56	Recommendations of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU) on pouchitis in ulcerative colitis. Part 2: Treatment. ( Barreiro-de Acosta, M; Beltrán, B; Chaparro, M; Espín, E; Ferrer Bradley, I; Gisbert, JP; Guarner, F; Gutiérrez, A; Marín-Jimenez, I; Nos, P; Rodríguez-Lago, I, 2020)
"Cumulative incidence of surgical site infection was 2."	1.51	Adequacy of antibiotic prophylaxis protocol in appendectomies in children. ( Durán-Poveda, M; García-Cruces, J; Gil-Yonte, P; Rodríguez-Caravaca, G; Rodríguez-Villar, D; Román-Montero, JS, 2019)
"All patients with acute tonsillitis, peritonsillar abscess (PTA), and parapharyngeal abscess admitted to the Ear-Nose-Throat Department, Aarhus University Hospital, in the 2001-2014 period were included in the study."	1.51	Adherence to antibiotic guidelines in the treatment of acute pharyngeal infections. ( Danstrup, CS; Klug, TE; Øhrstrøm, MT, 2019)
"Recurrence is rare and it can be addressed efficiently with the administration of a second course of antibiotics."	1.40	Long-term results of nonoperative treatment for uncomplicated acute appendicitis. ( Aygen, E; Kırkıl, C; Yiğit, MV, 2014)
"The occurrence of subdural empyema is an uncommon but possible sequela of a complicated tooth extraction."	1.40	Parietal subdural empyema as complication of acute odontogenic sinusitis: a case report. ( Ferrara, S; Gambino, A; Martines, F; Mucia, M; Salvago, P; Sireci, F, 2014)
"Nonoperative treatment of acute diverticulitis with extraluminal air is safe and effective in patients with a small amount of distant intraperitoneal air or pericolic air without clinical signs of peritonitis."	1.40	Nonoperative management of perforated diverticulitis with extraluminal air is safe and effective in selected patients. ( Leppäniemi, AK; Mentula, PJ; Sallinen, VJ, 2014)
"This study evaluated the incidence and treatment of pouchitis in Japanese ulcerative colitis patients."	1.39	Clinical features and management of pouchitis in Japanese ulcerative colitis patients. ( Bando, T; Ikeuchi, H; Matsuoka, H; Takesue, Y; Tomita, N; Uchino, M, 2013)
" The antibiotic issued was of standard dosage and the choice of antibiotic prescribed varied depending on the type of infection present."	1.37	An outcome audit of three day antimicrobial prescribing for the acute dentoalveolar abscess. ( Ellison, SJ, 2011)
"Acute dacryocystitis is a rare complication of infectious mononucleosis with only three previous reports in the English literature."	1.37	Acute dacryocystitis associated with epstein-barr virus infection. ( Clarke, JL; Ghauri, AJ; Keane, PA; Madge, SN; Scotcher, SM, 2011)
"Acute epiglottitis was most common in May (16."	1.35	Efficacy of spinal needle aspiration for epiglottic abscess in 90 patients with acute epiglottitis. ( Hong, JW; Kim, MG; Kim, SG; Kim, TH; Lee, JH; Park, DJ; Shim, JS; Yeo, SG, 2009)
"In the routine management of peritonsillar abscess, bacteriologic studies are unnecessary on initial presentation."	1.34	[The microbiology of peritonsillar abscesses]. ( Gajda, M; Zagólski, O, 2007)
"Although it is rare, acute pancreatitis must be considered when evaluating patients presenting with abdominal pain and/or ascites in the postpartum period."	1.33	Ascites in the puerperium: a missed diagnosis of acute postpartum pancreatitis. ( Fakokunde, A; Gyang, A; Kalu, E; Whitlow, B, 2005)
"He had a 50-day-history of amebic dysentery and had been treated with 1,500 mg metronidazole per day."	1.33	[MRI and SPECT findings in a case of metronidazole-induced reversible acute cerebellar ataxia]. ( Ohta, S; Santa, Y; Takase, K; Yoshimura, T, 2005)
"Acute infectious lymphocytosis is characterized by marked peripheral blood lymphocytosis, often associated with a mild, nonspecific febrile illness."	1.31	[Acute infectious lymphocytosis associated to Giardia lamblia and Blastocystis hominis coinfection]. ( Arribas, JM; Escalera, GI; Fernández, GH; González De La Rosa, JB; Martín, TA; Pardilla, AI, 2001)
"Hepatitis A virus (HAV) infection and amoebic liver abscess have an identical mode of transmission (fecal-oral route) and similar epidemiology."	1.30	Simultaneous amoebic liver abscess and hepatitis A infection. ( Piper-Jenks, N; Schwartz, E, 1998)
"Acute generalized exanthemic pustulosis often presents dramatically with the abrupt onset of a widespread pustular eruption on an erythematous base, with a frequently positive Nikolsky sign."	1.29	Acute generalized exanthemic pustulosis. ( Heymann, WR; Manders, SM, 1994)
"Pancreatitis is generally regarded to be an extra-intestinal complication of Crohn's disease unless the duodenum is directly involved."	1.29	Crohn's disease associated with pancreatitis of unknown etiology: a case report. ( Arakawa, S; Omata, F; Takahashi, H; Ueno, F, 1993)
"Metronidazole, P."	1.29	[The clinical experience in Panama with metronidazole in treating Chagas' disease in the acute and chronic phases]. ( Blandón, R; Guevara, JF; Johnson, CM; Leandro, I; Sousa, O, 1993)
"Acute pericoronitis is a common oral infection characterised by a predominance of anaerobic micro-organisms such as peptococci, peptostreptococci, bacteroides and fusobacteria, and also spirochaetes."	1.28	British oral and maxillofacial surgeons' views on the aetiology and management of acute pericoronitis. ( Gill, Y; Scully, C, 1991)
"A 43-year-old female suffering from ulcerative colitis did not improve under therapy with sulfasalazine."	1.27	Acute ulcerative colitis--a rare complication of sulfasalazine therapy. ( Domschke, S; Ruppin, H, 1984)
"Uncomplicated amebic colitis is readily treated and has a mortality rate of less than 0."	1.27	Amebic colitis. Preventing morbidity and mortality from fulminant disease. ( Brooks, JL; Kozarek, RM, 1985)
"A case of non-fatal acute amoebic dysentery without symptoms of meningoencephalitis, due to free-living amoebae possibly of the genus Acanthamoeba, is reported."	1.26	Acute amoebic dysentery due to free-living amoebae treated with methronidazole. ( Guirges, SY; Mehta, AP, 1979)

Research

Studies (179)

Authors

Clinical Trials (19)

Trial Overview

Trial Outcomes

The Success of Antibiotic and Surgical Treatment in the Treatment of Acute Uncomplicated Appendicitis

Timeframe	Studies, this research(%)	All Research%
pre-1990	49 (27.37)	18.7374
1990's	38 (21.23)	18.2507
2000's	40 (22.35)	29.6817
2010's	43 (24.02)	24.3611
2020's	9 (5.03)	2.80

Authors	Studies
Rahadiani, N	1
Habiburrahman, M	1
Putranto, AS	1
Handjari, DR	1
Stephanie, M	1
Krisnuhoni, E	1
Gerber, F	1
Joseph, JM	1
Crisinel, PA	1
Andrey, V	1
Langlois, DK	1
Koenigshof, AM	1
Mani, R	1
Zilberman-Itskovich, S	1
Youngster, I	1
Lazarovitch, T	1
Bondarenco, M	1
Toledano, L	1
Kachlon, Y	1
Mengesha, B	1
Strul, N	1
Zaidenstein, R	1
Marchaim, D	1
Diouf, MS	1
Tall, A	1
Ndiaye, C	1
Thiam, A	1
Deguenonvo, R	1
Ndiaye, M	1
Barreiro-de Acosta, M	1
Marín-Jimenez, I	1
Rodríguez-Lago, I	1
Guarner, F	1
Espín, E	1
Ferrer Bradley, I	1
Gutiérrez, A	1
Beltrán, B	1
Chaparro, M	1
Gisbert, JP	1
Nos, P	1
Mishra, S	1
Mandavdhare, HS	1
Singh, H	1
Choudhury, A	1
Shah, J	1
Ram, S	1
Kalsi, D	1
Samanta, J	1
Prasad, KK	1
Sharma, AK	1
Dutta, U	1
Sharma, V	1
Bhat Yellanthoor, R	1
Sippola, S	3
Haijanen, J	2
Grönroos, J	3
Rautio, T	5
Nordström, P	5
Rantanen, T	5
Pinta, T	1
Ilves, I	1
Mattila, A	1
Rintala, J	1
Löyttyniemi, E	1
Hurme, S	5
Tammilehto, V	1
Marttila, H	1
Meriläinen, S	1
Laukkarinen, J	1
Sävelä, EL	1
Savolainen, H	1
Sippola, T	1
Aarnio, M	5
Paajanen, H	5
Salminen, P	5
Sellami, M	1
Mnejja, M	1
Masmoudi, M	1
Maalej, F	1
Charfeddine, I	1
Ghorbel, A	1
Tuominen, R	4
Dreznik, Y	1
Feigin, E	1
Samuk, I	1
Kravarusic, D	1
Baazov, A	1
Levy, I	1
Livni, G	1
Freud, E	1
Fukumoto, T	1
Katada, F	1
Sato, S	1
Shibayama, H	1
Murayama, S	1
Fukutake, T	1
Haumann, A	1
Ongaro, S	1
Detry, O	1
Meunier, P	1
Meurisse, M	1
Standing, JF	1
Ongas, MO	1
Ogwang, C	1
Kagwanja, N	1
Murunga, S	1
Mwaringa, S	1
Ali, R	1
Mturi, N	1
Timbwa, M	1
Manyasi, C	1
Mwalekwa, L	1
Bandika, VL	1
Ogutu, B	1
Waichungo, J	1
Kipper, K	1
Berkley, JA	1
Child, J	1
Chen, X	1
Mistry, RD	1
Somme, S	1
MacBrayne, C	1
Anderson, PL	1
Jones, RN	1
Parker, SK	1
Mekky, MA	1
Riad, AR	1
Gaber, MA	1
Abdel-Malek, MO	1
Swifee, YM	1
Mecklin, JP	2
Sand, J	2
Virtanen, J	2
Jartti, A	2
Grönroos, JM	2
Øhrstrøm, MT	1
Danstrup, CS	1
Klug, TE	1
Hagras, NA	1
Allam, AF	1
Farag, HF	1
Osman, MM	1
Shalaby, TI	1
Fawzy Hussein Mogahed, NM	1
Tolba, MM	1
Shehab, AY	1
Durán-Poveda, M	1
Gil-Yonte, P	1
Rodríguez-Villar, D	1
García-Cruces, J	1
Rodríguez-Caravaca, G	1
Román-Montero, JS	1
Park, JH	1
Park, HC	3
