Compounds > armeniaspirol a
Page last updated: 2024-11-13

armeniaspirol a

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Description

armeniaspirol A: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID58534983
CHEMBL ID2087639
SCHEMBL ID15848846
MeSH IDM0584908

Synonyms (5)

Synonym
armeniaspirole a
CHEMBL2087639 ,
bdbm50421230
SCHEMBL15848846
armeniaspirol a
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Cytochrome P450 3A4Homo sapiens (human)IC50 (µMol)10.00000.00011.753610.0000AID682781
Cytochrome P450 2D6Homo sapiens (human)IC50 (µMol)10.00000.00002.015110.0000AID682782
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (25)

Processvia Protein(s)Taxonomy
lipid hydroxylationCytochrome P450 3A4Homo sapiens (human)
lipid metabolic processCytochrome P450 3A4Homo sapiens (human)
steroid catabolic processCytochrome P450 3A4Homo sapiens (human)
xenobiotic metabolic processCytochrome P450 3A4Homo sapiens (human)
steroid metabolic processCytochrome P450 3A4Homo sapiens (human)
cholesterol metabolic processCytochrome P450 3A4Homo sapiens (human)
androgen metabolic processCytochrome P450 3A4Homo sapiens (human)
estrogen metabolic processCytochrome P450 3A4Homo sapiens (human)
alkaloid catabolic processCytochrome P450 3A4Homo sapiens (human)
monoterpenoid metabolic processCytochrome P450 3A4Homo sapiens (human)
calcitriol biosynthetic process from calciolCytochrome P450 3A4Homo sapiens (human)
xenobiotic catabolic processCytochrome P450 3A4Homo sapiens (human)
vitamin D metabolic processCytochrome P450 3A4Homo sapiens (human)
vitamin D catabolic processCytochrome P450 3A4Homo sapiens (human)
retinol metabolic processCytochrome P450 3A4Homo sapiens (human)
retinoic acid metabolic processCytochrome P450 3A4Homo sapiens (human)
long-chain fatty acid biosynthetic processCytochrome P450 3A4Homo sapiens (human)
aflatoxin metabolic processCytochrome P450 3A4Homo sapiens (human)
oxidative demethylationCytochrome P450 3A4Homo sapiens (human)
xenobiotic metabolic processCytochrome P450 2D6Homo sapiens (human)
steroid metabolic processCytochrome P450 2D6Homo sapiens (human)
cholesterol metabolic processCytochrome P450 2D6Homo sapiens (human)
estrogen metabolic processCytochrome P450 2D6Homo sapiens (human)
coumarin metabolic processCytochrome P450 2D6Homo sapiens (human)
alkaloid metabolic processCytochrome P450 2D6Homo sapiens (human)
alkaloid catabolic processCytochrome P450 2D6Homo sapiens (human)
monoterpenoid metabolic processCytochrome P450 2D6Homo sapiens (human)
isoquinoline alkaloid metabolic processCytochrome P450 2D6Homo sapiens (human)
xenobiotic catabolic processCytochrome P450 2D6Homo sapiens (human)
retinol metabolic processCytochrome P450 2D6Homo sapiens (human)
long-chain fatty acid biosynthetic processCytochrome P450 2D6Homo sapiens (human)
negative regulation of bindingCytochrome P450 2D6Homo sapiens (human)
oxidative demethylationCytochrome P450 2D6Homo sapiens (human)
negative regulation of cellular organofluorine metabolic processCytochrome P450 2D6Homo sapiens (human)
arachidonic acid metabolic processCytochrome P450 2D6Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (24)

