metronidazole has been researched along with Emergencies in 22 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Emergencies: Situations or conditions requiring immediate intervention to avoid serious adverse results.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After appendectomy due to complicated acute appendicitis (CAA), there are some alternatives as antibiotic scheme: ciprofloxacin/metronidazole; as well as monoscheme based on carbapenems: ertapenem, meropenem, and imipenem." | 7.96 | Carbapenems versus ciprofloxacin/metronidazole for decreasing complications and hospital stay following complicated acute appendicitis surgery: A prospective cohort in an Ecuadorian population. ( Arevalo-Vidal, E; Baquerizo-Burgos, J; Bunces-Orellana, O; Bustos-Galarza, K; Ferrín-Viteri, M; Oleas, R; Puga-Tejada, M, 2020) |
| "In a prospective study, 182 consecutive patients were included for the treatment of intraabdominal sepsis with adjuvant metronidazole lavage that was carried out at the end of the operative procedures." | 7.69 | Efficacy of metronidazole lavage in treatment of intraperitoneal sepsis. A prospective study. ( Saha, SK, 1996) |
| "After appendectomy due to complicated acute appendicitis (CAA), there are some alternatives as antibiotic scheme: ciprofloxacin/metronidazole; as well as monoscheme based on carbapenems: ertapenem, meropenem, and imipenem." | 3.96 | Carbapenems versus ciprofloxacin/metronidazole for decreasing complications and hospital stay following complicated acute appendicitis surgery: A prospective cohort in an Ecuadorian population. ( Arevalo-Vidal, E; Baquerizo-Burgos, J; Bunces-Orellana, O; Bustos-Galarza, K; Ferrín-Viteri, M; Oleas, R; Puga-Tejada, M, 2020) |
| "In a prospective study, 182 consecutive patients were included for the treatment of intraabdominal sepsis with adjuvant metronidazole lavage that was carried out at the end of the operative procedures." | 3.69 | Efficacy of metronidazole lavage in treatment of intraperitoneal sepsis. A prospective study. ( Saha, SK, 1996) |
| " This study aimed to determine the comparative efficacy of a single dose of gentamicin in combination with metronidazole versus multiple doses for prevention of post-caesarean infection." | 2.78 | Single dose of gentamicin in combination with metronidazole versus multiple doses for prevention of post-caesarean infection at Bugando Medical Centre in Mwanza, Tanzania: a randomized, equivalence, controlled trial. ( Kidenya, BR; Konje, ET; Lyimo, FM; Massinde, AN; Mshana, SE, 2013) |
| "A dosing regimen for administration of metronidazole to patients undergoing emergency surgery was designed using pharmacokinetic data." | 2.66 | Design and trial of a metronidazole loading dose regimen for patients undergoing emergency surgery. ( Farmer, C; Ioannides-Demos, LL; McLean, AJ; Spicer, WJ, 1989) |
| "The metronidazole-treated patients left hospital approximately 2 days earlier than patients in the other two groups." | 2.65 | Clinical and economic consequences of wound sepsis after appendicectomy and their modification by metronidazole or povidone iodine. ( Balfour, TW; Bolwell, J; Bourke, JB; Doran, J; Foster, GE; Hardcastle, JD; Holliday, A; Marshall, DJ, 1981) |
| " Severe obese patients need higher dosage of antibiotics." | 1.34 | [Use of antibiotics in colorectal surgery in Denmark]. ( Frimodt-Møller, N; Jensen, TG; Madsen, H; Pedersen, C; Qvist, N; Salomon, S, 2007) |