Lee, BH	3
Cohen-Bucay, A	1
Garimella, P	1
Ezeokonkwo, C	1
Bijol, V	1
Strom, JA	1
Jaber, BL	1
Kim, MJ	2
Ng, PS	1
Saini, M	1
Sallinen, VJ	1
Mentula, PJ	1
Leppäniemi, AK	1
Svensson, JF	1
Patkova, B	1
Almström, M	1
Naji, H	1
Hall, NJ	1
Eaton, S	1
Pierro, A	1
Wester, T	1
Martines, F	1
Salvago, P	1
Ferrara, S	1
Mucia, M	1
Gambino, A	1
Sireci, F	1
Kırkıl, C	1
Yiğit, MV	1
Aygen, E	1
Kowar, M	1
Frackowiak, M	1
Friedrich, C	1
Wilhelm, K	1
Walger, P	1
Jacobs, AH	1
Ward, F	1
Crowley, P	1
Cotter, PE	1
Mamedov, MM	1
Mustafayeva, MF	1
Rinta-Kiikka, I	1
Yousaf, A	1
Ahmed, M	1
Aurangzeb, M	1
Moya, P	2
Bellon, M	1
Arroyo, A	2
Galindo, I	1
Candela, F	2
Lacueva, J	1
Calpena, R	2
Steurer, J	1
Zagólski, O	1
Gajda, M	1
Kim, SG	1
Lee, JH	1
Park, DJ	1
Hong, JW	1
Kim, TH	1
Kim, MG	1
Shim, JS	1
Yeo, SG	1
Repanos, C	1
Mukherjee, P	1
Alwahab, Y	1
Martín Gil, J	1
Serralta De Colsa, D	1
García Marín, A	1
Vaquero Rodríguez, A	1
Rey Valcárcel, C	1
Pérez Díaz, MD	1
Sanz Sánchez, M	1
Turégano Fuentes, F	1
Pezzilli, R	1
Ellison, SJ	2
Heystek, M	1
Ross, JD	1
Alonso, S	1
Pera, M	2
Parés, D	2
Pascual, M	1
Gil, MJ	2
Courtier, R	2
Grande, L	1
Slim, R	1
Ben Salem, C	1
Zamy, M	1
Fathallah, N	1
Raynaud, JJ	1
Bouraoui, K	1
Biour, M	1
Nakanishi, Y	1
Seno, H	1
Chiba, T	1
Yamashita, Y	1
Olwoch, IP	1
Khan, SA	1
Dutta, P	1
Chowdhury, P	1
Borah, J	1
Topno, R	1
Mahanta, J	1
Treszezamsky, AD	1
Feldman, D	1
Sarabanchong, VO	1
Ghauri, AJ	1
Keane, PA	1
Scotcher, SM	1
Clarke, JL	1
Madge, SN	1
Hansson, J	1
Körner, U	1
Ludwigs, K	1
Johnsson, E	1
Jönsson, C	1
Lundholm, K	1
Knežević, M	1
Rašić, D	1
Stojković, M	1
Jovanović, M	1
Božić, M	1
Ghafoor, M	1
Halsnad, M	1
Fowell, C	1
Millar, BG	1
Pérez-Legaz, J	1
Serrano, P	1
Soriano-Irigaray, L	1
Uchino, M	1
Ikeuchi, H	1
Matsuoka, H	1
Bando, T	1
Takesue, Y	1
Tomita, N	1
Xu, R	1
Fang, L	1
Jiang, X	1
Wan, Y	1
Huang, S	1
Jiang, K	1
Lin, N	1
Pan, W	1
Kiesslich, R	1
Will, D	1
Hahn, M	1
Nafe, B	1
Genitsariotis, R	1
Mäurer, M	1
Jung, M	1
Velez, MC	1
Athale, UH	1
Loe, W	1
Warrier, RP	1
Emil, S	1
Laberge, JM	1
Mikhail, P	1
Baican, L	1
Flageole, H	1
Nguyen, L	1
Shaw, K	1
Song, HC	1
Bom, HS	1
Cho, KH	1
Kim, BC	1
Seo, JJ	1
Kim, CG	1
Yang, DJ	1
Kim, EE	1
Beglinger, Ch	1
Mansour-Ghanaei, F	1
Dehbashi, N	1
Yazdanparast, K	1
Shafaghi, A	1
Lodha, A	1
Wales, PW	1
James, A	1
Smith, CR	1
Langer, JC	1
Yang, H	1
Guo, XC	1
Yan, XD	1
Elizalde, JI	1
Pérez-Pujol, S	1
Heras, M	1
Sionis, A	1
Casanovas, N	1
Martorell, T	1
Lozano, M	1
González, J	1
Escolar, G	1
Sanz, G	1
Piqué, JM	1
Nedin, D	1
Aleksandrova, A	1
Nørgaard, M	1
Ratanajamit, C	1
Jacobsen, J	1
Skriver, MV	1
Pedersen, L	1
Sørensen, HT	1
Kolyvanos Naumann, U	1
Käser, L	1
Vetter, W	1
Okazaki, K	1
Matsushita, M	1
Kawamata, S	1
Shimatani, M	1
Fujii, T	1
Takase, K	1
Santa, Y	1
Ohta, S	1
Yoshimura, T	1
Gyang, A	1
Kalu, E	1
Fakokunde, A	1
Whitlow, B	1
Marotta, F	1
Barreto, R	1
Wu, CC	1
Naito, Y	1
Gelosa, F	1
Lorenzetti, A	1
Yoshioka, M	1
Fesce, E	1
Gaggl, AJ	1
Rainer, H	1
Grund, E	1
Chiari, FM	1
Ferrer, J	1
Fondevila, C	1
Bombuy, E	1
Fuster, J	1
Alvarez, G	1
Charco, R	1
García-Valdecasas, JC	1
Peláez, N	1
Sánchez, J	1
Grandea, L	1
Weitzel, T	1
Miyake, Y	1
Iwasaki, Y	1
Ishikawa, S	1
Tatsukawa, M	1
Nawa, T	1
Kato, J	1
Takaki, A	1
Kobashi, H	1
Sakaguchi, K	1
Shiratori, Y	1
Abreu, MT	1
Harpaz, N	1
Samieh-Tucker, A	1
Rupasinghe, M	1
Tsesmeli, NE	1
Giannoulis, KE	1
Savopoulos, CG	1
Vretou, EE	1
Ekonomou, IA	1
Giannoulis, EK	1
Jiménez-Puya, R	1
Gómez-García, F	1
Rodríguez-Bujaldón, A	1
Moreno-Giménez, JC	1
Loulergue, P	1
Mir, O	1
Romero Ganuza, FJ	1
Singleton, JW	1
Capron, JP	1
Gineston, JL	1
Herve, MA	1
Braillon, A	1
Ruppin, H	1
Domschke, S	1
Malchow, H	1
Flannigan, GM	1
Clifford, RP	1
Carver, RA	1
Yule, AG	1
Madden, NP	1
Gelfer, S	1
Scharf, J	1
Zonis, S	1
Mertzbach, D	1
Aguado, JM	1
Gómez Berne, J	1
Figuera, A	1
de Villalobos, E	1
Fernández-Guerrero, ML	1
Sanchez Fayos, J	1
Feki, A	1
van Gelderen, CJ	1
Reilly, S	1
Timmis, P	1
Beeden, AG	1
Willis, AT	1
Gianotti, L	1
Munda, R	1
Gennari, R	1
Pyles, R	1
Alexander, JW	1
Sudar, JM	1
Alleman, MJ	1
Jonkers, GJ	1
de Groot, R	1
Jongejan, C	1
Manders, SM	1
Heymann, WR	1
Yamada, T	1
Deitch, E	1
Specian, RD	1
Perry, MA	1
Sartor, RB	1
Grisham, MB	1
Badía, JM	1
Martínez-Ródenas, F	1
Oms, LM	1
Valverde, J	1
Franch, G	1
Rosales, A	1
Serrano, R	1
Sitges-Serra, A	1
Omata, F	1
Arakawa, S	1
Takahashi, H	1
Ueno, F	1
Mantzaris, GJ	1
Hatzis, A	1
Kontogiannis, P	1
Triadaphyllou, G	1
Ducroz, V	1
Le Pajolec, C	1
Harboun, E	1
Bobin, S	1
Blandón, R	1
Johnson, CM	1
Sousa, O	1
Leandro, I	1
Guevara, JF	1
Moss, SF	1
Calam, J	1
Witte, EH	1
Peters, AA	1
Smit, IB	1
van der Linden, MC	1
Mouton, RP	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
The Use of Clinell Universal Wipes, Clinell Sporicidal Wipes, and Clinell EvaluClean Fluorescent Marker System, in Reducing Environmental Contamination and Acquisitions of Multidrug Resistant Organisms and Hospital Acquired Infections[NCT05522725]		7,725 participants (Actual)	Interventional	2016-10-20	Completed
Use of Antibiotics as an Adjuvant in Patients With Acute Severe Ulcerative Colitis: A Randomised Trial[NCT03794765]	Phase 2	50 participants (Actual)	Interventional	2019-04-01	Completed
Optimizing the Antibiotic Treatment of Uncomplicated Acute Appendicitis: a Prospective Randomised Multicenter Study (The APPAC II Study)[NCT03236961]		552 participants (Anticipated)	Interventional	2017-04-03	Active, not recruiting
First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition[NCT03174236]	Phase 3	2,000 participants (Anticipated)	Interventional	2017-09-04	Active, not recruiting
Study of Surgical Treatment (Open Appendicectomy) Versus Antibiotic Treatment (Ertapenem) in the Treatment of Acute Uncomplicated Appendicitis[NCT01022567]		530 participants (Actual)	Interventional	2009-11-30	Active, not recruiting
Are the Changes in Immature Granulocyte Count and Percentage Significant in the Decision to Continue Medical Treatment of Uncomplicated Acute Appendicitis Cases[NCT04462588]		64 participants (Actual)	Observational [Patient Registry]	2019-06-01	Completed
Conservative Treatment of Acute Appendicitis in Children Pilot Trial[NCT01572558]		51 participants (Actual)	Interventional	2012-02-29	Completed
Preoperative Immature Granulocyte Count and Percentage for Complicated and Uncomplicated Appendisitis[NCT04440150]		70 participants (Actual)	Interventional	2018-06-01	Completed
Multicenter Prospective Randomized Clinical Trial Comparing Endoscopic Retrograde Appendicitis Therapy (ERAT) vs Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis[NCT02789865]	Phase 2	240 participants (Anticipated)	Interventional	2016-05-31	Not yet recruiting
Mutil-institutions Comparing Antibiotic Therapy With Laparscopic Appendectomy in Pediatric Chronic Appendicitis[NCT03754387]		200 participants (Anticipated)	Interventional	2019-01-01	Enrolling by invitation
A Prospective Non-randomized Controlled, Multicenter, Multidisciplinary Trial Comparing Appendectomy and Conservative Treatment for Patients With Uncomplicated Acute Appendicitis (the ACTUAA STUDY).[NCT03080103]		300 participants (Actual)	Observational	2017-06-01	Completed
Randomized Multicentric Controlled Clinical Trial of Parallel Groups to Evaluate the Non-therapeutic Inferiority of a Free Diet With a Progressive Diet, in the Treatment of Non-complicated Acute Diverticulitis[NCT03496090]		134 participants (Actual)	Interventional	2018-04-16	Completed
Multicentre Controlled, Randomized Clinical Trial to Compare the Efficacy and Safety of Ambulatory Treatment of Mild Acute Diverticulitis Without Antibiotics With the Standard Treatment With Antibiotics[NCT02785549]	Phase 4	480 participants (Actual)	Interventional	2016-11-30	Completed
PROTOP: Study of the Efficacy of Topical Antibiotherapy in the Prophylaxis of Incisional Surgical Localization Infection in Colorectal Surgery[NCT03574090]	Phase 4	268 participants (Actual)	Interventional	2020-10-20	Completed
"A Phase 1b/2 Study to Demonstrate the Safety and Efficacy of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects With an Ileal Pouch-Anal Anastomosis (PROF). The PROF Study."[NCT05938465]	Phase 1/Phase 2	50 participants (Anticipated)	Interventional	2023-10-11	Recruiting
Efficacy of the Application of Moxifloxacin and Cefixime in Reduction of Inflammatory Sequelae and Complications After Mandibular Third Molar Surgery[NCT05027893]		157 participants (Actual)	Interventional	2019-06-07	Active, not recruiting
A Pilot Study of the Safety and Efficacy of AST-120 in the Treatment of Antibiotic-Refractory Pouchitis[NCT00583531]	Phase 2	2 participants (Actual)	Interventional	2007-03-31	Terminated (stopped due to Lack of enrollment)