Processvia Protein(s)Taxonomy
monooxygenase activityCytochrome P450 3A4Homo sapiens (human)
steroid bindingCytochrome P450 3A4Homo sapiens (human)
iron ion bindingCytochrome P450 3A4Homo sapiens (human)
protein bindingCytochrome P450 3A4Homo sapiens (human)
steroid hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
retinoic acid 4-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
oxidoreductase activityCytochrome P450 3A4Homo sapiens (human)
oxygen bindingCytochrome P450 3A4Homo sapiens (human)
enzyme bindingCytochrome P450 3A4Homo sapiens (human)
heme bindingCytochrome P450 3A4Homo sapiens (human)
vitamin D3 25-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
caffeine oxidase activityCytochrome P450 3A4Homo sapiens (human)
quinine 3-monooxygenase activityCytochrome P450 3A4Homo sapiens (human)
testosterone 6-beta-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
anandamide 8,9 epoxidase activityCytochrome P450 3A4Homo sapiens (human)
anandamide 11,12 epoxidase activityCytochrome P450 3A4Homo sapiens (human)
anandamide 14,15 epoxidase activityCytochrome P450 3A4Homo sapiens (human)
aromatase activityCytochrome P450 3A4Homo sapiens (human)
vitamin D 24-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
estrogen 16-alpha-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
estrogen 2-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
1,8-cineole 2-exo-monooxygenase activityCytochrome P450 3A4Homo sapiens (human)
monooxygenase activityCytochrome P450 2D6Homo sapiens (human)
iron ion bindingCytochrome P450 2D6Homo sapiens (human)
oxidoreductase activityCytochrome P450 2D6Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenCytochrome P450 2D6Homo sapiens (human)
heme bindingCytochrome P450 2D6Homo sapiens (human)
anandamide 8,9 epoxidase activityCytochrome P450 2D6Homo sapiens (human)
anandamide 11,12 epoxidase activityCytochrome P450 2D6Homo sapiens (human)
anandamide 14,15 epoxidase activityCytochrome P450 2D6Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (5)

Processvia Protein(s)Taxonomy
cytoplasmCytochrome P450 3A4Homo sapiens (human)
endoplasmic reticulum membraneCytochrome P450 3A4Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 3A4Homo sapiens (human)
mitochondrionCytochrome P450 2D6Homo sapiens (human)
endoplasmic reticulumCytochrome P450 2D6Homo sapiens (human)
endoplasmic reticulum membraneCytochrome P450 2D6Homo sapiens (human)
cytoplasmCytochrome P450 2D6Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 2D6Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (56)