| "Fournier gangrene is a necrotizing fasciitis of the perineal and genital region, which almost exclusively affects men." | 1.33 | [Extensive Fournier gangrene. A dermatologic emergency]. ( Aschoff, R; Baldauf, A; Leike, S; Meurer, M; Wirth, MP, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (40.91) | 18.7374 |
| 1990's | 4 (18.18) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Bunces-Orellana, O | 1 |
| Arevalo-Vidal, E | 1 |
| Bustos-Galarza, K | 1 |
| Ferrín-Viteri, M | 1 |
| Oleas, R | 1 |
| Baquerizo-Burgos, J | 1 |
| Puga-Tejada, M | 1 |
| Füessl, HS | 1 |
| Lyimo, FM | 1 |
| Massinde, AN | 1 |
| Kidenya, BR | 1 |
| Konje, ET | 1 |
| Mshana, SE | 1 |
| Mittal, MK | 1 |
| Zimmerman, RA | 1 |
| Montes, MI | 1 |
| Hernández Ortiz, OH | 1 |
| Guerra Palacio, A | 1 |
| Velez, MC | 1 |
| Athale, UH | 1 |
| Loe, W | 1 |
| Warrier, RP | 1 |
| Zhou, JG | 1 |
| Shen, HP | 1 |
| Shen, Y | 1 |
| Aschoff, R | 1 |
| Baldauf, A | 1 |
| Leike, S | 1 |
| Wirth, MP | 1 |
| Meurer, M | 1 |
| Salomon, S | 1 |
| Jensen, TG | 1 |
| Qvist, N | 1 |
| Frimodt-Møller, N | 1 |
| Pedersen, C | 1 |
| Madsen, H | 1 |
| Foster, GE | 1 |
| Bourke, JB | 1 |
| Bolwell, J | 1 |
| Doran, J | 1 |
| Balfour, TW | 1 |
| Holliday, A | 1 |
| Hardcastle, JD | 1 |
| Marshall, DJ | 1 |
| Tanner, WA | 1 |
| Ali, AE | 1 |
| Collins, PG | 1 |
| Fahy, AM | 1 |
| Lane, BE | 1 |
| McCormack, T | 1 |
| Moodley, J | 1 |
| Zeeman, DJ | 1 |
| Serour, F | 1 |
| Efrati, Y | 1 |
| Klin, B | 1 |
| Barr, J | 1 |
| Gorenstein, A | 1 |
| Vinograd, I | 1 |
| Saha, SK | 1 |
| Kovachev, L | 1 |
| Presolski, I | 1 |
| Tsvetkov, I | 1 |
| Rodgers, J | 1 |
| Ross, D | 1 |
| McNaught, W | 1 |
| Gillespie, G | 1 |
| Burkitt, DS | 1 |
| Donovan, IA | 1 |
| Wise, R | 1 |
| Lowe, P | 1 |
| Ioannides-Demos, LL | 1 |
| Farmer, C | 1 |
| Spicer, WJ | 1 |
| McLean, AJ | 1 |
| Bardeau, A | 1 |
| Pelletier, A | 1 |
| Lefevre, P | 1 |
| Farinotti, R | 1 |
| Dauphin, A | 1 |
| Desmonts, JM | 1 |
| Tudor, RG | 1 |
| Haynes, I | 1 |
| Youngs, DJ | 1 |
| Burdon, DW | 1 |
| Keighley, MR | 1 |
| Nelson, MS | 1 |
| Crichton, D | 1 |
| Knobel, J | 1 |
10 trials available for metronidazole and Emergencies
| Article | Year |
|---|---|
Single dose of gentamicin in combination with metronidazole versus multiple doses for prevention of post-caesarean infection at Bugando Medical Centre in Mwanza, Tanzania: a randomized, equivalence, controlled trial.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis; Cesarean Section; Drug | 2013 |
Clinical and economic consequences of wound sepsis after appendicectomy and their modification by metronidazole or povidone iodine.
Topics: Appendectomy; Clinical Trials as Topic; Costs and Cost Analysis; Double-Blind Method; Emergencies; H | 1981 |
Single dose intra-rectal metronidazole as prophylaxis against wound infection following emergency appendicectomy.
Topics: Adolescent; Adult; Aged; Appendectomy; Child; Clinical Trials as Topic; Emergencies; Female; Humans; | 1980 |
Prophylactic and antimicrobial therapy using lincomycin in patients undergoing emergency caesarean section.
Topics: Cesarean Section; Clinical Trials as Topic; Double-Blind Method; Emergencies; Female; Humans; Lincom | 1981 |
Subcuticular skin closure as a standard approach to emergency appendectomy in children: prospective clinical trial.