Fecal Microbiota Transplantation for the Treatment of Chronic Pouchitis[NCT03538366]		10 participants (Actual)	Interventional	2018-05-15	Completed
A Pilot Study of the Safety and Efficacy of AST-120 in the Treatment of Active Pouchitis[NCT00583076]	Phase 2	19 participants (Actual)	Interventional	2007-02-28	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

A successful treatment is determined by resolution of the appendicitis by means of the assigned treatment. (NCT01022567)
Timeframe: Up to 10 years

Article	Year
Fulminant necrotizing amoebic colitis presenting as acute appendicitis: a case report and comprehensive literature review. Journal of infection in developing countries, 2022, 04-30, Volume: 16, Issue:4 Topics: Acute Disease; Appendicitis; Dysentery, Amebic; Entamoeba histolytica; Humans; Intestines; Male; Met	2022
The role of phenoxymethylpenicillin, amoxicillin, metronidazole and clindamycin in the management of acute dentoalveolar abscesses--a review. British dental journal, 2009, Apr-11, Volume: 206, Issue:7 Topics: Acute Disease; Adult; Amoxicillin; Anti-Bacterial Agents; Clindamycin; Drainage; Drug Resistance, Ba	2009
Acute post-surgical bilateral orbital gas-producing infection - a case report and literature review. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2012, Volume: 250, Issue:9 Topics: Acute Disease; Anti-Bacterial Agents; Drug Therapy, Combination; Emphysema; Eye Infections, Bacteria	2012
[Treatment of Crohn's disease]. Therapeutische Umschau. Revue therapeutique, 2003, Volume: 60, Issue:3 Topics: Acute Disease; Adjuvants, Immunologic; Adrenal Cortex Hormones; Algorithms; Aminosalicylic Acids; An	2003
[Pancreatitis accompanying inflammatory bowel diseases, and our observations]. Khirurgiia, 2004, Volume: 60, Issue:1 Topics: Acute Disease; Amylases; Anti-Infective Agents; Anti-Inflammatory Agents; Bulgaria; Cholangitis, Scl	2004
[Diverticulitis (acute)/diverticulosis of the colon]. Praxis, 2005, Jan-26, Volume: 94, Issue:4 Topics: Acute Disease; Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Diagnosis, Differential;	2005
[Diagnosis and medical treatment of pouchitis in ileal pouch-anal anastomosis in patients with ulcerative colitis]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63, Issue:5 Topics: Acute Disease; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Humans; Immunologic Factor	2005
Diagnosis of colitis: making the initial diagnosis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2007, Volume: 5, Issue:3 Topics: Acute Disease; Adult; Biopsy, Needle; Clostridioides difficile; Clostridium Infections; Early Diagno	2007
[Pancreatitis associated with metronidazole]. Gastroenterologia y hepatologia, 2008, Volume: 31, Issue:4 Topics: Abdominal Injuries; Acute Disease; Adult; Anti-Bacterial Agents; Cervical Vertebrae; Clostridium Inf	2008
Effect of different regimens of gut decontamination on bacterial translocation and mortality in experimental acute pancreatitis. The European journal of surgery = Acta chirurgica, 1995, Volume: 161, Issue:2 Topics: Acute Disease; Animals; Anti-Bacterial Agents; Decontamination; Erythromycin; Gram-Negative Bacteria	1995
Acute thyroiditis caused by Moraxella nonliquefaciens. The Netherlands journal of medicine, 1994, Volume: 45, Issue:4 Topics: Acute Disease; Adult; Cephradine; Drug Therapy, Combination; Female; Humans; Metronidazole; Moraxell	1994
[Acute mastoiditis due to anaerobic bacteria. Review of the literature apropos of a case]. Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris, 1993, Volume: 110, Issue:1 Topics: Acute Disease; Child, Preschool; Ear, Middle; Fusobacterium Infections; Fusobacterium necrophorum; H	1993
[Septic thrombophlebitis of the internal jugular vein and Lemierre syndrome]. Revue medicale de Bruxelles, 1998, Volume: 19, Issue:1 Topics: Abscess; Acute Disease; Aged; Amoxicillin-Potassium Clavulanate Combination; Angina Pectoris; Anti-B	1998
Antibiotic prophylaxis in acute non-perforated appendicitis in children: single dose of metronidazole and gentamicin. Journal of the Royal College of Surgeons of Edinburgh, 1992, Volume: 37, Issue:2 Topics: Acute Disease; Adolescent; Appendicitis; Child; Child, Preschool; Female; Gentamicins; Humans; Male;	1992
Current concepts in periodontal diseases. The Medical journal of Australia, 1985, May-27, Volume: 142, Issue:11 Topics: Acute Disease; Adult; Child; Chronic Disease; Dental Plaque; Gingivitis; Gingivitis, Necrotizing Ulc	1985

Article	Year
Metronidazole treatment of acute diarrhea in dogs: A randomized double blinded placebo-controlled clinical trial. Journal of veterinary internal medicine, 2020, Volume: 34, Issue:1 Topics: Acute Disease; Animals; Diarrhea; Dog Diseases; Dogs; Double-Blind Method; Feces; Female; Male; Metr	2020
Adjuvant use of combination of antibiotics in acute severe ulcerative colitis: A placebo controlled randomized trial. Expert review of anti-infective therapy, 2021, Volume: 19, Issue:7 Topics: Acute Disease; Adult; Anti-Bacterial Agents; Ceftriaxone; Colitis, Ulcerative; Double-Blind Method;	2021
Effect of Oral Moxifloxacin vs Intravenous Ertapenem Plus Oral Levofloxacin for Treatment of Uncomplicated Acute Appendicitis: The APPAC II Randomized Clinical Trial. JAMA, 2021, 01-26, Volume: 325, Issue:4 Topics: Acute Disease; Administration, Intravenous; Administration, Oral; Adult; Anti-Bacterial Agents; Appe	2021
Economic evaluation of antibiotic therapy versus appendicectomy for the treatment of uncomplicated acute appendicitis from the APPAC randomized clinical trial. The British journal of surgery, 2017, Volume: 104, Issue:10 Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; Appendicitis; beta-Lactams; C	2017
Dosing of Ceftriaxone and Metronidazole for Children With Severe Acute Malnutrition. Clinical pharmacology and therapeutics, 2018, Volume: 104, Issue:6 Topics: Acute Disease; Age Factors; Anti-Infective Agents; Ceftriaxone; Child Nutrition Disorders; Child Nut	2018
Rifaximin versus metronidazole in management of acute episode of hepatic encephalopathy: An open labeled randomized clinical trial. Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology, 2018, Volume: 19, Issue:2 Topics: Acute Disease; Adult; Ammonia; Anti-Infective Agents; Female; Hepatic Encephalopathy; Humans; Length	2018
Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial. JAMA, 2018, 09-25, Volume: 320, Issue:12 Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; Appendicitis; beta-Lactams; D	2018
Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial. JAMA, 2018, 09-25, Volume: 320, Issue:12 Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; Appendicitis; beta-Lactams; D	2018
Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial. JAMA, 2018, 09-25, Volume: 320, Issue:12 Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; Appendicitis; beta-Lactams; D	2018
Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial. JAMA, 2018, 09-25, Volume: 320, Issue:12 Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; Appendicitis; beta-Lactams; D	2018
One-day versus four-day antibiotic treatment for acute right colonic uncomplicated diverticulitis: A randomized clinical trial. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2019, Volume: 30, Issue:7 Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Bacterial Agents; Cefmetazole; Diverticulitis, Colonic;	2019
Cost analysis of antibiotic therapy versus appendectomy for treatment of uncomplicated acute appendicitis: 5-year results of the APPAC randomized clinical trial. PloS one, 2019, Volume: 14, Issue:7 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2019
The outcome of antibiotic therapy for uncomplicated appendicitis with diameters ≤ 10 mm. International journal of surgery (London, England), 2014, Volume: 12, Issue:9 Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Bacterial Agents; Appendectomy; Appendicitis; Cephalosp	2014
Nonoperative treatment with antibiotics versus surgery for acute nonperforated appendicitis in children: a pilot randomized controlled trial. Annals of surgery, 2015, Volume: 261, Issue:1 Topics: Abdominal Pain; Acute Disease; Adolescent; Anti-Bacterial Agents; Appendectomy; Appendicitis; Child;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Praxis, 2017, Volume: 106, Issue:3 Topics: Acute Disease; Administration, Oral; Amoxicillin-Potassium Clavulanate Combination; Ciprofloxacin; C	2017
