metronidazole has been researched along with Liver Diseases in 26 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Liver Diseases: Pathological processes of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole was administered intravenously for 20 min to healthy volunteers, and to patients with alcohol-induced, non-cirrhotic hepatopathy and liver cirrhosis." | 1.30 | Plasma hydroxy-metronidazole/metronidazole ratio can detect early changes in hepatic function in ethanol-induced liver injury. ( Da Silva, CM; David, FL; De Nucci, G; Ferraz, JG; Muscará, MN; Pedrazzoli, J; Polimeno, NC; Sousa, SS, 1999) |
| "Of 33 patients with amoebic liver abscess (ALA) seen over a 5-year period, 24 had intrathoracic complications." | 1.27 | Intrathoracic complications of amoebic liver abscess. ( Aderounmu, A; Adeyemo, AO, 1984) |
| " The metronidazole half-life ranged between 4." | 1.27 | The pharmacokinetics of metronidazole and its metabolites in critically ill patients. ( Nightingale, CH; Plaisance, KI; Quintiliani, R, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (46.15) | 18.7374 |
| 1990's | 6 (23.08) | 18.2507 |
| 2000's | 2 (7.69) | 29.6817 |
| 2010's | 5 (19.23) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, WJ | 1 |
| Wu, ZR | 1 |
| Yang, Q | 1 |
| Hu, HJ | 1 |
| Wang, JK | 1 |
| Shi, YJ | 1 |
| Li, FY | 1 |
| Cheng, NS | 1 |
| Karantanos, T | 1 |
| Karanika, S | 1 |
| Obiokoye, K | 1 |
| Sullivan, M | 1 |
| Phillips, C | 1 |
| Ananthakrishnan, S | 1 |
| Sayma, M | 1 |
| Walters, HR | 1 |
| Hesford, C | 1 |
| Tariq, Z | 1 |
| Nakhosteen, A | 1 |
| Galvez, M | 1 |
| Brahm, J | 1 |
| Miranda, M | 1 |
| Günşar, C | 1 |
| Vatansever, S | 1 |
| Var, A | 1 |
| Aygören, R | 1 |
| Yilmaz, O | 1 |
| Türköz, E | 1 |
| Sencan, A | 1 |
| Mir, E | 1 |
| Eshar, D | 1 |
| Peddle, GD | 1 |
| Briscoe, JA | 1 |
| Kumar, R | 1 |
| Sundar, S | 1 |
| Sharma, P | 1 |
| Sarin, SK | 1 |
| Loprinzi, C | 1 |
| Heaton, JW | 1 |
| Kelly, PC | 1 |
| Kocherovets, VI | 1 |
| Stolbovoĭ, AV | 1 |
| Dzhalashev, IaKh | 1 |
| Daneshmend, TK | 1 |
| Roberts, CJ | 1 |
| Farrell, G | 1 |
| Buchanan, N | 1 |
| Baird-Lambert, J | 1 |
| Adeyemo, AO | 1 |
| Aderounmu, A | 1 |
| von Birgelen, C | 1 |
| von Schönfeld, J | 1 |
| Görge, G | 1 |
| Fabry, W | 1 |
| Layer, P | 1 |
| O'Brien, S | 1 |
| Mulcahy, H | 1 |
| Fenlon, H | 1 |
| O'Broin, A | 1 |
| Casey, M | 1 |
| Burke, A | 1 |
| FitzGerald, MX | 1 |
| Hegarty, JE | 1 |
| Combes, R | 1 |
| Laurent, V | 1 |
| Cheysson, E | 1 |
| Bouvry, M | 1 |
| Da Silva, CM | 1 |
| David, FL | 1 |
| Muscará, MN | 1 |
| Sousa, SS | 1 |
| Ferraz, JG | 1 |
| De Nucci, G | 1 |
| Polimeno, NC | 1 |
| Pedrazzoli, J | 1 |
| West, SD | 1 |
| Brunskill, NJ | 1 |
| Tubis, M | 1 |
| Krishnamurthy, GT | 1 |
| Endow, JS | 1 |
| Stein, RA | 1 |
| Suwanik, R | 1 |
| Blahd, WH | 1 |
| Lichtman, SN | 1 |
| Keku, J | 1 |
| Schwab, JH | 1 |
| Sartor, RB | 1 |
| Weiss, M | 1 |
| Larchet, M | 1 |