Topics: Adolescent; Anti-Bacterial Agents; Antibiotic Prophylaxis; Antitrichomonal Agents; Appendectomy; Chi | 1996 |
Intrarectal metronidazole in the prevention of anaerobic infections after emergency appendicectomy: a controlled clinical trial.
Topics: Adolescent; Adult; Anaerobiosis; Appendectomy; Clinical Trials as Topic; Emergencies; Female; Humans | 1979 |
A comparison between imipenem and metronidazole prophylaxis against sepsis following appendicectomy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Appendectomy; Child; Cilastatin; Drug Combinations; Emer | 1990 |
Design and trial of a metronidazole loading dose regimen for patients undergoing emergency surgery.
Topics: Abdomen; Adult; Aged; Aged, 80 and over; Bacteria, Anaerobic; Bacterial Infections; Clinical Trials | 1989 |
[Prevention of postoperative anaerobic bacterial infections in abdominal surgery with metronidazole suppositories].
Topics: Abdomen; Adult; Aged; Bacteria, Anaerobic; Bacterial Infections; Emergencies; Female; Humans; Male; | 1985 |
Comparison of short-term antibiotic cover with a third-generation cephalosporin against conventional five-day therapy using metronidazole with an aminoglycoside in emergency and complicated colorectal surgery.
Topics: Cefotetan; Cephamycins; Colonic Diseases; Drug Administration Schedule; Drug Therapy, Combination; E | 1988 |
12 other studies available for metronidazole and Emergencies
| Article | Year |
|---|---|
Carbapenems versus ciprofloxacin/metronidazole for decreasing complications and hospital stay following complicated acute appendicitis surgery: A prospective cohort in an Ecuadorian population.
Topics: Adult; Aged; Anti-Bacterial Agents; Antibiotic Prophylaxis; Appendectomy; Appendicitis; Carbapenems; | 2020 |
[Acute cholecystitis].
Topics: Adult; Amoxicillin; Analgesics, Opioid; Anti-Bacterial Agents; Butylscopolammonium Bromide; Cholecys | 2013 |
Meningitis and epidural abscess related to pansinusitis.
Topics: Bacteroidaceae Infections; Cefotaxime; Ceftriaxone; Child; Combined Modality Therapy; Consciousness | 2009 |
[Electroencephalographic burst-suppression pattern due to baclofen intoxication].
Topics: Baclofen; Coma; Drug Overdose; Electroencephalography; Emergencies; Fatal Outcome; Female; Humans; I | 2011 |
Acute perforative appendicitis during preoperative chemotherapy for Wilms tumor.
Topics: Abdominal Pain; Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Appendicitis; Ceftazi | 2003 |
[Clinical study on the causes and treatment of endodontic interappointment emergencies].
Topics: Adult; Aged; Dexamethasone; Emergencies; Female; Humans; Male; Metronidazole; Middle Aged; Root Cana | 2003 |
[Extensive Fournier gangrene. A dermatologic emergency].
Topics: Adult; Cefotaxime; Combined Modality Therapy; Drug Therapy, Combination; Emergencies; Follow-Up Stud | 2006 |
[Use of antibiotics in colorectal surgery in Denmark].
Topics: Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis; Cefuroxime; Colore | 2007 |
Efficacy of metronidazole lavage in treatment of intraperitoneal sepsis. A prospective study.
Topics: Abdominal Abscess; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Bacterial Infe | 1996 |
[Decontamination in colorectal surgery].
Topics: Aged; Anti-Infective Agents; Antibiotic Prophylaxis; Cause of Death; Cephalosporins; Colorectal Surg | 1998 |
Clinical diagnosis of bacterial vaginosis.
Topics: Adolescent; Adult; Emergencies; Female; Humans; Hydrogen-Ion Concentration; Metronidazole; Middle Ag | 1987 |
The principles of prevention of avoidable maternal death. A study of 538 consecutive maternal deaths in the obstetric unit, King Edward 8th Hospital, Durban, 1953-1971.
Topics: Anesthesia, Inhalation; Anesthesia, Obstetrical; Cesarean Section; Dysentery, Amebic; Emergencies; F | 1973 |