[Safety and efficiency of ambulatory treatment of acute diverticulitis]. Gastroenterologia y hepatologia, 2009, Volume: 32, Issue:2 Topics: Abdominal Pain; Abscess; Acute Disease; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Ambulatory C	2009
A randomized double-blind comparison of moxifloxacin and doxycycline/metronidazole/ciprofloxacin in the treatment of acute, uncomplicated pelvic inflammatory disease. International journal of STD & AIDS, 2009, Volume: 20, Issue:10 Topics: Acute Disease; Adult; Anti-Infective Agents; Aza Compounds; Ciprofloxacin; Double-Blind Method; Doxy	2009
Outpatient treatment of patients with uncomplicated acute diverticulitis. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2010, Volume: 12, Issue:10 Online Topics: Acute Disease; Administration, Oral; Adult; Aged; Aged, 80 and over; Ambulatory Care; Amoxicillin-Po	2010
[Ceftriaxone versus Levofloxacin for antibiotic therapy in patients with acute cholangitis]. Zeitschrift fur Gastroenterologie, 2003, Volume: 41, Issue:1 Topics: Acute Disease; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Bact	2003
Prognostication of recovery in patients with acute ischemic stroke through the use of brain SPECT with Technetium-99m--labeled metronidazole. Stroke, 2003, Volume: 34, Issue:4 Topics: Acute Disease; Aged; Brain; Brain Ischemia; Cysteine; Diffusion Magnetic Resonance Imaging; Female;	2003
Efficacy of saccharomyces boulardii with antibiotics in acute amoebiasis. World journal of gastroenterology, 2003, Volume: 9, Issue:8 Topics: Acute Disease; Administration, Oral; Amebiasis; Amebicides; Anti-Bacterial Agents; Anti-Infective Ag	2003
[Physiotherapy with drugs for acute lymphadenitis of face and neck]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, 2003, Volume: 28, Issue:3 Topics: Acute Disease; Child; Child, Preschool; Combined Modality Therapy; Face; Female; Humans; Lymphadenit	2003
Effects of Helicobacter pylori eradication on platelet activation and disease recurrence in patients with acute coronary syndromes. Helicobacter, 2004, Volume: 9, Issue:6 Topics: Acute Disease; Amoxicillin; Antigens, CD; Coronary Disease; Female; Helicobacter Infections; Helicob	2004
Local oxygen therapy for treating acute necrotizing periodontal disease in smokers. Journal of periodontology, 2006, Volume: 77, Issue:1 Topics: Acute Disease; Administration, Topical; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin-Po	2006
[Controlled, open, parallel-group study of the clinical and microbiological efficacy of piperacillin-tazobactam versus metronidazole + gentamicin in urgent colorectal surgery]. Cirugia espanola, 2006, Volume: 79, Issue:6 Topics: Acute Disease; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Appendicitis; Drug Administratio	2006
Antibiotic prophylaxis in acute appendicitis. Surgery, gynecology & obstetrics, 1983, Volume: 156, Issue:2 Topics: Acute Disease; Administration, Oral; Adolescent; Appendectomy; Appendicitis; Clinical Trials as Topi	1983
'One-visit' therapy for pelvic inflammatory disease. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1980, Aug-09, Volume: 58, Issue:6 Topics: Acute Disease; Blood Sedimentation; Drug Therapy, Combination; Escherichia coli; Female; Fever; Huma	1980
Effect of different regimens of gut decontamination on bacterial translocation and mortality in experimental acute pancreatitis. The European journal of surgery = Acta chirurgica, 1995, Volume: 161, Issue:2 Topics: Acute Disease; Animals; Anti-Bacterial Agents; Decontamination; Erythromycin; Gram-Negative Bacteria	1995
[A randomized prospective study of antibiotic prophylaxis compared to lavage of the surgical wound in nonperforating appendicitis]. Medicina clinica, 1994, Jul-09, Volume: 103, Issue:6 Topics: Acute Disease; Adolescent; Adult; Appendectomy; Appendicitis; Chi-Square Distribution; Child; Female	1994
Intravenous tobramycin and metronidazole as an adjunct to corticosteroids in acute, severe ulcerative colitis. The American journal of gastroenterology, 1994, Volume: 89, Issue:1 Topics: Acute Disease; Adolescent; Adult; Aged; Chemotherapy, Adjuvant; Colitis, Ulcerative; Drug Therapy, C	1994
A comparison of pefloxacin/metronidazole and doxycycline/metronidazole in the treatment of laparoscopically confirmed acute pelvic inflammatory disease. European journal of obstetrics, gynecology, and reproductive biology, 1993, Volume: 50, Issue:2 Topics: Acute Disease; Chlamydia trachomatis; Double-Blind Method; Doxycycline; Drug Therapy, Combination; F	1993
[An evaluation of nonsurgical treatment for severe acute pancreatitis]. Zhonghua wai ke za zhi [Chinese journal of surgery], 1995, Volume: 33, Issue:9 Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Bacterial Agents; Cefazolin; Cephalosporins; Combined M	1995
Prophylactic antibiotics in treatment of severe acute alcoholic pancreatitis. Pancreas, 1996, Volume: 13, Issue:2 Topics: Acute Disease; Adult; Amikacin; Anti-Bacterial Agents; Bacterial Infections; Ceftazidime; Female; Hu	1996
Preventing infection of the incision after appendectomy by using metronidazole preoperatively to infiltrate tissues at the incision. American journal of surgery, 1997, Volume: 174, Issue:4 Topics: Acute Disease; Adult; Antibiotic Prophylaxis; Appendectomy; Appendicitis; Cefazolin; Cephalosporins;	1997
The DU-MACH study: eradication of Helicobacter pylori and ulcer healing in patients with acute duodenal ulcer using omeprazole based triple therapy. Alimentary pharmacology & therapeutics, 1999, Volume: 13, Issue:3 Topics: Acute Disease; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Clarithromycin; Double-B	1999
Can oral metronidazole substitute parenteral drug therapy in acute appendicitis? A new policy in the management of simple or complicated appendicitis with localized peritonitis: a randomized controlled clinical trial. The American surgeon, 1999, Volume: 65, Issue:5 Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Anti-Infective Agents; Appendicitis; Ceftizo	1999
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. Inflammatory bowel diseases, 2001, Volume: 7, Issue:4 Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal	2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. Inflammatory bowel diseases, 2001, Volume: 7, Issue:4 Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal	2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. Inflammatory bowel diseases, 2001, Volume: 7, Issue:4 Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal	2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. Inflammatory bowel diseases, 2001, Volume: 7, Issue:4 Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal	2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. Inflammatory bowel diseases, 2001, Volume: 7, Issue:4 Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal	2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. Inflammatory bowel diseases, 2001, Volume: 7, Issue:4 Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal	2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. Inflammatory bowel diseases, 2001, Volume: 7, Issue:4 Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal	2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. Inflammatory bowel diseases, 2001, Volume: 7, Issue:4 Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal	2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. Inflammatory bowel diseases, 2001, Volume: 7, Issue:4 Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal	2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. Inflammatory bowel diseases, 2001, Volume: 7, Issue:4 Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal	2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. Inflammatory bowel diseases, 2001, Volume: 7, Issue:4 Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal	2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. Inflammatory bowel diseases, 2001, Volume: 7, Issue:4 Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal	2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. Inflammatory bowel diseases, 2001, Volume: 7, Issue:4 Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal	2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. Inflammatory bowel diseases, 2001, Volume: 7, Issue:4 Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal	2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. Inflammatory bowel diseases, 2001, Volume: 7, Issue:4 Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal	2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. Inflammatory bowel diseases, 2001, Volume: 7, Issue:4 Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal	2001