| Duhamel, G | 1 |
| Pariente, D | 1 |
| Dumont, M | 1 |
| Degott, C | 1 |
| Godeau, E | 1 |
| Erlinger, S | 1 |
| Goulet, O | 1 |
| Ricour, C | 1 |
| Plaisance, KI | 1 |
| Quintiliani, R | 1 |
| Nightingale, CH | 1 |
| Lewin, MR | 1 |
| Araujo, JG | 1 |
| Sarmiento, JL | 1 |
| Barton, TP | 1 |
| Jayaraj, AP | 1 |
| Harrison, RA | 1 |
| Freund, HR | 1 |
| Muggia-Sullam, M | 1 |
| LaFrance, R | 1 |
| Enrione, EB | 1 |
| Popp, MB | 1 |
| Bjornson, HS | 1 |
| Crichton, D | 1 |
| Knobel, J | 1 |
| Goldberg, A | 1 |
| Krasner, N | 1 |
| Dow, J | 1 |
| MacDonald, CM | 1 |
| Moore, MR | 1 |
2 reviews available for metronidazole and Liver Diseases
| Article | Year |
|---|---|
[Non-clostridial anaerobic infection in diseases of the liver and biliary tract (review of the Soviet and foreign literature)].
Topics: Age Factors; Aged; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Infections; Biliary Tract D | 1984 |
[Hepatobiliary changes during exclusive parenteral feeding in infants with severe diarrhea].
Topics: Bile Acids and Salts; Bile Duct Diseases; Diarrhea, Infantile; Female; Humans; Infant; Liver; Liver | 1988 |
1 trial available for metronidazole and Liver Diseases
| Article | Year |
|---|---|
[Hepatobiliary changes during exclusive parenteral feeding in infants with severe diarrhea].
Topics: Bile Acids and Salts; Bile Duct Diseases; Diarrhea, Infantile; Female; Humans; Infant; Liver; Liver | 1988 |
24 other studies available for metronidazole and Liver Diseases
| Article | Year |
|---|---|
Biliary antibiotics irrigation for E. coli-induced chronic proliferative cholangitis and hepatolithiasis: A pathophysiological study in rabbits.
Topics: Animals; Anti-Bacterial Agents; Bacitracin; Chlorhexidine; Cholangitis; Chronic Disease; Collagen Ty | 2020 |
Pyogenic Liver Abscess Due to Fusobacterium nucleatum in a Patient With Liver Hemangiomas.
Topics: Adult; Fever; Fusobacterium Infections; Fusobacterium nucleatum; Hemangioma; Humans; Liver; Liver Ab | 2017 |
Rapidly enlarging, giant hepatic cyst growing pseudomonas.
Topics: Aged; Anti-Bacterial Agents; Cardiac Output, Low; Cysts; Drainage; Dyspnea; Female; Humans; Liver Di | 2019 |
Movement disorders as a manifestation of metronidazole-induced encephalopathy in a patient with chronic liver disease.
Topics: Anti-Infective Agents; Brain Diseases; Chronic Disease; Diffusion Magnetic Resonance Imaging; Humans | 2009 |
Antibiotic treatment is superior to ursodeoxycholic acid on total parenteral nutrition associated hepatic dysfunction.
Topics: Analysis of Variance; Animals; Apoptosis; bcl-2-Associated X Protein; Bilirubin; Caspase 3; Fas Liga | 2010 |
Diagnosis and treatment of congestive heart failure secondary to hypertrophic cardiomyopathy in a kinkajou (Potos flavus).
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Infective Agents; Cardiomyopathy, Hypertroph | 2010 |
Conservative management of liver abscess complicated by hepatogastric fistula.