Assay IDTitleYearJournalArticle
AID682778Antibacterial activity against vancomycin-resistant Enterococcus faecium DSM 17050 at >1 ug/mL after 48 hrs2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682765Antibacterial activity against Escherichia coli ATCC 35218 expressing LacR2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID1537404Antibacterial activity against Klebsiella pneumoniae ATCC 35657 after 24 hrs by broth microdilution assay2019Journal of natural products, 02-22, Volume: 82, Issue:2
Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus.
AID682787Half life in Swiss mouse plasma at 7.5 mg/kg, iv2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID1537397Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 after 24 hrs by broth microdilution assay2019Journal of natural products, 02-22, Volume: 82, Issue:2
Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus.
AID682770Drug degradation in PBS buffer over 24 hrs in presence of i-BuNH22012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682780Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at >1 ug/mL after 48 hrs2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682923Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 infected in mouse assessed as log reduction in bacteremia at 10 mg/kg/day, iv relative to control2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682788Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 infected in mouse assessed as host survival at 20 mg/kg/day, sc relative to control2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682931Bacteriostatic activity against Escherichia coli ATCC 35218 expressing LacR by time kill study in presence of fetal calf serum2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID1537402Antibacterial activity against Acinetobacter baumannii ATCC 19606 after 24 hrs by broth microdilution assay2019Journal of natural products, 02-22, Volume: 82, Issue:2
Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus.
AID682763Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 335922012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682790Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 infected in mouse assessed as host survival at 80 mg/kg/day, sc relative to control2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID1537399Antibacterial activity against Enterococcus faecalis FA2-2 after 24 hrs by broth microdilution assay2019Journal of natural products, 02-22, Volume: 82, Issue:2
Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus.
AID682791Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 infected in mouse assessed as host survival at 3 mg/kg/day, iv relative to control2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682775Bacteriostatic activity against Pseudomonas aeruginosa ATCC 27853 by time kill study2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID1537403Antibacterial activity against Pseudomonas aeruginosa PAO1 after 24 hrs by broth microdilution assay2019Journal of natural products, 02-22, Volume: 82, Issue:2
Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus.
AID1537398Antibacterial activity against Enterococcus faecium ATCC 19434 after 24 hrs by broth microdilution assay2019Journal of natural products, 02-22, Volume: 82, Issue:2
Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus.
AID682772Bacteriostatic activity against penicillin-resistant Streptococcus pneumoniae DSM 11865 by time kill study2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682762Antibacterial activity against penicillin-resistant Streptococcus pneumoniae DSM 118652012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682773Bacteriostatic activity against vancomycin-resistant Enterococcus faecium DSM 17050 by time kill study2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682784Clearance in Swiss mouse at 7.5 mg/kg, iv2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682766Antibacterial activity against Pseudomonas aeruginosa ATCC 278532012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682793Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 infected in mouse assessed as host survival at 15 mg/kg/day, iv relative to control2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID1537396Antibacterial activity against Staphylococcus aureus Newman after 24 hrs by broth microdilution assay2019Journal of natural products, 02-22, Volume: 82, Issue:2
Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus.
AID682785Volume of distribution at steady state in Swiss mouse at 7.5 mg/kg, iv2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682922Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 infected in mouse assessed as log reduction in bacteremia at 3 mg/kg/day, iv relative to control2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682926Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 infected in iv dosed mouse assessed as increase in host survival2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682789Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 infected in mouse assessed as host survival at 40 mg/kg/day, sc relative to control2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID1537406Antibacterial activity against Shigella dysenteriae ATCC 13313 after 24 hrs by broth microdilution assay2019Journal of natural products, 02-22, Volume: 82, Issue:2
Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus.
AID682920Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 infected in mouse assessed as log reduction in bacteremia at 40 mg/kg/day, sc relative to control2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682924Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 infected in mouse assessed as log reduction in bacteremia at 15 mg/kg/day, iv relative to control2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID1537405Antibacterial activity against Salmonella typhimurium ATCC 14028 after 24 hrs by broth microdilution assay2019Journal of natural products, 02-22, Volume: 82, Issue:2
Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus.
AID682777Antibacterial activity against penicillin-resistant Streptococcus pneumoniae DSM 11865 at >1 ug/mL after 48 hrs2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682932Bacteriostatic activity against Pseudomonas aeruginosa ATCC 27853 by time kill study in presence of fetal calf serum2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682927Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 infected in iv dosed mouse assessed as decrease in bacteremia2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682792Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 infected in mouse assessed as host survival at 10 mg/kg/day, iv relative to control2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682764Antibacterial activity against vancomycin-resistant Enterococcus faecium DSM 170502012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682776Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 at >1 ug/mL after 48 hrs2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682779Antibacterial activity against Escherichia coli ATCC 35218 expressing LacR at >1 ug/mL after 48 hrs2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682771Bacteriostatic activity against methicillin-resistant Staphylococcus aureus ATCC 33592 by time kill study2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682783Inhibition of human ERG at 10 uM2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682795Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 infected in mouse assessed as log reduction in bacteremia at 20 mg/kg/day, sc relative to control2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID1537401Antibacterial activity against Escherichia coli MG1655 after 24 hrs by broth microdilution assay2019Journal of natural products, 02-22, Volume: 82, Issue:2
Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus.
AID682781Inhibition of CYP3A42012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682921Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 infected in mouse assessed as log reduction in bacteremia at 80 mg/kg/day, sc relative to control2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682929Bacteriostatic activity against penicillin-resistant Streptococcus pneumoniae DSM 11865 by time kill study in presence of fetal calf serum2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682774Bacteriostatic activity against Escherichia coli ATCC 35218 expressing LacR by time kill study2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682768Chemical stability of the compound in PBS buffer up to 24 hrs at pH 7.42012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682786Cmax in Swiss mouse at 7.5 mg/kg, iv2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682782Inhibition of CYP2D62012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID1537400Antibacterial activity against Bacillus subtilis 168 after 24 hrs by broth microdilution assay2019Journal of natural products, 02-22, Volume: 82, Issue:2
Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus.
AID682930Bacteriostatic activity against vancomycin-resistant Enterococcus faecium DSM 17050 by time kill study in presence of fetal calf serum2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682769Drug degradation in PBS buffer over 24 hrs in presence of GSH2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682928Bacteriostatic activity against methicillin-resistant Staphylococcus aureus ATCC 33592 by time kill study in presence of fetal calf serum2012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
AID682767Solubility of the compound in PBS buffer at pH 7.42012Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (50.00)24.3611
2020's3 (50.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.85

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.85 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.85)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
metronidazole
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.		2.4110C-nitro compound;
imidazoles;
primary alcohol		antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		3.3150pyrrole;
secondary amine
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.5220glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Helicobacter
[description not available]		02.4110
Helicobacter Infections
Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.		02.4110
Infections, Staphylococcal
[description not available]		02.0710
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.		02.0710