The place of metronidazole in the treatment of acute oro-facial infection. The Journal of antimicrobial chemotherapy, 1978, Volume: 4 Suppl C Topics: Acute Disease; Anaerobiosis; Clinical Trials as Topic; Humans; Metronidazole; Microbial Sensitivity	1978
Metronidazole in the treatment of severe acute pericoronitis. A clinical trail. British dental journal, 1977, Apr-05, Volume: 142, Issue:7 Topics: Acute Disease; Adolescent; Adult; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male; M	1977
Antibiotic prophylaxis in acute non-perforated appendicitis in children: single dose of metronidazole and gentamicin. Journal of the Royal College of Surgeons of Edinburgh, 1992, Volume: 37, Issue:2 Topics: Acute Disease; Adolescent; Appendicitis; Child; Child, Preschool; Female; Gentamicins; Humans; Male;	1992
Piperacillin compared with cefuroxime plus metronidazole in diffuse peritonitis. The European journal of surgery = Acta chirurgica, 1991, Volume: 157, Issue:9 Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Cefuroxime; Drug Therapy, Combination; Fe	1991
[General or individually calculated preventive antibiotic administration. Summary of the Magdeburg appendicitis study]. Zentralblatt fur Chirurgie, 1991, Volume: 116, Issue:13 Topics: Acute Disease; Adult; Ampicillin; Appendectomy; Appendicitis; Female; Humans; Infusions, Intravenous	1991
A comparison of ciprofloxacin with doxycycline plus metronidazole in the treatment of acute pelvic inflammatory disease. Scandinavian journal of infectious diseases. Supplementum, 1989, Volume: 60 Topics: Acute Disease; Adolescent; Adult; Bacterial Infections; Ciprofloxacin; Doxycycline; Drug Evaluation;	1989
Systemic metronidazole combined with either topical povidone-iodine or ampicillin in acute appendicitis. The Journal of hospital infection, 1985, Volume: 6 Suppl A Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Infective Agents; Anti-Infective Agents, Local; Appende	1985
Factors predicting abnormal hysterosalpingographic findings in patients treated for acute pelvic inflammatory disease. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1985, Volume: 23, Issue:3 Topics: Acute Disease; Adolescent; Adult; Amoxicillin; Chlamydia Infections; Clinical Trials as Topic; Doxyc	1985
A comparative study of metronidazole and sulfasalazine in active, not severe, ulcerative colitis. An Israeli multicenter trial. Journal of clinical gastroenterology, 1987, Volume: 9, Issue:4 Topics: Acute Disease; Clinical Trials as Topic; Colitis, Ulcerative; Double-Blind Method; Female; Humans; I	1987
Comparison between the efficacy of a single dose of secnidazole with a 5-day course of tetracycline and clioquinol in the treatment of acute intestinal amoebiasis. Pharmatherapeutica, 1985, Volume: 4, Issue:4 Topics: Acute Disease; Adolescent; Adult; Aged; Child; Clinical Trials as Topic; Clioquinol; Drug Therapy, C	1985
[Treatment of acute non-chlamydial salpingitis. Study of the efficacy and tolerance of a single-therapy antibiotic: Augmentin]. Journal de gynecologie, obstetrique et biologie de la reproduction, 1988, Volume: 17, Issue:4 Topics: Acute Disease; Adolescent; Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-B	1988
The use of nitrimidazine in the treatment of acute ulcerative gingivitis. A double-blind controlled trial. British dental journal, 1971, Apr-06, Volume: 130, Issue:7 Topics: Acute Disease; Adolescent; Adult; Clinical Trials as Topic; Female; Gingivitis; Gingivitis, Necrotiz	1971

Article	Year
Evidence-based optimisation of empirical antibiotic regimens in paediatric complicated appendicitis: a retrospective study of 94 patients. Swiss medical weekly, 2022, 08-29, Volume: 152 Topics: Acute Disease; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Appendectomy; A	2022
Potential impact of removing metronidazole from treatment armamentarium of mild acute Future microbiology, 2019, Volume: 14 Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Clostridioides difficile; Clos	2019
Complications of sinusitis: An 80-case series from the ENT and neurosurgery departments of the Fann university hospital center of Dakar, Senegal. European annals of otorhinolaryngology, head and neck diseases, 2020, Volume: 137, Issue:6 Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Brain Abscess; Child; Child, Preschool; Cla	2020
Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere, 2020, Volume: 48, Issue:2 Topics: Acute Disease; Animals; Anti-Infective Agents; Diarrhea; Dog Diseases; Dogs; Metronidazole	2020
Recommendations of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU) on pouchitis in ulcerative colitis. Part 2: Treatment. Gastroenterologia y hepatologia, 2020, Volume: 43, Issue:10 Topics: Acute Disease; Advisory Committees; Algorithms; Anti-Bacterial Agents; Biological Products; Budesoni	2020
Acute gastroenteritis due to BMJ case reports, 2020, Dec-21, Volume: 13, Issue:12 Topics: Acute Disease; Adolescent; Antiprotozoal Agents; Blastocystis hominis; Blastocystis Infections; Fece	2020
[The complicated acute bacterial parotitis in adults]. Presse medicale (Paris, France : 1983), 2017, Volume: 46, Issue:5 Topics: Acute Disease; Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Cefotaxi	2017
Dual versus Triple Antibiotics Regimen in Children with Perforated Acute Appendicitis. European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, 2018, Volume: 28, Issue:6 Topics: Acute Disease; Ampicillin; Anti-Bacterial Agents; Appendectomy; Appendicitis; Ceftriaxone; Chemother	2018
[A case of acute leukoencephalopathy induced by a combination of 5-fluorouracil and metronidazole]. Rinsho shinkeigaku = Clinical neurology, 2018, Feb-28, Volume: 58, Issue:2 Topics: Acute Disease; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Drug Therapy, Combinatio	2018
Acute pelvic inflammatory disease as a rare cause of acute small bowel obstruction. Acta chirurgica Belgica, 2019, Volume: 119, Issue:5 Topics: Abdomen, Acute; Acute Disease; Adult; Anti-Bacterial Agents; Chlamydia Infections; Chlamydia trachom	2019
Pharmacokinetic and Pharmacodynamic Properties of Metronidazole in Pediatric Patients With Acute Appendicitis: A Prospective Study. Journal of the Pediatric Infectious Diseases Society, 2019, Sep-25, Volume: 8, Issue:4 Topics: Acute Disease; Adolescent; Appendicitis; Area Under Curve; Bacteroides fragilis; Child; Child, Presc	2019
Adherence to antibiotic guidelines in the treatment of acute pharyngeal infections. Danish medical journal, 2019, Volume: 66, Issue:2 Topics: Acute Disease; Adult; Anti-Bacterial Agents; Denmark; Drug Prescriptions; Female; Guideline Adherenc	2019
Successful treatment of acute experimental toxoplasmosis by spiramycin-loaded chitosan nanoparticles. Experimental parasitology, 2019, Volume: 204 Topics: Acute Disease; Animals; Ascitic Fluid; Biocompatible Materials; Blood-Brain Barrier; Brain; Chitosan	2019
Adequacy of antibiotic prophylaxis protocol in appendectomies in children. Cirugia y cirujanos, 2019, Volume: 87, Issue:4 Topics: Acute Disease; Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Antibiotic Prophylaxis; Ap	2019
Acute oxalate nephropathy associated with Clostridium difficile colitis. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2014, Volume: 63, Issue:1 Topics: Acute Disease; Aged; Anti-Infective Agents; Biopsy; Calcium Oxalate; Clostridioides difficile; Colon	2014
Antibiotic therapy for appendicitis in patients aged ≥80 years. The American journal of medicine, 2014, Volume: 127, Issue:6 Topics: Acute Disease; Aged, 80 and over; Anti-Bacterial Agents; Appendectomy; Appendicitis; Cephalosporins;	2014
Reversible metronidazole-induced subacute cerebellar syndrome. QJM : monthly journal of the Association of Physicians, 2014, Volume: 107, Issue:12 Topics: Acute Disease; Anti-Infective Agents; Cerebellar Diseases; Humans; Magnetic Resonance Imaging; Male;	2014
Nonoperative management of perforated diverticulitis with extraluminal air is safe and effective in selected patients. Diseases of the colon and rectum, 2014, Volume: 57, Issue:7 Topics: Acute Disease; Administration, Intravenous; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; C	2014
Parietal subdural empyema as complication of acute odontogenic sinusitis: a case report. Journal of medical case reports, 2014, Aug-21, Volume: 8 Topics: Acute Disease; Adolescent; Anti-Bacterial Agents; Craniotomy; Diagnosis, Differential; Empyema, Subd	2014