Topics: Adult; Anti-Bacterial Agents; Antiprotozoal Agents; Digestive System Fistula; Drainage; Gastric Fist | 2011 |
Enterohepatic fistula associated with amebic liver abscess.
Topics: Adult; Aged; Biopsy, Needle; Entamoeba histolytica; Entamoebiasis; Female; Fistula; Humans; Intestin | 1983 |
Impaired elimination of metronidazole in decompensated chronic liver disease.
Topics: Chronic Disease; Humans; Kinetics; Liver Diseases; Metronidazole | 1984 |
Impaired elimination of metronidazole in decompensated chronic liver disease.
Topics: Chronic Disease; Humans; Liver Diseases; Metronidazole | 1984 |
Intrathoracic complications of amoebic liver abscess.
Topics: Adolescent; Adult; Central Nervous System Diseases; Child; Drainage; Empyema; Female; Fistula; Human | 1984 |
[Amebic liver abscess with hepatobronchial fistula].
Topics: Bronchial Fistula; Female; Fistula; Humans; Liver Abscess, Amebic; Liver Diseases; Metronidazole; Mi | 1994 |
Intestinal bile acid malabsorption in cystic fibrosis.
Topics: Adolescent; Adult; Bile Acids and Salts; Breath Tests; Cystic Fibrosis; Feces; Female; Humans; Hydro | 1993 |
[Primary hepatic actinomycosis: current management of a rare disease].
Topics: Actinomyces; Actinomycosis; Antitrichomonal Agents; Drug Therapy, Combination; Humans; Liver Disease | 1995 |
Plasma hydroxy-metronidazole/metronidazole ratio can detect early changes in hepatic function in ethanol-induced liver injury.
Topics: Adolescent; Adult; Aged; Alcohol Drinking; Anti-Infective Agents; Chromatography, High Pressure Liqu | 1999 |
Complications associated with influenza infection.
Topics: Acute Kidney Injury; Alphainfluenzavirus; Drug Therapy, Combination; Humans; Imipenem; Influenza, Hu | 2002 |
Labeled metronidazoles as potential new agents for amebic hepatic abscess imaging.
Topics: Animals; Chemical Phenomena; Chemistry; Diagnosis, Differential; Dogs; Humans; Iodine Radioisotopes; | 1975 |
Hepatic injury associated with small bowel bacterial overgrowth in rats is prevented by metronidazole and tetracycline.
Topics: Animals; Bacteria; Bacterial Infections; Colony Count, Microbial; Female; Gentamicins; Hepatomegaly; | 1991 |
Use of metabolite AUC data in bioavailability studies to discriminate between absorption and first-pass extraction.
Topics: Absorption; Antipyrine; Biological Availability; Caffeine; Diphenhydramine; Dose-Response Relationsh | 1990 |
The pharmacokinetics of metronidazole and its metabolites in critically ill patients.
Topics: Adult; Aged; Aged, 80 and over; Critical Care; Half-Life; Humans; Kidney Diseases; Liver Diseases; M | 1988 |
Bypass induced liver disease: an experimental study of the effect of post-operative protein supplementation and metronidazole therapy in an animal model.
Topics: Animals; Body Weight; Dietary Proteins; Female; Jejunoileal Bypass; Liver; Liver Diseases; Liver Fun | 1987 |
A possible beneficial effect of metronidazole in reducing TPN-associated liver function derangements.
Topics: Amino Acids; Animals; Bacteria; Cholestasis, Intrahepatic; Fatty Liver; Injections, Intravenous; Int | 1985 |
The principles of prevention of avoidable maternal death. A study of 538 consecutive maternal deaths in the obstetric unit, King Edward 8th Hospital, Durban, 1953-1971.
Topics: Anesthesia, Inhalation; Anesthesia, Obstetrical; Cesarean Section; Dysentery, Amebic; Emergencies; F | 1973 |
Clinical and experimental studies on alcoholism.
Topics: Alcohol Deterrents; Alcoholism; Animals; Disulfiram; Ethanol; Fenfluramine; Humans; Liver Diseases; | 1973 |