Long-term results of nonoperative treatment for uncomplicated acute appendicitis. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2014, Volume: 25, Issue:4 Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Append	2014
Long-term results of nonoperative treatment for uncomplicated acute appendicitis. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2014, Volume: 25, Issue:4 Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Append	2014
Long-term results of nonoperative treatment for uncomplicated acute appendicitis. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2014, Volume: 25, Issue:4 Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Append	2014
Long-term results of nonoperative treatment for uncomplicated acute appendicitis. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2014, Volume: 25, Issue:4 Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Append	2014
[Sensory aphasia during therapy with metronidazole--an important differential diagnosis of acute cerebral ischemia]. Deutsche medizinische Wochenschrift (1946), 2014, Volume: 139, Issue:46 Topics: Acute Disease; Aged; Anti-Infective Agents; Aphasia, Wernicke; Brain Ischemia; Diagnosis, Differenti	2014
Acute cerebellar syndrome associated with metronidazole. Practical neurology, 2015, Volume: 15, Issue:4 Topics: Acute Disease; Adult; Anti-Infective Agents; Brain Stem; Cerebellar Diseases; Humans; Magnetic Reson	2015
[New approaches in surgical treatment of acute paraproctitis]. Klinichna khirurhiia, 2015, Issue:2 Topics: Acute Disease; Adolescent; Adult; Aged; Drainage; Enzymes, Immobilized; Female; Humans; Low-Level Li	2015
Acute Appendicitis Complicating into Portal and Superior Mesenteric Vein Thrombosis. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2016, Volume: 26, Issue:6 Suppl Topics: Acute Disease; Adult; Anti-Infective Agents; Anticoagulants; Appendicitis; Humans; Male; Mesenteric	2016
Outpatient treatment in uncomplicated acute diverticulitis: 5-year experience. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2016, Volume: 27, Issue:4 Topics: Acetaminophen; Acute Disease; Adult; Aged; Aged, 80 and over; Ambulatory Care; Analgesics, Non-Narco	2016
[The microbiology of peritonsillar abscesses]. Przeglad lekarski, 2007, Volume: 64, Issue:9 Topics: Acute Disease; Adult; Anti-Bacterial Agents; Drug Resistance, Bacterial; Female; Humans; Male; Metro	2007
Efficacy of spinal needle aspiration for epiglottic abscess in 90 patients with acute epiglottitis. Acta oto-laryngologica, 2009, Volume: 129, Issue:7 Topics: Acute Disease; Adult; Airway Obstruction; Anti-Bacterial Agents; Cephalosporins; Combined Modality T	2009
Role of microbiological studies in management of peritonsillar abscess. The Journal of laryngology and otology, 2009, Volume: 123, Issue:8 Topics: Acute Disease; Anti-Infective Agents; Bacteria, Anaerobic; Cephalosporins; England; Humans; Metronid	2009
Antibiotic prophylaxis in severe acute pancreatitis: do we need more meta-analytic studies? JOP : Journal of the pancreas, 2009, Mar-09, Volume: 10, Issue:2 Topics: Acute Disease; Antibiotic Prophylaxis; Carbapenems; Cefuroxime; Ciprofloxacin; Humans; Meta-Analysis	2009
Secnidazole-induced acute pancreatitis: a new side-effect for an old drug? JOP : Journal of the pancreas, 2010, Jan-08, Volume: 11, Issue:1 Topics: Acute Disease; Anti-Infective Agents; Female; Humans; Metronidazole; Pancreatitis; Young Adult	2010
Education and imaging. Hepatobiliary and pancreatic: multiple sexually transmitted infections. Journal of gastroenterology and hepatology, 2010, Volume: 25, Issue:4 Topics: Acute Disease; Anti-Infective Agents; Antiprotozoal Agents; Antiviral Agents; Colonoscopy; Entamoebi	2010
Microbiology of acute complicated bacterial sinusitis at the University of the Witwatersrand. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2010, Jul-26, Volume: 100, Issue:8 Topics: Acute Disease; Adolescent; Adult; Bacterial Infections; Brain Diseases; Child; Drug Resistance, Bact	2010
Co-infection of arboviruses presenting as Acute Encephalitis Syndrome. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2011, Volume: 51, Issue:1 Topics: Acute Disease; Adult; Anti-Infective Agents; Brain; Consciousness; Encephalitis; Encephalitis Virus,	2011
Concurrent postpartum uterine and abdominal wall dehiscence and Streptococcus anginosus infection. Obstetrics and gynecology, 2011, Volume: 118, Issue:2 Pt 2 Topics: Abdominal Wall; Acute Disease; Adolescent; Anti-Bacterial Agents; Ascitic Fluid; Cefazolin; Cesarean	2011
Acute dacryocystitis associated with epstein-barr virus infection. Orbit (Amsterdam, Netherlands), 2011, Volume: 30, Issue:5 Topics: Acute Disease; Ceftriaxone; Child; Child, Preschool; Combined Modality Therapy; Dacryocystitis; Drai	2011
An outcome audit of three day antimicrobial prescribing for the acute dentoalveolar abscess. British dental journal, 2011, Dec-23, Volume: 211, Issue:12 Topics: Abscess; Acute Disease; Adult; Amoxicillin; Anti-Bacterial Agents; Clindamycin; Dental Audit; Draina	2011
Antibiotics as first-line therapy for acute appendicitis: evidence for a change in clinical practice. World journal of surgery, 2012, Volume: 36, Issue:9 Topics: Acute Disease; Administration, Intravenous; Administration, Oral; Adult; Anti-Bacterial Agents; Appe	2012
Impetigo presenting as an acute necrotizing swelling of the lower lip in an adult patient. Oral surgery, oral medicine, oral pathology and oral radiology, 2012, Volume: 113, Issue:6 Topics: Acetamides; Acute Disease; Adult; Anti-Infective Agents; Diagnosis, Differential; Drug Combinations;	2012
Applicability, safety and efficiency of outpatient treatment in uncomplicated diverticulitis. Techniques in coloproctology, 2012, Volume: 16, Issue:4 Topics: Acetaminophen; Acute Disease; Adult; Aged; Aged, 80 and over; Ambulatory Care; Anti-Infective Agents	2012
Clinical features and management of pouchitis in Japanese ulcerative colitis patients. Surgery today, 2013, Volume: 43, Issue:9 Topics: Acute Disease; Adolescent; Adult; Age Factors; Age of Onset; Aged; Anti-Bacterial Agents; Asian Peop	2013
[Long-term curative effects of suture plus proximal gastric vagotomy or triad-therapy for duodenal ulcer with acute perforation]. Zhonghua wai ke za zhi [Chinese journal of surgery], 2002, Volume: 40, Issue:9 Topics: Acute Disease; Adolescent; Adult; Aged; Amoxicillin; Drug Therapy, Combination; Duodenal Ulcer; Fema	2002
Acute perforative appendicitis during preoperative chemotherapy for Wilms tumor. Pediatric hematology and oncology, 2003, Volume: 20, Issue:2 Topics: Abdominal Pain; Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Appendicitis; Ceftazi	2003
Appendicitis in children: a ten-year update of therapeutic recommendations. Journal of pediatric surgery, 2003, Volume: 38, Issue:2 Topics: Abdominal Abscess; Acute Disease; Adolescent; Ampicillin; Antibiotic Prophylaxis; Appendectomy; Appe	2003
Acute appendicitis with fulminant necrotizing fasciitis in a neonate. Journal of pediatric surgery, 2003, Volume: 38, Issue:11 Topics: Acute Disease; Appendectomy; Appendicitis; Clindamycin; Combined Modality Therapy; Debridement; Drug	2003
Metronidazole and risk of acute pancreatitis: a population-based case-control study. Alimentary pharmacology & therapeutics, 2005, Feb-15, Volume: 21, Issue:4 Topics: Acute Disease; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Case-Control Studies; Denmark; D	2005
[MRI and SPECT findings in a case of metronidazole-induced reversible acute cerebellar ataxia]. Rinsho shinkeigaku = Clinical neurology, 2005, Volume: 45, Issue:5 Topics: Acute Disease; Aged; Antiprotozoal Agents; Brain; Cerebellar Ataxia; Cysteine; Dysentery, Amebic; Hu	2005
Ascites in the puerperium: a missed diagnosis of acute postpartum pancreatitis. Archives of gynecology and obstetrics, 2005, Volume: 272, Issue:3 Topics: Abdominal Pain; Acute Disease; Adult; Anti-Infective Agents; Ascites; Clarithromycin; Diagnosis, Dif	2005
Experimental acute alcohol pancreatitis-related liver damage and endotoxemia: synbiotics but not metronidazole have a protective effect. Chinese journal of digestive diseases, 2005, Volume: 6, Issue:4 Topics: Acute Disease; Animals; Bacterial Translocation; Bifidobacterium; Ceruletide; Disease Models, Animal	2005
[Applicability, safety and efficacy of an ambulatory treatment protocol in patients with uncomplicated acute diverticulitis]. Cirugia espanola, 2006, Volume: 80, Issue:6 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aged, 80 and over; Ambulatory Care; Amoxicillin-Po	2006
2 children with acute abdominal pain and diarrhea. Journal of pediatric surgery, 2007, Volume: 42, Issue:2 Topics: Abdominal Pain; Acute Disease; Animals; Blastocystis; Blastocystis Infections; Child, Preschool; Dia	2007
A homosexual Japanese man with acute hepatitis due to hepatitis B virus genotype ae, concurrent with amebic colitis. Acta medica Okayama, 2007, Volume: 61, Issue:1 Topics: Acute Disease; Adult; Antiprotozoal Agents; Asian People; Dysentery, Amebic; Genotype; Hepatitis B;	2007
Anaesthesia for caesarean section in a patient with acute generalised pustular psoriasis. International journal of obstetric anesthesia, 2007, Volume: 16, Issue:4 Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Gener	2007
Acute pancreatitis as a possible consequence of metronidazole during a relapse of ulcerative colitis. European journal of gastroenterology & hepatology, 2007, Volume: 19, Issue:9 Topics: Acute Disease; Adult; Colitis, Ulcerative; Gastrointestinal Agents; Humans; Male; Metronidazole; Pan	2007
[Acute acneform eruption secondary to cetuximab with good response to metronidazole]. Actas dermo-sifiliograficas, 2007, Volume: 98, Issue:9 Topics: Acneiform Eruptions; Acute Disease; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cetux	2007
Metronidazole-induced pancreatitis during HIV infection. AIDS (London, England), 2008, Feb-19, Volume: 22, Issue:4 Topics: Acute Disease; Adult; Anti-Infective Agents; Enterocolitis, Pseudomembranous; HIV Infections; Homose	2008
Medical therapy of inflammatory bowel disease. The Medical clinics of North America, 1980, Volume: 64, Issue:6 Topics: Acute Disease; Adjuvants, Immunologic; Anus Diseases; Azathioprine; Colitis, Ulcerative; Crohn Disea	1980
Metronidazole in prevention of cholestasis associated with total parenteral nutrition. Lancet (London, England), 1983, Feb-26, Volume: 1, Issue:8322 Topics: Acute Disease; Anaerobiosis; Bacteria; Cholestasis, Intrahepatic; Crohn Disease; Female; Humans; Int	1983
Acute ulcerative colitis--a rare complication of sulfasalazine therapy. Hepato-gastroenterology, 1984, Volume: 31, Issue:4 Topics: Acute Disease; Adult; Colitis, Ulcerative; Female; Humans; Metronidazole; Sulfasalazine	1984
[Therapy of chronic inflammatory bowel diseases]. Zeitschrift fur Gastroenterologie. Verhandlungsband, 1983, Volume: 18 Topics: Acute Disease; Azathioprine; Colitis, Ulcerative; Crohn Disease; Humans; Mercaptopurine; Methylpredn	1983
[Acute uveitis associated with Giardia lamblia infection]. Harefuah, 1984, Volume: 107, Issue:3-4 Topics: Acute Disease; Adult; Giardiasis; Humans; Male; Metronidazole; Uveitis	1984
Visceral leishmaniasis (kala-azar) complicating acute leukaemia. The Journal of infection, 1983, Volume: 7, Issue:3 Topics: Acute Disease; Adolescent; Humans; Leishmaniasis, Visceral; Leukemia; Male; Metronidazole	1983
[Significance of a spiramycin-metronidazole combination in the treatment of acute, circumscribed perimaxillary cellulitis]. Le Chirurgien-dentiste de France, 1981, Dec-03, Volume: 51, Issue:136 Topics: Acute Disease; Adult; Cellulitis; Drug Combinations; Drug Tolerance; Female; Humans; Jaw Diseases; L	1981
Possible role of the anaerobe in tonsillitis. Journal of clinical pathology, 1981, Volume: 34, Issue:5 Topics: Acute Disease; Adolescent; Anaerobiosis; Bacteria; Bacterial Infections; Child; Child, Preschool; Hu	1981
Acute generalized exanthemic pustulosis. Cutis, 1994, Volume: 54, Issue:3 Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Ampicillin; Cefazolin; Dermatitis, Exfoliative; Diagn	1994
Mechanisms of acute and chronic intestinal inflammation induced by indomethacin. Inflammation, 1993, Volume: 17, Issue:6 Topics: Acute Disease; Animals; Bacteria; Bile; Chronic Disease; Disease Models, Animal; Enteritis; Indometh	1993
Crohn's disease associated with pancreatitis of unknown etiology: a case report. Gastroenterologia Japonica, 1993, Volume: 28, Issue:3 Topics: Acute Disease; Adult; Crohn Disease; Humans; Male; Metronidazole; Pancreatitis; Parenteral Nutrition	1993
[The clinical experience in Panama with metronidazole in treating Chagas' disease in the acute and chronic phases]. Revista medica de Panama, 1993, Volume: 18, Issue:2 Topics: Acute Disease; Adolescent; Adult; Aged; Animals; Antibodies, Protozoan; Chagas Disease; Child; Child	1993
Acid secretion and sensitivity to gastrin in patients with duodenal ulcer: effect of eradication of Helicobacter pylori. Gut, 1993, Volume: 34, Issue:7 Topics: Acute Disease; Adult; Aged; Bismuth; Drug Therapy, Combination; Duodenal Ulcer; Gastric Acid; Gastri	1993
Evaluation of the inflammatory infiltrate in pouchitis with 111In-labeled granulocytes. Gastroenterology, 1993, Volume: 104, Issue:4 Topics: Acute Disease; Biopsy; Chronic Disease; Gastrointestinal Hemorrhage; Granulocytes; Humans; Indium Ra	1993
Antimicrobial susceptibility patterns and resistance transferability among Bacteroides fragilis group isolates from patients with appendicitis in Bali, Indonesia. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1993, Volume: 16, Issue:4 Topics: Acute Disease; Anti-Bacterial Agents; Appendicitis; Bacteroides fragilis; Chloramphenicol Resistance	1993
[Acute pancreatitis caused by metronidazole]. Nederlands tijdschrift voor geneeskunde, 1996, Jan-06, Volume: 140, Issue:1 Topics: Acute Disease; Female; Humans; Metronidazole; Middle Aged; Pancreatitis	1996
Acute tongue abscess: report of two cases. International journal of oral and maxillofacial surgery, 1996, Volume: 25, Issue:4 Topics: Abscess; Acute Disease; Antitrichomonal Agents; Fusobacterium nucleatum; Humans; Male; Metronidazole	1996
Retropharyngeal abscess and acute torticollis. The Journal of laryngology and otology, 1997, Volume: 111, Issue:12 Topics: Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antitrichomonal Agent	1997
Acute diverticulitis. The New England journal of medicine, 1998, Oct-08, Volume: 339, Issue:15 Topics: Acute Disease; Anti-Infective Agents; Ciprofloxacin; Diverticulitis, Colonic; Drug Therapy, Combinat	1998
Simultaneous amoebic liver abscess and hepatitis A infection. Journal of travel medicine, 1998, Volume: 5, Issue:2 Topics: Acute Disease; Adult; Amebicides; Antitrichomonal Agents; Female; Furans; Hepatitis A; Humans; Liver	1998
Acute GVHD involving the gastrointestinal tract and infestation with Blastocystis hominis in a patient with chronic myeloid leukaemia following allogeneic bone marrow transplantation. Bone marrow transplantation, 1998, Volume: 22, Issue:11 Topics: Acute Disease; Adult; Animals; Antiprotozoal Agents; Blastocystis hominis; Blastocystis Infections;	1998
Misuse of drugs in acute diarrhoea in under-five children. Bangladesh Medical Research Council bulletin, 1998, Volume: 24, Issue:2 Topics: Acute Disease; Analysis of Variance; Anti-Bacterial Agents; Anti-Infective Agents; Antidiarrheals; B	1998
Use of antibiotics in the treatment of active Crohn's disease: experience with metronidazole and ciprofloxacin. Italian journal of gastroenterology and hepatology, 1998, Volume: 30, Issue:6 Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Ciprofloxacin; Cro	1998
Acute bronchopulmonary infection due to Streptococcus milleri in a child with cystic fibrosis. Archives of disease in childhood, 1999, Volume: 80, Issue:3 Topics: Acute Disease; Child; Colistin; Cystic Fibrosis; Drug Therapy, Combination; Female; Floxacillin; Hum	1999
The role of the resident intestinal flora in acute and chronic dextran sulfate sodium-induced colitis in mice. European journal of gastroenterology & hepatology, 2000, Volume: 12, Issue:3 Topics: Acute Disease; Animals; Anti-Bacterial Agents; Biopsy; Body Weight; Chronic Disease; Ciprofloxacin;	2000
A study of therapeutic antibiotic prescribing in National Health Service general dental practice in England. British dental journal, 2000, May-27, Volume: 188, Issue:10 Topics: Abscess; Acute Disease; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infecti	2000
Efficacy and safety of 'hot' tonsillectomy. International journal of clinical practice, 2001, Volume: 55, Issue:2 Topics: Acute Disease; Adolescent; Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Biopsy, Needl	2001
[Acute infectious lymphocytosis associated to Giardia lamblia and Blastocystis hominis coinfection]. Anales espanoles de pediatria, 2001, Volume: 54, Issue:5 Topics: Acute Disease; Animals; Anti-Infective Agents; Blastocystis hominis; Blastocystis Infections; Child,	2001
Metronidazole-resistant Bacteroides from untreated patient. Lancet (London, England), 1979, Apr-14, Volume: 1, Issue:8120 Topics: Acute Disease; Appendicitis; Bacteroides fragilis; Child; Drug Resistance, Microbial; Humans; Intest	1979
Acute amoebic dysentery due to free-living amoebae treated with methronidazole. The Journal of tropical medicine and hygiene, 1979, Volume: 82, Issue:7 Topics: Acute Disease; Adolescent; Amoeba; Dysentery, Amebic; Humans; Male; Metronidazole	1979
[Acute amebic liver abscess]. La Nouvelle presse medicale, 1977, Sep-10, Volume: 6, Issue:29 Topics: Acute Disease; France; Humans; Liver Abscess, Amebic; Metronidazole; Serologic Tests	1977
Changing concepts of infectious diarrheas. Geriatrics, 1975, Volume: 30, Issue:3 Topics: Acute Disease; Aged; Amebiasis; Anti-Bacterial Agents; Bacterial Infections; Clostridium Infections;	1975
Metronidazole and pancreatitis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1992, Volume: 15, Issue:4 Topics: Acute Disease; Amylases; Crohn Disease; Female; Humans; Metronidazole; Middle Aged; Pancreatitis	1992
The role of laparoscopy in acute pelvic infections. European journal of obstetrics, gynecology, and reproductive biology, 1991, Jun-05, Volume: 40, Issue:1 Topics: Acute Disease; Adult; Ampicillin; Chlamydia Infections; Drug Therapy, Combination; Female; Gonorrhea	1991
British oral and maxillofacial surgeons' views on the aetiology and management of acute pericoronitis. The British journal of oral & maxillofacial surgery, 1991, Volume: 29, Issue:3 Topics: Acute Disease; Administration, Oral; Anti-Bacterial Agents; Attitude of Health Personnel; Bacterial	1991
Otogenic Fusobacterium necrophorum meningitis. The Journal of laryngology and otology, 1991, Volume: 105, Issue:2 Topics: Acute Disease; Child, Preschool; Chloramphenicol; Drug Therapy, Combination; Female; Fusobacterium I	1991
[Incidence of giardiasis in adults patients with acute enteritis]. Minerva medica, 1991, Volume: 82, Issue:6 Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Cohort Studies; Diarrhea; Enteritis; Fema	1991
[Prophylactic administration of Klion in acute appendicitis]. Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti, 1990, Volume: 69, Issue:8 Topics: Acute Disease; Appendicitis; Child; Female; Humans; Male; Metronidazole; Postoperative Complications	1990
[Antibiotic prevention in acute appendicitis]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1990, May-10, Volume: 110, Issue:12 Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Bacterial Agents; Appendectomy; Appendicitis; Child; Ch	1990
Metronidazole-induced pancreatitis. Annals of internal medicine, 1985, Volume: 103, Issue:6 ( Pt 1) Topics: Acute Disease; Adult; Amylases; Female; Humans; Lipase; Metronidazole; Pancreatitis; Recurrence	1985
Post-appendectomy wound infection, a solved problem? The Netherlands journal of surgery, 1989, Volume: 41, Issue:5 Topics: Acute Disease; Appendectomy; Appendicitis; Humans; Length of Stay; Metronidazole; Premedication; Sur	1989
[Pharmacological prevention of wound infection in children after appendectomy]. Khirurgiia, 1989, Issue:11 Topics: Acute Disease; Anti-Bacterial Agents; Appendectomy; Appendicitis; Bacterial Infections; Child; Femal	1989
Fever and urticaria in acute giardiasis. Archives of internal medicine, 1989, Volume: 149, Issue:4 Topics: Acute Disease; Adult; Diarrhea; Fever; Giardiasis; Humans; Male; Metronidazole; Travel; Urticaria	1989
Antibiotic susceptibilities of bacteria isolated from acute dentoalveolar abscesses. The Journal of antimicrobial chemotherapy, 1989, Volume: 23, Issue:1 Topics: Acute Disease; Amoxicillin; Anti-Bacterial Agents; Bacteria; Clindamycin; Drug Resistance, Microbial	1989
Metronidazole-induced pancreatitis. The American journal of gastroenterology, 1989, Volume: 84, Issue:8 Topics: Acute Disease; Adult; Female; Humans; Metronidazole; Pancreatitis; Radiography	1989
Amebic colitis. Preventing morbidity and mortality from fulminant disease. Postgraduate medicine, 1985, Volume: 78, Issue:1 Topics: Acute Disease; Dysentery, Amebic; Entamoeba histolytica; Female; Humans; Iodoquinol; Metronidazole;	1985
Efficacy of a single dose of secnidazole in the treatment of acute and chronic amoebiasis. The Journal of tropical medicine and hygiene, 1988, Volume: 91, Issue:4 Topics: Acute Disease; Administration, Oral; Adult; Animals; Chronic Disease; Drug Evaluation; Dysentery, Am	1988
Excessive drug challenge. Annals of internal medicine, 1989, Mar-01, Volume: 110, Issue:5 Topics: Acute Disease; Female; Humans; Metronidazole; Pancreatitis	1989
Assessment of antimicrobial penetrance into the pancreatic juice in humans. Surgery, gynecology & obstetrics, 1986, Volume: 162, Issue:4 Topics: Acute Disease; Cholangiopancreatography, Endoscopic Retrograde; Chromatography, High Pressure Liquid	1986
Single-dose therapy for genitourinary infections. American family physician, 1987, Volume: 36, Issue:6 Topics: Acute Disease; Anti-Bacterial Agents; Antifungal Agents; Candidiasis, Vulvovaginal; Cystitis; Drug A	1987
[Effect of metronidazol on the postoperative course of acute appendicitis]. Harefuah, 1987, Volume: 113, Issue:1-2 Topics: Acute Disease; Appendicitis; Humans; Length of Stay; Methods; Metronidazole; Premedication; Surgical	1987
[Effect of metronidazole on the course of experimental anaerobic streptococcal pneumonia]. Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1986, Issue:8 Topics: Acute Disease; Animals; Bacterial Infections; Drug Evaluation, Preclinical; Guinea Pigs; Immunity, C	1986
Choice of antibiotics and length of therapy in the treatment of acute salpingitis. The American journal of medicine, 1985, Jun-28, Volume: 78, Issue:6B Topics: Acute Disease; Anti-Bacterial Agents; Cefoxitin; Chlamydia Infections; Chlamydia trachomatis; Doxycy	1985
[Metronidazole (Klion) in the prevention and therapy of septic complications of appendectomy]. Orvosi hetilap, 1985, Dec-29, Volume: 126, Issue:52 Topics: Acute Disease; Aged; Appendectomy; Humans; Intestinal Perforation; Male; Metronidazole; Middle Aged;	1985
The management of severe appendicitis in children. Annals of the Academy of Medicine, Singapore, 1985, Volume: 14, Issue:4 Topics: Acute Disease; Appendectomy; Appendicitis; Cefoxitin; Child; Drug Therapy, Combination; Humans; Metr	1985
Single and low dosage regimens of metronidazole in amoebic dysentery and amoebic liver abscess. Annals of tropical medicine and parasitology, 1969, Volume: 63, Issue:2 Topics: Acute Disease; Adult; Dysentery, Amebic; Entamoeba histolytica; Humans; Liver Abscess, Amebic; Male;	1969
Single-dose and short course regimens of metronidazole in the treatment of amoebiasis in Malaysia. Annals of tropical medicine and parasitology, 1972, Volume: 66, Issue:2 Topics: Acute Disease; Adolescent; Adult; Aged; Amebiasis; Child; Child, Preschool; Chronic Disease; Dysente	1972
Acute suppurative amebic pericarditis. The American journal of cardiology, 1974, Volume: 34, Issue:1 Topics: Acute Disease; Amebiasis; Blood Pressure; Cardiac Catheterization; Cardiac Tamponade; Cardiomegaly;	1974
[Clinical aspects of amebic dysentery]. Gastroenterologische Fortbildungskurse fur die Praxis, 1973, Volume: 3 Topics: Acute Disease; Antibody Formation; Chloroquine; Complement Fixation Tests; Dysentery, Amebic; Emetin	1973
Treatment of amoebiasis. The Journal of the Egyptian Public Health Association, 1973, Volume: 48, Issue:3 Topics: Acute Disease; Amebiasis; Anti-Bacterial Agents; Chloroquine; Chronic Disease; Dysentery, Amebic; Eg	1973
[Treatment of prostatitis]. Deutsche medizinische Wochenschrift (1946), 1971, Jun-18, Volume: 96, Issue:25 Topics: Abscess; Acute Disease; Anti-Bacterial Agents; Chronic Disease; Focal Infection; Gonorrhea; Humans;	1971
Trials of metronidazole in amebic dysentery and amebic liver abscess. Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association, 1971, Jul-28, Volume: 70, Issue:7 Topics: Acute Disease; Adult; Drug Evaluation; Dysentery, Amebic; Humans; Liver Abscess, Amebic; Metronidazo	1971
[Therapeutic problems of trichomoniasis of the urogenital apparatus in men]. Polski przeglad chirurgiczny, 1970, Volume: 42, Issue:6 Topics: Acute Disease; Adult; Aged; Chronic Disease; Female; Humans; Male; Metronidazole; Middle Aged; Time	1970
[Treatment of acute amebic rectocolitis]. Archivos de investigacion medica, 1970, Volume: 1 Topics: Acute Disease; Adult; Arsenicals; Child, Preschool; Colitis, Ulcerative; Dysentery, Amebic; Emetine;	1970

metronidazole and Acute Disease